| 6,43 % | BlackRock Institutional Trust Company, N.A. | 6 717 017 | 777 768 | 2023. 12. 31. |
| 6,27 % | Teoxane SA | 6 550 800 | 2 105 000 | 2023. 10. 20. |
| 5,58 % | GIC Private Limited | 5 825 881 | 332 916 | 2023. 12. 31. |
| 5,01 % | Palo Alto Investors LP | 5 237 284 | 8675 | 2023. 12. 31. |
| 4,84 % | The Vanguard Group, Inc. | 5 054 228 | 278 166 | 2023. 12. 31. |
| 4,51 % | Franklin Advisers, Inc. | 4 705 640 | 708 644 | 2023. 12. 31. |
| 3,03 % | Polar Capital LLP | 3 169 239 | -991 072 | 2023. 12. 31. |
| 2,45 % | JP Morgan Asset Management | 2 558 779 | -32 486 | 2023. 12. 31. |
| 2,41 % | State Street Global Advisors (US) | 2 521 693 | 188 585 | 2023. 12. 31. |
| 11,43 % | Capital World Investors | 11 939 076 | -21 744 | 2023. 12. 31. |
| 1,84 % | Geode Capital Management, L.L.C. | 1 924 421 | 144 144 | 2023. 12. 31. |
| 1,81 % | JPMorgan Asset Management U.K. Limited | 1 894 458 | -35 132 | 2023. 12. 31. |
| 1,49 % | Invesco Advisers, Inc. | 1 557 055 | -1 301 085 | 2023. 12. 31. |
| 1,40 % | Rubric Capital Management LP | 1 461 474 | -138 526 | 2023. 12. 31. |
| 1,10 % | CIBC Asset Management Inc. | 1 147 294 | 820 587 | 2023. 12. 31. |
| 1,06 % | Foley (Mark J) | 1 105 848 | 185 116 | 2024. 03. 15. |
| 0,99 % | Jennison Associates LLC | 1 032 352 | 34 736 | 2023. 12. 31. |
| 0,98 % | Baron Capital Management, Inc. | 1 023 663 | 3429 | 2023. 12. 31. |
| 0,89 % | Walleye Capital LLC | 927 814 | 622 022 | 2023. 12. 31. |
| 0,75 % | Northern Trust Investments, Inc. | 780 746 | 63 871 | 2023. 12. 31. |
| 0,73 % | Rice Hall James & Associates, LLC | 758 048 | 74 111 | 2023. 12. 31. |
| 0,66 % | Goldman Sachs & Company, Inc. | 687 534 | -353 120 | 2023. 12. 31. |
| 0,65 % | Charles Schwab Investment Management, Inc. | 677 364 | 13 826 | 2023. 12. 31. |
| 0,60 % | EULAV Asset Management | 630 000 | 30 000 | 2023. 12. 31. |
| 0,59 % | Morgan Stanley & Co. LLC | 615 697 | 305 886 | 2023. 12. 31. |
| 0,51 % | Nuveen LLC | 533 196 | -65 438 | 2023. 12. 31. |
| 0,48 % | Qube Research & Technologies Ltd | 503 874 | 389 624 | 2023. 12. 31. |
| 0,46 % | Rhenman & Partners Asset Management AB | 475 872 | 114 193 | 2023. 12. 31. |
| 0,44 % | EW Healthcare Partners | 457 085 | 0 | 2023. 12. 31. |
| 0,43 % | Integral Health Asset Management, LLC | 450 000 | 350 000 | 2023. 12. 31. |
| 0,43 % | Wellington Management Company, LLP | 449 685 | -632 735 | 2023. 12. 31. |
| 0,39 % | D. E. Shaw & Co., L.P. | 411 750 | -370 266 | 2023. 12. 31. |
| 0,39 % | Hightower Advisors, LLC | 406 421 | 116 920 | 2023. 12. 31. |
| 0,36 % | Ghost Tree Capital, LLC | 375 000 | 25 000 | 2023. 12. 31. |
