| 11,16972 % | Redmile Group, LLC | 12.884.277 | 11.331 | |
| 8,93989 % | ARK Investment Management LLC | 10.312.167 | 10.312.167 | |
| 7,60014 % | The Vanguard Group, Inc. | 8.766.764 | -1.543.689 | |
| 7,46665 % | BlackRock Institutional Trust Company, N.A. | 8.612.781 | 225.504 | |
| 3,93920 % | Citadel Advisors LLC | 4.543.867 | 254.708 | |
| 2,92940 % | Johnson & Johnson Innovation-JJDC, Inc. | 3.379.064 | 0 | |
| 2,18032 % | Vestal Point Capital, LP | 2.515.000 | -850 | |
| 2,15433 % | Baker Bros. Advisors LP | 2.485.018 | -773.384 | |
| 2,13260 % | Acadian Asset Management LLC | 2.459.954 | -13.611 | |
| 2,11333 % | Dimensional Fund Advisors, L.P. | 2.437.729 | -153.829 | |
| 2,10591 % | Geode Capital Management, L.L.C. | 2.429.167 | 159.558 | |
| 2,08503 % | Morgan Stanley & Co. LLC | 2.405.087 | 214.145 | |
| 1,94254 % | Goldman Sachs & Company, Inc. | 2.240.720 | -96.606 | |
| 1,93248 % | State Street Investment Management (US) | 2.229.121 | 119.056 | |
| 1,65040 % | Citi Investment Research (US) | 1.903.738 | -33.395 | |
| 1,61922 % | Tang Capital Management, LLC | 1.867.773 | 0 | |
| 1,46966 % | BlackRock Financial Management, Inc. | 1.695.249 | -16.076 | |
| 1,05222 % | Jacobs Levy Equity Management, Inc. | 1.213.736 | -989.587 | |
| 0,83457 % | UBS Financial Services, Inc. | 962.672 | -588.409 | |
| 0,80694 % | Schonfeld Strategic Advisors LLC | 930.809 | -6.863.704 | |
| 0,76263 % | Millennium Management LLC | 879.688 | 564.811 | |
| 0,73362 % | AQR Capital Management, LLC | 846.233 | 261.208 | |
| 0,71257 % | Northern Trust Investments, Inc. | 821.955 | 43.987 | |
| 0,63625 % | Charles Schwab Investment Management, Inc. | 733.911 | 30.086 | |
| 0,62549 % | Two Sigma Investments, LP | 721.505 | -307.367 | |
| 0,61782 % | Woodline Partners LP | 712.650 | -711.517 | |
| 0,58518 % | Monaco asset management S.A.M. | 675.000 | -474.708 | |
| 0,53526 % | Rastetter (William H) | 617.424 | 0 | |
| 0,40383 % | Jane Street Capital, L.L.C. | 465.820 | 402.129 | |
| 0,38853 % | Barclays Bank PLC | 448.164 | 80.879 | |
| 0,37480 % | XTX Markets LLC | 432.328 | -26.980 | |
| 0,37322 % | BlackRock Investment Management, LLC | 430.514 | 100.881 | |
| 0,37207 % | Bruce & Company, Inc. | 429.188 | -120.812 | |
| 0,29451 % | Columbia Threadneedle Investments (US) | 339.714 | -71.618 | |
| 0,29060 % | Bressi (Jerome Charles) | 335.203 | 59.020 | |
| 0,26981 % | Mendlein (John D) | 311.231 | 0 | |
| 0,25074 % | Susquehanna International Group, LLP | 289.232 | 111.872 | |
| 0,24917 % | BNP Paribas Securities Corp. North America | 287.412 | -54.824 | |
| 0,23490 % | Goldman Sachs Asset Management, L.P. | 270.956 | 149.308 | |
| 0,23345 % | Nuveen LLC | 269.282 | -42.216 | |
| 0,22256 % | GSA Capital Partners LLP | 256.722 | 256.722 | |
| 0,20542 % | Conestoga Capital Advisors, LLC | 236.948 | 0 | |
| 0,19763 % | Invesco Capital Management LLC | 227.966 | 49.979 | |
| 0,18592 % | Renaissance Technologies LLC | 214.463 | 214.463 | |
| 0,16272 % | AllianceBernstein L.P. | 187.700 | 41.120 | |
| 0,14876 % | Wolchko (John Scott) | 171.595 | -102.370 | |
| 0,14756 % | Dimensional Fund Advisors, Ltd. | 170.211 | -12.068 | |
| 0,14559 % | BNY Mellon Asset Management | 167.934 | -721 | |
| 0,13512 % | Rhumbline Advisers Ltd. Partnership | 155.858 | 5.610 | |
