19.03673 % | BVF Partners L.P. | 18,834,936 | 4,263,700 | 6/30/2024 |
12.12856 % | Varuma AG | 11,999,999 | 0 | 12/31/2023 |
6.64857 % | Affiris AG | 6,578,100 | -3,555,374 | 12/15/2023 |
2.44717 % | Pfeifer (Andrea M. A Ph.D.) | 2,421,226 | 56,308 | 12/31/2023 |
1.93441 % | BlackRock Financial Management, Inc. | 1,913,910 | 0 | 6/30/2024 |
1.82707 % | Redmile Group, LLC | 1,807,704 | -199,327 | 6/30/2024 |
1.13404 % | Wells Fargo Advisors | 1,122,017 | 2,314 | 6/30/2024 |
0.96227 % | Platinum Asset Management | 952,069 | -142,957 | 6/30/2024 |
0.83384 % | Avidity Partners Management LP | 825,000 | -3,645,000 | 6/30/2024 |
0.65907 % | Renaissance Technologies LLC | 652,079 | 136,300 | 6/30/2024 |
0.42488 % | BlackRock Institutional Trust Company, N.A. | 420,373 | -14,611 | 6/30/2024 |
0.31529 % | Monin (Jean-Fabien) | 311,950 | 13,794 | 12/31/2023 |
0.25609 % | DWS Investment GmbH | 253,375 | 0 | 6/30/2024 |
0.22628 % | Assenagon Asset Management S.A. | 223,880 | -215,850 | 9/30/2024 |
0.21181 % | ARIAD Asset Management GmbH | 209,568 | 0 | 7/31/2024 |
0.16743 % | BlackRock Investment Management (UK) Ltd. | 165,654 | 79,069 | 6/30/2024 |
0.15161 % | Handelsbanken Kapitalf¿rvaltning AB | 150,000 | 0 | 9/30/2024 |
0.12450 % | Lanthaler (Werner) | 123,184 | 111,278 | 12/31/2023 |
0.10750 % | Millennium Management LLC | 106,363 | 106,363 | 6/30/2024 |
0.10041 % | Two Sigma Investments, LP | 99,343 | 99,343 | 6/30/2024 |
0.10038 % | Eversept Partners, LP | 99,313 | -25,276 | 6/30/2024 |
0.07820 % | Alps Advisors, Inc. | 77,376 | 77,376 | 6/30/2024 |
0.06357 % | Morgan Stanley Smith Barney LLC | 62,894 | 10,497 | 6/30/2024 |
0.06084 % | Dimensional Fund Advisors, L.P. | 60,198 | 446 | 6/30/2024 |
0.05538 % | Geode Capital Management, L.L.C. | 54,797 | 0 | 6/30/2024 |
0.05520 % | Cubist Systematic Strategies, LLC | 54,610 | 54,610 | 6/30/2024 |
0.05493 % | BlackRock Asset Management Ireland Limited | 54,344 | 1,021 | 6/30/2024 |
0.05493 % | BlackRock Advisors (UK) Limited | 54,344 | 1,204 | 9/30/2024 |
0.05372 % | BlackRock Investment Management, LLC | 53,150 | 0 | 6/30/2024 |
0.04176 % | Jump Financial, LLC | 41,321 | 41,321 | 6/30/2024 |
0.03935 % | Williams (Douglas E) | 38,929 | 26,111 | 12/31/2023 |
0.03518 % | Citadel Advisors LLC | 34,808 | -25,924 | 6/30/2024 |
0.03452 % | Twyman (Roy M.D.) | 34,150 | 34,150 | 12/31/2023 |
0.02749 % | Fidelity Management & Research Company LLC | 27,202 | 0 | 6/30/2024 |
0.02569 % | Banque Cantonale Vaudoise | 25,418 | -28,716 | 6/30/2024 |
0.02478 % | Donati (Piergiorgio) | 24,521 | 14,974 | 12/31/2023 |
0.02225 % | Renta 4 Gestora, S.G.I.I.C., S.A. | 22,010 | -6,009 | 6/30/2024 |
0.02035 % | Donovan (Howard) | 20,136 | 15,040 | 12/31/2023 |
0.02021 % | Nomura Securities Co., Ltd. | 20,000 | 20,000 | 6/30/2024 |
0.01960 % | Group One Trading, L.P. | 19,397 | 18,946 | 6/30/2024 |
0.01922 % | China Universal Asset Management Co., Ltd. | 19,021 | 7,400 | 9/30/2024 |
0.01631 % | UBS Financial Services, Inc. | 16,140 | -7,525 | 6/30/2024 |
0.01517 % | Morgan Stanley & Co. LLC | 15,005 | -1,315,547 | 6/30/2024 |
0.01347 % | Goldman Sachs & Company, Inc. | 13,329 | -10,280 | 6/30/2024 |
0.01274 % | Roberts (Christopher) | 12,601 | 10,101 | 12/31/2023 |
0.01202 % | Invesco Capital Management LLC | 11,891 | 8,530 | 6/30/2024 |
0.01152 % | Schonfeld Strategic Advisors LLC | 11,400 | 11,400 | 6/30/2024 |
0.01147 % | J.P. Morgan Securities plc | 11,352 | -10,763 | 6/30/2024 |
