| 18,46690 % | Federated Hermes Global Investment Management Corp. | 14.034.712 | 2.755.385 | |
| 16,41880 % | Fidelity Management & Research Company LLC | 12.478.176 | 6.189.376 | |
| 11,08350 % | Handok Inc | 8.423.386 | 1.230.769 | |
| 6,40795 % | Invus Public Equities LP | 4.870.000 | 4.870.000 | |
| 5,29292 % | The Vanguard Group, Inc. | 4.022.580 | 1.647.202 | |
| 4,90917 % | BlackRock Institutional Trust Company, N.A. | 3.730.933 | 3.341.212 | |
| 4,68463 % | Blackstone Alternative Asset Management, L.P. | 3.560.289 | 1.815.549 | |
| 3,99631 % | UBS Financial Services, Inc. | 3.037.168 | 2.420.653 | |
| 3,99143 % | Great Point Partners, LLC | 3.033.462 | 2.200.420 | |
| 3,79804 % | Marshall Wace LLP | 2.886.481 | 1.041.234 | |
| 3,02304 % | Mangrove Partners | 2.297.489 | 2.297.489 | |
| 3,01502 % | Nantahala Capital Management, LLC | 2.291.395 | 1.000.000 | |
| 2,89476 % | Affinity Asset Advisors LLC | 2.200.000 | 500.000 | |
| 2,77954 % | Vivo Capital, LLC | 2.112.432 | 0 | |
| 2,50546 % | Woodline Partners LP | 1.904.131 | 875.920 | |
| 2,36844 % | Integral Health Asset Management, LLC | 1.800.000 | 1.300.000 | |
| 2,29109 % | Rosalind Advisors, Inc. | 1.741.211 | 1.741.211 | |
| 2,25139 % | Geode Capital Management, L.L.C. | 1.711.043 | 1.143.834 | |
| 2,11053 % | Caxton Associates LP | 1.603.986 | 285.019 | |
| 2,03030 % | Caligan Partners, LP | 1.543.014 | 1.401.705 | |
| 1,30172 % | Adar1 Capital Management LLC | 989.297 | -126.750 | |
| 1,18875 % | Opaleye Management Inc. | 903.442 | 438.442 | |
| 1,09221 % | State Street Investment Management (US) | 830.074 | 632.402 | |
| 0,98876 % | Sphera Funds Management Ltd. | 751.447 | -330.000 | |
| 0,98685 % | Velan Capital Investment Management LP | 750.000 | 350.000 | |
| 0,84824 % | StemPoint Capital LP | 644.654 | 644.654 | |
| 0,80404 % | Medical Strategy GmbH | 611.067 | 0 | |
| 0,76274 % | Northern Trust Investments, Inc. | 579.675 | 476.899 | |
| 0,63948 % | J. Goldman & Co., L.P. | 486.000 | 253.373 | |
| 0,59961 % | UBS O'Connor LLC | 455.701 | -47.207 | |
| 0,57123 % | PFM Health Sciences, LP | 434.134 | 434.134 | |
| 0,43908 % | Fidelity Institutional Asset Management | 333.700 | 114.782 | |
| 0,36957 % | Barclays Capital Inc. | 280.874 | 239.311 | |
| 0,35089 % | Boothbay Fund Management, LLC | 266.671 | 252.222 | |
| 0,34397 % | Columbia Threadneedle Investments (US) | 261.411 | 261.411 | |
| 0,33935 % | Evans (Daron G) | 257.900 | -93.000 | |
| 0,30761 % | Morgan Stanley & Co. LLC | 233.782 | 87.809 | |
| 0,30658 % | Driehaus Capital Management, LLC | 233.000 | 233.000 | |
| 0,29070 % | Dimensional Fund Advisors, L.P. | 220.932 | -33.547 | |
| 0,28816 % | Stonepine Capital Management, LLC | 219.000 | 219.000 | |
| 0,27830 % | Point72 Asset Management, L.P. | 211.509 | 211.509 | |
| 0,27239 % | BlackRock Investment Management, LLC | 207.013 | 198.973 | |
| 0,26787 % | Charles Schwab Investment Management, Inc. | 203.581 | 180.824 | |
| 0,22748 % | Nuveen LLC | 172.886 | 172.886 | |
| 0,18892 % | BlackRock Financial Management, Inc. | 143.579 | 143.579 | |
| 0,16447 % | Paloma Partners Management Company | 124.994 | 108.393 | |
| 0,15824 % | Campbell & Company, Inc. | 120.265 | 120.265 | |
| 0,15785 % | Cantor Fitzgerald, L.P | 119.963 | 42.463 | |
| 0,15697 % | Allostery Investments LP | 119.294 | 119.294 | |
