| 6,04 % | BlackRock Institutional Trust Company, N.A. | 8 995 574 | 593 702 | 2023. 12. 31. |
| 4,76 % | The Vanguard Group, Inc. | 7 086 345 | 60 181 | 2023. 12. 31. |
| 3,98 % | Stonepine Capital Management, LLC | 5 937 000 | 21 628 | 2023. 12. 31. |
| 3,79 % | Caxton Associates LP | 5 641 920 | 0 | 2023. 12. 31. |
| 2,58 % | BioImpact Capital LLC | 3 847 232 | -140 735 | 2023. 12. 31. |
| 2,38 % | Rosalind Advisors, Inc. | 3 543 685 | 3 543 685 | 2023. 12. 31. |
| 1,94 % | Geode Capital Management, L.L.C. | 2 892 077 | 118 784 | 2023. 12. 31. |
| 1,83 % | State Street Global Advisors (US) | 2 724 126 | 154 004 | 2023. 12. 31. |
| 1,68 % | Medical Strategy GmbH | 2 505 175 | -220 231 | 2023. 12. 31. |
| 1,59 % | Edick (Paul Raymond) | 2 373 211 | 1 500 000 | 2024. 01. 31. |
| 1,08 % | Pieper (Steven) | 1 611 858 | 450 000 | 2024. 01. 31. |
| 1,04 % | Millennium Management LLC | 1 547 955 | -726 189 | 2023. 12. 31. |
| 0,93 % | Renaissance Technologies LLC | 1 381 640 | 359 600 | 2023. 12. 31. |
| 0,79 % | Morgan Stanley & Co. LLC | 1 184 474 | 588 213 | 2023. 12. 31. |
| 0,73 % | Shannon John Patrick Jr | 1 094 092 | 750 000 | 2024. 01. 31. |
| 0,72 % | Northern Trust Investments, Inc. | 1 077 211 | 41 744 | 2023. 12. 31. |
| 0,71 % | D. E. Shaw & Co., L.P. | 1 054 610 | 179 200 | 2023. 12. 31. |
| 0,70 % | Redmile Group, LLC | 1 046 587 | 0 | 2023. 12. 31. |
| 0,61 % | Hecht (Beth P) | 916 324 | 750 000 | 2024. 01. 31. |
| 0,55 % | Johnson John H | 825 983 | 305 171 | 2024. 03. 18. |
| 0,49 % | Prestrelski (Steven) | 729 524 | 150 000 | 2023. 01. 31. |
| 0,39 % | BlackRock Financial Management, Inc. | 579 257 | 31 275 | 2023. 12. 31. |
| 0,38 % | Invenomic Capital Management LP | 568 619 | 568 619 | 2023. 12. 31. |
| 0,37 % | Tudor Investment Corporation | 553 411 | -88 087 | 2023. 12. 31. |
| 0,35 % | Columbia Threadneedle Investments (US) | 520 121 | -67 817 | 2023. 12. 31. |
| 0,30 % | Johnson (Kenneth Erland) | 441 890 | 175 000 | 2024. 01. 31. |
| 0,28 % | Nuveen LLC | 419 567 | -293 130 | 2023. 12. 31. |
| 0,28 % | GSA Capital Partners LLP | 416 267 | 35 036 | 2023. 12. 31. |
| 0,27 % | Lazard Asset Management, L.L.C. | 403 813 | 88 326 | 2023. 12. 31. |
| 0,27 % | Citadel Advisors LLC | 400 577 | 371 383 | 2023. 12. 31. |
| 0,26 % | Knott Partners Management, LLC | 387 910 | 387 910 | 2023. 12. 31. |
| 0,24 % | Charles Schwab Investment Management, Inc. | 364 382 | -631 | 2023. 12. 31. |
| 0,23 % | BlackRock Investment Management, LLC | 347 708 | -3 | 2023. 12. 31. |
| 0,22 % | BNY Mellon Asset Management | 331 188 | -42 501 | 2023. 12. 31. |
| 0,19 % | IHT Wealth Management, LLC | 279 392 | -5000 | 2023. 12. 31. |
| 0,19 % | Barclays Bank PLC | 275 963 | 170 220 | 2023. 12. 31. |
| 0,18 % | AQR Capital Management, LLC | 273 222 | 230 942 | 2023. 12. 31. |
| 0,18 % | Alpine Global Management, LLC | 270 000 | -30 000 | 2023. 12. 31. |
| 0,17 % | BofA Global Research (US) | 260 379 | 190 592 | 2023. 12. 31. |
| 0,15 % | Jane Street Capital, L.L.C. | 223 584 | 79 980 | 2023. 12. 31. |
| 0,14 % | Brown Advisory | 211 405 | -18 100 | 2023. 12. 31. |
| 0,14 % | J.P. Morgan Securities LLC | 207 442 | 207 442 | 2023. 12. 31. |
| 0,13 % | Commonwealth Financial Network | 187 003 | 40 769 | 2023. 12. 31. |
| 0,12 % | Goldman Sachs & Company, Inc. | 180 585 | 102 571 | 2023. 12. 31. |
| 0,12 % | Diversified Trust Company | 175 741 | 20 091 | 2024. 03. 31. |
| 0,11 % | Rhumbline Advisers Ltd. Partnership | 171 292 | -2516 | 2023. 12. 31. |
| 0,11 % | Susquehanna International Group, LLP | 163 229 | 56 998 | 2023. 12. 31. |
| 0,10 % | Hamblin Watsa Investment Counsel Ltd. | 151 395 | 0 | 2023. 12. 31. |
| 0,10 % | Tang Capital Management, LLC | 150 000 | 0 | 2023. 12. 31. |
| 0,09 % | PanAgora Asset Management Inc. | 140 318 | -109 882 | 2023. 12. 31. |
