| 19,74150 % | BVF Partners L.P. | 19.822.436 | 0 | |
| 16,25012 % | DH Capital GmbH & Co. KG | 16.316.742 | 0 | |
| 11,95100 % | Varuma AG | 11.999.999 | 0 | |
| 6,40185 % | Affiris AG | 6.428.100 | -150.000 | |
| 2,94400 % | Pfeifer (Andrea M. A Ph.D.) | 2.956.067 | 534.841 | |
| 1,02042 % | Wells Fargo Advisors | 1.024.608 | 26.987 | |
| 0,82494 % | Renaissance Technologies LLC | 828.321 | 24.852 | |
| 0,41001 % | Acadian Asset Management LLC | 411.696 | 40.519 | |
| 0,37916 % | Northern Trust Global Investments Limited | 380.714 | 3.628 | |
| 0,36232 % | BlackRock Institutional Trust Company, N.A. | 363.803 | -29.712 | |
| 0,29034 % | Millennium Management LLC | 291.532 | 78.782 | |
| 0,25234 % | DWS Investment GmbH | 253.375 | 0 | |
| 0,19787 % | Dimensional Fund Advisors, L.P. | 198.686 | -38.872 | |
| 0,18912 % | Assenagon Asset Management S.A. | 189.892 | 155.740 | |
| 0,14540 % | Citadel Advisors LLC | 145.999 | -5.462 | |
| 0,13943 % | Lanthaler (Werner) | 140.003 | 16.819 | |
| 0,13529 % | Marshall Wace LLP | 135.841 | -76.343 | |
| 0,12947 % | ARIAD Asset Management GmbH | 130.000 | 0 | |
| 0,10457 % | Handelsbanken Kapitalförvaltning AB | 105.000 | -25.000 | |
| 0,10034 % | Eversept Partners, LP | 100.752 | 0 | |
| 0,06930 % | Two Sigma Investments, LP | 69.585 | 45.975 | |
| 0,06334 % | Geode Capital Management, L.L.C. | 63.601 | -489 | |
| 0,06217 % | Morgan Stanley Smith Barney LLC | 62.424 | 0 | |
| 0,06012 % | Dimensional Fund Advisors, Ltd. | 60.362 | -173 | |
| 0,05777 % | Williams (Douglas E) | 58.008 | 19.079 | |
| 0,05667 % | BlackRock Advisors (UK) Limited | 56.901 | 1.718 | |
| 0,05076 % | Twyman (Roy M.D.) | 50.969 | 16.819 | |
| 0,04731 % | BlackRock Asset Management Ireland Limited | 47.504 | -855 | |
| 0,04561 % | Donati (Piergiorgio) | 45.800 | 21.279 | |
| 0,04063 % | Donovan (Howard) | 40.797 | 20.661 | |
| 0,03789 % | Roberts (Christopher) | 38.048 | 25.447 | |
| 0,02988 % | Cantor Fitzgerald, L.P | 30.000 | 10.000 | |
| 0,02699 % | Butler (Monika) | 27.099 | 17.949 | |
| 0,02678 % | Renta 4 Gestora, S.G.I.I.C., S.A. | 26.889 | -115 | |
| 0,02586 % | June (Carl) | 25.969 | 16.819 | |
| 0,02487 % | Shaw (Monica M.D.) | 24.969 | 15.819 | |
| 0,02480 % | SEI Investments Management Corporation | 24.897 | 0 | |
| 0,02008 % | China Universal Asset Management Co., Ltd. | 20.167 | 330 | |
| 0,01836 % | Banque Cantonale Vaudoise | 18.440 | -8.272 | |
| 0,01259 % | Squarepoint Capital LLP | 12.642 | -9.764 | |
| 0,01039 % | Victory Capital Management Inc. | 10.434 | 0 | |
| 0,01033 % | Goldman Sachs & Company, Inc. | 10.369 | 10.369 | |
| 0,01006 % | Quinn Opportunity Partners LLC | 10.100 | 0 | |
| 0,00996 % | Silverberg Bernstein Capital Management, LLC | 10.000 | 0 | |
| 0,00995 % | Morgan Stanley & Co. LLC | 9.991 | 476 | |
| 0,00976 % | Post (Anke) | 9.804 | 9.804 | |
| 0,00954 % | Schroder Investment Management North America Inc. | 9.575 | 0 | |
| 0,00787 % | Barclays Bank PLC | 7.907 | 498 | |
| 0,00744 % | UBS Financial Services, Inc. | 7.467 | -9.221 | |
