12,13451 % | State Street Global Advisors (US) | 16.002.989 | 2.260.435 | 31.12.2022 |
6,68261 % | BVF Partners L.P. | 8.813.021 | 0 | 31.12.2022 |
4,87271 % | BlackRock Institutional Trust Company, N.A. | 6.426.136 | 405.152 | 31.12.2022 |
4,20730 % | The Vanguard Group, Inc. | 5.548.591 | 762.568 | 31.12.2022 |
3,74136 % | Stonepine Capital Management, LLC | 4.934.100 | -735.288 | 31.12.2022 |
3,61144 % | Millennium Management LLC | 4.762.769 | 8.641 | 31.12.2022 |
3,49297 % | Sofinnova Investments, Inc | 4.606.527 | 994.151 | 31.12.2022 |
2,95248 % | Bleichroeder LP | 3.893.730 | -50.000 | 31.12.2022 |
2,86420 % | Bain Capital Life Sciences Investors, LLC | 3.777.308 | 3.777.308 | 31.12.2022 |
2,80759 % | Lion Point Capital, L.P. | 3.702.651 | -686.895 | 31.12.2022 |
2,79472 % | New Enterprise Associates (NEA) | 3.685.683 | 0 | 31.12.2022 |
2,09198 % | Wellington Management Company, LLP | 2.758.903 | -60.760 | 31.12.2022 |
1,94735 % | Medical Strategy GmbH | 2.568.167 | 0 | 30.9.2022 |
1,45113 % | Geode Capital Management, L.L.C. | 1.913.754 | 134.785 | 31.12.2022 |
1,40279 % | Ghost Tree Capital, LLC | 1.850.000 | -150.000 | 31.12.2022 |
1,33288 % | Point72 Asset Management, L.P. | 1.757.800 | 1.649.890 | 31.12.2022 |
1,32514 % | Schonfeld Strategic Advisors LLC | 1.747.600 | 418.124 | 31.12.2022 |
1,11568 % | Rafferty Asset Management LLC | 1.471.357 | 378.314 | 31.12.2022 |
1,10372 % | Verition Fund Management LLC | 1.455.589 | 214.278 | 31.12.2022 |
1,06812 % | Parkman Healthcare Partners LLC | 1.408.642 | 198.497 | 31.12.2022 |
1,00551 % | Ensign Peak Advisors, Inc. | 1.326.062 | 619.785 | 31.12.2022 |
0,98844 % | Nuveen LLC | 1.303.552 | -49.957 | 31.12.2022 |
0,94143 % | Two Sigma Investments, LP | 1.241.564 | 101.702 | 31.12.2022 |
0,86019 % | Goldman Sachs & Company, Inc. | 1.134.419 | -213.286 | 31.12.2022 |
0,80378 % | AIGH Capital Management, LLC. | 1.060.023 | 1.060.023 | 31.12.2022 |
0,74333 % | Sectoral Asset Management Inc. | 980.300 | 12.000 | 31.12.2022 |
0,73476 % | JP Morgan Asset Management | 969.004 | -33.191 | 31.12.2022 |
0,70243 % | BofA Global Research (US) | 926.363 | 211.300 | 31.12.2022 |
0,70239 % | UBS Financial Services, Inc. | 926.309 | 782.053 | 31.12.2022 |
0,66076 % | Balyasny Asset Management LP | 871.409 | 871.409 | 31.12.2022 |
0,59477 % | Northern Trust Investments, Inc. | 784.389 | 57.217 | 31.12.2022 |
0,57504 % | Barclays Bank PLC | 758.361 | 79.748 | 31.12.2022 |
0,48690 % | Citi Investment Research (US) | 642.121 | -347.325 | 31.12.2022 |
0,48295 % | J. Goldman & Co., L.P. | 636.920 | 372.507 | 31.12.2022 |
0,42970 % | Knott Partners Management, LLC | 566.687 | 0 | 31.12.2022 |
0,37011 % | Norges Bank Investment Management (NBIM) | 488.100 | 488.100 | 31.12.2022 |
0,34122 % | Altium Capital Management LP | 450.000 | 23.000 | 31.12.2022 |
0,32306 % | Morgan Stanley & Co. LLC | 426.046 | 134.548 | 31.12.2022 |
0,32082 % | Susquehanna International Group, LLP | 423.104 | -220.888 | 31.12.2022 |
0,27676 % | Worth Venture Partners, LLC | 364.995 | 364.995 | 31.12.2022 |
0,25023 % | Sio Capital Management, LLC | 330.000 | 330.000 | 31.12.2022 |
0,23416 % | ExodusPoint Capital Management, LP | 308.813 | 308.813 | 31.12.2022 |
0,22748 % | Tang Capital Management, LLC | 300.000 | 0 | 31.12.2022 |
0,22430 % | BlackRock Investment Management, LLC | 295.807 | -6.506 | 31.12.2022 |
0,20986 % | BlackRock Financial Management, Inc. | 276.767 | 28.717 | 31.12.2022 |
0,20758 % | BNP Paribas Securities Corp. North America | 273.763 | -56.043 | 31.12.2022 |
0,20481 % | Charles Schwab Investment Management, Inc. | 270.101 | 12.405 | 31.12.2022 |
0,19801 % | BNY Mellon Asset Management | 261.142 | 15.190 | 31.12.2022 |
0,19287 % | SilverArc Capital Management, LLC | 254.361 | -729.155 | 31.12.2022 |
