| 7,84624 % | RTW Investments L.P. | 4 131 045 | -259 513 | 2023. 12. 31. |
| 7,06868 % | Cowen & Co., LLC | 3 721 659 | 0 | 2023. 12. 31. |
| 6,37822 % | Morgan Stanley & Co. LLC | 3 358 132 | 455 474 | 2023. 12. 31. |
| 5,61618 % | Lynx1 Capital Advisors LLC | 2 956 918 | 292 760 | 2023. 12. 31. |
| 4,98672 % | Redmile Group, LLC | 2 625 506 | -1 247 190 | 2023. 12. 31. |
| 3,85591 % | Baker Bros. Advisors LP | 2 030 134 | 544 219 | 2023. 12. 31. |
| 3,56185 % | Harrison (Seth Loring) | 1 875 313 | 0 | 2023. 09. 01. |
| 3,44859 % | BlackRock Institutional Trust Company, N.A. | 1 815 681 | -121 639 | 2023. 12. 31. |
| 3,13106 % | The Vanguard Group, Inc. | 1 648 502 | 19 118 | 2023. 12. 31. |
| 20,59579 % | Skorpios Trust | 10 843 681 | -3 600 000 | 2024. 04. 17. |
| 2,51946 % | Goldman Sachs & Company, Inc. | 1 326 494 | 1 282 757 | 2023. 12. 31. |
| 2,16123 % | Granahan Investment Management, LLC | 1 137 887 | 286 686 | 2023. 12. 31. |
| 2,06611 % | Cormorant Asset Management, LP | 1 087 807 | 0 | 2023. 12. 31. |
| 1,16947 % | Geode Capital Management, L.L.C. | 615 724 | 24 607 | 2023. 12. 31. |
| 1,03235 % | State Street Global Advisors (US) | 543 533 | -42 475 | 2023. 12. 31. |
| 0,78400 % | DWS Investments UK Limited | 412 778 | 399 016 | 2023. 12. 31. |
| 0,76870 % | Krainer (Adrian R) | 404 718 | 0 | 2023. 09. 01. |
| 0,47364 % | Victory Capital Management Inc. | 249 370 | 249 370 | 2023. 12. 31. |
| 0,45451 % | HOOPP Investment Management | 239 300 | 0 | 2023. 12. 31. |
| 0,43125 % | Northern Trust Investments, Inc. | 227 055 | -5619 | 2023. 12. 31. |
| 0,40892 % | Dimensional Fund Advisors, L.P. | 215 294 | -43 128 | 2023. 12. 31. |
| 0,39886 % | Birchview Capital, LP | 210 000 | 125 000 | 2023. 12. 31. |
| 0,38982 % | Charles Schwab Investment Management, Inc. | 205 242 | -12 097 | 2023. 12. 31. |
| 0,31914 % | Jacobs Levy Equity Management, Inc. | 168 028 | -49 577 | 2023. 12. 31. |
| 0,27106 % | D. E. Shaw & Co., L.P. | 142 711 | -62 455 | 2023. 12. 31. |
| 0,19394 % | GSA Capital Partners LLP | 102 107 | -245 962 | 2023. 12. 31. |
| 0,17872 % | BlackRock Financial Management, Inc. | 94 096 | 12 369 | 2023. 12. 31. |
| 0,16448 % | State of Wisconsin Investment Board | 86 600 | 7076 | 2023. 12. 31. |
| 0,15375 % | BlackRock Investment Management, LLC | 80 950 | -1039 | 2023. 12. 31. |
| 0,14326 % | Fort Point Capital Partners, LLC | 75 429 | 0 | 2023. 12. 31. |
| 0,14309 % | BofA Global Research (US) | 75 339 | 17 781 | 2023. 12. 31. |
| 0,13172 % | Kaye (Edward M) | 69 350 | 24 350 | 2024. 03. 19. |
| 0,12959 % | BNY Mellon Asset Management | 68 230 | -9952 | 2023. 12. 31. |
