7,19 % | Samsara BioCapital, LLC | 5.161.888 | 0 | 31.12.2022 |
6,05 % | Frazier Healthcare Partners | 4.345.559 | 80.000 | 31.12.2022 |
4,94 % | BlackRock Institutional Trust Company, N.A. | 3.550.018 | 273.697 | 31.12.2022 |
4,23 % | Versant Ventures | 3.035.207 | -400.000 | 1.3.2023 |
4,18 % | Deep Track Capital LP | 3.000.000 | 0 | 31.12.2022 |
3,88 % | The Vanguard Group, Inc. | 2.784.681 | 392.808 | 31.12.2022 |
3,70 % | State Street Global Advisors (US) | 2.658.956 | 193.237 | 31.12.2022 |
3,55 % | Octagon Capital Advisors LP | 2.551.703 | 0 | 31.12.2022 |
3,53 % | Baker Bros. Advisors LP | 2.534.102 | 0 | 31.12.2022 |
2,83 % | OrbiMed Advisors, LLC | 2.029.300 | 0 | 31.12.2022 |
2,01 % | Suvretta Capital Management, LLC | 1.444.830 | 54.830 | 31.12.2022 |
1,77 % | Point72 Asset Management, L.P. | 1.267.660 | -1.173.094 | 31.12.2022 |
1,72 % | Dimensional Fund Advisors, L.P. | 1.238.080 | 124.336 | 31.12.2022 |
1,62 % | Pictet Asset Management Ltd. | 1.166.164 | 484.052 | 31.12.2022 |
1,62 % | Victory Capital Management Inc. | 1.163.245 | 136.182 | 31.12.2022 |
1,29 % | Candriam Luxembourg S.A. | 926.155 | 0 | 31.1.2023 |
1,29 % | Candriam Belgium S.A. | 926.155 | 55.000 | 31.12.2022 |
1,28 % | Nuveen LLC | 916.765 | -44.493 | 31.12.2022 |
1,27 % | Geode Capital Management, L.L.C. | 914.226 | 39.669 | 31.12.2022 |
1,24 % | Assenagon Asset Management S.A. | 888.249 | -543.145 | 31.12.2022 |
1,21 % | Vivo Capital, LLC | 872.151 | 0 | 31.12.2022 |
1,21 % | Federated Hermes Global Investment Management Corp. | 867.900 | 867.900 | 31.12.2022 |
1,16 % | Laurion Capital Management LP | 829.750 | 643 | 31.12.2022 |
1,14 % | Adage Capital Management, L.P. | 820.178 | 720.178 | 31.12.2022 |
1,14 % | Affinity Asset Advisors LLC | 818.035 | 4.037 | 31.12.2022 |
1,12 % | Sofinnova Investments, Inc | 806.459 | 518.558 | 31.12.2022 |
1,08 % | Driehaus Capital Management, LLC | 772.700 | -108.984 | 31.12.2022 |
1,03 % | Davis (Jerel C) | 739.051 | 1.646 | 22.12.2022 |
1,00 % | Rubric Capital Management LP | 719.809 | -229.357 | 31.12.2022 |
0,96 % | EcoR1 Capital, LLC | 690.000 | 0 | 31.12.2022 |
0,90 % | Nicholas Investment Partners, L.P. | 642.720 | 75.305 | 31.12.2022 |
0,71 % | Citadel Advisors LLC | 511.167 | 290.148 | 31.12.2022 |
0,71 % | Rock Springs Capital Management LP | 507.512 | 0 | 31.12.2022 |
0,68 % | Baillie Gifford & Co. | 489.708 | 25.394 | 31.12.2022 |
0,61 % | Millennium Management LLC | 440.738 | 41.769 | 31.12.2022 |
0,59 % | Saturn V Capital Management LLC | 423.177 | 423.177 | 31.12.2022 |
0,54 % | Northern Trust Investments, Inc. | 387.144 | 11.216 | 31.12.2022 |
0,54 % | Altium Capital Management LP | 385.000 | -140.000 | 31.12.2022 |
0,53 % | Charles Schwab Investment Management, Inc. | 383.712 | 9.225 | 31.12.2022 |
0,52 % | Two Sigma Investments, LP | 375.608 | -90.517 | 31.12.2022 |
0,51 % | Eventide Asset Management, LLC | 368.811 | 368.811 | 31.12.2022 |
0,50 % | Ensign Peak Advisors, Inc. | 361.838 | 124.933 | 31.12.2022 |
0,50 % | D. E. Shaw & Co., L.P. | 359.785 | -119.742 | 31.12.2022 |
0,47 % | International Biotechnology Trust PLC | 340.389 | 0 | 31.12.2022 |
0,43 % | Fidelity Management & Research Company LLC | 306.810 | -22.429 | 31.12.2022 |
0,42 % | Norges Bank Investment Management (NBIM) | 304.326 | 304.326 | 31.12.2022 |
0,42 % | Dobmeier (Eric L. J.D.) | 301.138 | 12.151 | 10.2.2023 |
0,39 % | Ikarian Capital LLC | 283.464 | 0 | 31.12.2022 |
0,33 % | Connor, Clark & Lunn Investment Management Ltd. | 235.816 | -51.468 | 31.12.2022 |
0,27 % | Invesco Capital Management LLC | 193.400 | 13.264 | 31.12.2022 |
