9,53 % | Fidelity Management & Research Company LLC | 6 423 322 | 3 291 775 | 31. 12. 2023 |
7,97 % | Pfizer Inc | 5 376 344 | 5 376 344 | 23. 12. 2022 |
6,57 % | VR Adviser, LLC | 4 428 385 | 2 000 000 | 22. 1. 2024 |
6,36 % | Nextech Invest, Ltd. | 4 285 714 | 0 | 31. 12. 2023 |
6,14 % | Frazier Healthcare Partners | 4 142 855 | 2 000 000 | 23. 1. 2024 |
5,93 % | Viking Global Investors LP | 4 000 000 | 4 000 000 | 20. 1. 2024 |
5,29 % | The Column Group LP | 3 568 181 | 0 | 31. 12. 2023 |
5,07 % | EcoR1 Capital, LLC | 3 418 068 | 0 | 31. 12. 2023 |
4,45 % | Alkeon Capital Management LLC | 3 001 241 | 89 828 | 31. 12. 2023 |
4,12 % | BlackRock Institutional Trust Company, N.A. | 2 778 872 | -701 474 | 31. 12. 2023 |
3,34 % | The Vanguard Group, Inc. | 2 252 519 | -336 350 | 31. 12. 2023 |
2,57 % | ArrowMark Colorado Holdings, LLC | 1 733 819 | 83 863 | 31. 12. 2023 |
2,57 % | Boxer Capital, L.L.C. | 1 732 571 | 0 | 31. 12. 2023 |
2,34 % | Prosight Capital | 1 578 263 | -1 001 539 | 31. 12. 2023 |
1,74 % | SilverArc Capital Management, LLC | 1 170 000 | 46 655 | 31. 12. 2023 |
1,49 % | Invus Financial Advisors, LLC | 1 007 575 | 0 | 31. 12. 2023 |
1,47 % | Euclidean Capital, L.L.C. | 989 410 | 0 | 31. 12. 2023 |
1,30 % | Geode Capital Management, L.L.C. | 874 891 | 54 444 | 31. 12. 2023 |
1,26 % | Vivo Capital, LLC | 849 681 | 71 737 | 31. 12. 2023 |
1,18 % | State Street Global Advisors (US) | 793 074 | 74 060 | 31. 12. 2023 |
1,11 % | Franklin Advisers, Inc. | 750 336 | 10 | 31. 12. 2023 |
1,07 % | Chacko (Jacob M) | 720 780 | -40 000 | 6. 3. 2024 |
1,00 % | Altium Capital Management LP | 676 000 | 257 294 | 31. 12. 2023 |
0,98 % | Janus Henderson Investors | 659 054 | 659 054 | 31. 12. 2023 |
0,94 % | T. Rowe Price Associates, Inc. | 632 686 | 605 854 | 31. 12. 2023 |
0,89 % | Oppenheimer Asset Management Inc. | 602 855 | 34 979 | 31. 12. 2023 |
0,89 % | Memorial Sloan-Kettering Cancer Center | 602 272 | 0 | 30. 9. 2023 |
0,86 % | Fidelity Institutional Asset Management | 578 786 | 578 139 | 31. 12. 2023 |
0,78 % | OrbiMed Advisors, LLC | 522 968 | -370 700 | 31. 12. 2023 |
0,77 % | Point72 Asset Management, L.P. | 521 142 | 521 142 | 31. 12. 2023 |
0,54 % | Morgan Stanley & Co. LLC | 364 317 | 344 043 | 31. 12. 2023 |
0,52 % | Invesco Capital Management LLC | 351 317 | 24 150 | 31. 12. 2023 |
0,47 % | Northern Trust Investments, Inc. | 320 117 | 11 612 | 31. 12. 2023 |
0,42 % | Monaco asset management S.A.M. | 280 000 | -104 793 | 31. 12. 2023 |
0,39 % | UBS O'Connor LLC | 262 956 | -88 546 | 31. 12. 2023 |
0,34 % | Heyman (Richard A) | 228 772 | 0 | 31. 3. 2023 |
0,28 % | Renaissance Technologies LLC | 188 500 | -191 300 | 31. 12. 2023 |
0,23 % | BlackRock Financial Management, Inc. | 152 403 | 29 612 | 31. 12. 2023 |
0,21 % | Driehaus Capital Management, LLC | 143 943 | 0 | 31. 12. 2023 |
0,20 % | Two Sigma Investments, LP | 136 710 | 79 096 | 31. 12. 2023 |
0,20 % | Nuveen LLC | 135 009 | -34 010 | 31. 12. 2023 |
0,19 % | Sphera Funds Management Ltd. | 126 800 | 126 800 | 31. 12. 2023 |
0,19 % | Victory Capital Management Inc. | 126 030 | 1 180 | 31. 12. 2023 |
0,17 % | BlackRock Investment Management, LLC | 115 595 | -835 | 31. 12. 2023 |
0,16 % | Rafferty Asset Management LLC | 111 146 | 111 146 | 31. 3. 2024 |
0,16 % | Charles Schwab Investment Management, Inc. | 106 601 | 719 | 31. 12. 2023 |
0,16 % | BofA Global Research (US) | 105 690 | -27 416 | 31. 12. 2023 |
0,15 % | Parametric Portfolio Associates LLC | 102 087 | 13 478 | 31. 12. 2023 |
0,15 % | D. E. Shaw & Co., L.P. | 98 433 | -209 046 | 31. 12. 2023 |
0,14 % | BNY Mellon Asset Management | 97 077 | 4 263 | 31. 12. 2023 |
