| 8,91330 % | Wellington Management Company, LLP | 7 585 221 | -57 225 | 2023. 12. 31. |
| 6,73731 % | BlackRock Institutional Trust Company, N.A. | 5 733 451 | 811 058 | 2023. 12. 31. |
| 6,65100 % | Kynam Capital Management LP | 5 660 000 | 2 060 000 | 2023. 12. 31. |
| 5,89451 % | State Street Global Advisors (US) | 5 016 224 | 1 415 576 | 2023. 12. 31. |
| 5,07684 % | The Vanguard Group, Inc. | 4 320 388 | 712 749 | 2023. 12. 31. |
| 4,96148 % | Avoro Capital Advisors LLC | 4 222 222 | 1 666 667 | 2023. 12. 31. |
| 4,64160 % | Avidity Partners Management LP | 3 950 000 | 1 129 000 | 2023. 12. 31. |
| 3,97561 % | Eversept Partners, LP | 3 383 244 | 786 999 | 2023. 12. 31. |
| 3,33079 % | Point72 Asset Management, L.P. | 2 834 499 | -322 483 | 2023. 12. 31. |
| 3,18596 % | T. Rowe Price Investment Management, Inc. | 2 711 253 | 1 644 705 | 2023. 12. 31. |
| 2,46993 % | Marshall Wace LLP | 2 101 911 | 1 497 949 | 2023. 12. 31. |
| 2,20329 % | BVF Partners L.P. | 1 875 000 | 1 875 000 | 2023. 12. 31. |
| 2,05523 % | OrbiMed Advisors, LLC | 1 749 000 | 465 000 | 2023. 12. 31. |
| 1,81459 % | Woodline Partners LP | 1 544 216 | 1 510 149 | 2023. 12. 31. |
| 1,80382 % | Geode Capital Management, L.L.C. | 1 535 055 | 174 135 | 2023. 12. 31. |
| 1,64231 % | Morgan Stanley & Co. LLC | 1 397 603 | 946 055 | 2023. 12. 31. |
| 1,56819 % | Franklin Advisers, Inc. | 1 334 531 | 1 334 531 | 2023. 12. 31. |
| 1,38073 % | Cormorant Asset Management, LP | 1 175 000 | 1 175 000 | 2023. 12. 31. |
| 1,30121 % | Goldman Sachs & Company, Inc. | 1 107 330 | -74 741 | 2023. 12. 31. |
| 1,28613 % | StemPoint Capital LP | 1 094 494 | 1 094 494 | 2023. 12. 31. |
| 1,26414 % | Sofinnova Investments, Inc | 1 075 786 | 133 969 | 2023. 12. 31. |
| 1,25852 % | Candriam Luxembourg S.A. | 1 071 000 | 0 | 2024. 02. 29. |
| 1,20447 % | Aisling Capital Management LP | 1 025 000 | 0 | 2023. 12. 31. |
| 1,19980 % | Candriam Belgium S.A. | 1 021 032 | 781 022 | 2023. 12. 31. |
| 1,11875 % | BofA Global Research (US) | 952 057 | 759 276 | 2023. 12. 31. |
| 1,10769 % | Millennium Management LLC | 942 642 | 502 872 | 2023. 12. 31. |
| 1,05758 % | Adage Capital Management, L.P. | 900 000 | -100 000 | 2023. 12. 31. |
| 1,02820 % | Foresite Capital Management, LLC | 875 000 | 0 | 2023. 12. 31. |
| 0,98475 % | BlackRock Financial Management, Inc. | 838 023 | 258 358 | 2023. 12. 31. |
| 0,91657 % | HOOPP Investment Management | 780 000 | 780 000 | 2023. 12. 31. |
| 0,90830 % | Sphera Funds Management Ltd. | 772 964 | -97 | 2023. 12. 31. |
| 0,87696 % | Kingdon Capital Management, L.L.C. | 746 293 | 746 293 | 2023. 12. 31. |
| 0,87259 % | Dafna Capital Management, LLC | 742 574 | 284 201 | 2023. 12. 31. |