0.01011 % | Compagnie Lombard Odier SCmA | 10,000 | 0 | 9/30/2024 |
0.01011 % | Silverberg Bernstein Capital Management, LLC | 10,000 | 0 | 9/30/2024 |
0.00925 % | Shaw (Monica M.D.) | 9,150 | 9,150 | 12/31/2023 |
0.00925 % | Butler (Monika) | 9,150 | 9,150 | 12/31/2023 |
0.00925 % | June (Carl) | 9,150 | 9,150 | 12/31/2023 |
0.00831 % | Mendonca (Nuno) | 8,225 | 8,225 | 12/31/2023 |
0.00817 % | Dimensional Fund Advisors, Ltd. | 8,079 | 0 | 7/31/2024 |
0.00591 % | ProShare Advisors LLC | 5,844 | -77 | 9/30/2024 |
0.00389 % | Z¿rcher Kantonalbank (Asset Management) | 3,851 | -68 | 6/30/2024 |
0.00381 % | Mirae Asset Global Investments Co., Ltd. | 3,774 | 276 | 7/31/2024 |
0.00360 % | BNP Paribas Securities Corp. North America | 3,564 | -7,528 | 6/30/2024 |
0.00321 % | Derouazi (Madiha) | 3,175 | 3,175 | 12/31/2023 |
0.00311 % | Tower Research Capital LLC | 3,074 | -2,756 | 6/30/2024 |
0.00298 % | Mirae Asset Global Investments (USA) LLC | 2,953 | 2,953 | 6/30/2024 |
0.00292 % | BofA Global Research (US) | 2,892 | -22 | 6/30/2024 |
0.00212 % | Citi Investment Research (US) | 2,096 | 1,786 | 6/30/2024 |
0.00169 % | BlackRock Fund Advisors | 1,668 | 0 | 9/30/2024 |
0.00155 % | GF Fund Management Co., Ltd. | 1,536 | 1,536 | 12/31/2023 |
0.00101 % | Activest Wealth Management LLC | 1,000 | 1,000 | 6/30/2024 |
0.00078 % | Parametric Portfolio Associates LLC | 768 | 0 | 6/30/2024 |
0.00077 % | RBC Dominion Securities, Inc. | 760 | -240 | 6/30/2024 |
0.00037 % | Capital Investment Trust Corporation | 367 | -244 | 4/30/2024 |
0.00020 % | Hoopoe Advisors | 200 | 0 | 6/30/2024 |
0.00020 % | SJS Investment Services | 200 | 0 | 9/30/2024 |
0.00005 % | Qube Research & Technologies Ltd | 48 | 0 | 6/30/2024 |
0 % | Vanguard Capital Wealth Advisors, LLC. | 0 | -14,000 | 9/30/2024 |
0 % | Invus Public Equities Advisors, LLC | 0 | -1,000,000 | 3/31/2023 |
0 % | Ergoteles Capital | 0 | -20,014 | 6/30/2023 |
0 % | Squarepoint Capital LLP | 0 | -11,036 | 9/30/2023 |
0 % | Osaic Holdings, Inc. | 0 | -2,000 | 3/31/2024 |
0 % | Watch Point Trust Company LLC | 0 | -12,850 | 3/31/2024 |
0 % | Simplex Trading, LLC | 0 | -635 | 6/30/2024 |
0 % | Bruno Walter Finance SA | 0 | -5,372 | 5/31/2023 |
0 % | Belpointe Asset Management LLC | 0 | -1,000 | 6/30/2023 |
0 % | Glassman Wealth Services LLC | 0 | -26 | 9/30/2023 |
0 % | Landscape Capital Management, L.L.C. | 0 | -117,418 | 6/30/2024 |
0 % | Mariner Wealth Advisors | 0 | -14,368 | 6/30/2023 |
0 % | Virtu Americas LLC | 0 | -11,552 | 3/31/2024 |
0 % | Nixon Peabody Financial Advisors LLC | 0 | -12,850 | 12/31/2023 |
0 % | Jane Street Capital, L.L.C. | 0 | -14,418 | 6/30/2024 |
0 % | Susquehanna International Group, LLP | 0 | -71,487 | 12/31/2023 |
0 % | Morgan Stanley & Co. International Plc | 0 | -137 | 6/30/2024 |
0 % | RBC Capital Partners | 0 | -987 | 6/30/2024 |
0 % | Medical Strategy GmbH | 0 | -87,612 | 3/31/2023 |
0 % | Scoggin Management LP | 0 | -84,401 | 6/30/2024 |
0 % | Acadian Asset Management LLC | 0 | -3,845 | 6/30/2023 |
0 % | Edmond de Rothschild Asset Management (France) S.A. | 0 | -2,000 | 3/31/2024 |
0 % | State Street Global Advisors (US) | 0 | -56,369 | 9/30/2023 |
0 % | Northwestern Mutual Capital, LLC | 0 | -3,400 | 6/30/2023 |
0 % | Lazard Asset Management, L.L.C. | 0 | -10,260 | 6/30/2024 |
0 % | RBC Capital Markets Wealth Management | 0 | -5,100 | 3/31/2024 |
0 % | Farther Finance Advisors, LLC | 0 | -10 | 9/30/2024 |