| 5,86811 % | Abingworth Management Limited | 3 496 808 | 0 | 2023. 12. 31. |
| 4,85443 % | Invesco Advisers, Inc. | 2 892 757 | -240 804 | 2023. 12. 31. |
| 4,68280 % | Takeda Pharmaceutical Co Ltd | 2 790 480 | -362 737 | 2024. 04. 09. |
| 4,00127 % | BlackRock Institutional Trust Company, N.A. | 2 384 358 | 205 229 | 2023. 12. 31. |
| 3,82615 % | Ensign Peak Advisors, Inc. | 2 280 000 | 547 828 | 2023. 12. 31. |
| 3,28943 % | New Enterprise Associates (NEA) | 1 960 169 | 683 574 | 2023. 12. 31. |
| 3,27219 % | The Vanguard Group, Inc. | 1 949 896 | 33 767 | 2023. 12. 31. |
| 2,88904 % | Avidity Partners Management LP | 1 721 580 | 104 280 | 2023. 12. 31. |
| 2,44191 % | Gilder Gagnon Howe & Co. LLC | 1 455 132 | 145 084 | 2023. 12. 31. |
| 2,14801 % | 683 Capital Management LLC | 1 280 000 | 180 000 | 2023. 12. 31. |
| 2,04859 % | Socks (David A) | 1 220 756 | 9000 | 2023. 05. 25. |
| 16,96472 % | Frazier Healthcare Partners | 10 109 279 | 0 | 2023. 12. 31. |
| 12,52655 % | Medicxi Ventures (UK) LLP | 7 464 572 | 0 | 2024. 03. 31. |
| 1,83944 % | Woodline Partners LP | 1 096 121 | 356 100 | 2023. 12. 31. |
| 1,49735 % | Jennison Associates LLC | 892 270 | 474 848 | 2024. 03. 31. |
| 1,42641 % | Decheng Capital LLC | 850 000 | 0 | 2023. 12. 31. |
| 1,30314 % | Nabulsi (Azmi) | 776 539 | 32 500 | 2023. 11. 01. |
| 1,23389 % | Geode Capital Management, L.L.C. | 735 273 | 52 703 | 2023. 12. 31. |
| 1,21155 % | Catalys Pacific, LLC | 721 962 | 721 962 | 2023. 12. 31. |
| 1,15428 % | State Street Global Advisors (US) | 687 837 | 20 241 | 2023. 12. 31. |
| 1,08535 % | Newtyn Management, LLC | 646 760 | 146 760 | 2023. 12. 31. |
| 1,03602 % | Jacobs Levy Equity Management, Inc. | 617 365 | 327 513 | 2023. 12. 31. |
| 0,95985 % | Kennedy Capital Management LLC | 571 976 | -489 769 | 2023. 12. 31. |
| 0,94226 % | GW&K Investment Management, LLC | 561 490 | -15 960 | 2023. 12. 31. |
| 0,74349 % | Propel Bio Management, LLC | 443 047 | 205 112 | 2023. 12. 31. |
| 0,70832 % | StepStone Group LP | 422 085 | 0 | 2023. 12. 31. |
| 0,64649 % | Ghost Tree Capital, LLC | 385 241 | -9759 | 2023. 12. 31. |
| 0,60320 % | Checkpoint Capital L.P. | 359 446 | 359 446 | 2023. 12. 31. |
| 0,50815 % | Nuveen LLC | 302 809 | 14 975 | 2023. 12. 31. |
| 0,48592 % | Two Sigma Investments, LP | 289 557 | 205 494 | 2023. 12. 31. |
| 0,45907 % | Invesco Canada Ltd. | 273 560 | -10 707 | 2023. 12. 31. |
| 0,44399 % | Northern Trust Investments, Inc. | 264 574 | 24 732 | 2023. 12. 31. |
| 0,44055 % | Charles Schwab Investment Management, Inc. | 262 524 | 15 843 | 2023. 12. 31. |
| 0,40287 % | Curran (Terrie) | 240 068 | -16 851 | 2024. 03. 22. |
