7,34 % | The Vanguard Group, Inc. | 10.130.061 | 4.027.497 | 31.12.2022 |
6,35 % | BlackRock Institutional Trust Company, N.A. | 8.757.830 | 1.460.583 | 31.12.2022 |
5,71 % | Deep Track Capital LP | 7.878.119 | 878.119 | 31.12.2022 |
4,89 % | Avoro Capital Advisors LLC | 6.750.000 | 850.000 | 31.12.2022 |
4,59 % | State Street Global Advisors (US) | 6.336.836 | 92.480 | 31.12.2022 |
3,73 % | TCG Crossover Management, LLC | 5.141.118 | 1.263.215 | 31.12.2022 |
3,47 % | T. Rowe Price Associates, Inc. | 4.788.545 | 1.392.712 | 31.12.2022 |
3,30 % | Janus Henderson Investors | 4.553.904 | -559.587 | 31.12.2022 |
3,26 % | Redmile Group, LLC | 4.502.111 | 1.102.211 | 31.12.2022 |
3,07 % | AllianceBernstein L.P. | 4.231.917 | 1.870.847 | 31.12.2022 |
2,62 % | Yiheng Capital Management, L.P. | 3.613.254 | 0 | 31.12.2022 |
2,48 % | Deerfield Management Company, L.P. | 3.424.852 | -2.176.148 | 31.12.2022 |
2,42 % | Braidwell LP | 3.341.300 | 3.341.300 | 31.12.2022 |
2,15 % | Point72 Asset Management, L.P. | 2.967.729 | 2.360.829 | 31.12.2022 |
1,75 % | Geode Capital Management, L.L.C. | 2.415.829 | 355.148 | 31.12.2022 |
1,73 % | DWS Investments UK Limited | 2.383.230 | 13.555 | 31.12.2022 |
1,57 % | Millennium Management LLC | 2.171.533 | 846.603 | 31.12.2022 |
1,57 % | Capital International Investors | 2.164.099 | 0 | 31.12.2022 |
1,53 % | Soleus Capital Management, L.P. | 2.114.728 | -387.873 | 31.12.2022 |
1,35 % | Polar Capital LLP | 1.868.628 | 0 | 31.12.2022 |
1,30 % | Armistice Capital LLC | 1.792.000 | 428.000 | 31.12.2022 |
1,24 % | Franklin Advisers, Inc. | 1.706.581 | -714 | 31.12.2022 |
1,09 % | Nuveen LLC | 1.508.711 | 134.188 | 31.12.2022 |
1,09 % | Samlyn Capital, LLC | 1.501.875 | 301.389 | 31.12.2022 |
1,09 % | Logos Global Management LLC | 1.500.000 | 0 | 31.12.2022 |
1,06 % | Farallon Capital Management, L.L.C. | 1.462.000 | 145.000 | 31.12.2022 |
1,04 % | Dimensional Fund Advisors, L.P. | 1.434.275 | -124.938 | 31.12.2022 |
0,99 % | Emerald Advisers LLC | 1.359.225 | -335.773 | 31.12.2022 |
0,96 % | American Century Investment Management, Inc. | 1.331.374 | 1.331.374 | 31.12.2022 |
0,93 % | Octagon Capital Advisors LP | 1.278.000 | 1.278.000 | 31.12.2022 |
0,86 % | Pura Vida Investments, LLC | 1.182.975 | 207.545 | 31.12.2022 |
0,84 % | Candriam Luxembourg S.A. | 1.160.832 | 25.000 | 31.1.2023 |
0,83 % | Goldman Sachs & Company, Inc. | 1.141.541 | 347.009 | 31.12.2022 |
0,82 % | Candriam Belgium S.A. | 1.135.832 | 533.000 | 31.12.2022 |
0,79 % | Northern Trust Investments, Inc. | 1.084.058 | 135.848 | 31.12.2022 |
0,78 % | Invesco Advisers, Inc. | 1.081.592 | 1.031.076 | 31.12.2022 |
0,77 % | BioImpact Capital LLC | 1.059.688 | 9.688 | 31.12.2022 |
0,77 % | Columbia Threadneedle Investments (US) | 1.056.364 | 813.701 | 31.12.2022 |
0,73 % | TimesSquare Capital Management, LLC | 1.011.640 | 953.640 | 31.12.2022 |
0,72 % | Invus Public Equities Advisors, LLC | 1.000.000 | 250.000 | 31.12.2022 |
0,70 % | Charles Schwab Investment Management, Inc. | 964.361 | 140.208 | 31.12.2022 |
0,67 % | PFM Health Sciences, LP | 917.557 | 661.273 | 31.12.2022 |
0,62 % | Kingdon Capital Management, L.L.C. | 853.000 | 853.000 | 31.12.2022 |
0,61 % | Balyasny Asset Management LP | 843.311 | -839.924 | 31.12.2022 |
0,61 % | Avidity Partners Management LP | 838.407 | 838.407 | 31.12.2022 |
0,60 % | Boxer Capital, L.L.C. | 825.000 | 825.000 | 31.12.2022 |
0,60 % | Great Point Partners, LLC | 825.000 | 825.000 | 31.12.2022 |
0,60 % | RTW Investments L.P. | 821.288 | -2.803.712 | 31.12.2022 |
0,59 % | D. E. Shaw & Co., L.P. | 812.967 | 726.378 | 31.12.2022 |
0,59 % | Samsara BioCapital, LLC | 808.041 | 0 | 31.12.2022 |
