| 9,45724 % | Deep Track Capital LP | 5 750 000 | 250 000 | 2023. 12. 31. |
| 7,11182 % | BlackRock Institutional Trust Company, N.A. | 4 323 984 | 464 976 | 2023. 12. 31. |
| 6,51878 % | Fidelity Management & Research Company LLC | 3 963 418 | -177 586 | 2023. 12. 31. |
| 5,98452 % | T. Rowe Price Associates, Inc. | 3 638 586 | 426 362 | 2023. 12. 31. |
| 5,90753 % | First Light Asset Management, LLC | 3 591 776 | 658 516 | 2023. 12. 31. |
| 5,89402 % | Laurion Capital Management LP | 3 583 567 | 397 056 | 2023. 12. 31. |
| 5,02717 % | The Vanguard Group, Inc. | 3 056 518 | 120 557 | 2023. 12. 31. |
| 4,95756 % | Cowen Investment Management LLC | 3 014 199 | -102 818 | 2023. 09. 30. |
| 4,94112 % | Blue Owl Capital Holdings LP | 3 004 199 | 3 004 199 | 2023. 12. 31. |
| 4,43528 % | Redmile Group, LLC | 2 696 648 | 18 549 | 2023. 12. 31. |
| 4,06583 % | Third Rock Ventures, LLC | 2 472 027 | 0 | 2023. 12. 31. |
| 3,54198 % | Novartis AG | 2 153 526 | 0 | 2022. 08. 08. |
| 3,31414 % | Polar Capital LLP | 2 015 000 | 350 000 | 2023. 12. 31. |
| 2,99866 % | Great Point Partners, LLC | 1 823 184 | 68 000 | 2023. 12. 31. |
| 2,59624 % | Citadel Advisors LLC | 1 578 514 | 58 436 | 2023. 12. 31. |
| 2,59393 % | Casdin Capital, LLC | 1 577 108 | 0 | 2023. 12. 31. |
| 2,57049 % | Franklin Advisers, Inc. | 1 562 858 | 57 935 | 2023. 12. 31. |
| 2,19618 % | State Street Global Advisors (US) | 1 335 278 | 17 477 | 2023. 12. 31. |
| 2,16909 % | Pictet Asset Management Ltd. | 1 318 804 | 417 514 | 2023. 12. 31. |
| 2,10691 % | RA Capital Management, LP | 1 281 000 | -481 000 | 2023. 12. 31. |
| 1,95263 % | Geode Capital Management, L.L.C. | 1 187 198 | 60 984 | 2023. 12. 31. |
| 1,89271 % | Granahan Investment Management, LLC | 1 150 766 | 211 557 | 2023. 12. 31. |
| 1,57094 % | DWS Investment GmbH | 955 133 | 0 | 2023. 12. 31. |
| 1,50077 % | Capital International Investors | 912 467 | 0 | 2023. 12. 31. |
| 1,16373 % | Coulie (Bernard J) | 707 549 | 102 429 | 2024. 01. 23. |
| 0,87513 % | Bessemer Trust Company, N.A. (US) | 532 079 | 0 | 2023. 12. 31. |
| 0,76478 % | Northern Trust Investments, Inc. | 464 987 | 18 846 | 2023. 12. 31. |
| 0,74507 % | Candriam Luxembourg S.A. | 453 000 | 0 | 2024. 02. 29. |
| 0,74507 % | Candriam Belgium S.A. | 453 000 | 138 000 | 2023. 12. 31. |
| 0,69769 % | Charles Schwab Investment Management, Inc. | 424 196 | 5990 | 2023. 12. 31. |
| 0,69601 % | Fernwood Investment Management, LLC. | 423 177 | 43 475 | 2023. 12. 31. |
| 0,63322 % | Rock Springs Capital Management LP | 384 996 | -106 225 | 2023. 12. 31. |
| 0,62727 % | Morgan Stanley & Co. LLC | 381 381 | 311 215 | 2023. 12. 31. |
