| 10,65346 % | The Vanguard Group, Inc. | 41.620.949 | 1.367.173 | |
| 5,59196 % | Baillie Gifford & Co. | 21.846.666 | -247.458 | |
| 5,02650 % | BlackRock Institutional Trust Company, N.A. | 19.637.528 | 1.762.948 | |
| 4,98112 % | Fidelity Management & Research Company LLC | 19.460.247 | -1.366.827 | |
| 4,42066 % | State Street Investment Management (US) | 17.270.631 | -507.927 | |
| 3,78184 % | Two Sigma Investments, LP | 14.774.908 | 6.512.305 | |
| 2,35760 % | Boston Biotech Ventures, L.L.C. | 9.210.686 | 0 | |
| 2,27226 % | Geode Capital Management, L.L.C. | 8.877.280 | 1.420.690 | |
| 2,01413 % | Theleme Partners LLP | 7.868.810 | 626.420 | |
| 1,91040 % | D. E. Shaw & Co., L.P. | 7.463.555 | 1.827.404 | |
| 1,68037 % | OCHA, L.L.C. | 6.564.880 | 0 | |
| 1,60424 % | Invesco Capital Management LLC | 6.267.436 | 1.091.957 | |
| 1,40624 % | Bancel (Stephane J) | 5.493.897 | 0 | |
| 1,18566 % | Flagship Ventures | 4.632.149 | 0 | |
| 1,16838 % | Morgan Stanley & Co. LLC | 4.564.637 | 167.910 | |
| 0,96799 % | Jane Street Capital, L.L.C. | 3.781.759 | 193.722 | |
| 0,88052 % | Norges Bank Investment Management (NBIM) | 3.439.999 | -500.195 | |
| 0,87116 % | Voloridge Investment Management, LLC | 3.403.434 | 142.888 | |
| 0,80135 % | Banque Pictet & Cie S.A. | 3.130.724 | -2.250 | |
| 0,77816 % | Charles Schwab Investment Management, Inc. | 3.040.117 | 410.252 | |
| 0,72927 % | Susquehanna International Group, LLP | 2.849.112 | 1.620.401 | |
| 0,72923 % | Federated MDTA LLC | 2.848.944 | 2.232.933 | |
| 0,65883 % | BlackRock Asset Management Ireland Limited | 2.573.907 | -469.874 | |
| 0,64735 % | Parametric Portfolio Associates LLC | 2.529.068 | 593.944 | |
| 0,63664 % | Northern Trust Investments, Inc. | 2.487.243 | 42.631 | |
| 0,63176 % | BlackRock Financial Management, Inc. | 2.468.165 | 769.574 | |
| 0,62548 % | Citi Investment Research (US) | 2.443.644 | -65.288 | |
| 0,59081 % | Merck & Co Inc | 2.308.190 | 0 | |
| 0,56927 % | Afeyan (Noubar Boghos) | 2.224.015 | 0 | |
| 0,55539 % | BlackRock Investment Management (UK) Ltd. | 2.169.800 | 303.152 | |
| 0,52924 % | UBS Switzerland AG | 2.067.624 | -1.796.860 | |
| 0,47879 % | UBS Financial Services, Inc. | 1.870.555 | -626.091 | |
| 0,46962 % | Citadel Advisors LLC | 1.834.708 | 74.423 | |
| 0,45566 % | Barclays Bank PLC | 1.780.158 | 763.594 | |
| 0,41199 % | Hoge (Stephen) | 1.609.561 | 0 | |
| 0,40571 % | Goldman Sachs Asset Management, L.P. | 1.585.017 | 187.150 | |
| 0,38022 % | BofA Global Research (US) | 1.485.457 | 520.123 | |
| 0,36505 % | Legal & General Investment Management Ltd. | 1.426.164 | -845.459 | |
| 0,35770 % | Capital Fund Management S.A. | 1.397.477 | 895.400 | |
| 0,34451 % | Jacobs Levy Equity Management, Inc. | 1.345.950 | 347.447 | |
| 0,33668 % | Goldman Sachs Bank AG | 1.315.332 | 320 | |
| 0,31705 % | Bellevue Asset Management AG | 1.238.668 | -279.454 | |
| 0,31559 % | First Trust Advisors L.P. | 1.232.952 | 318.183 | |
| 0,31359 % | BNP Paribas Securities Corp. North America | 1.225.135 | -222.939 | |
| 0,28884 % | Douglas C. Lane & Associates | 1.128.434 | 198.269 | |
| 0,28837 % | UBS Asset Management (Switzerland) | 1.126.610 | -238.912 | |
| 0,28545 % | DWS Investments UK Limited | 1.115.187 | -290.089 | |
| 0,28398 % | Dimensional Fund Advisors, L.P. | 1.109.467 | -421.563 | |
| 0,25696 % | Renaissance Technologies LLC | 1.003.900 | -356.200 | |