0,26 % | Putnam Investment Management, L.L.C. | 183.343 | -7.200 | 31.12.2022 |
0,25 % | Renaissance Technologies LLC | 181.662 | -37.680 | 31.12.2022 |
0,24 % | BofA Global Research (US) | 175.023 | 35.910 | 31.12.2022 |
0,24 % | Integral Health Asset Management, LLC | 175.000 | 175.000 | 31.12.2022 |
0,24 % | Rafferty Asset Management LLC | 174.011 | 30.893 | 31.12.2022 |
0,23 % | BlackRock Financial Management, Inc. | 165.075 | 1.760 | 31.12.2022 |
0,23 % | Goldman Sachs & Company, Inc. | 163.702 | -182.336 | 31.12.2022 |
0,21 % | BlackRock Investment Management, LLC | 152.658 | 6.369 | 31.12.2022 |
0,21 % | Frohlich (Tom) | 150.777 | 3.103 | 10.2.2023 |
0,21 % | Polar Asset Management Partners Inc. | 149.600 | 0 | 31.12.2022 |
0,20 % | Woodline Partners LP | 142.563 | -166.821 | 31.12.2022 |
0,19 % | Northern Trust Global Investments | 137.619 | 98.593 | 31.12.2022 |
0,19 % | BNY Mellon Asset Management | 137.243 | 2.292 | 31.12.2022 |
0,19 % | Morgan Stanley & Co. LLC | 137.025 | 5.694 | 31.12.2022 |
0,18 % | Algert Global LLC | 131.427 | -1.430 | 31.12.2022 |
0,18 % | Walleye Capital LLC | 131.375 | -166.009 | 31.12.2022 |
0,18 % | ExodusPoint Capital Management, LP | 128.955 | -41.701 | 31.12.2022 |
0,18 % | Sphera Funds Management Ltd. | 127.200 | -407.158 | 31.12.2022 |
0,16 % | Nan Fung Group Holdings Ltd | 113.950 | 0 | 31.12.2022 |
0,15 % | JP Morgan Asset Management | 104.622 | 15.119 | 31.12.2022 |
0,14 % | EAM Investors, LLC | 102.007 | -21.903 | 31.12.2022 |
0,14 % | Barclays Bank PLC | 101.941 | 9.670 | 31.12.2022 |
0,14 % | Schweizerische Nationalbank | 98.700 | 5.200 | 31.12.2022 |
0,14 % | UBS Asset Management (Americas), Inc. | 97.801 | -3.870 | 31.1.2023 |
0,13 % | Balyasny Asset Management LP | 90.140 | -190.147 | 31.12.2022 |
0,13 % | Pura Vida Investments, LLC | 90.000 | 90.000 | 31.12.2022 |
0,11 % | Parametric Portfolio Associates LLC | 81.705 | -5.203 | 31.12.2022 |
0,11 % | Rhumbline Advisers Ltd. Partnership | 81.093 | 4.382 | 31.12.2022 |
0,11 % | BioImpact Capital LLC | 80.000 | 80.000 | 31.12.2022 |
0,11 % | Nomura Asset Management Co., Ltd. | 78.400 | 78.400 | 30.11.2022 |
0,11 % | Citi Investment Research (US) | 78.195 | -53.812 | 31.12.2022 |
0,11 % | Soleus Capital Management, L.P. | 78.000 | 0 | 31.12.2022 |
0,10 % | New York State Common Retirement Fund | 70.116 | 7.241 | 31.12.2022 |
0,10 % | UBS Financial Services, Inc. | 68.764 | 45.316 | 31.12.2022 |
0,09 % | EAM Global Investors LLC | 66.787 | -17.559 | 31.12.2022 |
0,09 % | BlackRock Advisors (UK) Limited | 63.636 | 2.432 | 28.2.2023 |
0,08 % | HealthCor Management, L.P. | 60.000 | -206.830 | 31.12.2022 |
0,08 % | Baillie Gifford Overseas Ltd. | 58.957 | 0 | 31.1.2023 |
0,08 % | Mellon Investments Corporation | 58.648 | 21.230 | 31.12.2022 |
0,08 % | Wellington Management Company, LLP | 57.593 | 12.503 | 31.12.2022 |
0,08 % | California State Teachers Retirement System | 55.811 | 1.952 | 31.12.2022 |
0,08 % | BlackRock Asset Management Ireland Limited | 54.454 | 15.710 | 31.12.2022 |
0,07 % | AllianceBernstein L.P. | 52.520 | 17.400 | 31.12.2022 |
0,07 % | HighVista Strategies LLC | 49.495 | -34.056 | 31.12.2022 |
0,07 % | Goldman Sachs Asset Management, L.P. | 48.474 | -8.078 | 31.12.2022 |
0,07 % | FundLogic SAS | 47.430 | 0 | 31.12.2022 |
0,06 % | Jump Financial, LLC | 45.868 | 2.234 | 31.12.2022 |
0,06 % | Dimensional Fund Advisors, Ltd. | 45.833 | 0 | 31.1.2023 |
0,06 % | Martingale Asset Management, L.P. | 45.533 | 206 | 31.12.2022 |
0,06 % | Fisher Investments | 44.003 | -7.004 | 31.12.2022 |