| 0,60649 % | Columbia Wanger Asset Management, LLC | 368 744 | 0 | 2023. 12. 31. |
| 0,58042 % | Barclays Bank PLC | 352 897 | 108 871 | 2023. 12. 31. |
| 0,57089 % | AXA Investment Managers UK Ltd. | 347 100 | -8397 | 2023. 12. 31. |
| 0,56278 % | UBS Financial Services, Inc. | 342 173 | 71 369 | 2023. 12. 31. |
| 0,55374 % | Goldman Sachs & Company, Inc. | 336 674 | 217 112 | 2023. 12. 31. |
| 0,52413 % | Tepper (Robert I) | 318 672 | 89 168 | 2023. 12. 31. |
| 0,52389 % | SilverArc Capital Management, LLC | 318 524 | 68 115 | 2023. 12. 31. |
| 0,47482 % | Partners HealthCare System, Inc | 288 690 | 288 690 | 2024. 03. 31. |
| 0,46248 % | ArrowMark Colorado Holdings, LLC | 281 189 | 0 | 2023. 12. 31. |
| 0,32149 % | Cummings (Keith Lamont) | 195 468 | 45 469 | 2024. 01. 23. |
| 0,31967 % | Hull (Johannes P.) | 194 360 | 21 714 | 2024. 01. 23. |
| 0,31835 % | Sphera Funds Management Ltd. | 193 554 | 37 420 | 2023. 12. 31. |
| 0,31096 % | Nuveen LLC | 189 064 | -16 767 | 2023. 12. 31. |
| 0,25908 % | BNY Mellon Asset Management | 157 521 | 9063 | 2023. 12. 31. |
| 0,25341 % | Dimensional Fund Advisors, L.P. | 154 072 | 97 420 | 2023. 12. 31. |
| 0,25172 % | BlackRock Financial Management, Inc. | 153 045 | 12 189 | 2023. 12. 31. |
| 0,24232 % | T. Rowe Price International Ltd | 147 330 | 8067 | 2023. 12. 31. |
| 0,24159 % | Medical Strategy GmbH | 146 884 | -15 994 | 2023. 12. 31. |
| 0,23490 % | Lefebvre Eric | 142 820 | 32 605 | 2024. 01. 23. |
| 0,22158 % | BlackRock Investment Management, LLC | 134 720 | 77 | 2023. 12. 31. |
| 0,20923 % | BlackRock Advisors (UK) Limited | 127 210 | 5701 | 2024. 03. 31. |
| 0,20410 % | Woodline Partners LP | 124 090 | -312 162 | 2023. 12. 31. |
| 0,20031 % | Fred Alger Management, LLC | 121 787 | 5782 | 2023. 12. 31. |
| 0,18543 % | Rhenman & Partners Asset Management AB | 112 741 | 112 741 | 2023. 12. 31. |
| 0,18462 % | TD Asset Management Inc. | 112 248 | 0 | 2023. 12. 31. |
| 0,16925 % | BlackRock Asset Management Ireland Limited | 102 905 | 1653 | 2023. 12. 31. |
| 0,16474 % | Bond & Devick Wealth Partners | 100 160 | 0 | 2023. 12. 31. |
| 0,16447 % | Artia Global Partners LP | 100 000 | 0 | 2023. 12. 31. |
| 0,16408 % | Huh (Hoyoung) | 99 759 | 99 759 | 2023. 04. 14. |
| 0,15230 % | Two Sigma Investments, LP | 92 600 | -171 509 | 2023. 12. 31. |
| 0,14856 % | T. Rowe Price Investment Management, Inc. | 90 325 | 0 | 2024. 02. 29. |
| 0,14662 % | Jane Street Capital, L.L.C. | 89 144 | 65 905 | 2023. 12. 31. |
| 0,14539 % | Schweizerische Nationalbank | 88 400 | -2700 | 2023. 12. 31. |
| 0,13259 % | Rhumbline Advisers Ltd. Partnership | 80 614 | 1517 | 2023. 12. 31. |