| 0,15482 % | Barclays Bank PLC | 117.661 | 51.161 | |
| 0,15191 % | Kim (Young-Jin) | 115.450 | -34.500 | |
| 0,13850 % | BNY Mellon Asset Management | 105.258 | 105.258 | |
| 0,13158 % | Caption Management, LLC | 100.000 | 50.098 | |
| 0,12758 % | Rhumbline Advisers Ltd. Partnership | 96.960 | 96.960 | |
| 0,11389 % | Jane Street Capital, L.L.C. | 86.556 | -93.503 | |
| 0,10913 % | Lumyna Investments Ltd | 82.939 | 82.939 | |
| 0,10706 % | Susquehanna International Group, LLP | 81.366 | -845.291 | |
| 0,10073 % | BofA Global Research (US) | 76.554 | -496.141 | |
| 0,09191 % | Roberts (Brian Kenneth) | 69.852 | -104.376 | |
| 0,07882 % | Decheng Capital LLC | 59.900 | 59.900 | |
| 0,07763 % | NISA Investment Advisors, L.L.C. | 59.000 | 59.000 | |
| 0,07701 % | Hogenhuis (Wladimir) | 58.525 | -34.500 | |
| 0,07049 % | Labrucherie (Gilbert M JR) | 53.572 | -37.500 | |
| 0,06959 % | Rafferty Asset Management LLC | 52.887 | 52.887 | |
| 0,06952 % | Renaissance Technologies LLC | 52.833 | -325.967 | |
| 0,06463 % | Pale Fire Capital SE | 49.122 | 2.000 | |
| 0,06219 % | DWS Investments UK Limited | 47.263 | 47.263 | |
| 0,06067 % | Alps Advisors, Inc. | 46.105 | 3.019 | |
| 0,05556 % | MetLife Investment Management, LLC | 42.229 | 42.229 | |
| 0,05533 % | Hudson Bay Capital Management LP | 42.050 | 42.050 | |
| 0,05070 % | Point72 Europe (London) LLP | 38.534 | -108.398 | |
| 0,05046 % | Wexford Capital LP | 38.348 | 38.348 | |
| 0,04822 % | Mirae Asset Global Investments (USA) LLC | 36.645 | 36.645 | |
| 0,04676 % | RBC Capital Markets Wealth Management | 35.541 | 35.541 | |
| 0,04672 % | Mellon Investments Corporation | 35.509 | 35.509 | |
| 0,04658 % | Wells Fargo Bank, N.A. | 35.398 | 35.398 | |
| 0,04606 % | Invesco Advisers, Inc. | 35.009 | 35.009 | |
| 0,04415 % | T. Rowe Price International Ltd | 33.556 | 33.556 | |
| 0,04324 % | INTECH Investment Management LLC | 32.860 | 32.860 | |
| 0,04215 % | Altfest Personal Wealth Management | 32.031 | 32.031 | |
| 0,04162 % | JPMorgan Private Bank (United States) | 31.634 | 31.634 | |
| 0,03705 % | Massar Capital Management, LP | 28.155 | 28.155 | |
| 0,03463 % | XTX Markets LLC | 26.321 | -6.278 | |
| 0,03354 % | Metropolitan Life Insurance Co. (US) | 25.492 | 25.492 | |
| 0,03224 % | Quadrature Capital LLP | 24.504 | 12.065 | |
| 0,03186 % | AllianceBernstein L.P. | 24.210 | 24.210 | |
| 0,03120 % | Manulife Investment Management (North America) Limited | 23.714 | 22.502 | |
| 0,03108 % | Citi Investment Research (US) | 23.623 | 19.985 | |
| 0,03066 % | New York State Common Retirement Fund | 23.300 | 23.300 | |
| 0,02959 % | Goldman Sachs & Company, Inc. | 22.485 | -188.840 | |
| 0,02904 % | PGGM Vermogensbeheer B.V. | 22.071 | 3.292 | |
| 0,02647 % | Elam (Nevan C) | 20.119 | -272.000 | |
| 0,02553 % | Even Herd, LLC | 19.405 | 19.405 | |
| 0,02317 % | Mandarine Gestion | 17.607 | -4.093 | |
| 0,02303 % | Huntleigh Advisors, Inc. | 17.500 | 2.500 | |
| 0,02184 % | Citadel Advisors LLC | 16.601 | -92.990 | |
| 0,02026 % | Kennedy Capital Management LLC | 15.397 | 15.397 | |
| 0,02011 % | Police and Firemen's Retirement System of New Jersey | 15.280 | 15.280 | |
| 0,01806 % | ProShare Advisors LLC | 13.727 | 13.727 | |
| 0,01692 % | American Century Investment Management, Inc. | 12.859 | -55.066 | |