| 0,12643 % | Assenagon Asset Management S.A. | 145.838 | -66.504 | |
| 0,12310 % | DWS Investments UK Limited | 142.001 | 142.001 | |
| 0,12221 % | Bellecapital AG | 140.971 | 0 | |
| 0,10639 % | Mellon Investments Corporation | 122.718 | -382 | |
| 0,10588 % | BofA Global Research (US) | 122.130 | -266.313 | |
| 0,10148 % | IEQ Capital LLC | 117.057 | 42.551 | |
| 0,09853 % | Ohio Public Employees Retirement System | 113.655 | -49.000 | |
| 0,09667 % | Cubist Systematic Strategies, LLC | 111.512 | 111.512 | |
| 0,09631 % | Privium Fund Management BV | 111.090 | 2.064 | |
| 0,08926 % | HSBC Global Asset Management (UK) Limited | 102.966 | -6.380 | |
| 0,08745 % | Virtu Americas LLC | 100.879 | 100.879 | |
| 0,08252 % | Los Angeles Capital Management LLC | 95.185 | 95.185 | |
| 0,07424 % | Graham Capital Management, L.P. | 85.633 | -54.431 | |
| 0,06502 % | Adawi (Kamal) | 75.000 | 75.000 | |
| 0,06361 % | INTECH Investment Management LLC | 73.379 | -5.004 | |
| 0,06107 % | Leo Wealth, LLC | 70.439 | 0 | |
| 0,06051 % | Wells Fargo Bank, N.A. | 69.795 | 9.702 | |
| 0,05894 % | MetLife Investment Management, LLC | 67.990 | 67.990 | |
| 0,05871 % | SEI Investments Management Corporation | 67.721 | -122 | |
| 0,05860 % | Nuveen Asset Management, LLC | 67.590 | 0 | |
| 0,05746 % | Coughlin (Timothy P) | 66.282 | 0 | |
| 0,05730 % | Carson Wealth Management Group | 66.093 | 16.655 | |
| 0,05688 % | Valamehr (Bahram) | 65.614 | -14.466 | |
| 0,05569 % | Vanguard Personalized Indexing Management, LLC | 64.243 | -7.121 | |
| 0,05353 % | Mirae Asset Global Investments (USA) LLC | 61.749 | -2.054 | |
| 0,05339 % | BlackRock Advisors (UK) Limited | 61.585 | 1.490 | |
| 0,05062 % | Tahl (Cindy R) | 58.386 | -9.037 | |
| 0,05051 % | BlackRock Fund Advisors | 58.263 | -1.858 | |
| 0,04542 % | Wells Fargo Advisors | 52.397 | 9.552 | |
| 0,04490 % | BlackRock Asset Management Ireland Limited | 51.795 | -181.607 | |
| 0,04455 % | JPMorgan Private Bank (United States) | 51.394 | -208.566 | |
| 0,04405 % | Cerity Partners LLC | 50.817 | 19.810 | |
| 0,04296 % | Headlands Technologies LLC | 49.556 | 49.556 | |
| 0,04252 % | Corebridge Financial Inc. | 49.045 | -727 | |
| 0,04161 % | Abaris Investment Management AG | 48.000 | -56.000 | |
| 0,04062 % | T. Rowe Price International Ltd | 46.855 | 8.806 | |
| 0,03910 % | Vaughan Nelson Investment Management, L.P. | 45.098 | 0 | |
| 0,03566 % | Manulife Investment Management (North America) Limited | 41.134 | 4.038 | |
| 0,03558 % | Metropolitan Life Insurance Co. (US) | 41.043 | 41.043 | |
| 0,03359 % | Wealth Enhancement Advisory Services, LLC | 38.743 | 3.396 | |
| 0,03296 % | Simplex Trading, LLC | 38.019 | 23.639 | |
| 0,03225 % | Hightower Advisors, LLC | 37.200 | 27.000 | |
| 0,03218 % | Thrivent Asset Management, LLC | 37.116 | -52.206 | |
| 0,02953 % | Fidelity Management & Research Company LLC | 34.063 | -23.834 | |
| 0,02836 % | Focus Partners Wealth, LLC | 32.716 | 2.515 | |
| 0,02577 % | Corient Private Wealth LLC | 29.724 | 75 | |
| 0,02573 % | Irish Life Investment Managers Ltd. | 29.674 | 0 | |
| 0,02560 % | Sygnia Asset Management | 29.525 | 20.973 | |
| 0,02429 % | Florida State Board of Administration | 28.016 | 0 | |
| 0,02429 % | New York State Common Retirement Fund | 28.015 | 0 | |
| 0,02376 % | Invesco Advisers, Inc. | 27.406 | -8.110 | |