9,70610 % | Suvretta Capital Management, LLC | 5 346 119 | 141 177 | |
8,22440 % | Eventide Asset Management, LLC | 4 529 997 | 0 | |
8,17512 % | Tang Capital Management, LLC | 4 502 857 | 4 502 857 | |
6,96050 % | Franklin Advisers, Inc. | 3 833 845 | 49 598 | |
6,85359 % | BlackRock Institutional Trust Company, N.A. | 3 774 956 | 293 832 | |
5,90051 % | Cormorant Asset Management, LP | 3 250 000 | 625 000 | |
5,71895 % | Avoro Capital Advisors LLC | 3 150 000 | 0 | |
5,37248 % | Jennison Associates LLC | 2 959 161 | 3 818 | |
4,85336 % | The Vanguard Group, Inc. | 2 673 231 | 95 756 | |
4,68637 % | Adage Capital Management, L.P. | 2 581 250 | −323 226 | |
3,87498 % | Lion Point Capital, L.P. | 2 134 337 | −11 000 | |
3,39953 % | Bleichroeder LP | 1 872 463 | 0 | |
3,21841 % | Sofinnova Investments, Inc | 1 772 699 | 787 093 | |
3,12762 % | GMT Capital Corp. | 1 722 695 | 0 | |
2,59814 % | Bain Capital Life Sciences Investors, LLC | 1 431 058 | 0 | |
2,06880 % | Geode Capital Management, L.L.C. | 1 139 494 | 94 546 | |
1,82627 % | State Street Global Advisors (US) | 1 005 907 | 10 352 | |
1,45243 % | Woodline Partners LP | 800 000 | 168 480 | |
1,35452 % | Ikarian Capital LLC | 746 069 | 0 | |
1,15129 % | BlackRock Financial Management, Inc. | 634 128 | 151 711 | |
1,08278 % | Citadel Advisors LLC | 596 396 | 118 387 | |
1,04715 % | Morgan Stanley & Co. LLC | 576 772 | 537 090 | |
1,02306 % | Opaleye Management Inc. | 563 500 | −20 500 | |
1,00322 % | abrdn Inc. | 552 572 | 552 572 | |
0,89579 % | Point72 Asset Management, L.P. | 493 400 | −571 637 | |
0,83959 % | Superstring Capital Management LP | 462 444 | 462 444 | |
0,77090 % | Northern Trust Investments, Inc. | 424 613 | 36 214 | |
0,74637 % | Tekla Capital Management LLC_NLE | 411 101 | −45 679 | |
0,61728 % | PGIM Securities Investment Trust Enterprise | 340 000 | 80 000 | |
0,52651 % | Schroder Investment Management Ltd. (SIM) | 290 000 | 290 000 | |
0,52651 % | International Biotechnology Trust PLC | 290 000 | 200 000 | |
0,49230 % | Assenagon Asset Management S.A. | 271 157 | −240 036 | |
0,46275 % | Medical Strategy GmbH | 254 884 | 0 | |
0,45843 % | Walleye Capital LLC | 252 501 | −88 099 | |
0,43809 % | Wellington Management Company, LLP | 241 299 | 85 455 | |
0,36311 % | Altium Capital Management LP | 200 000 | 74 967 | |
0,32698 % | Propel Bio Management, LLC | 180 100 | 30 100 | |
0,30156 % | Jefferies LLC | 166 101 | −88 633 | |
0,29352 % | Boothbay Fund Management, LLC | 161 672 | −292 200 | |
0,27693 % | BNY Mellon Asset Management | 152 531 | 3 097 | |
0,27233 % | Simplify Asset Management Inc | 150 000 | 0 | |
0,27129 % | Charles Schwab Investment Management, Inc. | 149 426 | 10 497 | |
0,26126 % | Susquehanna International Group, LLP | 143 904 | 10 814 | |
0,25105 % | Nuveen LLC | 138 277 | 0 | |
0,24510 % | Ghost Tree Capital, LLC | 135 000 | 135 000 | |
0,24203 % | BlackRock Investment Management, LLC | 133 309 | 169 | |
0,19485 % | Braunstein (Scott N.) | 107 324 | −166 188 | |
0,19133 % | Campbell & Company, Inc. | 105 383 | 105 383 | |
0,17799 % | Jane Street Capital, L.L.C. | 98 039 | −40 828 | |
