| 10,68477 % | ARK Investment Management LLC | 10.182.590 | 17.190 | |
| 5,86962 % | Capital International Investors | 5.593.747 | -479.371 | |
| 5,68625 % | BlackRock Institutional Trust Company, N.A. | 5.418.993 | 3.004.147 | |
| 3,86467 % | T. Rowe Price Investment Management, Inc. | 3.683.026 | -115.077 | |
| 3,43190 % | State Street Investment Management (US) | 3.270.596 | 859.334 | |
| 3,03323 % | Two Sigma Investments, LP | 2.890.666 | 904.307 | |
| 2,90087 % | Orbis Investment Management Ltd. | 2.764.532 | 1.201.600 | |
| 2,71515 % | UBS Financial Services, Inc. | 2.587.541 | 859.429 | |
| 2,53334 % | Amova Asset Management Americas, Inc | 2.414.271 | -125.618 | |
| 2,39144 % | The Vanguard Group, Inc. | 2.279.038 | 528.380 | |
| 2,27038 % | Amova Asset Management Co., Ltd. | 2.163.675 | -251.163 | |
| 2,17406 % | Geode Capital Management, L.L.C. | 2.071.883 | 1.025.979 | |
| 2,02430 % | Fidelity Management & Research Company LLC | 1.929.154 | -11.391 | |
| 1,66616 % | New Enterprise Associates (NEA) | 1.587.854 | 0 | |
| 1,45779 % | EcoR1 Capital, LLC | 1.389.276 | 0 | |
| 1,41695 % | BofA Global Research (US) | 1.350.349 | 55.367 | |
| 1,10068 % | George (Simeon J.) | 1.048.951 | 0 | |
| 1,10068 % | SR One Capital Management, LP | 1.048.951 | 0 | |
| 0,97923 % | Charles Schwab Investment Management, Inc. | 933.204 | 219.665 | |
| 0,96297 % | Dimensional Fund Advisors, L.P. | 917.712 | -19.433 | |
| 0,89915 % | Loomis, Sayles & Company, L.P. | 856.887 | -52.905 | |
| 0,80792 % | Susquehanna International Group, LLP | 769.945 | 478.929 | |
| 0,77188 % | National Bank of Canada | 735.600 | 735.600 | |
| 0,73000 % | Northern Trust Investments, Inc. | 695.691 | 504.099 | |
| 0,52315 % | Versant Ventures | 498.558 | 0 | |
| 0,51186 % | BMO Capital Markets (US) | 487.800 | 487.800 | |
| 0,50889 % | Vestmark Advisory Solutions, Inc | 484.975 | 259.669 | |
| 0,47405 % | UBS Asset Management (Switzerland) | 451.770 | -663.966 | |
| 0,44124 % | UBS Asset Management (Americas) LLC | 420.500 | -330.776 | |
| 0,42653 % | Norges Bank Investment Management (NBIM) | 406.487 | -37.049 | |
| 0,39763 % | Barclays Bank PLC | 378.937 | 290.190 | |
| 0,39345 % | Contrarius Investment Management Ltd. | 374.954 | 42.982 | |
| 0,37388 % | Jump Financial, LLC | 356.306 | 356.306 | |
| 0,35658 % | Kulkarni (Samarth) | 339.823 | 53.197 | |
| 0,27501 % | Columbia Threadneedle Investments (US) | 262.089 | 44.029 | |
| 0,26963 % | BlackRock Financial Management, Inc. | 256.955 | 228.760 | |
| 0,26866 % | UBS Switzerland AG | 256.036 | -87.744 | |
| 0,24916 % | Morgan Stanley Smith Barney LLC | 237.453 | -1.728 | |
| 0,24756 % | Pictet Asset Management Ltd. | 235.920 | -10.166 | |
| 0,23991 % | Pictet Asset Management (Japan) Ltd. | 228.635 | 3.035 | |
| 0,23968 % | TD Asset Management Inc. | 228.416 | -13.904 | |
| 0,22141 % | BlackRock Investment Management, LLC | 211.006 | 211.006 | |
| 0,21914 % | JPMorgan Asset Management U.K. Limited | 208.836 | -11.485 | |
| 0,21014 % | Morgan Stanley & Co. LLC | 200.259 | -824.653 | |
| 0,20525 % | IQ EQ Fund Management (Ireland) Limited | 195.602 | 130.407 | |
| 0,20418 % | LPL Financial LLC | 194.579 | 9.121 | |
| 0,18944 % | Wells Fargo Advisors | 180.541 | -84.735 | |
| 0,18509 % | Nuveen LLC | 176.387 | 176.387 | |
| 0,16411 % | Schweizerische Nationalbank | 156.400 | -700 | |
| 0,15990 % | Goldman Sachs & Company, Inc. | 152.383 | 21.258 | |
