16,69817 % | RA Capital Management, LP | 10.107.400 | -612.155 | 31.12.2023 |
9,49814 % | Artisan Partners Limited Partnership | 5.749.227 | -246.181 | 31.12.2023 |
7,88287 % | Fidelity Management & Research Company LLC | 4.771.502 | -21.813 | 31.12.2023 |
6,65890 % | Westfield Capital Management Company, L.P. | 4.030.634 | 228.457 | 31.12.2023 |
6,59968 % | Janus Henderson Investors | 3.994.785 | 140.252 | 31.12.2023 |
6,59149 % | T. Rowe Price Investment Management, Inc. | 3.989.830 | 5.327 | 31.12.2023 |
6,20445 % | Avoro Capital Advisors LLC | 3.755.555 | 85.555 | 31.12.2023 |
5,36642 % | Wellington Management Company, LLP | 3.248.293 | -28.879 | 31.12.2023 |
3,60361 % | Capital International Investors | 2.181.268 | 12.825 | 31.12.2023 |
2,50844 % | MFS Investment Management | 1.518.356 | 254.634 | 31.12.2023 |
2,38716 % | T. Rowe Price Associates, Inc. | 1.444.950 | -192.898 | 31.12.2023 |
1,74944 % | Franklin Advisers, Inc. | 1.058.937 | -148.698 | 31.12.2023 |
1,41451 % | Invesco Advisers, Inc. | 856.203 | 237.928 | 31.12.2023 |
1,31000 % | TimesSquare Capital Management, LLC | 792.945 | -49.856 | 31.12.2023 |
1,24572 % | Sofinnova Investments, Inc | 754.032 | 0 | 31.12.2023 |
1,19883 % | Putnam Investment Management, L.L.C. | 725.651 | -46.711 | 31.12.2023 |
1,03255 % | Vestal Point Capital, LP | 625.000 | 625.000 | 31.12.2023 |
0,97297 % | AllianceBernstein L.P. | 588.936 | -13.938 | 31.12.2023 |
0,89203 % | Spyglass Capital Management LLC | 539.948 | -74.670 | 31.12.2023 |
0,87875 % | Capital World Investors | 531.910 | 3.296 | 31.3.2024 |
0,83586 % | Brown Advisory | 505.947 | -4.162 | 31.12.2023 |
0,69929 % | Mikkelsen Jan Moller | 423.279 | 423.279 | 31.12.2023 |
0,69859 % | Goldman Sachs & Company, Inc. | 422.854 | 12.881 | 31.12.2023 |
0,68479 % | Medical Strategy GmbH | 414.506 | -6.000 | 31.12.2023 |
0,59777 % | SEI Investments Management Corporation | 361.830 | -34.610 | 31.12.2023 |
0,59645 % | DWS Investment GmbH | 361.029 | 0 | 31.12.2023 |
0,58103 % | Paradigm BioCapital Advisors LP | 351.700 | 351.700 | 31.12.2023 |
0,56644 % | Fidelity Institutional Asset Management | 342.867 | -100 | 31.12.2023 |
0,50840 % | American Century Investment Management, Inc. | 307.737 | -21.537 | 31.12.2023 |
0,50365 % | BlackRock Institutional Trust Company, N.A. | 304.862 | 12.231 | 31.12.2023 |
0,48611 % | Florida State Board of Administration | 294.243 | 128.050 | 30.9.2022 |
0,47910 % | Rock Springs Capital Management LP | 290.000 | -135.500 | 31.12.2023 |
0,47084 % | Q Global Advisors, LLC | 285.000 | 0 | 31.12.2023 |
0,46711 % | ARS Investment Partners LLC | 282.744 | -3.174 | 31.12.2023 |
0,43806 % | D. E. Shaw & Co., L.P. | 265.157 | 44.604 | 31.12.2023 |
0,40406 % | TD Asset Management Inc. | 244.578 | -22.782 | 31.12.2023 |
0,33793 % | New York State Common Retirement Fund | 204.548 | -152 | 31.12.2023 |
0,33645 % | Pictet Asset Management Ltd. | 203.654 | 32.784 | 31.12.2023 |
0,32959 % | The Vanguard Group, Inc. | 199.499 | -233.494 | 31.12.2023 |
0,31968 % | Fred Alger Management, LLC | 193.502 | -76.503 | 31.12.2023 |
0,31259 % | Allspring Global Investments, LLC | 189.208 | -13.964 | 31.3.2024 |
0,29879 % | Eventide Asset Management, LLC | 180.857 | -394.581 | 31.12.2023 |
0,28345 % | Citadel Advisors LLC | 171.571 | 171.323 | 31.12.2023 |
0,27901 % | Rice Hall James & Associates, LLC | 168.883 | -904 | 31.12.2023 |
0,27259 % | Camber Capital Management LP | 165.000 | 165.000 | 31.12.2023 |
0,27056 % | Finepoint Capital LP | 163.772 | 0 | 31.12.2023 |
0,26619 % | Mellon Investments Corporation | 161.126 | -16.274 | 31.12.2023 |
0,25043 % | First Turn Management, LLC | 151.587 | 151.587 | 31.12.2023 |
0,23790 % | Adage Capital Management, L.P. | 144.000 | -382.371 | 31.12.2023 |
