9,20473 % | Kynam Capital Management LP | 4.420.349 | 2.747.308 | 31. 12. 2022 |
7,55686 % | BVF Partners L.P. | 3.629.000 | 0 | 31. 12. 2022 |
3,97934 % | The Vanguard Group, Inc. | 1.910.984 | 69.214 | 31. 12. 2022 |
3,60744 % | Nantahala Capital Management, LLC | 1.732.388 | −54.771 | 31. 12. 2022 |
3,00220 % | Millennium Management LLC | 1.441.735 | 122.227 | 31. 12. 2022 |
2,89718 % | Citadel Advisors LLC | 1.391.302 | 269.873 | 31. 12. 2022 |
2,79098 % | Point72 Asset Management, L.P. | 1.340.300 | 1.069.700 | 31. 12. 2022 |
2,72452 % | BofA Global Research (US) | 1.308.386 | 4.391 | 31. 12. 2022 |
2,69838 % | Ingalls & Snyder LLC (Asset Management) | 1.295.833 | −34.600 | 31. 12. 2022 |
2,50608 % | Parkman Healthcare Partners LLC | 1.203.484 | 65.897 | 31. 12. 2022 |
2,46141 % | BlackRock Institutional Trust Company, N.A. | 1.182.032 | 380.848 | 31. 12. 2022 |
2,39471 % | Tang Capital Management, LLC | 1.150.000 | 146.983 | 31. 12. 2022 |
2,26622 % | RA Capital Management, LP | 1.088.296 | 0 | 31. 12. 2022 |
2,08815 % | Sphera Funds Management Ltd. | 1.002.783 | 50.000 | 31. 12. 2022 |
2,03927 % | Medical Strategy GmbH | 979.309 | 0 | 30. 9. 2022 |
1,61366 % | Dimensional Fund Advisors, L.P. | 774.922 | 112.822 | 31. 12. 2022 |
1,60203 % | Assenagon Asset Management S.A. | 769.336 | −140.554 | 31. 12. 2022 |
1,56830 % | Acadian Asset Management LLC | 753.140 | 123.841 | 31. 12. 2022 |
1,38822 % | AWM Investment Company, Inc. | 666.661 | 0 | 31. 12. 2022 |
1,14145 % | Barclays Bank PLC | 548.155 | 97.922 | 31. 12. 2022 |
1,14009 % | NewEdge Wealth, LLC | 547.501 | 0 | 31. 12. 2022 |
1,13113 % | BMO Capital Markets (US) | 543.200 | 543.200 | 31. 12. 2022 |
1,12151 % | Alyeska Investment Group, L.P. | 538.579 | 38.579 | 31. 12. 2022 |
1,09038 % | Goldman Sachs & Company, Inc. | 523.630 | 189.551 | 31. 12. 2022 |
1,08237 % | Morgan Stanley & Co. LLC | 519.782 | −32.140 | 31. 12. 2022 |
1,04883 % | Schonfeld Strategic Advisors LLC | 503.674 | 244.574 | 31. 12. 2022 |
1,04244 % | Renaissance Technologies LLC | 500.605 | −142.000 | 31. 12. 2022 |
1,02265 % | Two Sigma Investments, LP | 491.105 | −365.147 | 31. 12. 2022 |
0,95823 % | IndexIQ Advisors LLC | 460.165 | 460.165 | 28. 2. 2023 |
0,87013 % | Geode Capital Management, L.L.C. | 417.858 | 9.369 | 31. 12. 2022 |
0,60512 % | Connor, Clark & Lunn Investment Management Ltd. | 290.595 | −9.763 | 31. 12. 2022 |
0,57106 % | J.P. Morgan Securities LLC | 274.240 | 186.915 | 31. 12. 2022 |
0,50016 % | Susquehanna International Group, LLP | 240.190 | 202.781 | 31. 12. 2022 |
0,43866 % | Stuart Nancy | 210.654 | −6.048 | 15. 2. 2023 |
0,43006 % | Pura Vida Investments, LLC | 206.525 | 206.525 | 31. 12. 2022 |
0,41814 % | International Biotechnology Trust PLC | 200.800 | 0 | 31. 12. 2022 |
0,40416 % | Citi Investment Research (US) | 194.090 | 73.373 | 31. 12. 2022 |
0,31849 % | Manulife Investment Management (North America) Limited | 152.947 | 151.883 | 31. 1. 2023 |
0,30860 % | Bridgeway Capital Management, LLC | 148.200 | 0 | 31. 12. 2022 |
0,29340 % | State Street Global Advisors (US) | 140.898 | 20.300 | 31. 12. 2022 |
0,23707 % | D. E. Shaw & Co., L.P. | 113.848 | 113.848 | 31. 12. 2022 |
0,23656 % | Aberdeen Asset Managers Ltd. | 113.600 | −105.700 | 28. 2. 2023 |
0,22506 % | Northern Trust Investments, Inc. | 108.079 | −437 | 31. 12. 2022 |
0,21511 % | ClariVest Asset Management LLC | 103.300 | −1.500 | 31. 12. 2022 |
0,20824 % | BZ Bank AG (Asset Management) | 100.000 | 0 | 30. 11. 2022 |
0,18408 % | Florida State Board of Administration | 88.400 | 88.400 | 30. 9. 2022 |
0,18396 % | Ensign Peak Advisors, Inc. | 88.341 | 0 | 31. 12. 2022 |
0,18158 % | City National Rochdale, LLC | 87.200 | 87.200 | 31. 12. 2022 |