| 0,39929 % | Simplify Asset Management Inc | 237 935 | 0 | 2023. 12. 31. |
| 0,37376 % | Medical Strategy GmbH | 222 722 | 39 780 | 2023. 12. 31. |
| 0,33924 % | Walleye Capital LLC | 202 154 | 116 782 | 2023. 12. 31. |
| 0,33308 % | EcoR1 Capital, LLC | 198 480 | -501 520 | 2023. 12. 31. |
| 0,30172 % | Goldman Sachs & Company, Inc. | 179 796 | 74 192 | 2023. 12. 31. |
| 0,28536 % | Millennium Management LLC | 170 044 | 30 696 | 2023. 12. 31. |
| 0,26863 % | Saturn V Capital Management LLC | 160 075 | 160 075 | 2023. 12. 31. |
| 0,25909 % | Wellington Management Company, LLP | 154 391 | 54 581 | 2023. 12. 31. |
| 0,21713 % | D. E. Shaw & Co., L.P. | 129 389 | -1175 | 2023. 12. 31. |
| 0,18971 % | JP Morgan Asset Management | 113 049 | -21 090 | 2023. 12. 31. |
| 0,17934 % | Azimut Capital Management Sgr SpA | 106 866 | 4222 | 2024. 02. 29. |
| 0,16781 % | Moore Capital Management, LP | 100 000 | 20 000 | 2023. 12. 31. |
| 0,16630 % | Morgan Stanley & Co. LLC | 99 100 | 44 405 | 2023. 12. 31. |
| 0,16037 % | BlackRock Advisors (UK) Limited | 95 563 | 3255 | 2024. 03. 31. |
| 0,15080 % | BlackRock Financial Management, Inc. | 89 863 | 2494 | 2023. 12. 31. |
| 0,14241 % | BlackRock Investment Management, LLC | 84 860 | 7404 | 2023. 12. 31. |
| 0,13903 % | BNY Mellon Asset Management | 82 849 | 8803 | 2023. 12. 31. |
| 0,13802 % | Columbia Threadneedle Investments (US) | 82 244 | 70 842 | 2023. 12. 31. |
| 0,13726 % | BofA Global Research (US) | 81 793 | 28 235 | 2023. 12. 31. |
| 0,13724 % | BlackRock Asset Management Ireland Limited | 81 781 | 23 356 | 2023. 12. 31. |
| 0,11747 % | BioImpact Capital LLC | 70 000 | -277 332 | 2023. 12. 31. |
| 0,11009 % | Renaissance Technologies LLC | 65 600 | 65 600 | 2023. 12. 31. |
| 0,10950 % | Jane Street Capital, L.L.C. | 65 254 | -5530 | 2023. 12. 31. |
| 0,10539 % | Penn Mutual Asset Management, LLC | 62 802 | 0 | 2023. 12. 31. |
| 0,10237 % | Schonfeld Strategic Advisors LLC | 61 000 | 22 256 | 2023. 12. 31. |
| 0,09398 % | Schweizerische Nationalbank | 56 000 | -4200 | 2023. 12. 31. |
| 0,08779 % | Susquehanna International Group, LLP | 52 313 | 52 313 | 2023. 12. 31. |
| 0,08391 % | Octagon Capital Advisors LP | 50 000 | 50 000 | 2023. 12. 31. |
| 0,08336 % | Barclays Bank PLC | 49 672 | 36 437 | 2023. 12. 31. |
| 0,08139 % | Rhumbline Advisers Ltd. Partnership | 48 502 | -8035 | 2023. 12. 31. |
| 0,07940 % | State of Wisconsin Investment Board | 47 314 | -36 442 | 2023. 12. 31. |
| 0,07251 % | UBS O'Connor LLC | 43 209 | -74 071 | 2023. 12. 31. |
| 0,06617 % | UBS Financial Services, Inc. | 39 432 | 5732 | 2023. 12. 31. |
