4.41580 % | BlackRock Institutional Trust Company, N.A. | 16,974,342 | 442,348 | 12/31/2023 |
3.80430 % | State Street Global Advisors (US) | 14,623,723 | 672,447 | 12/31/2023 |
2.99411 % | Langer (Robert S Jr.) | 11,509,357 | 0 | 3/7/2024 |
2.51458 % | Flagship Ventures | 9,666,038 | 0 | 3/7/2024 |
2.35442 % | Boston Biotech Ventures, L.L.C. | 9,050,372 | 0 | 3/7/2024 |
11.87683 % | Baillie Gifford & Co. | 45,654,527 | 5,344 | 12/31/2023 |
10.15525 % | The Vanguard Group, Inc. | 39,036,765 | 5,275,392 | 3/28/2024 |
1.91193 % | Theleme Partners LLP | 7,349,456 | 451,844 | 12/31/2023 |
1.87970 % | Wellington Management Company, LLP | 7,225,579 | 1,614,460 | 12/31/2023 |
1.86744 % | Invesco Capital Management (QQQ Trust) | 7,178,424 | -15,597 | 3/31/2024 |
1.70783 % | OCHA, L.L.C. | 6,564,880 | 0 | 3/7/2024 |
1.70381 % | Geode Capital Management, L.L.C. | 6,549,461 | 134,452 | 12/31/2023 |
1.60415 % | Fidelity Management & Research Company LLC | 6,166,336 | 2,325,236 | 12/31/2023 |
1.42045 % | Bancel (Stephane J) | 5,460,224 | 0 | 3/7/2024 |
0.94417 % | Capital World Investors | 3,629,389 | -338,342 | 12/31/2023 |
0.92169 % | Manulife Investment Management (North America) Limited | 3,542,967 | -333,180 | 12/31/2023 |
0.90918 % | Norges Bank Investment Management (NBIM) | 3,494,874 | -3,393 | 12/31/2023 |
0.85147 % | Coatue Management, L.L.C. | 3,273,052 | -1,636,526 | 12/31/2023 |
0.81536 % | Banque Pictet & Cie S.A. | 3,134,229 | -9,198 | 12/31/2023 |
0.73644 % | Legal & General Investment Management Ltd. | 2,830,894 | 459,120 | 12/31/2023 |
0.71825 % | Capital Research Global Investors | 2,760,948 | 23,296 | 3/31/2024 |
0.66049 % | BlackRock Asset Management Ireland Limited | 2,538,933 | 19,319 | 12/31/2023 |
0.63504 % | Invesco Capital Management LLC | 2,441,106 | -263,350 | 12/31/2023 |
0.54248 % | Northern Trust Investments, Inc. | 2,085,285 | 23,661 | 12/31/2023 |
0.53510 % | Afeyan (Noubar Boghos) | 2,056,931 | -45,000 | 4/17/2024 |
0.52423 % | Morgan Stanley & Co. LLC | 2,015,130 | -725,471 | 12/31/2023 |
0.49874 % | Baillie Gifford Overseas Ltd. | 1,917,148 | -65,547 | 2/29/2024 |
0.49647 % | Bellevue Asset Management AG | 1,908,420 | 413,095 | 12/31/2023 |
0.48684 % | Charles Schwab Investment Management, Inc. | 1,871,399 | 70,368 | 12/31/2023 |
0.46760 % | Pictet Asset Management Ltd. | 1,797,450 | 407,441 | 12/31/2023 |
0.46721 % | Mawer Investment Management Ltd. | 1,795,949 | -25,399 | 12/31/2023 |
0.42723 % | Hoge (Stephen) | 1,642,290 | -15,000 | 4/15/2024 |
0.41955 % | Goldman Sachs Bank AG | 1,612,759 | 169,386 | 12/31/2023 |
0.40214 % | Sumitomo Mitsui Trust Bank, Limited | 1,545,829 | 463,960 | 3/31/2024 |
0.39032 % | BlackRock Financial Management, Inc. | 1,500,372 | 92,337 | 12/31/2023 |
0.38792 % | Goldman Sachs & Company, Inc. | 1,491,182 | 453,722 | 12/31/2023 |
0.38241 % | BlackRock Investment Management (UK) Ltd. | 1,469,975 | -169,470 | 12/31/2023 |
0.37040 % | Goldman Sachs Asset Management, L.P. | 1,423,814 | -172,089 | 12/31/2023 |
0.34005 % | Dimensional Fund Advisors, L.P. | 1,307,164 | -530,849 | 12/31/2023 |
0.33765 % | Mellon Investments Corporation | 1,297,913 | -89,097 | 12/31/2023 |
0.33217 % | JP Morgan Asset Management | 1,276,847 | -165,162 | 12/31/2023 |
0.31670 % | ARK Investment Management LLC | 1,217,383 | 779,980 | 3/31/2024 |
0.31566 % | UBS Asset Management (Switzerland) | 1,213,379 | 168,975 | 12/31/2023 |
0.26316 % | Schweizerische Nationalbank | 1,011,600 | -30,700 | 12/31/2023 |
0.25162 % | BNY Mellon Asset Management | 967,232 | 20,005 | 12/31/2023 |
0.24244 % | UBS Asset Management (Americas), Inc. | 931,928 | 250,648 | 12/31/2023 |
0.23607 % | Nuveen LLC | 907,435 | -50,202 | 12/31/2023 |
0.23319 % | Parametric Portfolio Associates LLC | 896,385 | -52,804 | 12/31/2023 |
0.23239 % | First Trust Advisors L.P. | 893,316 | 102,251 | 12/31/2023 |
0.23085 % | Barclays Bank PLC | 887,398 | 244,923 | 12/31/2023 |