0,23241 % | BofA Global Research (US) | 140.677 | -94.453 | 31.12.2023 |
0,22929 % | Tekla Capital Management LLC_NLE | 138.791 | 15.000 | 30.6.2023 |
0,22929 % | abrdn Inc. | 138.791 | 138.791 | 31.12.2023 |
0,21836 % | Perceptive Advisors LLC | 132.176 | 132.176 | 31.12.2023 |
0,21768 % | Saturn V Capital Management LLC | 131.759 | 19.286 | 31.12.2023 |
0,20635 % | Schonfeld Strategic Advisors LLC | 124.901 | 86.001 | 31.12.2023 |
0,20398 % | Dafna Capital Management, LLC | 123.472 | -12.740 | 31.12.2023 |
0,18712 % | Thrivent Asset Management, LLC | 113.264 | -2.190 | 31.12.2023 |
0,18356 % | HSBC Global Asset Management (UK) Limited | 111.107 | 111.107 | 31.12.2023 |
0,16572 % | Principal Global Investors (Equity) | 100.313 | 15.598 | 29.2.2024 |
0,16446 % | Tri Locum Partners LP | 99.550 | 99.550 | 31.12.2023 |
0,16417 % | Candriam Luxembourg S.A. | 99.375 | 0 | 29.2.2024 |
0,16417 % | Candriam Belgium S.A. | 99.375 | -40.000 | 31.12.2023 |
0,14241 % | BNP Paribas Asset Management USA, Inc. | 86.202 | 41.334 | 31.3.2024 |
0,13492 % | Baillie Gifford & Co. | 81.670 | -4.651 | 31.12.2023 |
0,13415 % | Pictet Asset Management (Japan) Ltd. | 81.199 | 81.199 | 31.10.2023 |
0,12115 % | Voloridge Investment Management, LLC | 73.335 | 53.427 | 31.12.2023 |
0,11565 % | Tang Capital Management, LLC | 70.000 | 60.000 | 31.12.2023 |
0,11159 % | Ensign Peak Advisors, Inc. | 67.544 | 0 | 31.12.2023 |
0,10981 % | Morgan Stanley & Co. LLC | 66.470 | 44.517 | 31.12.2023 |
0,10294 % | Columbia Threadneedle Investments (US) | 62.310 | 1.734 | 31.12.2023 |
0,09101 % | Geode Capital Management, L.L.C. | 55.090 | 535 | 31.12.2023 |
0,08947 % | AEGON Investment Management B.V. | 54.156 | -2.390 | 31.10.2023 |
0,08541 % | Gray Foundation | 51.700 | 51.700 | 31.12.2023 |
0,07580 % | Adar1 Capital Management LLC | 45.884 | 45.884 | 31.12.2023 |
0,07463 % | JPMorgan Private Bank (United States) | 45.172 | -6.802 | 31.12.2023 |
0,07157 % | INVESCO Asset Management Limited | 43.320 | -2.486 | 31.12.2023 |
0,06298 % | Assenagon Asset Management S.A. | 38.120 | 2.800 | 29.2.2024 |
0,06014 % | Resolute Capital Asset Partners LLC | 36.400 | -1.100 | 31.12.2023 |
0,05910 % | Baillie Gifford Overseas Ltd. | 35.774 | 1.418 | 29.2.2024 |
0,05722 % | Matisse Capital | 34.635 | 8.380 | 31.12.2023 |
0,05654 % | Parametric Portfolio Associates LLC | 34.224 | 857 | 31.12.2023 |
0,05225 % | Newton Investment Management North America, LLC | 31.627 | -1.397 | 31.12.2023 |
0,05199 % | Jane Street Capital, L.L.C. | 31.468 | 6.751 | 31.12.2023 |
0,05163 % | State Street Global Advisors (US) | 31.252 | 525 | 31.12.2023 |
0,05111 % | BlackRock Advisors (UK) Limited | 30.939 | 1.697 | 31.3.2024 |
0,05026 % | Goldman Sachs Asset Management International | 30.423 | 0 | 31.1.2024 |
0,04956 % | Deka Vermögensmanagement GmbH | 30.000 | 0 | 31.12.2023 |
0,04656 % | BlackRock Asset Management Ireland Limited | 28.183 | 3.454 | 31.12.2023 |
0,04634 % | CAPTRUST Financial Advisors | 28.051 | 4.022 | 31.12.2023 |
0,04626 % | Jefferies LLC | 28.000 | 25.500 | 31.12.2023 |
0,04614 % | UBS Financial Services, Inc. | 27.927 | -15.304 | 31.12.2023 |
0,04472 % | Evoke Advisors | 27.069 | 27.069 | 31.12.2023 |
0,04130 % | Altium Capital Management LP | 25.000 | 25.000 | 31.12.2023 |
0,04047 % | Henry James International Management, Inc. | 24.495 | 0 | 31.12.2023 |
0,03981 % | Wellington Management Japan Pte Ltd | 24.099 | 3.863 | 30.6.2023 |
0,03765 % | Manulife Investment Management (North America) Limited | 22.788 | -2.785 | 31.12.2023 |
0,03699 % | Millennium Management LLC | 22.391 | -20.461 | 31.12.2023 |
0,03378 % | Morgan Stanley Smith Barney LLC | 20.450 | -180 | 31.12.2023 |
0,03304 % | Deka Investment GmbH | 20.000 | 4.940 | 31.12.2022 |
0,03304 % | Ghost Tree Capital, LLC | 20.000 | -65.000 | 31.12.2023 |