| 8,16066 % | The Vanguard Group, Inc. | 9 293 363 | -1 600 786 | 2023. 12. 31. |
| 6,54288 % | BlackRock Institutional Trust Company, N.A. | 7 451 035 | -850 122 | 2023. 12. 31. |
| 5,41886 % | Boxer Capital, L.L.C. | 6 171 000 | 5 671 000 | 2024. 01. 31. |
| 4,26026 % | Bellevue Asset Management AG | 4 851 579 | 0 | 2023. 12. 31. |
| 4,15411 % | Point72 Asset Management, L.P. | 4 730 700 | 1 196 770 | 2024. 01. 24. |
| 3,14540 % | D. E. Shaw & Co., L.P. | 3 581 979 | -1 129 685 | 2023. 12. 31. |
| 3,00980 % | Two Sigma Investments, LP | 3 427 559 | -156 513 | 2023. 12. 31. |
| 2,96721 % | Johnson & Johnson Innovation-JJDC, Inc. | 3 379 064 | 0 | 2023. 12. 31. |
| 2,40701 % | Jacobs Levy Equity Management, Inc. | 2 741 104 | 224 452 | 2023. 12. 31. |
| 2,40012 % | BlackRock Financial Management, Inc. | 2 733 253 | -160 455 | 2023. 12. 31. |
| 2,34124 % | Citadel Advisors LLC | 2 666 208 | 646 576 | 2023. 12. 31. |
| 2,00314 % | Acadian Asset Management LLC | 2 281 171 | 131 574 | 2023. 12. 31. |
| 11,57393 % | Redmile Group, LLC | 13 180 388 | 11 331 | 2024. 03. 21. |
| 1,91713 % | Monaco asset management S.A.M. | 2 183 228 | 335 284 | 2023. 12. 31. |
| 1,80014 % | Casdin Capital, LLC | 2 050 000 | 0 | 2023. 12. 31. |
| 1,63636 % | Geode Capital Management, L.L.C. | 1 863 485 | 88 141 | 2023. 12. 31. |
| 1,63498 % | State Street Global Advisors (US) | 1 861 919 | -410 006 | 2023. 12. 31. |
| 1,62440 % | Federated MDTA LLC | 1 849 872 | -601 672 | 2023. 12. 31. |
| 1,49280 % | Adage Capital Management, L.P. | 1 700 000 | 1 700 000 | 2023. 12. 31. |
| 1,13277 % | Vestal Point Capital, LP | 1 290 000 | 1 290 000 | 2023. 12. 31. |
| 0,99773 % | JP Morgan Asset Management | 1 136 219 | -784 480 | 2023. 12. 31. |
| 0,95565 % | Morgan Stanley & Co. LLC | 1 088 296 | -20 725 | 2023. 12. 31. |
| 0,86321 % | Charles Schwab Investment Management, Inc. | 983 019 | 96 304 | 2023. 12. 31. |
| 0,79031 % | Integral Health Asset Management, LLC | 900 000 | 900 000 | 2023. 12. 31. |
| 0,78872 % | StemPoint Capital LP | 898 196 | 898 196 | 2023. 12. 31. |
| 0,78473 % | Millennium Management LLC | 893 648 | -1 170 590 | 2023. 12. 31. |
| 0,74449 % | Superstring Capital Management LP | 847 823 | 847 823 | 2023. 12. 31. |
| 0,74110 % | Citi Investment Research (US) | 843 962 | 835 245 | 2023. 12. 31. |
| 0,64072 % | Rafferty Asset Management LLC | 729 657 | 729 657 | 2024. 03. 31. |
| 0,62459 % | Jane Street Capital, L.L.C. | 711 287 | -12 986 | 2023. 12. 31. |
| 0,61468 % | Tang Capital Management, LLC | 700 000 | 0 | 2023. 12. 31. |
| 0,56709 % | Northern Trust Investments, Inc. | 645 801 | -55 686 | 2023. 12. 31. |
| 0,53457 % | Rastetter (William H) | 608 774 | -5969 | 2023. 03. 31. |
