| 7,91 % | Perceptive Advisors LLC | 3 074 542 | 0 | 2023. 12. 31. |
| 7,35 % | Abingworth Management Limited | 2 857 804 | 0 | 2023. 12. 31. |
| 7,35 % | Nantahala Capital Management, LLC | 2 856 351 | 2 463 947 | 2023. 12. 31. |
| 6,49 % | Janus Henderson Investors | 2 523 897 | 319 844 | 2023. 12. 31. |
| 4,70 % | Adage Capital Management, L.P. | 1 826 814 | 499 814 | 2023. 12. 31. |
| 3,34 % | Vestal Point Capital, LP | 1 300 000 | 1 300 000 | 2023. 12. 31. |
| 21,66 % | Vivo Capital, LLC | 8 418 093 | 0 | 2023. 12. 31. |
| 2,49 % | The Vanguard Group, Inc. | 967 191 | 911 940 | 2023. 12. 31. |
| 2,38 % | Balyasny Asset Management LP | 926 876 | 468 053 | 2023. 12. 31. |
| 2,02 % | Avoro Capital Advisors LLC | 785 000 | 785 000 | 2023. 12. 31. |
| 1,80 % | Commodore Capital LP | 700 000 | -185 741 | 2023. 12. 31. |
| 1,52 % | Ikarian Capital LLC | 590 243 | 53 523 | 2023. 12. 31. |
| 1,29 % | State Street Global Advisors (US) | 501 402 | 485 954 | 2023. 12. 31. |
| 1,20 % | Frazier Healthcare Partners | 464 937 | 0 | 2023. 12. 31. |
| 1,17 % | Emerald Advisers LLC | 453 479 | 3479 | 2023. 12. 31. |
| 0,80 % | Ally Bridge Group NY LLC | 309 950 | 309 950 | 2023. 12. 31. |
| 0,78 % | Samlyn Capital, LLC | 301 777 | 301 777 | 2023. 12. 31. |
| 0,76 % | BlackRock Institutional Trust Company, N.A. | 296 468 | 296 215 | 2023. 12. 31. |
| 0,59 % | Mario (Ernest B) | 228 071 | -3523 | 2024. 01. 08. |
| 0,55 % | Wellington Management Company, LLP | 212 606 | 212 606 | 2023. 12. 31. |
| 0,51 % | Woodline Partners LP | 200 000 | -63 860 | 2023. 12. 31. |
| 0,43 % | Farallon Capital Management, L.L.C. | 165 219 | -222 781 | 2023. 12. 31. |
| 0,42 % | Geode Capital Management, L.L.C. | 162 844 | 110 291 | 2023. 12. 31. |
| 0,39 % | Anish (Bhatnagar) | 152 790 | -18 980 | 2024. 04. 01. |
| 0,37 % | Schuler (Jack W) | 145 207 | -372 143 | 2023. 05. 24. |
| 0,32 % | Boothbay Fund Management, LLC | 123 139 | 14 762 | 2023. 12. 31. |
| 0,29 % | Ghost Tree Capital, LLC | 112 385 | 112 385 | 2023. 12. 31. |
| 0,27 % | Altium Capital Management LP | 104 909 | 57 828 | 2023. 12. 31. |
| 0,27 % | Allspring Global Investments, LLC | 103 839 | 50 822 | 2024. 03. 31. |
| 0,24 % | EAM Investors, LLC | 93 425 | -45 905 | 2023. 12. 31. |
| 0,22 % | 683 Capital Management LLC | 87 000 | 0 | 2023. 12. 31. |
| 0,19 % | SilverArc Capital Management, LLC | 73 665 | -296 335 | 2023. 12. 31. |
| 0,19 % | J. Goldman & Co., L.P. | 73 252 | 7252 | 2023. 12. 31. |
| 0,18 % | Principal Global Investors (Equity) | 70 696 | 0 | 2024. 02. 29. |
| 0,18 % | Goldman Sachs & Company, Inc. | 68 599 | 68 599 | 2023. 12. 31. |
| 0,16 % | Mackaness (James H) | 62 955 | -5175 | 2024. 04. 01. |
| 0,16 % | Schonfeld Strategic Advisors LLC | 60 890 | 37 690 | 2023. 12. 31. |
| 0,15 % | Cubist Systematic Strategies, LLC | 57 006 | 57 006 | 2023. 12. 31. |
| 0,14 % | BofA Global Research (US) | 53 751 | 51 615 | 2023. 12. 31. |
| 0,13 % | Rafferty Asset Management LLC | 51 874 | 51 874 | 2023. 12. 31. |
| 0,12 % | Jane Street Capital, L.L.C. | 45 456 | 45 456 | 2023. 12. 31. |
| 0,11 % | Hirano (Patricia C) | 40 924 | -2218 | 2024. 04. 01. |
| 0,09 % | Jefferies LLC | 35 091 | 35 091 | 2023. 12. 31. |
| 0,09 % | Citi Investment Research (US) | 33 962 | 33 859 | 2023. 12. 31. |
| 0,08 % | Northern Trust Investments, Inc. | 32 927 | 25 897 | 2023. 12. 31. |
| 0,07 % | Parametric Portfolio Associates LLC | 26 605 | -6495 | 2023. 12. 31. |
| 0,06 % | Maplelane Capital, LLC | 25 000 | 0 | 2023. 12. 31. |
| 0,06 % | Yen (Kristen) | 23 423 | -2218 | 2024. 04. 01. |
| 0,06 % | Schweizerische Nationalbank | 22 800 | 22 800 | 2023. 12. 31. |
| 0,06 % | MFS Investment Management | 22 647 | 0 | 2024. 02. 29. |