0,16758 % | Schweizerische Nationalbank | 221.000 | 221.000 | 31.12.2022 |
0,15713 % | BG Fund Management Luxembourg S.A. | 207.226 | 47.847 | 31.12.2022 |
0,14647 % | Walleye Capital LLC | 193.170 | -203.802 | 31.12.2022 |
0,14622 % | Gyon Technologies Capital Management, LP | 192.831 | 111.891 | 31.12.2022 |
0,13785 % | Allspring Global Investments, LLC | 181.791 | -921 | 31.12.2022 |
0,13567 % | Parametric Portfolio Associates LLC | 178.919 | -202.220 | 31.12.2022 |
0,13389 % | Kennedy Capital Management, Inc. | 176.571 | -135 | 31.12.2022 |
0,12634 % | Nomura Securities Co., Ltd. | 166.622 | 165.612 | 31.12.2022 |
0,11374 % | Islet Management, LP | 150.000 | -475.000 | 31.12.2022 |
0,10949 % | Rhumbline Advisers Ltd. Partnership | 144.396 | 2.481 | 31.12.2022 |
0,10741 % | Capital Fund Management S.A. | 141.656 | 141.656 | 31.12.2022 |
0,10448 % | Cubist Systematic Strategies, LLC | 137.794 | -126.162 | 31.12.2022 |
0,10410 % | JPMorgan Private Bank (United States) | 137.292 | 377 | 31.12.2022 |
0,10040 % | William Blair & Company, L.L.C. (Research) | 132.413 | -43.785 | 31.12.2022 |
0,09058 % | California State Teachers Retirement System | 119.460 | 79.936 | 31.12.2022 |
0,08356 % | AllianceBernstein L.P. | 110.200 | 0 | 31.12.2022 |
0,08110 % | Boothbay Fund Management, LLC | 106.949 | 106.949 | 31.12.2022 |
0,07225 % | Lakeside Advisors, Inc. | 95.280 | 0 | 31.12.2022 |
0,07120 % | SEB Investment Management AB | 93.903 | -5.442 | 31.12.2022 |
0,06954 % | State of Wisconsin Investment Board | 91.714 | 91.714 | 31.12.2022 |
0,06954 % | Mackenzie Financial Corporation | 91.714 | 80.801 | 31.12.2022 |
0,06953 % | Jump Financial, LLC | 91.693 | 58.204 | 31.12.2022 |
0,06824 % | Candriam Belgium S.A. | 90.000 | 90.000 | 31.12.2022 |
0,06824 % | Candriam Luxembourg S.A. | 90.000 | 0 | 31.1.2023 |
0,06061 % | Jane Street Capital, L.L.C. | 79.936 | -302.750 | 31.12.2022 |
0,06035 % | J.P. Morgan Securities LLC | 79.595 | 79.595 | 31.12.2022 |
0,05970 % | GSA Capital Partners LLP | 78.729 | -55.625 | 31.12.2022 |
0,05846 % | E Fund Management Co. Ltd. | 77.101 | 1.968 | 31.12.2022 |
0,05705 % | Northern Trust Global Investments | 75.232 | -2.115 | 31.12.2022 |
0,05621 % | Credit Suisse Asset Management | 74.129 | 74.129 | 31.12.2022 |
0,05458 % | Hightower Advisors, LLC | 71.982 | 1.500 | 31.12.2022 |
0,05436 % | Mellon Investments Corporation | 71.692 | 581 | 31.12.2022 |
0,04978 % | Goldman Sachs Asset Management, L.P. | 65.654 | -122.185 | 31.12.2022 |
0,04910 % | New York State Common Retirement Fund | 64.753 | 53 | 31.12.2022 |
0,04724 % | Bayesian Capital Management, LP | 62.300 | 62.300 | 31.12.2022 |
0,04108 % | State Street Global Advisors Ireland Limited | 54.175 | 3.400 | 30.11.2022 |
0,03991 % | Apo Asset Management GmbH | 52.627 | 0 | 31.1.2023 |
0,03920 % | UBS Asset Management (Switzerland) | 51.700 | 51.700 | 31.12.2022 |
0,03908 % | Virtus Etf Advisers LLC | 51.542 | 8.172 | 31.12.2022 |
0,03908 % | LifeSci Index Partners, LLC | 51.542 | 0 | 28.2.2023 |
0,03891 % | Citadel Advisors LLC | 51.311 | -439.486 | 31.12.2022 |
0,03816 % | HRT Financial LP | 50.326 | 50.326 | 31.12.2022 |
0,03791 % | Caption Management, LLC | 50.000 | 50.000 | 31.12.2022 |
0,03727 % | SG Americas Securities, L.L.C. | 49.149 | -2.555 | 31.12.2022 |
0,03692 % | MetLife Investment Management, LLC | 48.688 | 0 | 31.12.2022 |
0,03688 % | Tuckson (Reed Vaughn M.D.) | 48.639 | -43.785 | 16.12.2022 |
0,03592 % | SunAmerica Asset Management, LLC | 47.365 | -172 | 31.12.2022 |
0,03329 % | Seeley (Bruce J) | 43.905 | 0 | 21.3.2022 |
0,03271 % | Perry Matthew D | 43.139 | 0 | 9.8.2022 |
0,03231 % | DWS Investments UK Limited | 42.610 | 668 | 31.12.2022 |
0,02986 % | Manulife Investment Management (North America) Limited | 39.378 | 1.652 | 31.12.2022 |