| 0,35 % | Balyasny Asset Management LP | 362 760 | -107 089 | 2023. 12. 31. |
| 0,34 % | Citadel Advisors LLC | 353 662 | 227 280 | 2023. 12. 31. |
| 0,29 % | Cubist Systematic Strategies, LLC | 305 447 | 85 234 | 2023. 12. 31. |
| 0,28 % | William Blair & Company, L.L.C. (Research) | 292 949 | -33 357 | 2023. 12. 31. |
| 0,28 % | Schroder Investment Management Ltd. (SIM) | 288 726 | 288 726 | 2023. 12. 31. |
| 0,28 % | International Biotechnology Trust PLC | 288 726 | 0 | 2023. 09. 30. |
| 0,26 % | Voloridge Investment Management, LLC | 271 852 | -272 595 | 2023. 12. 31. |
| 0,26 % | Principal Global Investors (Equity) | 269 718 | -693 311 | 2023. 12. 31. |
| 0,25 % | Schonfeld Strategic Advisors LLC | 266 039 | 64 405 | 2023. 12. 31. |
| 0,25 % | DCF Advisers, LLC | 256 872 | 230 372 | 2023. 12. 31. |
| 0,22 % | Great Lakes Advisors, LLC | 233 958 | 11 881 | 2023. 12. 31. |
| 0,22 % | BNY Mellon Asset Management | 230 350 | 4368 | 2023. 12. 31. |
| 0,22 % | BlackRock Financial Management, Inc. | 225 141 | -100 477 | 2023. 12. 31. |
| 0,21 % | AlphaCentric Advisors LLC. | 220 000 | 30 000 | 2023. 12. 31. |
| 0,21 % | LifeSci Fund Management LLC | 220 000 | 30 000 | 2023. 12. 31. |
| 0,21 % | BlackRock Investment Management, LLC | 215 923 | 8426 | 2023. 12. 31. |
| 0,20 % | BofA Global Research (US) | 208 673 | 118 712 | 2023. 12. 31. |
| 0,19 % | Susquehanna Portfolio Strategies, LLC | 203 192 | 203 192 | 2023. 12. 31. |
| 0,19 % | Barclays Capital Inc. | 200 332 | -183 202 | 2023. 12. 31. |
| 0,19 % | Assenagon Asset Management S.A. | 198 846 | -215 209 | 2023. 12. 31. |
| 0,19 % | UBS Financial Services, Inc. | 194 153 | 76 108 | 2023. 12. 31. |
| 0,18 % | Schilke (Tobin C) | 192 666 | 29 166 | 2024. 03. 18. |
| 0,17 % | BlackRock Advisors (UK) Limited | 179 873 | 5486 | 2024. 03. 31. |
| 0,17 % | Columbia Threadneedle Investments (US) | 178 103 | 52 284 | 2023. 12. 31. |
| 0,16 % | Credit Suisse Funds AG | 172 007 | 31 392 | 2023. 12. 31. |
| 0,16 % | JPMorgan Private Bank (United States) | 171 284 | 76 104 | 2023. 12. 31. |
| 0,16 % | Parametric Portfolio Associates LLC | 169 180 | -69 670 | 2023. 12. 31. |
| 0,16 % | Sjuts (Dustin S) | 167 550 | 40 217 | 2024. 03. 18. |
| 0,16 % | Schweizerische Nationalbank | 164 650 | -20 100 | 2023. 12. 31. |
| 0,16 % | Conestoga Capital Advisors, LLC | 162 368 | -4453 | 2024. 02. 29. |
| 0,15 % | Norges Bank Investment Management (NBIM) | 161 000 | 0 | 2023. 12. 31. |
| 0,15 % | Group One Trading, L.P. | 157 445 | 73 327 | 2023. 12. 31. |
| 0,15 % | Barclays Bank PLC | 157 224 | 6436 | 2023. 12. 31. |
