9,65345 % | BVF Partners L.P. | 6 851 051 | 0 | |
8,61970 % | EcoR1 Capital, LLC | 6 117 400 | 0 | |
7,49045 % | Rubric Capital Management LP | 5 315 969 | −129 941 | |
5,55738 % | BlackRock Institutional Trust Company, N.A. | 3 944 073 | 748 785 | |
5,14608 % | Levin (Jeremy M) | 3 652 176 | 18 248 | |
5,14092 % | Madison Avenue Partners LP | 3 648 509 | 0 | |
4,21273 % | The Vanguard Group, Inc. | 2 989 777 | 23 360 | |
3,52262 % | Invus Public Equities Advisors, LLC | 2 500 000 | 0 | |
2,33320 % | Acadian Asset Management LLC | 1 655 871 | −45 357 | |
2,07871 % | JP Morgan Asset Management | 1 475 260 | −30 973 | |
10,61293 % | Takeda Pharmaceutical Co Ltd | 7 531 996 | 1 250 000 | |
1,85949 % | TLS Advisors LLC | 1 319 679 | 0 | |
1,73725 % | Geode Capital Management, L.L.C. | 1 232 923 | 32 146 | |
1,57862 % | State Street Global Advisors (US) | 1 120 347 | 11 288 | |
1,21857 % | Cowen Investment Management LLC | 864 822 | 0 | |
1,21857 % | Blue Owl Capital Holdings LP | 864 822 | 864 822 | |
0,63407 % | Northern Trust Investments, Inc. | 449 998 | 14 862 | |
0,61906 % | Bridgeway Capital Management, LLC | 439 345 | −19 355 | |
0,60624 % | Wells Fargo Advisors | 430 247 | 0 | |
0,55766 % | FFT Wealth Management LLC | 395 774 | 395 774 | |
0,44403 % | Medical Strategy GmbH | 315 131 | 48 816 | |
0,35226 % | ARIAD Asset Management GmbH | 250 000 | −94 634 | |
0,34281 % | Dimensional Fund Advisors, L.P. | 243 295 | 100 437 | |
0,23976 % | BlackRock Investment Management, LLC | 170 159 | −1 630 | |
0,23093 % | BNY Mellon Asset Management | 163 890 | −1 769 | |
0,22799 % | Charles Schwab Investment Management, Inc. | 161 808 | −8 228 | |
0,22578 % | BlackRock Financial Management, Inc. | 160 236 | 6 969 | |
0,21681 % | JPMorgan Private Bank (United States) | 153 873 | 47 058 | |
0,20361 % | UBS O'Connor LLC | 144 500 | −5 500 | |
0,17465 % | Morgan Stanley & Co. LLC | 123 948 | 93 237 | |
0,16689 % | ETF Architect | 118 445 | 10 645 | |
0,16075 % | Nuveen LLC | 114 085 | 0 | |
0,12037 % | Vestal Point Capital, LP | 85 429 | 85 429 | |
0,12009 % | Fidelity Management & Research Company LLC | 85 225 | −6 281 | |
0,11563 % | Barclays Bank PLC | 82 060 | 71 280 | |
0,11438 % | Connor, Clark & Lunn Investment Management Ltd. | 81 175 | 2 | |
0,11225 % | Rhumbline Advisers Ltd. Partnership | 79 666 | −3 125 | |
0,11058 % | Assenagon Asset Management S.A. | 78 479 | 77 447 | |
0,11028 % | D. E. Shaw & Co., L.P. | 78 267 | −6 041 | |
0,10308 % | Tejara Capital Ltd. | 73 153 | 73 153 | |
0,10136 % | UBS Financial Services, Inc. | 71 933 | 23 826 | |
0,08784 % | Jacobs Levy Equity Management, Inc. | 62 341 | 0 | |
0,07652 % | BofA Global Research (US) | 54 308 | 14 612 | |
0,07366 % | Newton Investment Management North America, LLC | 52 280 | 0 | |
0,07214 % | Renaissance Technologies LLC | 51 200 | −29 600 | |
0,07172 % | Jane Street Capital, L.L.C. | 50 901 | 50 901 | |
0,06404 % | BlackRock Asset Management Ireland Limited | 45 450 | 45 450 | |
0,06308 % | Dimensional Fund Advisors, Ltd. | 44 768 | 3 357 | |
0,06221 % | Bank of Nova Scotia | 44 152 | 0 | |
0,05787 % | Perone (Thomas Michael) | 41 067 | 41 067 | |
