| 9,39372 % | The Vanguard Group, Inc. | 8 658 189 | 1 438 611 | 2023. 12. 31. |
| 7,47216 % | RTW Investments L.P. | 6 887 086 | 1 481 997 | 2023. 12. 31. |
| 4,79009 % | Wellington Management Company, LLP | 4 415 029 | -780 851 | 2023. 12. 31. |
| 4,46784 % | Sands Capital Management, LLC | 4 118 008 | 1 540 791 | 2023. 12. 31. |
| 4,43252 % | BlackRock Institutional Trust Company, N.A. | 4 085 450 | 240 486 | 2023. 12. 31. |
| 3,64076 % | T. Rowe Price Associates, Inc. | 3 355 689 | 280 049 | 2023. 12. 31. |
| 3,52881 % | State Street Global Advisors (US) | 3 252 502 | 684 644 | 2023. 12. 31. |
| 2,96064 % | Kakkis (Emil D) | 2 728 824 | 24 143 | 2024. 03. 01. |
| 2,65433 % | Federated Hermes Global Investment Management Corp. | 2 446 500 | 250 000 | 2023. 12. 31. |
| 2,58597 % | ClearBridge Investments, LLC | 2 383 492 | 89 922 | 2023. 12. 31. |
| 2,30694 % | Suvretta Capital Management, LLC | 2 126 306 | 1 446 847 | 2023. 12. 31. |
| 2,02661 % | Alkeon Capital Management LLC | 1 867 928 | 242 438 | 2023. 12. 31. |
| 1,90305 % | Rock Springs Capital Management LP | 1 754 038 | 277 597 | 2023. 12. 31. |
| 1,71271 % | AllianceBernstein L.P. | 1 578 603 | 46 098 | 2023. 12. 31. |
| 1,61602 % | Marshall Wace LLP | 1 489 486 | 548 723 | 2023. 12. 31. |
| 1,59113 % | Baker Bros. Advisors LP | 1 466 547 | 100 000 | 2023. 12. 31. |
| 1,39267 % | Geode Capital Management, L.L.C. | 1 283 622 | 200 335 | 2023. 12. 31. |
| 1,26188 % | First Trust Advisors L.P. | 1 163 077 | -38 611 | 2023. 12. 31. |
| 1,11208 % | Adage Capital Management, L.P. | 1 025 000 | 935 000 | 2023. 12. 31. |
| 1,11005 % | Pictet Asset Management Ltd. | 1 023 136 | 153 748 | 2023. 12. 31. |
| 1,07730 % | Fidelity Management & Research Company LLC | 992 951 | -34 834 | 2023. 12. 31. |
| 0,97646 % | Camber Capital Management LP | 900 000 | 900 000 | 2023. 12. 31. |
| 0,97203 % | DWS Investment GmbH | 895 920 | 258 | 2023. 12. 31. |
| 0,94117 % | Emerald Advisers LLC | 867 478 | -11 534 | 2023. 12. 31. |
| 0,91624 % | Avidity Partners Management LP | 844 500 | 300 500 | 2023. 12. 31. |
| 0,88276 % | Jacobs Levy Equity Management, Inc. | 813 637 | -25 058 | 2023. 12. 31. |
| 0,83596 % | Norges Bank Investment Management (NBIM) | 770 506 | 46 874 | 2023. 12. 31. |
| 0,80793 % | First Light Asset Management, LLC | 744 665 | -380 367 | 2023. 12. 31. |
| 0,76496 % | Mellon Investments Corporation | 705 063 | 309 621 | 2023. 12. 31. |
| 0,72616 % | BlackRock Financial Management, Inc. | 669 300 | -15 133 | 2023. 12. 31. |
| 0,70305 % | Great Point Partners, LLC | 648 000 | -79 426 | 2023. 12. 31. |
| 0,65528 % | Fred Alger Management, LLC | 603 976 | -34 890 | 2023. 12. 31. |
| 0,53163 % | Hudson Bay Capital Management LP | 490 000 | -244 272 | 2023. 12. 31. |