| 0,25596 % | Deerfield Management Company, L.P. | 1.000.000 | 1.000.000 | |
| 0,24003 % | UBS Asset Management (UK) Ltd. | 937.765 | -173.884 | |
| 0,23502 % | Letko, Brosseau & Associates Inc. | 918.190 | 21.765 | |
| 0,23278 % | Amundi Asset Management, SAS | 909.429 | -424.445 | |
| 0,23247 % | Nuveen LLC | 908.207 | 245.010 | |
| 0,22256 % | Millennium Management LLC | 869.492 | 720.698 | |
| 0,21516 % | WorldQuant Millennium Advisors LLC | 840.595 | 840.595 | |
| 0,21397 % | J.P. Morgan Securities LLC | 835.925 | 827.279 | |
| 0,21226 % | Invesco Advisers, Inc. | 829.248 | 139.078 | |
| 0,20451 % | J.P. Morgan Securities plc | 798.972 | 627.866 | |
| 0,19020 % | Sessa Capital | 743.081 | 0 | |
| 0,18800 % | RBC Capital Markets Wealth Management | 734.464 | 130.568 | |
| 0,18401 % | Mellon Investments Corporation | 718.884 | -295.094 | |
| 0,17989 % | BNY Mellon Asset Management | 702.792 | -75.837 | |
| 0,17470 % | Pictet Asset Management Ltd. | 682.499 | 2.751 | |
| 0,16988 % | Schweizerische Nationalbank | 663.700 | -258.800 | |
| 0,16865 % | TB Alternative Assets Ltd. | 658.881 | -602.072 | |
| 0,16499 % | Acadian Asset Management LLC | 644.571 | 477.072 | |
| 0,15943 % | Rhumbline Advisers Ltd. Partnership | 622.857 | 25.390 | |
| 0,15436 % | BlackRock Investment Management, LLC | 603.071 | 153.143 | |
| 0,15387 % | CPP Investment Board | 601.146 | 232.874 | |
| 0,15170 % | UBS Asset Management (Americas) LLC | 592.651 | -288.930 | |
| 0,15158 % | National Bank of Canada | 592.194 | -432.917 | |
| 0,13711 % | Tudor Investment Corporation | 535.665 | 219.273 | |
| 0,13535 % | Pictet Asset Management (Japan) Ltd. | 528.773 | 23.668 | |
| 0,13238 % | Suvretta Capital Management, LLC | 517.163 | 0 | |
| 0,12852 % | HSBC Global Asset Management (UK) Limited | 502.083 | -49.626 | |
| 0,12682 % | Goldman Sachs & Company, Inc. | 495.463 | 7.747 | |
| 0,12648 % | Sagan (Paul L) | 494.133 | 0 | |
| 0,12136 % | T. Rowe Price International Ltd | 474.138 | -18.773 | |
| 0,11395 % | California Public Employees' Retirement System | 445.190 | 73.654 | |
| 0,11366 % | Aperio Group, LLC | 444.034 | 57.031 | |
| 0,11229 % | IMC Chicago, LLC | 438.683 | -53.574 | |
| 0,11193 % | Morgan Stanley Smith Barney LLC | 437.290 | -167.420 | |
| 0,10947 % | AllianceBernstein L.P. | 427.664 | 73.896 | |
| 0,10649 % | Mitsubishi UFJ Asset Management Co., Ltd. | 416.020 | -243.230 | |
| 0,10332 % | BlackRock (Netherlands) B.V. | 403.644 | -511.969 | |
| 0,10100 % | Rafferty Asset Management LLC | 394.599 | 45.740 | |
| 0,10007 % | Manulife Investment Management (North America) Limited | 390.954 | 688 | |
| 0,09991 % | Carson Wealth Management Group | 390.333 | 130.200 | |
| 0,09772 % | Simplex Trading, LLC | 381.787 | 190.557 | |
| 0,09565 % | Group One Trading, L.P. | 373.688 | -70.750 | |
| 0,09550 % | Lingotto Investment Management LLP | 373.095 | 0 | |
| 0,09512 % | Principal Global Investors (Equity) | 371.612 | -9 | |
| 0,09294 % | JPMorgan Private Bank (United States) | 363.106 | 6.010 | |
| 0,09108 % | UBS Fund Management (Switzerland) AG | 355.821 | 124.767 | |
| 0,08822 % | Boston Management and Research | 344.651 | 0 | |
| 0,08381 % | California State Teachers Retirement System | 327.429 | -168.739 | |
| 0,08310 % | Pictet & Cie (Europe) S.A. | 324.665 | -409.021 | |
| 0,08143 % | Florida State Board of Administration | 318.137 | -12.749 | |
| 0,08041 % | Peak6 Capital Management LLC | 314.138 | 48.888 | |