| 0,12578 % | BlackRock Asset Management Ireland Limited | 66 225 | -31 938 | 2023. 12. 31. |
| 0,12334 % | Goldman Sachs Asset Management, L.P. | 64 937 | -20 631 | 2023. 12. 31. |
| 0,11940 % | Nuveen LLC | 62 864 | 0 | 2023. 12. 31. |
| 0,11825 % | Los Angeles Capital Management LLC | 62 257 | 0 | 2024. 03. 31. |
| 0,11823 % | Gilder Gagnon Howe & Co. LLC | 62 248 | -11 | 2023. 12. 31. |
| 0,11392 % | Bellecapital Partners AG | 59 980 | 0 | 2023. 09. 30. |
| 0,11116 % | BlackRock Advisors (UK) Limited | 58 525 | -3224 | 2024. 03. 31. |
| 0,10808 % | Woodline Partners LP | 56 904 | 0 | 2023. 12. 31. |
| 0,09646 % | Jane Street Capital, L.L.C. | 50 786 | 50 786 | 2023. 12. 31. |
| 0,08568 % | Susquehanna Portfolio Strategies, LLC | 45 108 | 45 108 | 2023. 12. 31. |
| 0,07782 % | Rhumbline Advisers Ltd. Partnership | 40 971 | -38 | 2023. 12. 31. |
| 0,07559 % | Trexquant Investment LP | 39 800 | -87 781 | 2023. 12. 31. |
| 0,07459 % | Barclays Bank PLC | 39 271 | 30 831 | 2023. 12. 31. |
| 0,07092 % | AllianceBernstein L.P. | 37 340 | -3980 | 2023. 12. 31. |
| 0,06520 % | Dimensional Fund Advisors, Ltd. | 34 328 | 0 | 2024. 01. 31. |
| 0,06028 % | Tzianabos (Arthur) | 31 739 | 31 739 | 2024. 02. 13. |
| 0,05800 % | Northern Trust Global Investments | 30 537 | -208 | 2023. 12. 31. |
| 0,05658 % | T. Rowe Price International Ltd | 29 789 | 0 | 2023. 12. 31. |
| 0,05655 % | UBS Financial Services, Inc. | 29 773 | 9498 | 2023. 12. 31. |
| 0,05517 % | Avantis Investors | 29 048 | 8696 | 2024. 03. 31. |
| 0,05321 % | Acuitas Investments LLC | 28 014 | 9034 | 2023. 12. 31. |
| 0,04646 % | Mellon Investments Corporation | 24 462 | 600 | 2023. 12. 31. |
| 0,04542 % | Millennium Management LLC | 23 914 | -251 425 | 2023. 12. 31. |
| 0,04217 % | Two Sigma Investments, LP | 22 200 | -19 900 | 2023. 12. 31. |
| 0,04189 % | Columbia Threadneedle Investments (US) | 22 054 | -10 978 | 2023. 12. 31. |
| 0,04043 % | Susquehanna International Group, LLP | 21 284 | -50 957 | 2023. 12. 31. |
| 0,03995 % | American Century Investment Management, Inc. | 21 036 | 4893 | 2023. 12. 31. |
| 0,03940 % | Tulipano (Stephen J) | 20 746 | 8984 | 2024. 03. 19. |
| 0,03627 % | Squarepoint Capital LLP | 19 096 | 3886 | 2023. 12. 31. |
| 0,03415 % | Levin Arthur A | 17 979 | 0 | 2023. 09. 01. |
| 0,03396 % | JPMorgan Private Bank (United States) | 17 880 | 17 880 | 2023. 12. 31. |
| 0,03283 % | Ohio Public Employees Retirement System | 17 283 | 948 | 2023. 12. 31. |
| 0,03248 % | Bridgeway Capital Management, LLC | 17 100 | 17 100 | 2023. 12. 31. |
| 0,02959 % | Citadel Advisors LLC | 15 577 | -60 543 | 2023. 12. 31. |
