| 8,92988 % | Avoro Capital Advisors LLC | 2 565 555 | 0 | 2023. 12. 31. |
| 8,46515 % | The Vanguard Group, Inc. | 2 432 038 | 35 632 | 2023. 12. 31. |
| 8,28822 % | Fidelity Management & Research Company LLC | 2 381 205 | -82 166 | 2023. 12. 31. |
| 6,09907 % | Krishnan (Krish S) | 1 752 262 | -25 000 | 2024. 03. 25. |
| 6,03268 % | Redmile Group, LLC | 1 733 189 | -270 178 | 2023. 12. 31. |
| 5,71139 % | Krishnan (Suma M) | 1 640 882 | -25 000 | 2024. 03. 25. |
| 5,70581 % | BlackRock Institutional Trust Company, N.A. | 1 639 280 | 120 409 | 2023. 12. 31. |
| 4,30733 % | State Street Global Advisors (US) | 1 237 497 | 205 670 | 2023. 12. 31. |
| 3,44052 % | Frazier Healthcare Partners | 988 460 | 0 | 2023. 12. 31. |
| 2,52121 % | Jennison Associates LLC | 724 344 | 383 495 | 2023. 12. 31. |
| 2,15266 % | Lord, Abbett & Co. LLC | 618 458 | -52 853 | 2023. 12. 31. |
| 1,91718 % | Dimensional Fund Advisors, L.P. | 550 806 | 30 169 | 2023. 12. 31. |
| 1,77948 % | Geode Capital Management, L.L.C. | 511 246 | 28 011 | 2023. 12. 31. |
| 1,67762 % | Woodline Partners LP | 481 979 | 160 035 | 2023. 12. 31. |
| 1,65153 % | Credit Suisse Funds AG | 474 484 | 241 361 | 2023. 12. 31. |
| 1,59594 % | Hood River Capital Management LLC | 458 513 | -1976 | 2023. 12. 31. |
| 1,44035 % | T. Rowe Price Associates, Inc. | 413 813 | 169 616 | 2023. 12. 31. |
| 0,95762 % | Morgan Stanley & Co. LLC | 275 124 | 36 452 | 2023. 12. 31. |
| 0,92516 % | Medical Strategy GmbH | 265 798 | 2000 | 2023. 12. 31. |
| 0,89316 % | Balyasny Asset Management LP | 256 604 | 223 962 | 2023. 12. 31. |
| 0,87181 % | TimesSquare Capital Management, LLC | 250 470 | 127 435 | 2023. 12. 31. |
| 0,84950 % | SEB Investment Management AB | 244 061 | 0 | 2023. 12. 31. |
| 0,84836 % | Nuveen LLC | 243 733 | 10 080 | 2023. 12. 31. |
| 0,84297 % | First Turn Management, LLC | 242 185 | 242 185 | 2023. 12. 31. |
| 0,68356 % | Driehaus Capital Management, LLC | 196 386 | -2297 | 2023. 12. 31. |
| 0,68291 % | Braidwell LP | 196 200 | 118 703 | 2023. 12. 31. |
| 0,67134 % | Pictet Asset Management Ltd. | 192 875 | -180 937 | 2023. 12. 31. |
| 0,66676 % | Northern Trust Investments, Inc. | 191 560 | 5440 | 2023. 12. 31. |
| 0,64674 % | C WorldWide Asset Management Fondsmaeglerselskab A/S | 185 809 | 0 | 2023. 12. 31. |
| 0,64406 % | Charles Schwab Investment Management, Inc. | 185 038 | 5258 | 2023. 12. 31. |
| 0,62459 % | JPMorgan Asset Management U.K. Limited | 179 444 | -8734 | 2023. 12. 31. |
| 0,60174 % | Victory Capital Management Inc. | 172 879 | -36 608 | 2023. 12. 31. |
| 0,59331 % | Fidelity Investments Canada ULC | 170 459 | -4066 | 2023. 12. 31. |