0,05731 % | Northern Trust Global Investments | 40 674 | −3 000 | |
0,05607 % | SG Americas Securities, L.L.C. | 39 792 | 13 728 | |
0,05476 % | Goldman Sachs & Company, Inc. | 38 862 | 5 194 | |
0,05283 % | BlackRock Advisors (UK) Limited | 37 490 | 1 800 | |
0,04790 % | Mirae Asset Global Investments (USA) LLC | 33 996 | 1 765 | |
0,04599 % | Mellon Investments Corporation | 32 639 | 498 | |
0,04469 % | MetLife Investment Management, LLC | 31 717 | 0 | |
0,04352 % | Tardio (Jason) | 30 886 | 28 125 | |
0,04321 % | Rona (Jeffrey A) | 30 666 | 28 125 | |
0,04176 % | SunAmerica Asset Management, LLC | 29 639 | −120 | |
0,03863 % | Invesco Advisers, Inc. | 27 416 | 5 463 | |
0,03776 % | Voya Investment Management LLC | 26 797 | 972 | |
0,03664 % | First Manhattan Co. LLC | 26 000 | 0 | |
0,03626 % | Vaughan Nelson Investment Management, L.P. | 25 732 | 0 | |
0,03501 % | Manulife Investment Management (North America) Limited | 24 850 | 0 | |
0,03419 % | Virtu Americas LLC | 24 264 | 24 264 | |
0,03231 % | Goldman Sachs Asset Management, L.P. | 22 933 | −155 | |
0,03224 % | DWS Investments UK Limited | 22 884 | −1 136 | |
0,03131 % | Susquehanna International Group, LLP | 22 220 | 22 220 | |
0,03054 % | William Blair & Company, L.L.C. (Research) | 21 676 | −401 | |
0,02818 % | Bernstein (Karen) | 20 000 | 0 | |
0,02675 % | New York State Common Retirement Fund | 18 982 | −128 | |
0,02639 % | DCF Advisers, LLC | 18 730 | −11 700 | |
0,02593 % | BNP Paribas Securities Corp. North America | 18 406 | 9 756 | |
0,02585 % | Wells Fargo Bank, N.A. | 18 344 | 3 625 | |
0,02428 % | Florida State Board of Administration | 17 230 | 0 | |
0,02328 % | Newman, Dignan & Sheerar, Inc. | 16 522 | 16 522 | |
0,02027 % | ProShare Advisors LLC | 14 385 | 6 681 | |
0,02008 % | T. Rowe Price International Ltd | 14 251 | 837 | |
0,01866 % | Adar1 Capital Management LLC | 13 246 | 13 246 | |
0,01792 % | RBC Wealth Management, International | 12 720 | 2 709 | |
0,01775 % | Bailard, Inc. | 12 600 | 0 | |
0,01604 % | Squarepoint Capital LLP | 11 381 | 11 381 | |
0,01578 % | Citadel Advisors LLC | 11 202 | 11 202 | |
0,01494 % | RBC Capital Partners | 10 602 | 7 794 | |
0,01413 % | Citi Investment Research (US) | 10 026 | 9 997 | |
0,01383 % | California State Teachers Retirement System | 9 815 | −3 342 | |
0,01263 % | Avantis Investors | 8 962 | 45 | |
0,01241 % | Parametric Portfolio Associates LLC | 8 807 | −886 | |
0,01230 % | Horizon Kinetics LLC | 8 731 | 0 | |
0,01152 % | China Universal Asset Management Co., Ltd. | 8 178 | 8 178 | |
0,00959 % | Principal Global Investors (Equity) | 6 809 | −247 | |
0,00911 % | Mackenzie Financial Corporation | 6 468 | −24 | |
0,00826 % | AllianceBernstein L.P. | 5 860 | 0 | |
0,00813 % | DFA Australia Ltd. | 5 768 | 10 | |
0,00733 % | Amalgamated Bank Institutional Asset Management & Custody | 5 202 | −598 | |
0,00733 % | Legal & General Investment Management Ltd. | 5 201 | 588 | |
0,00694 % | Ameritas Investment Partners, Inc. | 4 924 | 0 | |
0,00659 % | Wellington Management Company, LLP | 4 674 | −148 | |
0,00618 % | Tower Research Capital LLC | 4 383 | 346 | |