| 0,02918 % | Numeric Investors LLC | 15 361 | -98 179 | 2023. 12. 31. |
| 0,02868 % | SG Americas Securities, L.L.C. | 15 101 | 1544 | 2023. 12. 31. |
| 0,02830 % | Virginia Retirement System | 14 900 | -700 | 2023. 09. 30. |
| 0,02829 % | SEI Investments Management Corporation | 14 897 | 0 | 2024. 03. 31. |
| 0,02776 % | MetLife Investment Management, LLC | 14 616 | 0 | 2023. 12. 31. |
| 0,02738 % | LSV Asset Management | 14 416 | 0 | 2024. 03. 31. |
| 0,02671 % | Zacks Investment Management, Inc. | 14 064 | 14 064 | 2023. 12. 31. |
| 0,02604 % | SunAmerica Asset Management, LLC | 13 711 | -56 | 2023. 12. 31. |
| 0,02382 % | Algert Global LLC | 12 540 | -4010 | 2023. 12. 31. |
| 0,02301 % | Ikarian Capital LLC | 12 116 | 0 | 2023. 12. 31. |
| 0,02286 % | Principal Global Investors (Equity) | 12 037 | -94 | 2023. 12. 31. |
| 0,02268 % | Parametric Portfolio Associates LLC | 11 941 | 1325 | 2023. 12. 31. |
| 0,02263 % | Manulife Investment Management (North America) Limited | 11 916 | 0 | 2023. 12. 31. |
| 0,02136 % | Vaughan Nelson Investment Management, L.P. | 11 248 | 0 | 2023. 12. 31. |
| 0,02123 % | Voya Investment Management LLC | 11 175 | 0 | 2023. 12. 31. |
| 0,02054 % | Mairs and Power, Inc. | 10 815 | 0 | 2023. 12. 31. |
| 0,02021 % | New York State Common Retirement Fund | 10 642 | -46 | 2023. 12. 31. |
| 0,01943 % | State Street Global Advisors Ireland Limited | 10 228 | -37 | 2023. 04. 30. |
| 0,01614 % | Wells Fargo Bank, N.A. | 8500 | 1682 | 2023. 12. 31. |
| 0,01519 % | Nash (Huw Michael) | 7999 | 7999 | 2024. 03. 19. |
| 0,01515 % | Simplex Trading, LLC | 7979 | 5298 | 2023. 12. 31. |
| 0,01461 % | BNP Paribas Securities Corp. North America | 7694 | -20 458 | 2023. 12. 31. |
| 0,01366 % | Mackenzie Financial Corporation | 7192 | 2793 | 2023. 12. 31. |
| 0,01118 % | RBC Wealth Management, International | 5884 | 1252 | 2023. 12. 31. |
| 0,01098 % | Lazard Asset Management, L.L.C. | 5779 | 222 | 2023. 12. 31. |
| 0,01070 % | BNY Mellon Wealth Management | 5636 | 426 | 2023. 12. 31. |
| 0,00960 % | Conestoga Capital Advisors, LLC | 5054 | -17 000 | 2024. 02. 29. |
| 0,00957 % | Tower Research Capital LLC | 5039 | 1298 | 2023. 12. 31. |
| 0,00951 % | ProShare Advisors LLC | 5008 | 965 | 2024. 03. 31. |
| 0,00950 % | Fidelity Management & Research Company LLC | 5000 | 1272 | 2023. 12. 31. |
| 0,00878 % | Invesco Advisers, Inc. | 4625 | -11 646 | 2024. 02. 29. |
| 0,00862 % | California State Teachers Retirement System | 4540 | -19 111 | 2023. 12. 31. |
| 0,00804 % | Horizon Kinetics LLC | 4233 | 0 | 2024. 02. 29. |
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