| 6,98601 % | The Vanguard Group, Inc. | 8 710 158 | -109 771 | 2023. 12. 31. |
| 6,65590 % | Avidity Partners Management LP | 8 298 570 | 0 | 2023. 12. 31. |
| 6,54242 % | BlackRock Institutional Trust Company, N.A. | 8 157 094 | -580 111 | 2023. 12. 31. |
| 4,09223 % | Palo Alto Investors LP | 5 102 193 | -573 683 | 2023. 12. 31. |
| 3,52903 % | Chione, Ltd. | 4 400 000 | -600 000 | 2022. 12. 31. |
| 2,48749 % | Citadel Advisors LLC | 3 101 399 | -2489 | 2023. 12. 31. |
| 1,91083 % | Geode Capital Management, L.L.C. | 2 382 428 | 95 282 | 2023. 12. 31. |
| 1,87519 % | GSA Capital Partners LLP | 2 337 985 | 1 769 687 | 2023. 12. 31. |
| 1,64724 % | State Street Global Advisors (US) | 2 053 773 | 10 768 | 2023. 12. 31. |
| 1,57553 % | Renaissance Technologies LLC | 1 964 377 | 1 233 977 | 2023. 12. 31. |
| 1,54538 % | Marshall Wace LLP | 1 926 782 | -256 419 | 2023. 12. 31. |
| 1,41898 % | BNP Paribas Securities Corp. North America | 1 769 184 | 108 286 | 2023. 12. 31. |
| 1,38292 % | Delphi Ventures L.P. | 1 724 222 | 0 | 2024. 03. 29. |
| 1,33406 % | Adage Capital Management, L.P. | 1 663 300 | 1 663 300 | 2023. 12. 31. |
| 1,23056 % | Millennium Management LLC | 1 534 264 | 416 356 | 2023. 12. 31. |
| 1,20308 % | C WorldWide Asset Management Fondsmaeglerselskab A/S | 1 500 000 | 0 | 2023. 12. 31. |
| 1,03874 % | BlackRock Financial Management, Inc. | 1 295 105 | -180 263 | 2023. 12. 31. |
| 0,97127 % | Goldman Sachs & Company, Inc. | 1 210 975 | -542 212 | 2023. 12. 31. |
| 0,90231 % | AlphaCentric Advisors LLC. | 1 125 000 | 0 | 2023. 12. 31. |
| 0,90231 % | LifeSci Fund Management LLC | 1 125 000 | 0 | 2023. 12. 31. |
| 0,88844 % | J.P. Morgan Securities LLC | 1 107 708 | 44 994 | 2023. 12. 31. |
| 0,82720 % | Tejara Capital Ltd. | 1 031 348 | -46 040 | 2023. 12. 31. |
| 0,80205 % | Parkwood LLC | 1 000 000 | 1 000 000 | 2023. 09. 30. |
| 0,77804 % | Barclays Bank PLC | 970 058 | -182 240 | 2023. 12. 31. |
| 0,73422 % | Northern Trust Investments, Inc. | 915 422 | 28 968 | 2023. 12. 31. |
| 0,64351 % | UBS O'Connor LLC | 802 327 | -74 383 | 2023. 12. 31. |
| 0,59352 % | Altium Capital Management LP | 740 000 | 0 | 2023. 12. 31. |
| 0,57162 % | DWS Investment S.A. | 712 696 | 712 696 | 2023. 12. 31. |
| 0,55226 % | Morgan Stanley & Co. LLC | 688 558 | -181 606 | 2023. 12. 31. |
| 0,49504 % | D. E. Shaw & Co., L.P. | 617 216 | -5639 | 2023. 12. 31. |
| 0,49015 % | DWS Investments UK Limited | 611 116 | 556 081 | 2023. 12. 31. |
| 0,47974 % | AQR Capital Management, LLC | 598 142 | 96 343 | 2023. 12. 31. |
| 0,45072 % | SilverArc Capital Management, LLC | 561 955 | 0 | 2023. 12. 31. |