| 0,12883 % | BofA Global Research (US) | 78 330 | 41 145 | 2023. 12. 31. |
| 0,12764 % | Susquehanna International Group, LLP | 77 607 | -66 901 | 2023. 12. 31. |
| 0,12315 % | Manulife Investment Management (North America) Limited | 74 875 | 7694 | 2023. 12. 31. |
| 0,12056 % | Nomura Asset Management Co., Ltd. | 73 300 | 73 300 | 2023. 11. 30. |
| 0,11756 % | Citi Investment Research (US) | 71 475 | 57 949 | 2023. 12. 31. |
| 0,10915 % | Atom Investors LP | 66 361 | 19 210 | 2023. 12. 31. |
| 0,10787 % | SEB Investment Management AB | 65 582 | 0 | 2023. 12. 31. |
| 0,10178 % | Credit Suisse Funds AG | 61 882 | 4122 | 2023. 12. 31. |
| 0,09869 % | Russell Investments Trust Company | 60 001 | -46 740 | 2023. 12. 31. |
| 0,09717 % | AllianceBernstein L.P. | 59 080 | 0 | 2023. 12. 31. |
| 0,09640 % | Avantis Investors | 58 614 | 30 273 | 2024. 03. 31. |
| 0,09169 % | New York State Common Retirement Fund | 55 748 | 5173 | 2023. 12. 31. |
| 0,08928 % | Wells Fargo Advisors | 54 280 | 48 210 | 2023. 12. 31. |
| 0,08318 % | Goldman Sachs Asset Management, L.P. | 50 572 | 5020 | 2023. 12. 31. |
| 0,08155 % | Exome Asset Management LLC | 49 580 | 49 580 | 2023. 12. 31. |
| 0,08131 % | HarbourVest Partners, L.L.C. | 49 434 | 0 | 2023. 12. 31. |
| 0,08120 % | California State Teachers Retirement System | 49 368 | 304 | 2023. 12. 31. |
| 0,07853 % | Ouimette (Michael) | 47 746 | 26 303 | 2024. 01. 23. |
| 0,07782 % | RBC Capital Markets Wealth Management | 47 312 | 2881 | 2023. 12. 31. |
| 0,07582 % | UBS Asset Management (Switzerland) | 46 100 | 0 | 2023. 12. 31. |
| 0,07401 % | Hudson Bay Capital Management LP | 45 000 | 45 000 | 2023. 12. 31. |
| 0,07221 % | Mellon Investments Corporation | 43 906 | 1227 | 2023. 12. 31. |
| 0,07155 % | Arens (Mathew P) | 43 500 | 43 500 | 2023. 12. 31. |
| 0,06960 % | Voya Investment Management LLC | 42 318 | 250 | 2023. 12. 31. |
| 0,06864 % | Legal & General Investment Management Ltd. | 41 734 | -184 | 2023. 12. 31. |
| 0,06784 % | Assenagon Asset Management S.A. | 41 244 | 2981 | 2024. 02. 29. |
| 0,06754 % | Alps Advisors, Inc. | 41 062 | -3117 | 2023. 12. 31. |
| 0,06611 % | BlackRock Investment Management (UK) Ltd. | 40 197 | -3949 | 2023. 12. 31. |
| 0,06579 % | Deka Vermögensmanagement GmbH | 40 000 | 0 | 2023. 12. 31. |
| 0,06294 % | UBS Asset Management (Americas), Inc. | 38 270 | 90 | 2023. 03. 31. |
| 0,06217 % | JPMorgan Private Bank (United States) | 37 802 | 37 802 | 2023. 12. 31. |
| 0,06109 % | Balyasny Asset Management LP | 37 143 | 37 143 | 2023. 12. 31. |
| 0,05770 % | Bruhn (Suzanne Louise) | 35 081 | 0 | 2023. 04. 14. |
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