| 0,53302 % | BofA Global Research (US) | 607 004 | 414 932 | 2023. 12. 31. |
| 0,46372 % | OrbiMed Advisors, LLC | 528 080 | 528 080 | 2023. 12. 31. |
| 0,43683 % | Schonfeld Strategic Advisors LLC | 497 457 | 478 257 | 2023. 12. 31. |
| 0,43547 % | GCM Grosvenor Holdings, LLC | 495 916 | 0 | 2023. 12. 31. |
| 0,42929 % | JPMorgan Asset Management U.K. Limited | 488 879 | 0 | 2023. 12. 31. |
| 0,39253 % | PGIM Quantitative Solutions LLC | 447 011 | 304 000 | 2023. 12. 31. |
| 0,37280 % | BlackRock Investment Management (UK) Ltd. | 424 549 | -131 942 | 2023. 12. 31. |
| 0,36977 % | Goldman Sachs & Company, Inc. | 421 089 | 124 084 | 2023. 12. 31. |
| 0,34752 % | HRT Financial LP | 395 753 | -277 537 | 2023. 12. 31. |
| 0,33839 % | Woodline Partners LP | 385 364 | 385 364 | 2023. 12. 31. |
| 0,33096 % | Nikko Asset Management Americas, Inc. | 376 900 | -72 560 | 2022. 12. 31. |
| 0,31499 % | Barclays Bank PLC | 358 708 | 253 823 | 2023. 12. 31. |
| 0,31326 % | PanAgora Asset Management Inc. | 356 740 | -69 845 | 2023. 12. 31. |
| 0,28168 % | Dimensional Fund Advisors, L.P. | 320 774 | -394 375 | 2023. 12. 31. |
| 0,26570 % | Mendlein (John D) | 302 581 | -14 619 | 2023. 03. 31. |
| 0,26039 % | Nuveen LLC | 296 528 | 9578 | 2023. 12. 31. |
| 0,25568 % | Fidelity Management & Research Company LLC | 291 172 | -16 458 | 2023. 12. 31. |
| 0,25465 % | Davis (Aaron I) | 290 000 | 290 000 | 2024. 01. 31. |
| 0,24989 % | BlackRock Investment Management, LLC | 284 579 | 8006 | 2023. 12. 31. |
| 0,22423 % | BlackRock Asset Management Ireland Limited | 255 355 | -120 146 | 2023. 12. 31. |
| 0,22188 % | Numeric Investors LLC | 252 676 | 34 473 | 2023. 12. 31. |
| 0,22098 % | Columbia Threadneedle Investments (US) | 251 649 | -23 843 | 2023. 12. 31. |
| 0,21928 % | BlackRock Advisors (UK) Limited | 249 718 | -13 647 | 2024. 03. 31. |
| 0,21659 % | Wolchko (John Scott) | 246 657 | -14 391 | 2024. 01. 09. |
| 0,21486 % | Putnam Investment Management, L.L.C. | 244 684 | 111 434 | 2023. 12. 31. |
| 0,20807 % | Conestoga Capital Advisors, LLC | 236 948 | 0 | 2024. 02. 29. |
| 0,20641 % | AQR Capital Management, LLC | 235 058 | -97 853 | 2023. 12. 31. |
| 0,19665 % | BNY Mellon Asset Management | 223 940 | 4035 | 2023. 12. 31. |
| 0,19055 % | Parametric Portfolio Associates LLC | 217 003 | -86 089 | 2023. 12. 31. |
| 0,18831 % | Cubist Systematic Strategies, LLC | 214 446 | 101 | 2024. 01. 24. |
| 0,15659 % | BIT Capital GmbH | 178 324 | 178 324 | 2023. 12. 31. |
| 0,15498 % | Squarepoint Capital LLP | 176 495 | -98 306 | 2023. 12. 31. |
| 0,15482 % | UBS Financial Services, Inc. | 176 305 | 109 595 | 2023. 12. 31. |