| 0,42564 % | Candriam Belgium S.A. | 530 694 | -610 000 | 2023. 12. 31. |
| 0,38880 % | Lombard Odier Asset Management (Europe) Ltd | 484 750 | -18 519 | 2022. 09. 30. |
| 0,37683 % | Birchview Capital, LP | 469 832 | -102 000 | 2023. 12. 31. |
| 0,36669 % | UBS Financial Services, Inc. | 457 185 | -449 460 | 2023. 12. 31. |
| 0,36285 % | Nuveen LLC | 452 406 | 0 | 2023. 12. 31. |
| 0,32082 % | Ikarian Capital LLC | 400 000 | 0 | 2023. 12. 31. |
| 0,31081 % | Los Angeles Capital Management LLC | 387 520 | -4020 | 2024. 03. 31. |
| 0,30478 % | Macquarie Investment Management | 380 000 | 0 | 2023. 12. 31. |
| 0,26894 % | BlackRock Investment Management, LLC | 335 319 | 0 | 2023. 12. 31. |
| 0,24861 % | Columbia Threadneedle Investments (US) | 309 967 | -47 011 | 2023. 12. 31. |
| 0,24856 % | Charles Schwab Investment Management, Inc. | 309 909 | 51 000 | 2023. 12. 31. |
| 0,24767 % | Paulson (Richard A.) | 308 799 | -3563 | 2024. 04. 04. |
| 0,24579 % | BofA Global Research (US) | 306 455 | -46 167 | 2023. 12. 31. |
| 0,23219 % | Bridgeway Capital Management, LLC | 289 500 | 0 | 2023. 12. 31. |
| 0,22815 % | Jacobs Levy Equity Management, Inc. | 284 457 | -2 127 871 | 2023. 12. 31. |
| 0,22381 % | BlackRock Asset Management Ireland Limited | 279 048 | -82 390 | 2023. 12. 31. |
| 0,22093 % | Jane Street Capital, L.L.C. | 275 460 | 275 460 | 2023. 12. 31. |
| 0,22072 % | BNY Mellon Asset Management | 275 198 | -156 448 | 2023. 12. 31. |
| 0,22061 % | Acadian Asset Management LLC | 275 059 | 275 059 | 2023. 12. 31. |
| 0,21518 % | Fidelity Management & Research Company LLC | 268 286 | 1839 | 2023. 12. 31. |
| 0,19769 % | BlackRock Advisors (UK) Limited | 246 479 | -13 680 | 2024. 03. 31. |
| 0,18242 % | PanAgora Asset Management Inc. | 227 445 | 227 445 | 2023. 12. 31. |
| 0,18051 % | Two Sigma Investments, LP | 225 060 | 189 860 | 2023. 12. 31. |
| 0,17380 % | Atom Investors LP | 216 690 | 25 865 | 2023. 12. 31. |
| 0,17055 % | Exchange Traded Concepts, LLC | 212 638 | 96 774 | 2024. 03. 31. |
| 0,15464 % | AllianceBernstein L.P. | 192 810 | 0 | 2023. 12. 31. |
| 0,15454 % | Dafna Capital Management, LLC | 192 678 | 0 | 2023. 12. 31. |
| 0,12441 % | Newton Investment Management North America, LLC | 155 120 | 0 | 2023. 12. 31. |
| 0,12039 % | Morgan Stanley Smith Barney LLC | 150 099 | -10 257 | 2023. 12. 31. |
| 0,11277 % | Mano (Michael) | 140 602 | -3576 | 2024. 03. 01. |
| 0,11077 % | Rhumbline Advisers Ltd. Partnership | 138 107 | -50 | 2023. 12. 31. |
| 0,10622 % | Monashee Investment Management, LLC | 132 435 | 132 435 | 2023. 12. 31. |
| 0,09734 % | Mitchener (Stephen) | 121 366 | -6357 | 2023. 03. 01. |
| 0,09361 % | Woodline Partners LP | 116 718 | -17 394 | 2023. 12. 31. |