0,14 % | Caption Management, LLC | 95 260 | 95 260 | 31. 12. 2023 |
0,12 % | Wilmington Trust Investment Advisors, Inc. | 83 847 | 12 898 | 31. 12. 2023 |
0,12 % | TD Asset Management Inc. | 80 800 | 80 800 | 31. 12. 2023 |
0,11 % | Piscitelli (Dominic G.) | 76 045 | 8 760 | 15. 12. 2023 |
0,11 % | Dafna Capital Management, LLC | 72 797 | 72 797 | 31. 12. 2023 |
0,11 % | Wellington Management Company, LLP | 72 397 | -321 338 | 31. 12. 2023 |
0,09 % | Avantis Investors | 63 749 | 23 617 | 31. 3. 2024 |
0,09 % | Rhumbline Advisers Ltd. Partnership | 57 904 | -677 | 31. 12. 2023 |
0,08 % | Susquehanna International Group, LLP | 54 389 | 44 300 | 31. 12. 2023 |
0,08 % | Barclays Bank PLC | 54 199 | 46 484 | 31. 12. 2023 |
0,07 % | American Century Investment Management, Inc. | 49 550 | 17 114 | 31. 12. 2023 |
0,07 % | Manulife Investment Management (North America) Limited | 47 831 | 31 448 | 31. 12. 2023 |
0,07 % | Assenagon Asset Management S.A. | 45 759 | 11 222 | 29. 2. 2024 |
0,06 % | UBS Financial Services, Inc. | 40 973 | 23 701 | 31. 12. 2023 |
0,06 % | Atom Investors LP | 40 547 | 6 306 | 31. 12. 2023 |
0,06 % | Campbell & Company, Inc. | 37 619 | 37 619 | 31. 12. 2023 |
0,05 % | BlackRock Advisors (UK) Limited | 35 789 | 1 696 | 31. 3. 2024 |
0,05 % | Jane Street Capital, L.L.C. | 35 274 | 8 465 | 31. 12. 2023 |
0,05 % | Northern Trust Global Investments | 33 080 | -1 315 | 31. 12. 2023 |
0,04 % | Goldman Sachs & Company, Inc. | 28 749 | 1 907 | 31. 12. 2023 |
0,04 % | BlackRock Asset Management Ireland Limited | 26 805 | 26 805 | 31. 12. 2023 |
0,04 % | Squarepoint Capital LLP | 26 056 | 26 056 | 31. 12. 2023 |
0,04 % | JPMorgan Private Bank (United States) | 25 818 | 25 818 | 31. 12. 2023 |
0,04 % | Dimensional Fund Advisors, L.P. | 24 676 | -16 | 31. 12. 2023 |
0,04 % | GSA Capital Partners LLP | 24 515 | -9 503 | 31. 12. 2023 |
0,03 % | Legato Capital Management LLC | 23 100 | 23 100 | 31. 3. 2024 |
0,03 % | Bridgeway Capital Management, LLC | 22 500 | -26 200 | 31. 12. 2023 |
0,03 % | Mirae Asset Global Investments (USA) LLC | 22 043 | 1 362 | 31. 12. 2023 |
0,03 % | Goldman Sachs Asset Management, L.P. | 22 039 | 725 | 31. 12. 2023 |
0,03 % | Mellon Investments Corporation | 21 602 | 0 | 31. 12. 2023 |
0,03 % | Aperio Group, LLC | 21 471 | 8 934 | 31. 12. 2023 |
0,03 % | Jasper Ridge Partners, L.P. | 20 870 | 0 | 31. 12. 2023 |
0,03 % | MetLife Investment Management, LLC | 20 737 | 0 | 31. 12. 2023 |
0,03 % | DWS Investments UK Limited | 20 174 | -584 | 31. 12. 2023 |
0,03 % | SunAmerica Asset Management, LLC | 19 401 | -79 | 31. 12. 2023 |
0,03 % | T. Rowe Price International Ltd | 18 875 | 592 | 31. 12. 2023 |
0,03 % | Invesco Advisers, Inc. | 17 905 | 3 535 | 31. 12. 2023 |
0,02 % | Voya Investment Management LLC | 16 457 | 526 | 31. 12. 2023 |
0,02 % | Multani Pratik S | 16 045 | 8 760 | 15. 12. 2023 |
0,02 % | Vaughan Nelson Investment Management, L.P. | 15 609 | 0 | 31. 12. 2023 |
0,02 % | AllianceBernstein L.P. | 15 320 | 0 | 31. 12. 2023 |
0,02 % | AQR Capital Management, LLC | 14 146 | 2 947 | 31. 12. 2023 |
0,02 % | Morgan Stanley Smith Barney LLC | 13 557 | -1 350 | 31. 12. 2023 |
0,02 % | Baird Investment Management | 12 341 | 12 341 | 31. 12. 2023 |
0,02 % | Wells Fargo Bank, N.A. | 12 031 | 2 372 | 31. 12. 2023 |
0,02 % | ProShare Advisors LLC | 11 733 | 983 | 31. 3. 2024 |
0,02 % | Florida State Board of Administration | 11 310 | 0 | 31. 12. 2023 |
0,02 % | J.P. Morgan Securities plc | 10 902 | 10 621 | 31. 12. 2023 |
0,01 % | Virtus Etf Advisers LLC | 10 085 | 10 085 | 31. 12. 2023 |
0,01 % | LPL Financial LLC | 10 000 | 10 000 | 31. 12. 2023 |