| 0,06522 % | Assenagon Asset Management S.A. | 38 863 | 2828 | 2024. 02. 29. |
| 0,06472 % | Ohio Public Employees Retirement System | 38 569 | 29 669 | 2023. 12. 31. |
| 0,06383 % | Credit Suisse Funds AG | 38 036 | -2 | 2023. 12. 31. |
| 0,06327 % | AllianceBernstein L.P. | 37 700 | 0 | 2023. 12. 31. |
| 0,05896 % | Inspirion Wealth Advisors, LLC | 35 134 | 0 | 2024. 03. 31. |
| 0,05748 % | Legal & General Investment Management Ltd. | 34 253 | 251 | 2023. 12. 31. |
| 0,05454 % | Parikh (Asit) | 32 500 | 7500 | 2023. 11. 08. |
| 0,05133 % | California State Teachers Retirement System | 30 590 | -396 | 2023. 12. 31. |
| 0,05104 % | Goldman Sachs Asset Management, L.P. | 30 415 | -2481 | 2023. 12. 31. |
| 0,04979 % | Occidental Asset Management, LLC | 29 672 | 0 | 2024. 03. 31. |
| 0,04585 % | Dimensional Fund Advisors, L.P. | 27 321 | 165 | 2024. 01. 31. |
| 0,03996 % | Parametric Portfolio Associates LLC | 23 810 | 1379 | 2023. 12. 31. |
| 0,03957 % | FBB Capital Partners | 23 579 | 23 579 | 2023. 12. 31. |
| 0,03939 % | Mellon Investments Corporation | 23 470 | 2451 | 2023. 12. 31. |
| 0,03789 % | Allworth Financial, L.P. | 22 580 | 3000 | 2023. 12. 31. |
| 0,03729 % | JPMorgan Private Bank (United States) | 22 223 | 22 223 | 2023. 12. 31. |
| 0,03583 % | Creative Planning, Inc. | 21 352 | 877 | 2023. 12. 31. |
| 0,03460 % | Graham Capital Management, L.P. | 20 619 | 20 619 | 2023. 12. 31. |
| 0,03229 % | Northern Trust Global Investments | 19 242 | -1440 | 2023. 12. 31. |
| 0,03092 % | AQR Capital Management, LLC | 18 427 | -4408 | 2023. 12. 31. |
| 0,03037 % | Tocqueville Asset Management LP | 18 100 | 18 100 | 2023. 12. 31. |
| 0,03032 % | SG Americas Securities, L.L.C. | 18 070 | 5906 | 2023. 12. 31. |
| 0,02966 % | Henderson (Molly) | 17 675 | -3435 | 2024. 04. 08. |
| 0,02920 % | T. Rowe Price International Ltd | 17 401 | 4007 | 2023. 12. 31. |
| 0,02790 % | DWS Investments UK Limited | 16 628 | 4870 | 2023. 12. 31. |
| 0,02783 % | Aperio Group, LLC | 16 586 | 3705 | 2023. 12. 31. |
| 0,02770 % | Topper (James N) | 16 508 | 0 | 2023. 05. 26. |
| 0,02764 % | MetLife Investment Management, LLC | 16 471 | 0 | 2023. 12. 31. |
| 0,02745 % | BlackRock Investment Management (UK) Ltd. | 16 360 | -3744 | 2023. 12. 31. |
| 0,02675 % | SunAmerica Asset Management, LLC | 15 938 | 529 | 2023. 12. 31. |
| 0,02635 % | Arctic Fund Management AS | 15 700 | 15 700 | 2024. 02. 29. |
| 0,02631 % | Russell Investments Trust Company | 15 678 | 10 478 | 2023. 12. 31. |
| 0,02568 % | Apo Asset Management GmbH | 15 301 | 0 | 2024. 02. 29. |
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