0.22238 % | Morgan Stanley Smith Barney LLC | 854,829 | -136,227 | 12/31/2023 |
0.21947 % | Mitsubishi UFJ Trust and Banking Corporation | 843,632 | -67,536 | 12/31/2023 |
0.21848 % | UBS Asset Management (UK) Ltd. | 839,823 | 142,435 | 12/31/2023 |
0.21061 % | UBS Financial Services, Inc. | 809,587 | -144,578 | 12/31/2023 |
0.19477 % | DWS Investments UK Limited | 748,693 | 299,806 | 12/31/2023 |
0.18753 % | JPMorgan Asset Management U.K. Limited | 720,874 | -4,521 | 12/31/2023 |
0.18639 % | Amundi Asset Management, SAS | 716,476 | 201,050 | 12/31/2023 |
0.18524 % | National Pension Service | 712,056 | 19,961 | 12/31/2023 |
0.18107 % | Jane Street Capital, L.L.C. | 696,018 | 334,530 | 12/31/2023 |
0.17993 % | BNP Paribas Securities Corp. North America | 691,655 | 33,374 | 12/31/2023 |
0.17154 % | T. Rowe Price Associates, Inc. | 659,403 | -394,341 | 12/31/2023 |
0.17077 % | BlackRock (Netherlands) B.V. | 656,425 | 11,793 | 12/31/2023 |
0.16400 % | HSBC Global Asset Management (UK) Limited | 630,404 | 892 | 12/31/2023 |
0.16271 % | Northern Trust Global Investments | 625,448 | 92,500 | 12/31/2023 |
0.16107 % | Assetmark, Inc. | 619,152 | 403,428 | 12/31/2023 |
0.15969 % | Capital International Investors | 613,850 | -7 | 12/31/2023 |
0.15609 % | Olayan Investments Company Establishment | 600,000 | 600,000 | 12/31/2023 |
0.15377 % | California Public Employees' Retirement System | 591,073 | -19,766 | 12/31/2023 |
0.15329 % | BlackRock Japan Co., Ltd. | 589,252 | 32,279 | 12/31/2023 |
0.15196 % | Rhumbline Advisers Ltd. Partnership | 584,131 | -3,281 | 12/31/2023 |
0.15055 % | Credit Suisse Funds AG | 578,702 | -24,567 | 12/31/2023 |
0.14074 % | Citadel Advisors LLC | 541,016 | 35,601 | 12/31/2023 |
0.13932 % | BlackRock Investment Management, LLC | 535,543 | 5,131 | 12/31/2023 |
0.13622 % | Pictet & Cie (Europe) S.A. | 523,626 | 29,338 | 12/31/2023 |
0.13481 % | California State Teachers Retirement System | 518,224 | -346 | 12/31/2023 |
0.13072 % | Citi Investment Research (US) | 502,470 | -176,908 | 12/31/2023 |
0.12032 % | Sagan (Paul L) | 462,513 | 0 | 3/7/2024 |
0.11963 % | Voya Investment Management LLC | 459,871 | 149,929 | 12/31/2023 |
0.11863 % | BofA Global Research (US) | 456,003 | -207,684 | 12/31/2023 |
0.11847 % | New York State Common Retirement Fund | 455,407 | -37,691 | 12/31/2023 |
0.11811 % | Matrix Capital Management Company, LP | 454,000 | 454,000 | 12/31/2023 |
0.11768 % | Pictet Asset Management (Japan) Ltd. | 452,349 | 78,103 | 10/31/2023 |
0.11657 % | T. Rowe Price International Ltd | 448,092 | 6,798 | 12/31/2023 |
0.11462 % | Invesco Advisers, Inc. | 440,587 | 45,496 | 12/31/2023 |
0.11436 % | Susquehanna International Group, LLP | 439,606 | 107,579 | 12/31/2023 |
0.10838 % | AllianceBernstein L.P. | 416,626 | -28,598 | 12/31/2023 |
0.10714 % | Grantham Mayo Van Otterloo & Co LLC | 411,846 | 105,431 | 12/31/2023 |
0.10616 % | Mirae Asset Global Investments (USA) LLC | 408,090 | -1,333 | 12/31/2023 |
0.10422 % | BMO Capital Markets (US) | 400,617 | 178,641 | 12/31/2023 |
0.10225 % | Douglas C. Lane & Associates | 393,039 | 56,901 | 3/31/2024 |
0.10125 % | Candriam Luxembourg S.A. | 389,205 | 25,174 | 2/29/2024 |
0.10061 % | Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 386,741 | 23,288 | 12/31/2023 |
0.09888 % | RBC Capital Markets Wealth Management | 380,093 | 74,145 | 12/31/2023 |
0.09785 % | Florida State Board of Administration | 376,117 | 8,409 | 12/31/2023 |
0.09682 % | CPP Investment Board | 372,158 | 2,402 | 12/31/2023 |
0.09662 % | JPMorgan Private Bank (United States) | 371,426 | 103,801 | 12/31/2023 |
0.09563 % | Royal London Asset Management Ltd. | 367,615 | 8,542 | 12/31/2023 |
0.09537 % | ProShare Advisors LLC | 366,604 | -61,975 | 12/31/2023 |
0.09444 % | Candriam Belgium S.A. | 363,044 | -79,316 | 12/31/2023 |
0.09422 % | D. E. Shaw & Co., L.P. | 362,177 | 303,845 | 12/31/2023 |