| 0,06 % | Susquehanna International Group, LLP | 21 620 | 21 620 | 2023. 12. 31. |
| 0,05 % | Barclays Bank PLC | 21 305 | 21 305 | 2023. 12. 31. |
| 0,05 % | Dimensional Fund Advisors, L.P. | 20 754 | 0 | 2023. 12. 31. |
| 0,05 % | AWM Investment Company, Inc. | 20 000 | 20 000 | 2023. 12. 31. |
| 0,05 % | Alps Advisors, Inc. | 19 486 | 19 486 | 2023. 12. 31. |
| 0,05 % | Qube Research & Technologies Ltd | 18 696 | 18 696 | 2023. 12. 31. |
| 0,05 % | UBS Financial Services, Inc. | 17 788 | 17 788 | 2023. 12. 31. |
| 0,04 % | T. Rowe Price Associates, Inc. | 16 002 | 700 | 2024. 02. 29. |
| 0,04 % | Morgan Stanley & Co. LLC | 15 175 | 15 175 | 2023. 12. 31. |
| 0,04 % | Medical Strategy GmbH | 14 200 | 14 200 | 2023. 12. 31. |
| 0,04 % | Millennium Management LLC | 13 683 | -41 773 | 2023. 12. 31. |
| 0,03 % | Credit Suisse Funds AG | 12 839 | 9668 | 2023. 12. 31. |
| 0,03 % | Aspiriant, LLC | 12 128 | 0 | 2024. 03. 31. |
| 0,03 % | Cannon Global Investment Management, LLC | 11 800 | 11 800 | 2024. 03. 31. |
| 0,03 % | Pictet Asset Management Ltd. | 10 977 | 10 977 | 2024. 02. 29. |
| 0,03 % | SEI Investments Management Corporation | 10 932 | 410 | 2024. 03. 31. |
| 0,03 % | California State Teachers Retirement System | 10 299 | 10 299 | 2023. 12. 31. |
| 0,02 % | State of Wisconsin Investment Board | 9496 | 9496 | 2023. 12. 31. |
| 0,02 % | Harris (William G) | 8901 | 0 | 2023. 04. 01. |
| 0,02 % | Atom Investors LP | 8846 | 8846 | 2023. 12. 31. |
| 0,02 % | Morgan Stanley Smith Barney LLC | 8772 | 8772 | 2023. 12. 31. |
| 0,02 % | ProFund Advisors LLC | 8187 | 8187 | 2023. 12. 31. |
| 0,02 % | Legal & General Investment Management Ltd. | 7727 | 7727 | 2023. 12. 31. |
| 0,02 % | Engineers Gate Manager, L.P. | 7702 | 7702 | 2023. 12. 31. |
| 0,02 % | UBS Asset Management (UK) Ltd. | 7557 | 0 | 2024. 02. 29. |
| 0,02 % | Charles Schwab Investment Management, Inc. | 7195 | 3117 | 2023. 12. 31. |
| 0,02 % | Volck (Birgitte) | 7045 | 0 | 2023. 04. 01. |
| 0,02 % | Squarepoint Capital LLP | 6909 | 6909 | 2023. 12. 31. |
| 0,02 % | BlackRock (Netherlands) B.V. | 6872 | 6872 | 2023. 12. 31. |
| 0,02 % | BNY Mellon Asset Management | 6742 | 3925 | 2023. 12. 31. |
| 0,02 % | USAA Asset Management Company | 6154 | 6154 | 2024. 03. 31. |
| 0,02 % | CAPTRUST Financial Advisors | 6058 | -4128 | 2023. 12. 31. |
| 0,01 % | T. Rowe Price International Ltd | 4862 | 4862 | 2024. 03. 31. |
| 0,01 % | Simplex Trading, LLC | 4192 | 4192 | 2023. 12. 31. |
| 0,01 % | BlackRock Financial Management, Inc. | 4118 | 4118 | 2023. 12. 31. |
| 0,01 % | BlackRock Advisors (UK) Limited | 3657 | 3657 | 2023. 12. 31. |
| 0,01 % | Managed Account Advisors LLC | 3625 | 1863 | 2023. 12. 31. |
| 0,01 % | LSV Asset Management | 3567 | 0 | 2024. 03. 31. |
| 0,01 % | Mercer Global Investments Management Ltd | 3300 | 3300 | 2024. 03. 31. |
| 0,01 % | Global X Management (AUS) Limited | 3207 | 1458 | 2024. 03. 31. |
| 0,01 % | E Fund Management Co. Ltd. | 2770 | 2770 | 2023. 12. 31. |
| 0,01 % | AlphaSimplex Group, LLC | 2589 | 2589 | 2024. 02. 29. |
| 0,01 % | Virtus Etf Advisers LLC | 2490 | 2490 | 2023. 12. 31. |
| 0,01 % | Vanguard Investments Australia Ltd. | 2431 | -91 | 2023. 12. 31. |
| 0,01 % | State Street Global Advisors Ireland Limited | 2300 | 2300 | 2024. 03. 31. |
| 0,01 % | The Bollard Group, LLC | 2288 | 0 | 2023. 12. 31. |
| 0,01 % | Shell Asset Management Company B.V. | 2096 | 2096 | 2023. 12. 31. |
| 0,01 % | KLP Fondsforvaltning AS | 2000 | 0 | 2024. 02. 29. |
| 0,00 % | BlackRock Investment Management (UK) Ltd. | 1535 | 1535 | 2023. 12. 31. |
| 0,00 % | Granite Investment Partners, LLC | 1471 | -212 | 2024. 02. 29. |
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