| 0,15815 % | BNY Mellon Asset Management | 150.720 | 131.272 | |
| 0,15663 % | Woodline Partners LP | 149.267 | 12.784 | |
| 0,15532 % | BlackRock Advisors (UK) Limited | 148.019 | 3.002 | |
| 0,15267 % | Mellon Investments Corporation | 145.497 | 92.808 | |
| 0,14000 % | T. Rowe Price Associates, Inc. | 133.424 | 10.956 | |
| 0,13778 % | Nordea Funds Oy | 131.300 | 3.800 | |
| 0,13596 % | Legal & General Investment Management Ltd. | 129.567 | 48.412 | |
| 0,13315 % | Citi Investment Research (US) | 126.892 | -78.756 | |
| 0,13000 % | Rhumbline Advisers Ltd. Partnership | 123.893 | 123.893 | |
| 0,12105 % | Rockefeller Capital Management | 115.356 | 24.853 | |
| 0,11999 % | Rafferty Asset Management LLC | 114.348 | -31.684 | |
| 0,11747 % | Private Advisor Group LLC | 111.949 | 3.531 | |
| 0,11693 % | Reynders, McVeigh Capital Management, LLC | 111.431 | 9.658 | |
| 0,11619 % | BlackRock Asset Management Ireland Limited | 110.730 | 8.057 | |
| 0,11410 % | Mirae Asset Global Investments (USA) LLC | 108.734 | 30.584 | |
| 0,10874 % | California Public Employees' Retirement System | 103.628 | 8.011 | |
| 0,10679 % | Northwest Asset Management | 101.769 | 83.454 | |
| 0,10662 % | RBC Capital Markets Wealth Management | 101.605 | -2.387 | |
| 0,10493 % | Integral Health Asset Management, LLC | 100.000 | -50.000 | |
| 0,10290 % | Managed Account Advisors LLC | 98.066 | 6.278 | |
| 0,09780 % | Marshall & Melhorn LLC | 93.205 | 0 | |
| 0,09753 % | EverSource Wealth Advisors, LLC | 92.943 | 8.063 | |
| 0,09603 % | Capital International Sarl | 91.517 | -11.425 | |
| 0,09089 % | AllianceBernstein L.P. | 86.620 | 86.620 | |
| 0,08816 % | Wealth Enhancement Advisory Services, LLC | 84.016 | 1.409 | |
| 0,08722 % | Himension Capital (Singapore) Pte. Ltd | 83.120 | -10.454 | |
| 0,08710 % | Van Eck Associates Corporation | 83.010 | 0 | |
| 0,08685 % | Kasinger (James R.) | 82.767 | 1.038 | |
| 0,07975 % | SELECTRA Management Company S.A. | 76.000 | 0 | |
| 0,07975 % | ACATIS Investment Kapitalverwaltungsgesellschaft GmbH | 76.000 | 0 | |
| 0,07860 % | California State Teachers Retirement System | 74.907 | 5.165 | |
| 0,07690 % | Slow Capital, Inc. | 73.287 | -2.109 | |
| 0,07355 % | Millennium Management LLC | 70.093 | -513.640 | |
| 0,07250 % | Commonwealth Financial Network | 69.097 | 6.523 | |
| 0,07158 % | Goldman Sachs Asset Management, L.P. | 68.217 | 52.014 | |
| 0,07147 % | Congress Asset Management Company, LLP | 68.110 | -294 | |
| 0,07129 % | Envestnet Asset Management, Inc. | 67.942 | -116 | |
| 0,06964 % | T. Rowe Price International Ltd | 66.367 | 39.004 | |
| 0,06910 % | Dimensional Fund Advisors, Ltd. | 65.855 | -16.204 | |
| 0,06823 % | UBS Fund Management (Switzerland) AG | 65.021 | -646 | |
| 0,06699 % | Del-Sette Capital Management, LLC | 63.843 | 63.843 | |
| 0,06459 % | Capital International Ltd. | 61.552 | -10.511 | |
| 0,06412 % | Raymond James Financial Services Advisors, Inc. | 61.105 | 4.538 | |
| 0,06226 % | Lazard Asset Management, L.L.C. | 59.333 | -4.357 | |
| 0,06137 % | Guggenheim Investments | 58.488 | -37.778 | |
| 0,06034 % | Saint Olive Gestion | 57.500 | 0 | |
| 0,06008 % | DWS Investments UK Limited | 57.260 | 51.860 | |
| 0,05773 % | Green Alpha Investments | 55.012 | -3.451 | |
| 0,05689 % | Benjamin Edwards, Inc | 54.220 | -3.540 | |
| 0,05605 % | Harris Associates L.P. | 53.418 | -294 | |