| 0,07279 % | LSV Asset Management | 90 760 | 0 | 2024. 03. 31. |
| 0,07231 % | SEI Investments Management Corporation | 90 160 | -4020 | 2024. 03. 31. |
| 0,06987 % | T. Rowe Price International Ltd | 87 113 | 0 | 2023. 12. 31. |
| 0,06867 % | Goldman Sachs Asset Management, L.P. | 85 618 | -76 242 | 2023. 12. 31. |
| 0,06556 % | Boothbay Fund Management, LLC | 81 736 | 0 | 2023. 12. 31. |
| 0,06475 % | Northern Trust Global Investments | 80 725 | -18 553 | 2023. 12. 31. |
| 0,06406 % | Mason (Michael P) | 79 865 | -110 622 | 2024. 03. 29. |
| 0,06304 % | Susquehanna International Group, LLP | 78 596 | -59 213 | 2023. 12. 31. |
| 0,05889 % | SG Americas Securities, L.L.C. | 73 430 | 54 839 | 2023. 12. 31. |
| 0,05888 % | JPMorgan Private Bank (United States) | 73 412 | 68 412 | 2023. 12. 31. |
| 0,05713 % | Connor, Clark & Lunn Investment Management Ltd. | 71 224 | 35 945 | 2023. 12. 31. |
| 0,05685 % | Cheng (Sohanya Roshan) | 70 884 | -125 085 | 2024. 03. 29. |
| 0,05364 % | Mellon Investments Corporation | 66 884 | 0 | 2023. 12. 31. |
| 0,05327 % | Vident Investment Advisory, LLC | 66 422 | 66 422 | 2023. 06. 30. |
| 0,04515 % | SunAmerica Asset Management, LLC | 56 295 | -228 | 2023. 12. 31. |
| 0,04138 % | Rangwala (Reshma) | 51 595 | -304 094 | 2024. 03. 29. |
| 0,03940 % | XTX Markets LLC | 49 122 | -260 943 | 2023. 12. 31. |
| 0,03647 % | Voya Investment Management LLC | 45 471 | 0 | 2023. 12. 31. |
| 0,03632 % | HSBC Global Asset Management (UK) Limited | 45 290 | 362 | 2023. 12. 31. |
| 0,03620 % | Bohlin (Garen G.) | 45 140 | 0 | 2024. 03. 29. |
| 0,03620 % | G.W. & Wade, LLC. | 45 140 | 0 | 2023. 12. 31. |
| 0,03349 % | RBC Capital Markets Wealth Management | 41 756 | -20 844 | 2023. 12. 31. |
| 0,03254 % | T. Rowe Price Associates, Inc. | 40 572 | 3700 | 2024. 02. 29. |
| 0,03048 % | LUNIS Vermögensmanagement AG | 38 000 | 0 | 2023. 12. 31. |
| 0,03043 % | Bleakley Financial Group LLC | 37 938 | 37 938 | 2023. 12. 31. |
| 0,03043 % | Sawtooth Asset Management, Inc. | 37 938 | 37 938 | 2023. 12. 31. |
| 0,02945 % | Poulton (Stuart) | 36 723 | -145 193 | 2024. 03. 29. |
| 0,02807 % | Kennedy Investment Group | 35 000 | 0 | 2023. 12. 31. |
| 0,02522 % | Principal Global Investors (Equity) | 31 442 | -1396 | 2023. 12. 31. |
| 0,02444 % | Group One Trading, L.P. | 30 473 | -24 040 | 2023. 12. 31. |
| 0,02385 % | Redwood Wealth Management Group, LLC | 29 730 | -3000 | 2023. 12. 31. |
| 0,02360 % | Florida State Board of Administration | 29 422 | 29 422 | 2023. 12. 31. |
| 0,02354 % | Wells Fargo Bank, N.A. | 29 351 | 6682 | 2023. 12. 31. |
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