6,89 % | Fred Alger Management, LLC | 3 327 132 | -932 323 | 31. 12. 2023 |
6,77 % | Adage Capital Management, L.P. | 3 266 645 | 0 | 31. 12. 2023 |
5,53 % | BlackRock Institutional Trust Company, N.A. | 2 671 316 | 504 121 | 31. 12. 2023 |
5,37 % | State Street Global Advisors (US) | 2 594 470 | 1 061 628 | 31. 12. 2023 |
5,31 % | VR Adviser, LLC | 2 563 952 | 590 699 | 31. 12. 2023 |
4,40 % | The Vanguard Group, Inc. | 2 126 124 | 163 823 | 31. 12. 2023 |
4,37 % | Lynx1 Capital Advisors LLC | 2 110 401 | 4 401 | 31. 12. 2023 |
4,16 % | Deerfield Management Company, L.P. | 2 007 729 | -332 389 | 31. 12. 2023 |
4,15 % | Perceptive Advisors LLC | 2 003 058 | 870 567 | 31. 12. 2023 |
4,14 % | Bain Capital Life Sciences Investors, LLC | 2 000 000 | 0 | 31. 12. 2023 |
3,98 % | Holocene Advisors, LP | 1 920 323 | 737 277 | 31. 12. 2023 |
3,94 % | Commodore Capital LP | 1 900 000 | -625 753 | 31. 12. 2023 |
3,80 % | T. Rowe Price Investment Management, Inc. | 1 832 854 | 1 832 854 | 31. 12. 2023 |
3,37 % | Jennison Associates LLC | 1 626 628 | 204 261 | 31. 12. 2023 |
2,85 % | Redmile Group, LLC | 1 374 189 | -400 063 | 31. 12. 2023 |
2,80 % | Nichtberger (Steven) | 1 349 483 | 0 | 31. 12. 2023 |
2,59 % | Polar Capital LLP | 1 250 000 | 1 250 000 | 31. 12. 2023 |
2,32 % | BlackRock Financial Management, Inc. | 1 121 700 | 947 483 | 31. 12. 2023 |
1,56 % | Geode Capital Management, L.L.C. | 753 176 | 61 304 | 31. 12. 2023 |
1,47 % | Invesco Capital Management LLC | 709 297 | -130 328 | 31. 12. 2023 |
1,39 % | Invesco Advisers, Inc. | 670 629 | 656 211 | 31. 12. 2023 |
1,12 % | Wellington Management Company, LLP | 539 876 | 293 306 | 31. 12. 2023 |
1,08 % | Integral Health Asset Management, LLC | 520 000 | 190 000 | 31. 12. 2023 |
1,06 % | T. Rowe Price Associates, Inc. | 511 979 | 502 722 | 31. 12. 2023 |
1,01 % | TCG Crossover Management, LLC | 486 795 | 0 | 31. 12. 2023 |
0,93 % | StemPoint Capital LP | 450 706 | 450 706 | 31. 12. 2023 |
0,89 % | Sofinnova Investments, Inc | 429 395 | 429 395 | 31. 12. 2023 |
0,87 % | BlackRock Investment Management (UK) Ltd. | 420 620 | 418 920 | 31. 12. 2023 |
0,84 % | Victory Capital Management Inc. | 403 927 | 337 277 | 31. 12. 2023 |
0,72 % | Blackstone Alternative Asset Management, L.P. | 347 494 | 347 494 | 31. 12. 2023 |
0,62 % | Alkeon Capital Management LLC | 299 955 | 299 955 | 31. 12. 2023 |
0,60 % | Northern Trust Investments, Inc. | 288 513 | 15 506 | 31. 12. 2023 |
0,59 % | Point72 Asset Management, L.P. | 284 666 | 284 666 | 31. 12. 2023 |
0,52 % | Schonfeld Strategic Advisors LLC | 251 615 | 251 615 | 31. 12. 2023 |
0,51 % | Morgan Stanley & Co. LLC | 245 787 | 169 460 | 31. 12. 2023 |
0,50 % | Woodline Partners LP | 241 453 | 107 269 | 31. 12. 2023 |
0,50 % | Nuveen LLC | 239 977 | 103 999 | 31. 12. 2023 |
0,49 % | Voloridge Investment Management, LLC | 236 400 | 225 638 | 31. 12. 2023 |
0,48 % | Cutter Capital Management, LP | 230 000 | 230 000 | 31. 12. 2023 |
0,45 % | Ikarian Capital LLC | 216 620 | 216 620 | 31. 12. 2023 |
0,43 % | Rafferty Asset Management LLC | 209 263 | 91 113 | 31. 12. 2023 |
0,42 % | Goldman Sachs & Company, Inc. | 204 632 | -65 053 | 31. 12. 2023 |
0,41 % | Candriam Luxembourg S.A. | 200 000 | 200 000 | 29. 2. 2024 |
0,36 % | First Turn Management, LLC | 175 359 | 175 359 | 31. 12. 2023 |
0,33 % | BofA Global Research (US) | 160 520 | 19 334 | 31. 12. 2023 |
0,31 % | Norges Bank Investment Management (NBIM) | 151 944 | 151 944 | 31. 12. 2023 |
0,31 % | Ghost Tree Capital, LLC | 150 000 | 150 000 | 31. 12. 2023 |
0,30 % | Simon (Mark) | 143 144 | 7 000 | 3. 4. 2023 |
0,29 % | UBS Financial Services, Inc. | 138 645 | 103 662 | 31. 12. 2023 |
0,27 % | Barclays Bank PLC | 129 072 | 64 486 | 31. 12. 2023 |