| 0,52902 % | Candriam Luxembourg S.A. | 487 597 | 135 000 | 2024. 02. 29. |
| 0,51191 % | Charles Schwab Investment Management, Inc. | 471 825 | 75 100 | 2023. 12. 31. |
| 0,48493 % | Nuveen LLC | 446 964 | 16 525 | 2023. 12. 31. |
| 0,46322 % | Morgan Stanley & Co. LLC | 426 949 | 99 873 | 2023. 12. 31. |
| 0,44395 % | Pictet Asset Management (Japan) Ltd. | 409 186 | 246 167 | 2023. 10. 31. |
| 0,43412 % | Woodline Partners LP | 400 124 | 194 641 | 2023. 12. 31. |
| 0,42955 % | Invesco Advisers, Inc. | 395 920 | 45 258 | 2023. 12. 31. |
| 0,41250 % | Oppenheimer Asset Management Inc. | 380 203 | 54 756 | 2023. 12. 31. |
| 0,38968 % | Driehaus Capital Management, LLC | 359 166 | 137 920 | 2023. 12. 31. |
| 0,38950 % | Eventide Asset Management, LLC | 359 000 | 0 | 2023. 12. 31. |
| 0,37973 % | Avoro Capital Advisors LLC | 350 000 | -1 150 000 | 2023. 12. 31. |
| 0,37193 % | Schonfeld Strategic Advisors LLC | 342 812 | 342 812 | 2023. 12. 31. |
| 0,36098 % | AXA Investment Managers UK Ltd. | 332 712 | -11 787 | 2023. 12. 31. |
| 0,34231 % | Two Sigma Investments, LP | 315 510 | 46 810 | 2023. 12. 31. |
| 0,33626 % | Northern Trust Investments, Inc. | 309 933 | 49 756 | 2023. 12. 31. |
| 0,33497 % | Medical Strategy GmbH | 308 740 | 0 | 2023. 12. 31. |
| 0,33365 % | GW&K Investment Management, LLC | 307 529 | -3386 | 2023. 12. 31. |
| 0,32857 % | MFS Investment Management | 302 845 | 19 838 | 2024. 02. 29. |
| 0,29547 % | Manulife Investment Management (North America) Limited | 272 339 | 31 482 | 2023. 12. 31. |
| 0,28560 % | Blue Owl Capital Holdings LP | 263 238 | 263 238 | 2023. 12. 31. |
| 0,27129 % | International Biotechnology Trust PLC | 250 052 | 170 000 | 2023. 09. 30. |
| 0,27129 % | Schroder Investment Management Ltd. (SIM) | 250 052 | 250 052 | 2023. 12. 31. |
| 0,24457 % | DWS Investment S.A. | 225 416 | 225 416 | 2023. 12. 31. |
| 0,24329 % | Macquarie Investment Management | 224 236 | 7000 | 2023. 12. 31. |
| 0,24076 % | Rafferty Asset Management LLC | 221 910 | 38 859 | 2023. 12. 31. |
| 0,24016 % | TD Asset Management Inc. | 221 360 | 16 000 | 2023. 12. 31. |
| 0,23934 % | Kassberg (Thomas Richard) | 220 597 | 5963 | 2024. 03. 11. |
| 0,23640 % | JPMorgan Asset Management U.K. Limited | 217 894 | -5277 | 2023. 12. 31. |
| 0,23326 % | Cowen Investment Management LLC | 215 000 | 130 000 | 2023. 09. 30. |
| 0,23085 % | Franklin Advisers, Inc. | 212 775 | 23 486 | 2023. 12. 31. |
| 0,21812 % | Sphera Funds Management Ltd. | 201 044 | -58 091 | 2023. 12. 31. |
| 0,21709 % | Weatherbie Capital, LLC | 200 096 | 13 187 | 2024. 02. 29. |
| 0,21705 % | Citadel Advisors LLC | 200 054 | 198 653 | 2023. 12. 31. |
| 0,20072 % | Moore Capital Management, LP | 185 000 | 35 000 | 2023. 12. 31. |