| 0,86791 % | Parkman Healthcare Partners LLC | 738 589 | 526 141 | 2023. 12. 31. |
| 0,80774 % | Two Sigma Investments, LP | 687 390 | 188 773 | 2023. 12. 31. |
| 0,75720 % | JP Morgan Asset Management | 644 374 | -3761 | 2023. 12. 31. |
| 0,73118 % | Nuveen LLC | 622 237 | 462 635 | 2023. 12. 31. |
| 0,72139 % | Northern Trust Investments, Inc. | 613 904 | 72 239 | 2023. 12. 31. |
| 0,69979 % | PFM Health Sciences, LP | 595 523 | -2 119 712 | 2023. 12. 31. |
| 0,67805 % | Charles Schwab Investment Management, Inc. | 577 022 | 70 555 | 2023. 12. 31. |
| 0,62063 % | Algert Global LLC | 528 157 | 71 938 | 2023. 12. 31. |
| 0,60963 % | Saturn V Capital Management LLC | 518 799 | -289 170 | 2023. 12. 31. |
| 0,60500 % | Ensign Peak Advisors, Inc. | 514 852 | 0 | 2023. 12. 31. |
| 0,60400 % | Soleus Capital Management, L.P. | 514 000 | 394 500 | 2023. 12. 31. |
| 0,55893 % | Columbia Threadneedle Investments (US) | 475 648 | 4459 | 2023. 12. 31. |
| 0,55535 % | Palo Alto Investors LP | 472 600 | 0 | 2023. 12. 31. |
| 0,55402 % | Schonfeld Strategic Advisors LLC | 471 475 | 253 062 | 2023. 12. 31. |
| 0,48410 % | Assenagon Asset Management S.A. | 411 965 | 21 427 | 2023. 12. 31. |
| 0,47401 % | Rafferty Asset Management LLC | 403 381 | 119 257 | 2023. 12. 31. |
| 0,42921 % | Nantahala Capital Management, LLC | 365 259 | 125 228 | 2023. 12. 31. |
| 0,41510 % | ExodusPoint Capital Management, LP | 353 252 | 197 538 | 2023. 12. 31. |
| 0,37710 % | Granahan Investment Management, LLC | 320 911 | 307 862 | 2023. 12. 31. |
| 0,34172 % | UBS Financial Services, Inc. | 290 801 | 215 444 | 2023. 12. 31. |
| 0,32327 % | Zimmer Partners, LP | 275 100 | 275 100 | 2023. 12. 31. |
| 0,29854 % | Barclays Bank PLC | 254 061 | 67 076 | 2023. 12. 31. |
| 0,28683 % | Macquarie Investment Management | 244 090 | 11 624 | 2023. 12. 31. |
| 0,28553 % | Citadel Advisors LLC | 242 985 | -192 508 | 2023. 12. 31. |
| 0,26901 % | Parametric Portfolio Associates LLC | 228 924 | 168 149 | 2023. 12. 31. |
| 0,23036 % | Peregrine Capital Management, LLC | 196 033 | -23 941 | 2023. 12. 31. |
| 0,22268 % | BlackRock Investment Management, LLC | 189 497 | 13 104 | 2023. 12. 31. |
| 0,21834 % | BNY Mellon Asset Management | 185 810 | 2784 | 2023. 12. 31. |
| 0,20463 % | PanAgora Asset Management Inc. | 174 144 | 82 645 | 2023. 12. 31. |
| 0,19510 % | Voya Investment Management LLC | 166 033 | 117 144 | 2023. 12. 31. |
| 0,19391 % | Balyasny Asset Management LP | 165 018 | 16 494 | 2023. 12. 31. |
| 0,19261 % | Metzger (Michael A) | 163 909 | 3750 | 2024. 03. 08. |
| 0,19143 % | BNP Paribas Securities Corp. North America | 162 905 | 44 906 | 2023. 12. 31. |