| 0,14 % | Moore Capital Management, LP | 150 000 | -10 000 | 2023. 12. 31. |
| 0,14 % | BlackRock Asset Management Ireland Limited | 146 321 | 15 843 | 2023. 12. 31. |
| 0,14 % | Algert Global LLC | 144 040 | 144 040 | 2023. 12. 31. |
| 0,13 % | Moxie (Dwight) | 137 815 | 30 955 | 2024. 03. 18. |
| 0,12 % | Essex Investment Management Company, LLC | 122 419 | 38 671 | 2023. 12. 31. |
| 0,11 % | Rhumbline Advisers Ltd. Partnership | 119 457 | 1678 | 2023. 12. 31. |
| 0,11 % | Jordan (Erica) | 114 864 | -2392 | 2024. 04. 16. |
| 0,11 % | Landscape Capital Management, L.L.C. | 111 194 | 111 194 | 2023. 12. 31. |
| 0,11 % | Commonwealth Financial Network | 111 144 | 12 015 | 2023. 12. 31. |
| 0,10 % | UBS O'Connor LLC | 109 667 | 20 867 | 2023. 12. 31. |
| 0,10 % | Hollander (David) | 108 853 | 0 | 2024. 03. 08. |
| 0,10 % | State of Wisconsin Investment Board | 107 418 | 29 386 | 2023. 12. 31. |
| 0,10 % | Nebula Research & Development LLC | 105 295 | 105 295 | 2023. 12. 31. |
| 0,10 % | Legato Capital Management LLC | 101 842 | 44 190 | 2024. 03. 31. |
| 0,09 % | Goldman Sachs Asset Management, L.P. | 96 094 | -7896 | 2023. 12. 31. |
| 0,09 % | Los Angeles Capital Management LLC | 92 918 | 92 918 | 2024. 03. 31. |
| 0,09 % | Morgan Stanley Smith Barney LLC | 92 617 | 40 937 | 2023. 12. 31. |
| 0,09 % | Citi Investment Research (US) | 91 288 | 42 063 | 2023. 12. 31. |
| 0,09 % | AllianceBernstein L.P. | 91 000 | 0 | 2023. 12. 31. |
| 0,09 % | California State Teachers Retirement System | 88 825 | -3850 | 2023. 12. 31. |
| 0,08 % | Sierra Summit Advisors LLC | 86 421 | 86 421 | 2023. 12. 31. |
| 0,08 % | Deka Investment GmbH | 86 100 | 86 100 | 2022. 12. 31. |
| 0,08 % | Deka Vermögensmanagement GmbH | 86 100 | 0 | 2023. 12. 31. |
| 0,08 % | Legal & General Investment Management Ltd. | 83 463 | 163 | 2023. 12. 31. |
| 0,08 % | UBS Asset Management (Switzerland) | 80 201 | 8686 | 2023. 12. 31. |
| 0,08 % | UBS Switzerland AG | 78 610 | 0 | 2023. 12. 31. |
| 0,07 % | CM Management, LLC | 75 000 | 75 000 | 2023. 12. 31. |
| 0,07 % | TwinBeech Capital LP | 74 438 | 74 438 | 2023. 12. 31. |
| 0,07 % | Point72 Asset Management, L.P. | 74 330 | -1 290 923 | 2023. 12. 31. |
| 0,07 % | Federated Hermes Global Investment Management Corp. | 73 087 | 73 087 | 2023. 12. 31. |
| 0,07 % | Federated Hermes Equity Management Company of Pennsylvania | 73 087 | 38 441 | 2023. 12. 31. |
| 0,06 % | Tekla Capital Management LLC_NLE | 67 699 | 67 699 | 2023. 09. 30. |
| 0,06 % | Trexquant Investment LP | 65 759 | 65 759 | 2023. 12. 31. |
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