| 0,19270 % | BNY Mellon Asset Management | 177 614 | 34 452 | 2023. 12. 31. |
| 0,19107 % | BlackRock Asset Management Ireland Limited | 176 111 | -14 072 | 2023. 12. 31. |
| 0,18519 % | AQR Capital Management, LLC | 170 689 | 170 689 | 2023. 12. 31. |
| 0,18301 % | Voya Investment Management LLC | 168 684 | 93 286 | 2023. 12. 31. |
| 0,18065 % | Privium Fund Management BV | 166 506 | 51 265 | 2023. 12. 31. |
| 0,17819 % | Motley Fool Wealth Management, LLC | 164 235 | -4024 | 2023. 12. 31. |
| 0,17064 % | BNP Paribas Securities Corp. North America | 157 281 | -56 994 | 2023. 12. 31. |
| 0,16462 % | Walleye Capital LLC | 151 727 | -78 278 | 2023. 12. 31. |
| 0,16214 % | Motley Fool Asset Management, LLC | 149 443 | -6661 | 2023. 12. 31. |
| 0,16109 % | Candriam Belgium S.A. | 148 480 | 99 000 | 2023. 12. 31. |
| 0,15810 % | BofA Global Research (US) | 145 720 | -29 089 | 2023. 12. 31. |
| 0,15734 % | Goldman Sachs Asset Management, L.P. | 145 020 | -239 977 | 2023. 12. 31. |
| 0,15465 % | Assenagon Asset Management S.A. | 142 541 | -68 380 | 2023. 12. 31. |
| 0,15358 % | Schweizerische Nationalbank | 141 552 | -14 100 | 2023. 12. 31. |
| 0,15311 % | abrdn Inc. | 141 117 | 141 117 | 2023. 12. 31. |
| 0,14659 % | AXA Investment Managers Paris | 135 112 | 0 | 2024. 02. 29. |
| 0,13582 % | Barclays Bank PLC | 125 187 | 5313 | 2023. 12. 31. |
| 0,13552 % | Allianz Global Investors GmbH | 124 905 | 0 | 2024. 01. 31. |
| 0,13126 % | WCM Investment Management | 120 985 | 13 220 | 2023. 12. 31. |
| 0,13097 % | Jane Street Capital, L.L.C. | 120 715 | 91 065 | 2023. 12. 31. |
| 0,13073 % | Credit Suisse International | 120 496 | -33 952 | 2023. 12. 31. |
| 0,12950 % | Pinnacle Associates Ltd. | 119 360 | 5 | 2023. 12. 31. |
| 0,12943 % | Peregrine Capital Management, LLC | 119 300 | -20 570 | 2023. 12. 31. |
| 0,11990 % | Citi Investment Research (US) | 110 510 | 19 930 | 2023. 12. 31. |
| 0,11810 % | Newton Investment Management North America, LLC | 108 850 | 41 590 | 2023. 12. 31. |
| 0,11756 % | Mirae Asset Global Investments (USA) LLC | 108 355 | -102 613 | 2023. 12. 31. |
| 0,11526 % | Arctic Fund Management AS | 106 231 | 100 | 2024. 02. 29. |
| 0,11448 % | BlackRock Investment Management, LLC | 105 516 | -6601 | 2023. 12. 31. |
| 0,11149 % | Russell Investments Trust Company | 102 756 | 9286 | 2023. 12. 31. |
| 0,11121 % | Point72 Asset Management, L.P. | 102 500 | -621 205 | 2023. 12. 31. |
| 0,11120 % | Sector Gamma AS | 102 490 | -12 676 | 2023. 12. 31. |
| 0,11031 % | California Public Employees' Retirement System | 101 672 | 0 | 2023. 12. 31. |
| 0,11007 % | BlackRock Investment Management (UK) Ltd. | 101 449 | -20 286 | 2023. 12. 31. |
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