| 9,24758 % | Quogue Capital L.L.C. | 28 067 333 | 5 000 000 | 2024. 02. 20. |
| 7,50049 % | The Vanguard Group, Inc. | 22 764 739 | 669 350 | 2023. 12. 31. |
| 6,58861 % | MHR Fund Management LLC | 19 997 103 | 0 | 2023. 12. 31. |
| 6,33315 % | Perceptive Advisors LLC | 19 221 743 | 7 242 328 | 2024. 02. 20. |
| 5,56760 % | BlackRock Institutional Trust Company, N.A. | 16 898 233 | 680 727 | 2023. 12. 31. |
| 5,41148 % | State Street Global Advisors (US) | 16 424 388 | -307 881 | 2023. 12. 31. |
| 2,20751 % | Avoro Capital Advisors LLC | 6 700 000 | 0 | 2023. 12. 31. |
| 1,73415 % | Pictet Asset Management Ltd. | 5 263 309 | -1 650 375 | 2023. 12. 31. |
| 1,65962 % | Geode Capital Management, L.L.C. | 5 037 098 | 287 687 | 2023. 12. 31. |
| 1,59061 % | Artisan Partners Limited Partnership | 4 827 670 | -208 809 | 2023. 12. 31. |
| 1,55101 % | OrbiMed Advisors, LLC | 4 707 458 | 0 | 2023. 12. 31. |
| 1,29358 % | Balyasny Asset Management LP | 3 926 159 | -550 677 | 2023. 12. 31. |
| 1,15877 % | Dimensional Fund Advisors, L.P. | 3 516 987 | -461 398 | 2023. 12. 31. |
| 1,08381 % | BioImpact Capital LLC | 3 289 470 | 2073 | 2023. 12. 31. |
| 1,03887 % | T. Rowe Price Associates, Inc. | 3 153 086 | -318 633 | 2023. 12. 31. |
| 0,96408 % | Morgan Stanley & Co. LLC | 2 926 065 | 929 531 | 2023. 12. 31. |
| 0,92647 % | Goldman Sachs & Company, Inc. | 2 811 932 | -161 559 | 2023. 12. 31. |
| 0,86861 % | Principal Global Investors (Equity) | 2 636 327 | -6828 | 2023. 12. 31. |
| 0,84260 % | Credit Suisse Funds AG | 2 557 380 | -2533 | 2023. 12. 31. |
| 0,70361 % | Long Focus Capital Management LLC | 2 135 521 | -335 000 | 2023. 12. 31. |
| 0,69414 % | Palo Alto Investors LP | 2 106 792 | 2 106 792 | 2023. 12. 31. |
| 0,65945 % | Hood River Capital Management LLC | 2 001 510 | 9175 | 2023. 12. 31. |
| 0,64412 % | Northern Trust Investments, Inc. | 1 954 979 | 183 827 | 2023. 12. 31. |
| 0,57689 % | Rice Hall James & Associates, LLC | 1 750 907 | 28 196 | 2023. 12. 31. |
| 0,57659 % | 683 Capital Management LLC | 1 750 000 | -300 000 | 2023. 12. 31. |
| 0,57561 % | Charles Schwab Investment Management, Inc. | 1 747 023 | 54 490 | 2023. 12. 31. |
| 0,56928 % | Candriam Belgium S.A. | 1 727 822 | -1 020 031 | 2023. 12. 31. |
| 0,55773 % | Candriam Luxembourg S.A. | 1 692 770 | 0 | 2024. 02. 29. |
| 0,52872 % | Woodline Partners LP | 1 604 706 | 958 411 | 2023. 12. 31. |
| 0,52808 % | JPMorgan Asset Management U.K. Limited | 1 602 777 | -44 401 | 2023. 12. 31. |
| 0,52681 % | Susquehanna International Group, LLP | 1 598 930 | 353 893 | 2023. 12. 31. |
| 0,50239 % | DWS Investments UK Limited | 1 524 812 | 1 412 125 | 2023. 12. 31. |
| 0,46127 % | Boxer Capital, L.L.C. | 1 400 000 | -2 305 133 | 2023. 12. 31. |