| 0,19084 % | Citi Investment Research (US) | 162 406 | 42 174 | 2023. 12. 31. |
| 0,18778 % | New Jersey Division of Investment | 159 803 | 26 769 | 2023. 12. 31. |
| 0,17626 % | Casdin Capital, LLC | 150 000 | 150 000 | 2023. 12. 31. |
| 0,16864 % | Trexquant Investment LP | 143 514 | 143 514 | 2023. 12. 31. |
| 0,16835 % | Verition Fund Management LLC | 143 266 | 128 266 | 2023. 12. 31. |
| 0,16733 % | Schweizerische Nationalbank | 142 400 | 21 400 | 2023. 12. 31. |
| 0,16427 % | Allianz Global Investors GmbH | 139 790 | 0 | 2024. 01. 31. |
| 0,16041 % | JPMorgan Private Bank (United States) | 136 509 | 55 546 | 2023. 12. 31. |
| 0,15520 % | BlackRock Advisors (UK) Limited | 132 075 | 6237 | 2024. 03. 31. |
| 0,15228 % | Goldman Sachs Asset Management, L.P. | 129 590 | 58 629 | 2023. 12. 31. |
| 0,15033 % | Walleye Capital LLC | 127 932 | 127 932 | 2023. 12. 31. |
| 0,13458 % | Yelin Lapidot Mutual Funds Management Ltd | 114 530 | 114 530 | 2023. 09. 30. |
| 0,13458 % | Yelin Lapidot Provident Funds Management Ltd | 114 530 | 0 | 2023. 12. 31. |
| 0,12844 % | Dimensional Fund Advisors, L.P. | 109 303 | 3163 | 2023. 12. 31. |
| 0,12581 % | Jane Street Capital, L.L.C. | 107 066 | -43 065 | 2023. 12. 31. |
| 0,12067 % | Victory Capital Management Inc. | 102 687 | 102 687 | 2023. 12. 31. |
| 0,11827 % | Crestline Investors, Inc. | 100 649 | -33 815 | 2023. 12. 31. |
| 0,11275 % | UBS O'Connor LLC | 95 949 | 95 949 | 2023. 12. 31. |
| 0,11201 % | Rhumbline Advisers Ltd. Partnership | 95 317 | -3652 | 2023. 12. 31. |
| 0,10967 % | Podlesak (Dennis G) | 93 333 | -2000 | 2024. 03. 08. |
| 0,10818 % | Sectoral Asset Management Inc. | 92 060 | 6060 | 2023. 12. 31. |
| 0,10448 % | BlackRock Asset Management Ireland Limited | 88 910 | 4125 | 2023. 12. 31. |
| 0,10126 % | Axiom Investors | 86 175 | 75 355 | 2023. 12. 31. |
| 0,10012 % | Wellington Management Japan Pte Ltd | 85 200 | -54 891 | 2023. 06. 30. |
| 0,09807 % | TwinBeech Capital LP | 83 456 | -104 654 | 2023. 12. 31. |
| 0,09255 % | State of Wisconsin Investment Board | 78 758 | 24 302 | 2023. 12. 31. |
| 0,09102 % | AllianceBernstein L.P. | 77 460 | 0 | 2023. 12. 31. |
| 0,08861 % | California State Teachers Retirement System | 75 407 | 12 215 | 2023. 12. 31. |
| 0,08552 % | Credit Suisse Funds AG | 72 775 | 3606 | 2023. 12. 31. |
| 0,08226 % | HealthCor Management, L.P. | 70 000 | -789 240 | 2022. 12. 31. |
| 0,08106 % | Tudor Investment Corporation | 68 981 | 39 042 | 2023. 12. 31. |
| 0,08047 % | Aperio Group, LLC | 68 479 | 37 344 | 2023. 12. 31. |
| 0,08014 % | Gyon Technologies Capital Management, LP | 68 195 | 35 226 | 2022. 12. 31. |
| 0,07885 % | Polar Asset Management Partners Inc. | 67 100 | 67 100 | 2023. 12. 31. |