0,26 % | Morgan Stanley Smith Barney LLC | 124 620 | -20 194 | 31. 12. 2023 |
0,24 % | Ensign Peak Advisors, Inc. | 118 002 | 118 002 | 31. 12. 2023 |
0,23 % | BlackRock Investment Management, LLC | 109 505 | 28 934 | 31. 12. 2023 |
0,20 % | BNY Mellon Asset Management | 97 558 | 2 996 | 31. 12. 2023 |
0,20 % | Charles Schwab Investment Management, Inc. | 96 310 | 305 | 31. 12. 2023 |
0,19 % | TD Asset Management Inc. | 93 630 | 93 630 | 31. 12. 2023 |
0,19 % | AllianceBernstein L.P. | 93 332 | -72 071 | 31. 12. 2023 |
0,18 % | Jane Street Capital, L.L.C. | 88 409 | 88 409 | 31. 12. 2023 |
0,18 % | RBC Capital Markets Wealth Management | 86 816 | -13 115 | 31. 12. 2023 |
0,18 % | Citi Investment Research (US) | 86 546 | 36 851 | 31. 12. 2023 |
0,17 % | BlackRock Advisors (UK) Limited | 82 375 | 2 553 | 31. 3. 2024 |
0,17 % | Rokos Capital Management LLP | 80 335 | -93 515 | 31. 12. 2023 |
0,16 % | Weatherbie Capital, LLC | 77 153 | 52 745 | 29. 2. 2024 |
0,15 % | Two Sigma Investments, LP | 74 791 | 28 066 | 31. 12. 2023 |
0,14 % | BlackRock Asset Management Ireland Limited | 69 114 | 50 924 | 31. 12. 2023 |
0,14 % | Neuberger Berman, LLC | 68 329 | 68 329 | 29. 2. 2024 |
0,14 % | PGIM Securities Investment Trust Enterprise | 67 000 | -118 000 | 31. 12. 2023 |
0,12 % | Oppenheimer Asset Management Inc. | 60 045 | 60 045 | 31. 12. 2023 |
0,12 % | Boothbay Fund Management, LLC | 58 755 | 58 755 | 31. 12. 2023 |
0,11 % | Nicholas Investment Partners, L.P. | 54 586 | 41 408 | 31. 12. 2023 |
0,11 % | Manulife Investment Management (North America) Limited | 52 677 | 39 427 | 31. 12. 2023 |
0,11 % | Qube Research & Technologies Ltd | 52 199 | 52 199 | 31. 12. 2023 |
0,11 % | Schweizerische Nationalbank | 51 000 | -10 100 | 31. 12. 2023 |
0,10 % | Marda (Anup) | 50 000 | 50 000 | 18. 10. 2022 |
0,10 % | Nan Fung Life Sciences | 47 150 | 0 | 31. 12. 2023 |
0,10 % | Exome Asset Management LLC | 46 700 | 46 700 | 31. 12. 2023 |
0,10 % | Churchill Management Group | 46 606 | -2 750 | 31. 3. 2024 |
0,10 % | Bridgeway Capital Management, LLC | 46 021 | -4 600 | 31. 12. 2023 |
0,09 % | Rhumbline Advisers Ltd. Partnership | 44 147 | 1 545 | 31. 12. 2023 |
0,09 % | MFS Investment Management | 42 890 | -1 560 | 29. 2. 2024 |
0,08 % | Newton Investment Management North America, LLC | 39 900 | 0 | 31. 12. 2023 |
0,08 % | Caption Management, LLC | 38 300 | 38 300 | 31. 12. 2023 |
0,08 % | LPL Financial LLC | 37 638 | -223 | 31. 12. 2023 |
0,07 % | SEB Investment Management AB | 35 072 | -137 | 29. 2. 2024 |
0,07 % | Citadel Advisors LLC | 33 880 | 31 417 | 31. 12. 2023 |
0,07 % | ProFund Advisors LLC | 33 858 | 13 737 | 31. 12. 2023 |
0,07 % | Goldman Sachs Asset Management, L.P. | 33 505 | 3 138 | 31. 12. 2023 |
0,07 % | Credit Suisse Funds AG | 33 388 | 13 360 | 31. 12. 2023 |
0,07 % | Envestnet Asset Management, Inc. | 33 081 | -42 284 | 31. 12. 2023 |
0,06 % | Assenagon Asset Management S.A. | 29 346 | 2 127 | 29. 2. 2024 |
0,06 % | Cubist Systematic Strategies, LLC | 29 241 | 29 241 | 31. 12. 2023 |
0,06 % | California State Teachers Retirement System | 28 717 | -3 444 | 31. 12. 2023 |
0,06 % | Osaic Holdings, Inc. | 27 680 | -19 690 | 31. 12. 2023 |
0,05 % | Legal & General Investment Management Ltd. | 25 611 | -6 032 | 31. 12. 2023 |
0,05 % | Dimensional Fund Advisors, L.P. | 25 375 | -53 330 | 31. 12. 2023 |
0,05 % | New York State Common Retirement Fund | 25 191 | 14 828 | 31. 12. 2023 |
0,05 % | Mirae Asset Global Investments (USA) LLC | 23 689 | 6 891 | 31. 12. 2023 |
0,05 % | Squarepoint Capital LLP | 23 633 | 4 341 | 31. 12. 2023 |
0,05 % | State of Wisconsin Investment Board | 23 053 | -5 656 | 31. 12. 2023 |
0,05 % | JPMorgan Private Bank (United States) | 22 779 | 22 779 | 31. 12. 2023 |