| 0,14920 % | Goldman Sachs Asset Management, L.P. | 169 904 | 24 083 | 2023. 12. 31. |
| 0,14908 % | J.P. Morgan Securities LLC | 169 777 | 131 849 | 2023. 12. 31. |
| 0,14322 % | Assenagon Asset Management S.A. | 163 097 | -217 640 | 2023. 12. 31. |
| 0,14117 % | AllianceBernstein L.P. | 160 760 | -800 | 2023. 12. 31. |
| 0,13539 % | Ohio Public Employees Retirement System | 154 178 | 0 | 2023. 12. 31. |
| 0,13392 % | Susquehanna International Group, LLP | 152 509 | -282 623 | 2023. 12. 31. |
| 0,12829 % | Pennant Investors, LP | 146 100 | 146 100 | 2023. 12. 31. |
| 0,12759 % | JPMorgan Private Bank (United States) | 145 297 | -2371 | 2023. 12. 31. |
| 0,12557 % | Bruce & Company, Inc. | 143 000 | -57 000 | 2023. 12. 31. |
| 0,12323 % | Rhumbline Advisers Ltd. Partnership | 140 335 | -7 | 2023. 12. 31. |
| 0,11620 % | J.P. Morgan Private Wealth Advisors LLC | 132 334 | 0 | 2023. 12. 31. |
| 0,10704 % | Lombard Odier Asset Management (Europe) Ltd | 121 894 | -4657 | 2022. 09. 30. |
| 0,10187 % | Avantis Investors | 116 014 | 69 978 | 2024. 03. 31. |
| 0,09923 % | PGIM Fixed Income | 113 000 | 61 100 | 2023. 12. 31. |
| 0,09424 % | Royce Investment Partners | 107 318 | 76 979 | 2023. 12. 31. |
| 0,08761 % | Invesco Capital Management LLC | 99 773 | -1483 | 2023. 12. 31. |
| 0,08535 % | Mellon Investments Corporation | 97 197 | 6638 | 2023. 12. 31. |
| 0,08298 % | State of Wyoming | 94 501 | 80 242 | 2023. 12. 31. |
| 0,08194 % | Voya Investment Management LLC | 93 313 | 11 492 | 2023. 12. 31. |
| 0,07952 % | SG Americas Securities, L.L.C. | 90 553 | 16 911 | 2023. 12. 31. |
| 0,07082 % | Algert Global LLC | 80 654 | -11 210 | 2023. 12. 31. |
| 0,06915 % | HSBC Global Asset Management (UK) Limited | 78 747 | -31 645 | 2023. 12. 31. |
| 0,06370 % | Dimensional Fund Advisors, Ltd. | 72 545 | 31 689 | 2024. 01. 31. |
| 0,05514 % | Northern Trust Global Investments | 62 788 | -425 135 | 2023. 12. 31. |
| 0,05207 % | Shell Asset Management Company B.V. | 59 302 | -17 897 | 2023. 12. 31. |
| 0,05061 % | Coughlin (Timothy P) | 57 632 | -5969 | 2023. 03. 31. |
| 0,04994 % | Valamehr (Bahram) | 56 877 | -11 271 | 2024. 01. 09. |
| 0,04917 % | Abaris Investment Management AG | 56 000 | 15 000 | 2023. 06. 30. |
| 0,04773 % | T. Rowe Price International Ltd | 54 357 | -30 637 | 2023. 12. 31. |
| 0,04652 % | American Century Investment Management, Inc. | 52 982 | 15 920 | 2023. 12. 31. |
| 0,04605 % | Qube Research & Technologies Ltd | 52 442 | -335 814 | 2023. 12. 31. |
| 0,04495 % | Russell Investments Trust Company | 51 189 | 4237 | 2023. 12. 31. |
| 0,04432 % | BlackRock Japan Co., Ltd. | 50 471 | 0 | 2023. 12. 31. |
| 0,04114 % | Engineers Gate Manager, L.P. | 46 847 | 31 460 | 2023. 12. 31. |