0,57 % | SEB Investment Management AB | 790.802 | -6.584 | 31.12.2022 |
0,57 % | Driehaus Capital Management, LLC | 782.722 | 31.232 | 31.12.2022 |
0,55 % | APG Asset Management N.V. | 762.721 | 696.975 | 30.6.2022 |
0,51 % | Finepoint Capital LP | 707.600 | -280.000 | 31.12.2022 |
0,46 % | Sofinnova Investments, Inc | 638.398 | -182.267 | 31.12.2022 |
0,44 % | Dafna Capital Management, LLC | 605.975 | 204.499 | 31.12.2022 |
0,43 % | Polar Asset Management Partners Inc. | 594.615 | -13.485 | 31.12.2022 |
0,43 % | Perceptive Advisors LLC | 587.400 | -446.769 | 31.12.2022 |
0,37 % | Ensign Peak Advisors, Inc. | 506.165 | -120.459 | 31.12.2022 |
0,37 % | Artia Global Partners LP | 504.615 | 504.615 | 31.12.2022 |
0,36 % | BofA Global Research (US) | 503.070 | 138.260 | 31.12.2022 |
0,34 % | Fidelity Management & Research Company LLC | 469.602 | -103.890 | 31.12.2022 |
0,33 % | Walleye Capital LLC | 454.815 | -187.136 | 31.12.2022 |
0,33 % | Ghost Tree Capital, LLC | 450.000 | -13.700 | 31.12.2022 |
0,32 % | JP Morgan Asset Management | 444.816 | 15.224 | 31.12.2022 |
0,31 % | Rhenman & Partners Asset Management AB | 430.000 | 65.000 | 31.12.2022 |
0,29 % | Rafferty Asset Management LLC | 398.356 | 25.594 | 31.12.2022 |
0,28 % | 5AM Ventures | 384.626 | -124.221 | 31.12.2022 |
0,27 % | Ikarian Capital LLC | 377.021 | -601.762 | 31.12.2022 |
0,27 % | Putnam Investment Management, L.L.C. | 376.909 | 232.209 | 31.12.2022 |
0,27 % | Asymmetry Capital Management, L.P | 375.989 | 20.593 | 31.12.2021 |
0,27 % | Voya Investment Management LLC | 373.531 | 171.434 | 31.12.2022 |
0,26 % | Acuta Capital Partners, LLC | 360.500 | -203.107 | 31.12.2022 |
0,26 % | BNY Mellon Asset Management | 355.796 | 39.027 | 31.12.2022 |
0,25 % | Eversept Partners, LP | 350.747 | 350.747 | 31.12.2022 |
0,25 % | BlackRock Investment Management, LLC | 350.441 | 45.191 | 31.12.2022 |
0,25 % | BlackRock Financial Management, Inc. | 350.009 | 55.348 | 31.12.2022 |
0,24 % | Invesco Capital Management LLC | 330.744 | -22.693 | 31.12.2022 |
0,22 % | J. Goldman & Co., L.P. | 305.378 | 270.971 | 31.12.2022 |
0,21 % | Thornburg Investment Management, Inc. | 294.841 | -14.427 | 31.12.2022 |
0,20 % | Schweizerische Nationalbank | 275.200 | 82.000 | 31.12.2022 |
0,20 % | UBS Financial Services, Inc. | 270.277 | 186.872 | 31.12.2022 |
0,19 % | Schonfeld Strategic Advisors LLC | 265.534 | 35.965 | 31.12.2022 |
0,18 % | Tri Locum Partners LP | 243.079 | 52.482 | 31.12.2022 |
0,17 % | SG Americas Securities, L.L.C. | 239.776 | 220.173 | 31.12.2022 |
0,17 % | Banque Lombard Odier & Cie SA | 235.559 | 173.942 | 31.12.2022 |
0,17 % | Lombard Odier Asset Management (Europe) Ltd | 235.484 | 69.199 | 31.12.2022 |
0,17 % | Barclays Bank PLC | 234.152 | -28.221 | 31.12.2022 |
0,17 % | Citadel Advisors LLC | 232.169 | -2.326.202 | 31.12.2022 |
0,17 % | Schroder Investment Management Ltd. (SIM) | 229.285 | 229.285 | 31.12.2022 |
0,17 % | Pier Capital, LLC | 228.752 | -3.230 | 31.12.2022 |
0,16 % | Sblendorio (Glenn P) | 227.087 | 14.053 | 3.1.2023 |
0,15 % | Mellon Investments Corporation | 211.360 | 125.254 | 31.12.2022 |
0,15 % | Moore Capital Management, LP | 210.000 | -29.944 | 31.12.2022 |
0,15 % | Nicholas Investment Partners, L.P. | 209.976 | 0 | 31.12.2022 |
0,15 % | Boothbay Fund Management, LLC | 207.977 | 27.908 | 31.12.2022 |
0,15 % | Lisanti Capital Growth, LLC | 201.760 | 201.760 | 31.12.2022 |
0,14 % | Alyeska Investment Group, L.P. | 200.000 | 200.000 | 31.12.2022 |
0,14 % | Sphera Funds Management Ltd. | 195.591 | -386.238 | 31.12.2022 |
0,14 % | Altium Capital Management LP | 190.000 | 65.000 | 31.12.2022 |