| 6,33590 % | Ikarian Capital LLC | 967.600 | 967.600 | |
| 2,79694 % | Invus Public Equities Advisors, LLC | 427.141 | 427.141 | |
| 2,47743 % | RTW Investments L.P. | 378.346 | 0 | |
| 2,45552 % | The Lind Partners, LLC | 375.000 | 305.000 | |
| 2,29883 % | Dellora Investments LP | 351.071 | 0 | |
| 2,22394 % | Point72 Asset Management, L.P. | 339.633 | 339.633 | |
| 2,22339 % | BVF Partners L.P. | 339.549 | 0 | |
| 1,53037 % | Millennium Management LLC | 233.714 | 207.088 | |
| 1,36418 % | Vivo Capital, LLC | 208.333 | 0 | |
| 1,14427 % | Morgan Stanley & Co. LLC | 174.750 | 56.916 | |
| 1,09353 % | Integral Health Asset Management, LLC | 167.000 | 0 | |
| 1,09134 % | Janus Henderson Investors | 166.666 | 0 | |
| 1,01860 % | Adar1 Capital Management LLC | 155.557 | 86.816 | |
| 0,64540 % | VR Adviser, LLC | 98.564 | -109.769 | |
| 0,54567 % | Adage Capital Management, L.P. | 83.333 | 0 | |
| 0,54567 % | Velan Capital Investment Management LP | 83.333 | 0 | |
| 0,34992 % | Vestal Point Capital, LP | 53.439 | -29.894 | |
| 0,22418 % | Geode Capital Management, L.L.C. | 34.236 | 895 | |
| 0,14594 % | The Vanguard Group, Inc. | 22.287 | 0 | |
| 0,10431 % | Dimensional Fund Advisors, L.P. | 15.930 | -3.313 | |
| 0,06774 % | Citadel Advisors LLC | 10.345 | -12.796 | |
| 0,02135 % | Morgan Stanley Smith Barney LLC | 3.260 | 0 | |
| 0,01886 % | Davidson (Michael H) | 2.881 | 0 | |
| 0,01738 % | Rich (Stuart) | 2.654 | 0 | |
| 0,01489 % | Doogan (Declan) | 2.274 | 0 | |
| 0,01092 % | Proehl (Gerald T) | 1.667 | 0 | |
| 0,00983 % | Raymond James Financial Services Advisors, Inc. | 1.501 | 1.501 | |
| 0,00818 % | Tower Research Capital LLC | 1.249 | 1.057 | |
| 0,00196 % | BlackRock Institutional Trust Company, N.A. | 300 | 0 | |
| 0,00163 % | BofA Global Research (US) | 249 | 20 | |
| 0,00009 % | UBS Financial Services, Inc. | 13 | -2.879 | |
| 0,00007 % | Barclays Capital Inc. | 11 | 11 | |
| 0,00001 % | Raymond James & Associates, Inc. | 2 | 2 | |
| 0,00001 % | Allworth Financial, L.P. | 1 | 0 | |
| 0,00001 % | Edward Jones | 1 | 1 | |
| 0,00001 % | UBS Switzerland AG | 1 | 0 | |
| 0,00001 % | Union Bancaire Privée, UBP SA | 1 | 0 | |
| 0,00001 % | UMA Financial Services, Inc. | 1 | 0 | |
| 0 % | Qube Research & Technologies Ltd | 0 | -4.407 | |
| 0 % | HRT Financial LP | 0 | -260 | |
| 0 % | Stonepine Capital Management, LLC | 0 | -50.000 | |
| 0 % | Sphera Funds Management Ltd. | 0 | -29.166 | |
| 0 % | Heights Capital Management, Inc. | 0 | -60.000 | |
| 0 % | Susquehanna International Group, LLP | 0 | -952 | |
| 0 % | Two Sigma Investments, LP | 0 | -13.521 | |
| 0 % | Renaissance Technologies LLC | 0 | -4.252 | |
| 0 % | SBI Securities Co., Ltd. | 0 | -5 | |
| 0 % | Banque Cantonale Vaudoise | 0 | -1 | |
| 0 % | Wells Fargo Bank, N.A. | 0 | -2 | |
| 0 % | State Street Investment Management (US) | 0 | -1.188 | |
| 0 % | T. Rowe Price Associates, Inc. | 0 | -24.000 | |
| 0 % | CIBC Private Wealth Management | 0 | -343 | |
| 0 % | Fidelity Management & Research Company LLC | 0 | -1 | |
| 0 % | RBC Capital Markets Wealth Management | 0 | -1 | |
| 0 % | Tucker Asset Management LLC | 0 | -1 | |
| 0 % | Corient Private Wealth LLC | 0 | -2.387 | |
| 0 % | S.H.N. Financial Investments Ltd | 0 | 0 | |
| 0 % | Lynx1 Capital Advisors LLC | 0 | -14.751 | |
| 0 % | XTX Markets LLC | 0 | -532 | |