| 0,59149 % | Baker Bros. Advisors LP | 169 934 | 0 | 2023. 12. 31. |
| 0,55808 % | Fred Alger Management, LLC | 160 335 | -7150 | 2023. 12. 31. |
| 0,55143 % | Allspring Global Investments, LLC | 158 425 | 99 101 | 2024. 03. 31. |
| 0,47778 % | Goldman Sachs & Company, Inc. | 137 265 | 32 011 | 2023. 12. 31. |
| 0,47506 % | Eventide Asset Management, LLC | 136 485 | 136 485 | 2023. 12. 31. |
| 0,42882 % | Handelsbanken Kapitalförvaltning AB | 123 200 | 10 400 | 2023. 12. 31. |
| 0,38362 % | S Squared Technology, LLC | 110 215 | 2000 | 2023. 12. 31. |
| 0,37369 % | Janney (Daniel Spencer) | 107 362 | -125 000 | 2024. 03. 25. |
| 0,36188 % | Rock Springs Capital Management LP | 103 969 | 13 409 | 2023. 12. 31. |
| 0,36095 % | OrbiMed Advisors, LLC | 103 700 | 103 700 | 2023. 12. 31. |
| 0,33814 % | Capital Research Global Investors | 97 147 | 97 147 | 2024. 03. 31. |
| 0,33400 % | Verition Fund Management LLC | 95 958 | -31 112 | 2023. 12. 31. |
| 0,31600 % | Goldman Sachs Asset Management, L.P. | 90 788 | 11 698 | 2023. 12. 31. |
| 0,29586 % | Integral Health Asset Management, LLC | 85 000 | 15 000 | 2023. 12. 31. |
| 0,29245 % | Rafferty Asset Management LLC | 84 021 | 12 215 | 2023. 12. 31. |
| 0,29130 % | Rossi (Dino A) | 83 691 | 0 | 2024. 03. 25. |
| 0,28275 % | BofA Global Research (US) | 81 233 | 18 008 | 2023. 12. 31. |
| 0,28123 % | Eversept Partners, LP | 80 798 | -27 973 | 2023. 12. 31. |
| 0,26086 % | Schroder Investment Management Ltd. (SIM) | 74 945 | 74 945 | 2023. 12. 31. |
| 0,24968 % | Nuveen Asset Management, LLC | 71 732 | 43 151 | 2023. 12. 31. |
| 0,24678 % | Marshall Wace LLP | 70 901 | 61 373 | 2023. 12. 31. |
| 0,23370 % | D. E. Shaw & Co., L.P. | 67 141 | 11 384 | 2023. 12. 31. |
| 0,22893 % | Decheng Capital LLC | 65 772 | 65 772 | 2023. 12. 31. |
| 0,22298 % | Barclays Bank PLC | 64 062 | 24 542 | 2023. 12. 31. |
| 0,22206 % | Wellington Management Company, LLP | 63 799 | -96 | 2024. 02. 29. |
| 0,21575 % | BlackRock Financial Management, Inc. | 61 986 | -3167 | 2023. 12. 31. |
| 0,21030 % | BNY Mellon Asset Management | 60 419 | 871 | 2023. 12. 31. |
| 0,20292 % | ACT Capital Management, L.L.C. | 58 300 | -700 | 2022. 09. 30. |
| 0,19144 % | Candriam Luxembourg S.A. | 55 000 | 0 | 2024. 02. 29. |
| 0,19144 % | Candriam Belgium S.A. | 55 000 | -15 000 | 2023. 12. 31. |
| 0,18903 % | BlackRock Investment Management, LLC | 54 308 | 390 | 2023. 12. 31. |
| 0,18763 % | Monarch Partners Asset Management LLC | 53 905 | 7411 | 2022. 12. 31. |
| 0,17694 % | AHL Partners LLP | 50 836 | 50 836 | 2023. 12. 31. |
| 0,17619 % | Jane Street Capital, L.L.C. | 50 618 | -24 508 | 2023. 12. 31. |
| 0,17403 % | Ghost Tree Capital, LLC | 50 000 | -30 000 | 2023. 12. 31. |