| 0,00686 % | Mercer Global Investments Management Ltd | 6.892 | 0 | |
| 0,00609 % | J.P. Morgan Securities plc | 6.110 | -997 | |
| 0,00555 % | BofA Global Research (US) | 5.573 | 3.062 | |
| 0,00511 % | Tennessee Consolidated Retirement System | 5.126 | 0 | |
| 0,00437 % | Mirae Asset Global Investments Co., Ltd. | 4.387 | -419 | |
| 0,00431 % | MFS Investment Management | 4.330 | 0 | |
| 0,00389 % | DFA Australia Ltd. | 3.907 | 3.337 | |
| 0,00386 % | Mirae Asset Global Investments (USA) LLC | 3.879 | 570 | |
| 0,00376 % | Invesco Capital Management LLC | 3.774 | 168 | |
| 0,00356 % | ProShare Advisors LLC | 3.577 | 48 | |
| 0,00306 % | Tower Research Capital LLC | 3.075 | -3.789 | |
| 0,00244 % | GF Fund Management Co., Ltd. | 2.454 | 0 | |
| 0,00191 % | Citi Investment Research (US) | 1.915 | 476 | |
| 0,00166 % | BlackRock Fund Advisors | 1.668 | 0 | |
| 0,00154 % | RBC Dominion Securities, Inc. | 1.550 | 790 | |
| 0,00132 % | BNP Paribas Securities Corp. North America | 1.327 | 116 | |
| 0,00129 % | Bessemer Trust Company, N.A. (US) | 1.295 | 1.295 | |
| 0,00100 % | Activest Wealth Management LLC | 1.000 | 0 | |
| 0,00073 % | RBC Capital Markets Wealth Management | 734 | 624 | |
| 0,00064 % | Northern Trust Global Investments | 640 | 640 | |
| 0,00056 % | SBI Securities Co., Ltd. | 565 | 4 | |
| 0,00041 % | Parametric Portfolio Associates LLC | 415 | 415 | |
| 0,00037 % | Capital Investment Trust Corporation | 367 | 0 | |
| 0,00032 % | Simplex Trading, LLC | 318 | 34 | |
| 0,00025 % | Osaic Holdings, Inc. | 251 | 251 | |
| 0,00020 % | Blackstone Alternative Investment Advisors LLC | 200 | 100 | |
| 0,00020 % | Hoopoe Advisors | 200 | 0 | |
| 0,00009 % | RBC Wealth Management, International | 94 | 94 | |
| 0,00006 % | Morgan Stanley & Co. International Plc | 65 | 0 | |
| 0 % | Qube Research & Technologies Ltd | 0 | -48 | |
| 0 % | Vanguard Capital Wealth Advisors, LLC. | 0 | -14.000 | |
| 0 % | Schonfeld Strategic Advisors LLC | 0 | -11.400 | |
| 0 % | Man Investments Inc | 0 | -37 | |
| 0 % | Watch Point Trust Company LLC | 0 | -12.850 | |
| 0 % | Boothbay Fund Management, LLC | 0 | -14.046 | |
| 0 % | Cubist Systematic Strategies, LLC | 0 | -11.667 | |
| 0 % | Compagnie Lombard Odier SCmA | 0 | -10.000 | |
| 0 % | Group One Trading, L.P. | 0 | -24.074 | |
| 0 % | Landscape Capital Management, L.L.C. | 0 | -117.418 | |
| 0 % | Virtu Americas LLC | 0 | -11.552 | |
| 0 % | Alps Advisors, Inc. | 0 | -76.630 | |
| 0 % | Redmile Group, LLC | 0 | -1.034.299 | |
| 0 % | Jane Street Capital, L.L.C. | 0 | -24.283 | |
| 0 % | Man Investments, Ltd. | 0 | -19 | |
| 0 % | RBC Capital Partners | 0 | -987 | |
| 0 % | Scoggin Management LP | 0 | -84.401 | |
| 0 % | SEI Investments Canada | 0 | -7.507 | |
| 0 % | Platinum Asset Management | 0 | -739.342 | |
| 0 % | Nomura Securities Co., Ltd. | 0 | -20.000 | |
| 0 % | BlackRock Investment Management (UK) Ltd. | 0 | -54.274 | |
| 0 % | Edmond de Rothschild Asset Management (France) S.A. | 0 | -2.000 | |