| 0,44809 % | C WorldWide Asset Management Fondsmaeglerselskab A/S | 1 360 000 | 0 | 2023. 12. 31. |
| 0,41103 % | Rafferty Asset Management LLC | 1 247 515 | -248 655 | 2023. 12. 31. |
| 0,36917 % | Norges Bank Investment Management (NBIM) | 1 120 457 | -1 854 400 | 2023. 12. 31. |
| 0,36797 % | Rhenman & Partners Asset Management AB | 1 116 818 | 166 818 | 2023. 12. 31. |
| 0,34702 % | Invenomic Capital Management LP | 1 053 251 | -42 946 | 2023. 12. 31. |
| 0,33667 % | New York State Common Retirement Fund | 1 021 824 | -5141 | 2023. 12. 31. |
| 0,33667 % | Schonfeld Strategic Advisors LLC | 1 021 818 | 1 021 818 | 2023. 12. 31. |
| 0,32948 % | Tang Capital Management, LLC | 1 000 000 | 1 000 000 | 2023. 12. 31. |
| 0,32390 % | Voloridge Investment Management, LLC | 983 080 | 782 656 | 2023. 12. 31. |
| 0,30956 % | Millennium Management LLC | 939 546 | -6 880 528 | 2023. 12. 31. |
| 0,30868 % | BofA Global Research (US) | 936 887 | -293 181 | 2023. 12. 31. |
| 0,30668 % | Nuveen LLC | 930 818 | -638 955 | 2023. 12. 31. |
| 0,30513 % | JP Morgan Asset Management | 926 109 | -63 353 | 2023. 12. 31. |
| 0,29554 % | Opaleye Management Inc. | 897 000 | 287 000 | 2023. 12. 31. |
| 0,28334 % | BlackRock Financial Management, Inc. | 859 954 | -119 170 | 2023. 12. 31. |
| 0,28273 % | T. Rowe Price Investment Management, Inc. | 858 100 | 858 100 | 2024. 03. 31. |
| 0,28246 % | UBS Financial Services, Inc. | 857 308 | 618 755 | 2023. 12. 31. |
| 0,27868 % | Goldman Sachs Asset Management, L.P. | 845 818 | 66 388 | 2023. 12. 31. |
| 0,27550 % | Barclays Bank PLC | 836 175 | 78 243 | 2023. 12. 31. |
| 0,25635 % | Banque Pictet & Cie S.A. | 778 038 | 144 244 | 2023. 12. 31. |
| 0,24581 % | Pictet Asset Management (Japan) Ltd. | 746 057 | 279 233 | 2023. 10. 31. |
| 0,23762 % | Citi Investment Research (US) | 721 210 | -182 340 | 2023. 12. 31. |
| 0,22825 % | Brevan Howard Capital Management LP | 692 775 | -869 911 | 2023. 12. 31. |
| 0,22357 % | QVT Financial LP | 678 564 | 0 | 2023. 12. 31. |
| 0,22317 % | Cutter Capital Management, LP | 677 350 | 677 350 | 2023. 12. 31. |
| 0,21583 % | Vivo Capital, LLC | 655 057 | 0 | 2023. 12. 31. |
| 0,21488 % | Invesco Capital Management LLC | 652 170 | 570 056 | 2023. 12. 31. |
| 0,21012 % | Laurion Capital Management LP | 637 742 | 637 742 | 2023. 12. 31. |
| 0,20295 % | BlackRock Investment Management, LLC | 615 971 | 22 555 | 2023. 12. 31. |
| 0,19841 % | BNY Mellon Asset Management | 602 181 | 4931 | 2023. 12. 31. |
| 0,19073 % | Parametric Portfolio Associates LLC | 578 893 | 268 044 | 2023. 12. 31. |
| 0,18988 % | Group One Trading, L.P. | 576 302 | -49 399 | 2023. 12. 31. |
| 0,18517 % | Farallon Capital Management, L.L.C. | 562 000 | 562 000 | 2023. 12. 31. |
| 0,18411 % | McPeak (Merrill A) | 558 783 | 250 000 | 2024. 02. 20. |