| 0,17081 % | Nicholas Investment Partners, L.P. | 49 073 | -306 538 | 2023. 12. 31. |
| 0,16043 % | International Biotechnology Trust PLC | 46 092 | 147 | 2023. 09. 30. |
| 0,15960 % | Voya Investment Management LLC | 45 853 | 17 413 | 2023. 12. 31. |
| 0,15504 % | Invesco Advisers, Inc. | 44 544 | 33 720 | 2023. 12. 31. |
| 0,14794 % | ExodusPoint Capital Management, LP | 42 502 | 14 752 | 2023. 12. 31. |
| 0,14672 % | Arctic Fund Management AS | 42 154 | 8180 | 2024. 02. 29. |
| 0,14258 % | TD Asset Management Inc. | 40 962 | 18 542 | 2023. 12. 31. |
| 0,13923 % | Soleus Capital Management, L.P. | 40 000 | -77 892 | 2023. 12. 31. |
| 0,13687 % | Putnam Investment Management, L.L.C. | 39 322 | 4529 | 2023. 12. 31. |
| 0,13600 % | BNP Paribas Securities Corp. North America | 39 072 | 10 057 | 2023. 12. 31. |
| 0,13157 % | PGIM Securities Investment Trust Enterprise | 37 800 | -200 | 2023. 12. 31. |
| 0,12727 % | Citi Investment Research (US) | 36 566 | 779 | 2023. 12. 31. |
| 0,12666 % | Mutual of America Capital Management LLC | 36 388 | -1151 | 2023. 12. 31. |
| 0,12496 % | Schweizerische Nationalbank | 35 900 | -3500 | 2023. 12. 31. |
| 0,12282 % | Mellon Investments Corporation | 35 287 | 2873 | 2023. 12. 31. |
| 0,11540 % | Hennion & Walsh Asset Management, Inc. | 33 154 | 1756 | 2024. 03. 31. |
| 0,11353 % | BlackRock Advisors (UK) Limited | 32 616 | 1224 | 2024. 03. 31. |
| 0,11260 % | CastleArk Management, LLC | 32 350 | 20 930 | 2023. 12. 31. |
| 0,11063 % | Rhumbline Advisers Ltd. Partnership | 31 785 | -618 | 2023. 12. 31. |
| 0,10871 % | Parametric Portfolio Associates LLC | 31 232 | -8113 | 2023. 12. 31. |
| 0,10707 % | UBS Financial Services, Inc. | 30 760 | 30 760 | 2023. 12. 31. |
| 0,10328 % | Kennedy Capital Management LLC | 29 673 | 29 673 | 2023. 12. 31. |
| 0,10181 % | Manulife Investment Management (North America) Limited | 29 250 | 8813 | 2023. 12. 31. |
| 0,09604 % | BlackRock Asset Management Ireland Limited | 27 592 | -3944 | 2023. 12. 31. |
| 0,09015 % | AllianceBernstein L.P. | 25 900 | 0 | 2023. 12. 31. |
| 0,08899 % | Schonfeld Strategic Advisors LLC | 25 566 | -58 069 | 2023. 12. 31. |
| 0,08702 % | Affinity Asset Advisors LLC | 25 000 | -32 500 | 2023. 12. 31. |
| 0,08655 % | Franklin Advisers, Inc. | 24 866 | 370 | 2023. 12. 31. |
| 0,08633 % | New Jersey Division of Investment | 24 804 | 4475 | 2023. 12. 31. |
| 0,08301 % | Carson Wealth Management Group | 23 850 | -6719 | 2024. 03. 31. |
| 0,08218 % | Scout Investments, Inc. | 23 611 | 23 611 | 2024. 02. 29. |
| 0,08214 % | GW&K Investment Management, LLC | 23 600 | 23 600 | 2024. 01. 31. |
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