0,16855 % | Qube Research & Technologies Ltd | 92 836 | 92 836 | |
0,15118 % | Victory Capital Management Inc. | 83 270 | −11 280 | |
0,15082 % | UBS Financial Services, Inc. | 83 070 | 26 926 | |
0,13865 % | Barclays Bank PLC | 76 371 | 67 361 | |
0,13759 % | Rhumbline Advisers Ltd. Partnership | 75 787 | 5 082 | |
0,10949 % | Shafer (Christina) | 60 308 | −2 153 | |
0,09616 % | Manning (Martha E) | 52 966 | −1 894 | |
0,09232 % | Trexquant Investment LP | 50 851 | 50 851 | |
0,09017 % | Alpha DNA Investment Management LLC | 49 664 | −27 419 | |
0,08301 % | BofA Global Research (US) | 45 723 | −7 125 | |
0,07957 % | Mach-1 Financial Group, Inc. | 43 828 | −24 375 | |
0,07862 % | AE Wealth Management LLC | 43 302 | −25 928 | |
0,07481 % | Two Sigma Investments, LP | 41 205 | −32 625 | |
0,07444 % | Abaris Investment Management AG | 41 000 | −62 000 | |
0,07443 % | Goldman Sachs & Company, Inc. | 40 997 | −13 821 | |
0,07130 % | AllianceBernstein L.P. | 39 270 | 4 580 | |
0,06091 % | Grimes & Company, Inc. | 33 549 | −751 | |
0,06090 % | JPMorgan Private Bank (United States) | 33 543 | 33 543 | |
0,05741 % | Goldman Sachs Asset Management, L.P. | 31 622 | −29 761 | |
0,05371 % | Aperio Group, LLC | 29 582 | 3 204 | |
0,05302 % | Dimensional Fund Advisors, L.P. | 29 201 | −2 888 | |
0,05255 % | BlackRock Advisors (UK) Limited | 28 944 | 1 395 | |
0,05139 % | T. Rowe Price International Ltd | 28 305 | 936 | |
0,05055 % | Northern Trust Global Investments | 27 841 | −13 987 | |
0,04869 % | BlackRock Asset Management Ireland Limited | 26 817 | 4 719 | |
0,04785 % | MetLife Investment Management, LLC | 26 356 | 0 | |
0,04659 % | Millennium Management LLC | 25 663 | 25 663 | |
0,04619 % | Mirae Asset Global Investments (USA) LLC | 25 444 | 174 | |
0,04576 % | SunAmerica Asset Management, LLC | 25 206 | −101 | |
0,04180 % | AQR Capital Management, LLC | 23 024 | 14 502 | |
0,04118 % | DWS Investments UK Limited | 22 681 | −748 | |
0,04048 % | Belvedere Trading, LLC | 22 297 | −10 414 | |
0,03846 % | Invesco Advisers, Inc. | 21 183 | −3 394 | |
0,03749 % | Voya Investment Management LLC | 20 648 | 0 | |
0,03637 % | Manulife Investment Management (North America) Limited | 20 035 | 0 | |
0,03173 % | Mayleben (Timothy M) | 17 475 | −4 600 | |
0,03108 % | New York State Common Retirement Fund | 17 120 | −2 926 | |
0,03025 % | Mellon Investments Corporation | 16 661 | 2 751 | |
0,02627 % | Florida State Board of Administration | 14 470 | 0 | |
0,02589 % | Tower Research Capital LLC | 14 262 | 6 721 | |
0,02578 % | Values First Advisors, Inc. | 14 197 | 736 | |
0,02469 % | Denali Advisors, LLC | 13 600 | 0 | |
0,02391 % | Wells Fargo Bank, N.A. | 13 168 | 3 023 | |
0,02309 % | Pfanstiel (Steven) | 12 720 | −58 977 | |
0,02253 % | Hulihan (Joseph M.D.) | 12 408 | −54 227 | |
0,02231 % | SG Americas Securities, L.L.C. | 12 289 | 12 289 | |
0,02172 % | Franklin Advisory Services, LLC | 11 965 | 11 965 | |
0,02157 % | ProShare Advisors LLC | 11 880 | 2 101 | |
0,01997 % | Corton Capital Inc | 10 999 | 10 999 | |
0,01966 % | PGIM Quantitative Solutions LLC | 10 830 | −450 | |
0,01964 % | RBC Wealth Management, International | 10 818 | 4 469 | |