| 0,09 % | UBS Financial Services, Inc. | 134 412 | 59 972 | 2023. 12. 31. |
| 0,09 % | Mariner Wealth Advisors | 129 390 | -62 354 | 2023. 12. 31. |
| 0,08 % | Cetera Advisor Networks LLC | 116 990 | 4704 | 2023. 12. 31. |
| 0,08 % | T. Rowe Price International Ltd | 115 003 | 2180 | 2023. 12. 31. |
| 0,08 % | Two Sigma Investments, LP | 114 213 | 4287 | 2023. 12. 31. |
| 0,07 % | CenterBook Partners LP | 110 627 | 110 627 | 2023. 12. 31. |
| 0,07 % | Sherman (Jeffrey W) | 99 380 | 6502 | 2024. 03. 15. |
| 0,07 % | Kong (Garheng) | 99 144 | 6474 | 2024. 03. 15. |
| 0,06 % | Assenagon Asset Management S.A. | 95 144 | 6877 | 2024. 02. 29. |
| 0,06 % | Northern Trust Global Investments | 88 152 | -21 598 | 2023. 12. 31. |
| 0,06 % | JPMorgan Private Bank (United States) | 88 016 | 88 016 | 2023. 12. 31. |
| 0,06 % | State Street Global Advisors Ireland Limited | 87 770 | -319 | 2023. 04. 30. |
| 0,06 % | HRT Financial LP | 87 334 | 87 334 | 2023. 12. 31. |
| 0,06 % | Fairley (Ricki Louise) | 85 000 | 85 000 | 2023. 03. 27. |
| 0,05 % | BlackRock Advisors (UK) Limited | 80 582 | 3885 | 2024. 03. 31. |
| 0,05 % | AllianceBernstein L.P. | 80 420 | 0 | 2023. 12. 31. |
| 0,05 % | Group One Trading, L.P. | 78 951 | 12 781 | 2023. 12. 31. |
| 0,05 % | Goldman Sachs Asset Management, L.P. | 78 104 | 23 278 | 2023. 12. 31. |
| 0,05 % | BlackRock Asset Management Ireland Limited | 74 649 | 18 323 | 2023. 12. 31. |
| 0,05 % | MetLife Investment Management, LLC | 71 237 | 0 | 2023. 12. 31. |
| 0,04 % | SunAmerica Asset Management, LLC | 66 140 | -267 | 2023. 12. 31. |
| 0,04 % | State Teachers Retirement System of Ohio | 64 300 | 0 | 2023. 12. 31. |
| 0,04 % | Soleus Capital Management, L.P. | 62 083 | -242 000 | 2023. 12. 31. |
| 0,04 % | GPS Wealth Strategies Group, LLC | 62 025 | -2000 | 2023. 12. 31. |
| 0,04 % | DWS Investments UK Limited | 61 635 | -2002 | 2023. 12. 31. |
| 0,04 % | Invesco Advisers, Inc. | 58 050 | -252 932 | 2023. 12. 31. |
| 0,04 % | LJI Wealth Management, LLC | 56 050 | -5300 | 2023. 12. 31. |
| 0,04 % | Voya Investment Management LLC | 55 877 | 2031 | 2023. 12. 31. |
| 0,04 % | Annandale Capital, LLC | 55 820 | 30 820 | 2023. 12. 31. |
| 0,04 % | Manulife Investment Management (North America) Limited | 55 742 | 0 | 2023. 12. 31. |
| 0,03 % | Deltec Asset Management, LLC | 52 000 | -207 246 | 2024. 03. 31. |
| 0,03 % | Chevy Chase Trust Company | 51 243 | 0 | 2023. 12. 31. |
| 0,03 % | IEQ Capital LLC | 50 169 | 0 | 2023. 12. 31. |
| 0,03 % | Schmid (John P) | 48 159 | 42 500 | 2023. 06. 07. |
| 0,03 % | Principal Global Investors (Equity) | 44 725 | 1601 | 2023. 12. 31. |
| 0,03 % | Halkuff (Dawn) | 42 500 | 42 500 | 2023. 06. 07. |
| 0,03 % | Persky (Marla S) | 42 500 | 42 500 | 2023. 06. 07. |
| 0,03 % | Bormann-Kennedy (Barbara-Jean Anne) | 42 500 | 42 500 | 2023. 06. 07. |
| 0,03 % | Centiva Capital, LP | 42 368 | 42 368 | 2023. 12. 31. |
| 0,03 % | Mellon Investments Corporation | 39 254 | 0 | 2023. 12. 31. |
| 0,03 % | Florida State Board of Administration | 37 970 | 0 | 2023. 12. 31. |
| 0,02 % | Graham Capital Management, L.P. | 36 784 | -20 625 | 2023. 12. 31. |
| 0,02 % | Walleye Capital LLC | 35 927 | -88 763 | 2023. 12. 31. |
| 0,02 % | Wells Fargo Bank, N.A. | 34 513 | 7853 | 2023. 12. 31. |
| 0,02 % | SG Americas Securities, L.L.C. | 33 777 | 15 414 | 2023. 12. 31. |
| 0,02 % | LPL Financial LLC | 33 375 | 33 375 | 2023. 12. 31. |
| 0,02 % | Cambridge Investment Research Advisors, Inc. | 32 170 | -3500 | 2023. 12. 31. |
| 0,02 % | PGIM Quantitative Solutions LLC | 31 475 | 0 | 2023. 12. 31. |
| 0,02 % | ProShare Advisors LLC | 30 849 | 4537 | 2023. 12. 31. |
| 0,02 % | RBC Wealth Management, International | 28 385 | 11 724 | 2023. 12. 31. |
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