0,17490 % | Caxton Associates LP | 83.993 | −40.122 | 31. 12. 2022 |
0,15524 % | Walleye Capital LLC | 74.548 | 74.548 | 31. 12. 2022 |
0,14785 % | Black Diamond Financial, LLC | 71.000 | 0 | 31. 12. 2022 |
0,14622 % | Morgan Stanley Smith Barney LLC | 70.221 | 0 | 31. 12. 2022 |
0,12513 % | BG Fund Management Luxembourg S.A. | 60.092 | 0 | 31. 12. 2022 |
0,12202 % | Kensington Investment Counsel, LLC | 58.599 | −18.202 | 31. 12. 2022 |
0,10229 % | RBF Capital, LLC | 49.122 | −15.781 | 31. 12. 2022 |
0,09816 % | Qube Research & Technologies Ltd | 47.137 | 13.399 | 31. 12. 2022 |
0,09614 % | Cubist Systematic Strategies, LLC | 46.167 | −26.901 | 31. 12. 2022 |
0,08168 % | Aldrich (Richard H) | 39.226 | −358.500 | 6. 3. 2023 |
0,08057 % | Cassella (James V) | 38.690 | −3.762 | 15. 2. 2023 |
0,07925 % | 683 Capital Management LLC | 38.058 | 38.058 | 31. 12. 2022 |
0,07689 % | van Heek (Christine) | 36.926 | 26.926 | 9. 6. 2022 |
0,07371 % | Lake Street Advisors | 35.398 | 0 | 31. 12. 2022 |
0,06771 % | Alps Advisors, Inc. | 32.516 | 6.319 | 31. 12. 2022 |
0,06395 % | BlackRock Advisors (UK) Limited | 30.710 | 8.243 | 28. 2. 2023 |
0,06247 % | ACCI Capital Investments SGIIC, SA | 30.000 | −10.000 | 31. 12. 2022 |
0,06123 % | Jane Street Capital, L.L.C. | 29.404 | 18.992 | 31. 12. 2022 |
0,06084 % | Dimensional Fund Advisors, Ltd. | 29.215 | 4.867 | 31. 1. 2023 |
0,06045 % | Marshall Wace LLP | 29.030 | 29.030 | 31. 12. 2022 |
0,06018 % | Auchincloss (Thomas G Jr) | 28.900 | 22.400 | 9. 6. 2022 |
0,05875 % | Apo Asset Management GmbH | 28.215 | 0 | 31. 1. 2023 |
0,05411 % | AHL Partners LLP | 25.987 | 25.987 | 31. 12. 2022 |
0,05085 % | Occudo Quantitative Strategies LP | 24.418 | −38.386 | 31. 12. 2022 |
0,05073 % | Hutt (Peter Barton) | 24.363 | 0 | 14. 10. 2022 |
0,05052 % | BlackRock Financial Management, Inc. | 24.259 | 8.692 | 31. 12. 2022 |
0,04963 % | Barclays Capital Inc. | 23.835 | 21.314 | 31. 12. 2022 |
0,04720 % | BlackRock Asset Management Ireland Limited | 22.668 | 22.668 | 31. 12. 2022 |
0,04334 % | Northern Trust Global Investments | 20.813 | −5 | 31. 12. 2022 |
0,04320 % | Lighthouse Partners | 20.746 | 20.746 | 31. 12. 2022 |
0,04240 % | SG Americas Securities, L.L.C. | 20.361 | 3.352 | 31. 12. 2022 |
0,04165 % | Birchview Capital, LP | 20.000 | 0 | 31. 12. 2022 |
0,03834 % | Boothbay Fund Management, LLC | 18.414 | 18.414 | 31. 12. 2022 |
0,03830 % | Becker (Marc A) | 18.392 | −3.762 | 15. 2. 2023 |
0,03598 % | BNY Mellon Asset Management | 17.278 | 0 | 31. 12. 2022 |
0,03540 % | Alpine Associates Management Inc. | 17.000 | −17.700 | 28. 2. 2023 |
0,03415 % | Hoeiland (Jesper) | 16.400 | 16.400 | 9. 6. 2022 |
0,03415 % | Jaeger (Wilfred E) | 16.400 | 16.400 | 9. 6. 2022 |
0,03290 % | Acuitas Investments LLC | 15.800 | −600 | 31. 12. 2022 |
0,03266 % | Charles Schwab Investment Management, Inc. | 15.686 | 0 | 31. 12. 2022 |
0,03242 % | HSBC Global Asset Management (UK) Limited | 15.571 | 0 | 31. 12. 2022 |
0,03209 % | Tung (Roger D) | 15.411 | −814.343 | 6. 3. 2023 |
0,03209 % | Mirabella Financial Services LLP | 15.410 | 15.410 | 31. 12. 2022 |
0,03002 % | Jump Financial, LLC | 14.418 | −21.782 | 31. 12. 2022 |
0,02499 % | Cantor Fitzgerald, L.P | 12.000 | −30.100 | 31. 12. 2022 |
0,02155 % | Flagship Harbor Advisors LLC | 10.350 | 0 | 31. 12. 2022 |
0,02082 % | Roanoke Asset Management Corp. | 10.000 | 0 | 31. 12. 2022 |
0,02041 % | Blackstone Alternative Investment Advisors LLC | 9.800 | 8.000 | 30. 9. 2022 |
0,01664 % | Lord, Abbett & Co. LLC | 7.992 | 0 | 31. 1. 2023 |
0,01664 % | BlackRock Investment Management, LLC | 7.992 | 242 | 31. 12. 2022 |
0,01541 % | Tower Research Capital LLC | 7.398 | 5.351 | 31. 12. 2022 |
0,01520 % | UBS Financial Services, Inc. | 7.301 | −6.560 | 31. 12. 2022 |