9,83 % | EcoR1 Capital, LLC | 6.726.491 | 1.259.428 | 31. 12. 2023. |
7,08 % | The Vanguard Group, Inc. | 4.842.174 | 243.167 | 31. 12. 2023. |
6,16 % | RTW Investments L.P. | 4.213.483 | 4.213.483 | 31. 12. 2023. |
6,09 % | BlackRock Institutional Trust Company, N.A. | 4.168.085 | 357.244 | 31. 12. 2023. |
5,45 % | T. Rowe Price Associates, Inc. | 3.728.873 | 1.132.898 | 31. 12. 2023. |
4,36 % | Avidity Partners Management LP | 2.985.117 | 370.157 | 31. 12. 2023. |
3,66 % | Bellevue Asset Management AG | 2.507.731 | 382.531 | 31. 12. 2023. |
3,57 % | Citadel Advisors LLC | 2.439.981 | 1.815.403 | 31. 12. 2023. |
2,48 % | Nextech Invest, Ltd. | 1.695.645 | 1.408.394 | 31. 12. 2023. |
2,29 % | ArrowMark Colorado Holdings, LLC | 1.569.895 | -517.397 | 31. 12. 2023. |
1,88 % | New Leaf Venture Partners LLC | 1.289.521 | 0 | 31. 12. 2023. |
1,74 % | Fidelity Institutional Asset Management | 1.189.011 | -374.164 | 31. 12. 2023. |
1,73 % | State Street Global Advisors (US) | 1.186.474 | 27.022 | 31. 12. 2023. |
1,64 % | Geode Capital Management, L.L.C. | 1.122.627 | 65.237 | 31. 12. 2023. |
1,57 % | JP Morgan Asset Management | 1.073.854 | -138.077 | 31. 12. 2023. |
1,54 % | Fidelity Management & Research Company LLC | 1.055.008 | -2.250.112 | 31. 12. 2023. |
1,54 % | Houston (John G) | 1.054.191 | 119.254 | 23. 2. 2024. |
1,49 % | JPMorgan Asset Management U.K. Limited | 1.017.463 | 307.192 | 31. 12. 2023. |
1,46 % | Commodore Capital LP | 1.000.000 | 1.000.000 | 31. 12. 2023. |
1,36 % | Paradigm BioCapital Advisors LP | 931.303 | 931.303 | 31. 12. 2023. |
1,28 % | Norges Bank Investment Management (NBIM) | 877.708 | 175.953 | 31. 12. 2023. |
1,15 % | Adage Capital Management, L.P. | 789.485 | 789.485 | 31. 12. 2023. |
1,09 % | Holocene Advisors, LP | 744.465 | 744.465 | 31. 12. 2023. |
1,09 % | BlackRock Financial Management, Inc. | 743.728 | -6.676 | 31. 12. 2023. |
0,92 % | VR Adviser, LLC | 627.788 | 627.788 | 31. 12. 2023. |
0,89 % | Boxer Capital, L.L.C. | 608.614 | 608.614 | 31. 12. 2023. |
0,83 % | Morgan Stanley & Co. LLC | 566.003 | 245.460 | 31. 12. 2023. |
0,74 % | Finepoint Capital LP | 504.700 | 0 | 31. 12. 2023. |
0,72 % | Dimensional Fund Advisors, L.P. | 491.877 | 22.479 | 31. 12. 2023. |
0,71 % | Aquilo Capital Management, LLC | 489.153 | 0 | 31. 12. 2023. |
0,71 % | Candriam Belgium S.A. | 487.555 | 40.004 | 31. 12. 2023. |
0,69 % | Charles Schwab Investment Management, Inc. | 469.474 | 39.484 | 31. 12. 2023. |
0,68 % | Candriam Luxembourg S.A. | 462.536 | -25.000 | 29. 2. 2024. |
0,65 % | Northern Trust Investments, Inc. | 442.512 | 24.794 | 31. 12. 2023. |
0,62 % | RA Capital Management, LP | 421.348 | 421.348 | 31. 12. 2023. |
0,58 % | American Century Investment Management, Inc. | 395.367 | -418.102 | 31. 12. 2023. |
0,57 % | Woodline Partners LP | 387.630 | 215.030 | 31. 12. 2023. |
0,52 % | Millennium Management LLC | 358.813 | -469.314 | 31. 12. 2023. |
0,52 % | Nuveen LLC | 354.898 | 17.738 | 31. 12. 2023. |
0,52 % | Perceptive Advisors LLC | 354.082 | 354.082 | 31. 12. 2023. |
0,49 % | Gilder Gagnon Howe & Co. LLC | 333.524 | 162.674 | 31. 12. 2023. |
0,45 % | Voloridge Investment Management, LLC | 309.663 | 309.663 | 31. 12. 2023. |
0,42 % | Frazier Healthcare Partners | 285.331 | 0 | 31. 12. 2023. |
0,41 % | Nordea Funds Oy | 278.737 | -6.317 | 31. 12. 2023. |
0,39 % | Brown Advisory | 265.431 | -170.163 | 31. 12. 2023. |
0,39 % | Opaleye Management Inc. | 263.700 | 263.700 | 31. 12. 2023. |
0,38 % | UBS Financial Services, Inc. | 256.986 | -62.752 | 31. 12. 2023. |
0,36 % | Schonfeld Strategic Advisors LLC | 245.868 | 181.874 | 31. 12. 2023. |
0,35 % | Renaissance Technologies LLC | 237.573 | 123.873 | 31. 12. 2023. |
0,34 % | Great Point Partners, LLC | 234.082 | 234.082 | 31. 12. 2023. |