| 0,18286 % | Soleus Capital Management, L.P. | 555 000 | -684 777 | 2023. 12. 31. |
| 0,18215 % | BNP Paribas Securities Corp. North America | 552 847 | 251 536 | 2023. 12. 31. |
| 0,17217 % | Jane Street Capital, L.L.C. | 522 561 | -27 354 | 2023. 12. 31. |
| 0,16309 % | Zimmer Partners, LP | 495 000 | -93 000 | 2023. 12. 31. |
| 0,15447 % | Cubist Systematic Strategies, LLC | 468 821 | 468 821 | 2023. 12. 31. |
| 0,14842 % | Eagle Asset Management, Inc. | 450 456 | 450 456 | 2023. 12. 31. |
| 0,14662 % | International Biotechnology Trust PLC | 445 000 | 380 000 | 2023. 09. 30. |
| 0,14479 % | Schweizerische Nationalbank | 439 456 | -49 900 | 2023. 12. 31. |
| 0,13424 % | Hennion & Walsh Asset Management, Inc. | 407 429 | 121 395 | 2024. 03. 31. |
| 0,12974 % | Medical Strategy GmbH | 393 779 | 0 | 2023. 09. 30. |
| 0,12869 % | DWS Investment GmbH | 390 600 | 0 | 2023. 12. 31. |
| 0,12686 % | Arctic Fund Management AS | 385 029 | -12 100 | 2024. 02. 29. |
| 0,12325 % | Simplex Trading, LLC | 374 067 | 198 650 | 2023. 12. 31. |
| 0,12140 % | Rhumbline Advisers Ltd. Partnership | 368 456 | 16 289 | 2023. 12. 31. |
| 0,12092 % | Corient Private Wealth LLC | 367 000 | 247 199 | 2023. 12. 31. |
| 0,11406 % | PanAgora Asset Management Inc. | 346 190 | 12 216 | 2023. 12. 31. |
| 0,10976 % | American Century Investment Management, Inc. | 333 136 | -75 622 | 2023. 12. 31. |
| 0,10931 % | Lombard Odier Asset Management (Europe) Ltd | 331 776 | -71 654 | 2022. 09. 30. |
| 0,10699 % | Schroder Investment Management Ltd. (SIM) | 324 736 | 324 736 | 2023. 12. 31. |
| 0,10552 % | Parametrica Management Ltd | 320 276 | 224 876 | 2023. 12. 31. |
| 0,10355 % | BlackRock Advisors (UK) Limited | 314 282 | 22 423 | 2024. 03. 31. |
| 0,10140 % | Stifel, Nicolaus & Company, Incorporated | 307 754 | 77 600 | 2023. 12. 31. |
| 0,10059 % | Nomura Asset Management Co., Ltd. | 305 301 | 9002 | 2023. 11. 30. |
| 0,09712 % | HRT Financial LP | 294 763 | 294 763 | 2023. 12. 31. |
| 0,09424 % | Citadel Advisors LLC | 286 034 | -103 101 | 2023. 12. 31. |
| 0,09061 % | Hudson Bay Capital Management LP | 275 000 | -155 200 | 2023. 12. 31. |
| 0,09037 % | Wells Fargo Advisors | 274 287 | 70 093 | 2023. 12. 31. |
| 0,08730 % | Manulife Investment Management (North America) Limited | 264 971 | 1042 | 2023. 12. 31. |
| 0,08499 % | Driehaus Capital Management, LLC | 257 959 | 257 959 | 2024. 02. 29. |
| 0,08483 % | TD Asset Management Inc. | 257 460 | -78 618 | 2023. 12. 31. |
| 0,08465 % | Credit Suisse International | 256 936 | -26 620 | 2023. 12. 31. |
| 0,08332 % | AllianceBernstein L.P. | 252 890 | -90 300 | 2023. 12. 31. |
| 0,08237 % | CM Management, LLC | 250 000 | 50 000 | 2023. 12. 31. |
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