0,32 % | Goldman Sachs & Company, Inc. | 215.728 | 115.219 | 31. 12. 2023. |
0,31 % | BlackRock Advisors (UK) Limited | 208.919 | 10.242 | 31. 3. 2024. |
0,30 % | Wasatch Global Investors Inc | 207.426 | -15.516 | 31. 3. 2024. |
0,29 % | BNP Paribas Securities Corp. North America | 197.052 | 97.661 | 31. 12. 2023. |
0,29 % | Amundi Asset Management US, Inc. | 195.720 | 4.423 | 31. 12. 2023. |
0,27 % | Cassidy (Sean A) | 186.707 | -1.702 | 23. 2. 2024. |
0,26 % | Integral Health Asset Management, LLC | 175.000 | 175.000 | 31. 12. 2023. |
0,26 % | BlackRock Asset Management Ireland Limited | 174.728 | 974 | 31. 12. 2023. |
0,24 % | Parkman Healthcare Partners LLC | 167.001 | 62.884 | 31. 12. 2023. |
0,23 % | UBS Asset Management (Americas), Inc. | 155.129 | 45.932 | 31. 12. 2023. |
0,23 % | BofA Global Research (US) | 155.036 | 47.492 | 31. 12. 2023. |
0,22 % | Invesco Capital Management LLC | 150.516 | 129.312 | 31. 12. 2023. |
0,22 % | Taylor (Ian) | 150.207 | 37.549 | 23. 2. 2024. |
0,22 % | Wanjia Asset Management Co., Ltd. | 150.000 | 0 | 30. 6. 2023. |
0,22 % | BlackRock Investment Management, LLC | 149.116 | 26.694 | 31. 12. 2023. |
0,21 % | TD Asset Management Inc. | 146.948 | 52.076 | 31. 12. 2023. |
0,21 % | Yale University | 143.522 | 143.522 | 31. 12. 2023. |
0,21 % | Credit Suisse Funds AG | 142.108 | 86.845 | 31. 12. 2023. |
0,20 % | Citi Investment Research (US) | 138.656 | 133.966 | 31. 12. 2023. |
0,20 % | Federated MDTA LLC | 138.028 | 33.770 | 31. 12. 2023. |
0,20 % | BNY Mellon Asset Management | 136.085 | -2.556 | 31. 12. 2023. |
0,20 % | Rhenman & Partners Asset Management AB | 134.270 | 49.270 | 31. 12. 2023. |
0,19 % | Nordea Investment Management AB (Denmark) | 131.494 | 55 | 29. 2. 2024. |
0,17 % | First Trust Advisors L.P. | 114.105 | 1.569 | 29. 2. 2024. |
0,17 % | Goldman Sachs Asset Management, L.P. | 113.731 | 19.590 | 31. 12. 2023. |
0,15 % | T. Rowe Price International Ltd | 103.250 | 10.554 | 31. 12. 2023. |
0,15 % | Putnam Investment Management, L.L.C. | 103.118 | 87.671 | 31. 12. 2023. |
0,15 % | Parametric Portfolio Associates LLC | 101.826 | 36.189 | 31. 12. 2023. |
0,14 % | Jane Street Capital, L.L.C. | 97.217 | 46.894 | 31. 12. 2023. |
0,14 % | Banque Pictet & Cie S.A. | 92.933 | 92.933 | 31. 12. 2023. |
0,13 % | UBS O'Connor LLC | 91.132 | -19.050 | 31. 12. 2023. |
0,13 % | Schweizerische Nationalbank | 89.500 | -10.200 | 31. 12. 2023. |
0,13 % | Manulife Investment Management (North America) Limited | 89.228 | 21.911 | 31. 12. 2023. |
0,12 % | D. E. Shaw & Co., L.P. | 84.931 | 64.131 | 31. 12. 2023. |
0,12 % | Barclays Bank PLC | 83.621 | 49.824 | 31. 12. 2023. |
0,12 % | Shannon (Timothy M) | 80.643 | 0 | 31. 3. 2023. |
0,12 % | Tang Capital Management, LLC | 80.000 | 0 | 31. 12. 2023. |
0,11 % | Algert Global LLC | 74.571 | -98.847 | 31. 12. 2023. |
0,11 % | HOOPP Investment Management | 74.000 | 74.000 | 31. 12. 2023. |
0,11 % | Columbia Threadneedle Investments (US) | 73.975 | 15.190 | 31. 12. 2023. |
0,10 % | Zacks Investment Management, Inc. | 71.695 | 64.306 | 31. 12. 2023. |
0,10 % | CastleArk Management, LLC | 71.570 | 71.570 | 31. 12. 2023. |
0,10 % | JPMorgan Private Bank (United States) | 70.612 | 22.263 | 31. 12. 2023. |
0,10 % | Rhumbline Advisers Ltd. Partnership | 68.890 | -110 | 31. 12. 2023. |
0,10 % | Conestoga Capital Advisors, LLC | 67.640 | -1.837 | 29. 2. 2024. |
0,10 % | Bank Vontobel AG | 66.000 | 66.000 | 31. 12. 2023. |
0,10 % | Sectoral Asset Management Inc. | 66.000 | 58.990 | 31. 12. 2023. |
0,09 % | Berkowitz (Noah) | 63.452 | 63.452 | 18. 3. 2024. |
0,09 % | Hennion & Walsh Asset Management, Inc. | 61.862 | 25.778 | 31. 3. 2024. |
0,09 % | Trexquant Investment LP | 61.243 | 61.243 | 31. 12. 2023. |