| 9,83 % | Wellington Management Company, LLP | 6 476 561 | 1 044 728 | 2023. 12. 31. |
| 9,21 % | Fidelity Management & Research Company LLC | 6 073 162 | -200 884 | 2023. 12. 31. |
| 5,51 % | Eventide Asset Management, LLC | 3 630 013 | 2 030 013 | 2023. 12. 31. |
| 5,25 % | RTW Investments L.P. | 3 463 201 | 0 | 2023. 12. 31. |
| 5,03 % | BlackRock Institutional Trust Company, N.A. | 3 313 502 | 429 668 | 2023. 12. 31. |
| 4,76 % | Polar Capital LLP | 3 135 871 | 709 115 | 2023. 12. 31. |
| 4,61 % | The Vanguard Group, Inc. | 3 035 675 | 425 500 | 2023. 12. 31. |
| 4,56 % | Kynam Capital Management LP | 3 005 904 | -194 096 | 2023. 12. 31. |
| 4,18 % | Point72 Asset Management, L.P. | 2 756 122 | -866 014 | 2023. 12. 31. |
| 3,67 % | Bellevue Asset Management AG | 2 416 296 | 516 296 | 2023. 12. 31. |
| 3,61 % | State Street Global Advisors (US) | 2 377 326 | 84 475 | 2023. 12. 31. |
| 3,38 % | Pictet Asset Management Ltd. | 2 225 448 | 374 478 | 2023. 12. 31. |
| 1,94 % | Marshall Wace LLP | 1 280 084 | 741 765 | 2023. 12. 31. |
| 1,70 % | Geode Capital Management, L.L.C. | 1 117 994 | 117 569 | 2023. 12. 31. |
| 1,51 % | Redmile Group, LLC | 993 803 | -642 135 | 2023. 12. 31. |
| 1,48 % | Fidelity Institutional Asset Management | 977 247 | 162 173 | 2023. 12. 31. |
| 1,47 % | Rock Springs Capital Management LP | 969 646 | 469 545 | 2023. 12. 31. |
| 1,28 % | Sofinnova Investments, Inc | 844 008 | 419 749 | 2023. 12. 31. |
| 1,14 % | Eversept Partners, LP | 754 107 | 165 964 | 2023. 12. 31. |
| 1,07 % | Octagon Capital Advisors LP | 707 526 | -52 372 | 2023. 12. 31. |
| 1,07 % | Commodore Capital LP | 701 967 | -4698 | 2023. 12. 31. |
| 0,94 % | Morgan Stanley & Co. LLC | 622 813 | 119 544 | 2023. 12. 31. |
| 0,75 % | 5AM Ventures | 497 270 | 187 000 | 2023. 12. 31. |
| 0,62 % | Charles Schwab Investment Management, Inc. | 409 391 | 47 844 | 2023. 12. 31. |
| 0,61 % | Northern Trust Investments, Inc. | 400 112 | 27 920 | 2023. 12. 31. |
| 0,61 % | Affinity Asset Advisors LLC | 400 000 | 250 000 | 2023. 12. 31. |
| 0,59 % | Goldman Sachs & Company, Inc. | 388 404 | 12 964 | 2023. 12. 31. |
| 0,59 % | Woodline Partners LP | 387 652 | 280 156 | 2023. 12. 31. |
| 0,59 % | T. Rowe Price Associates, Inc. | 385 809 | -47 814 | 2023. 12. 31. |
| 0,48 % | Candriam Luxembourg S.A. | 317 509 | 0 | 2024. 02. 29. |
| 0,48 % | Candriam Belgium S.A. | 317 509 | -5000 | 2023. 12. 31. |
| 0,48 % | Sphera Funds Management Ltd. | 315 644 | 135 644 | 2023. 12. 31. |
| 0,38 % | TSP Capital Management Group, LLC | 251 495 | -200 | 2023. 12. 31. |
| 0,38 % | Baker Bros. Advisors LP | 247 644 | 247 644 | 2023. 12. 31. |
| 0,38 % | SilverArc Capital Management, LLC | 247 215 | 247 215 | 2023. 12. 31. |
| 0,37 % | Medical Strategy GmbH | 243 942 | 6400 | 2023. 12. 31. |
| 0,36 % | Invesco Capital Management LLC | 235 612 | 217 783 | 2023. 12. 31. |
| 0,35 % | Dimensional Fund Advisors, L.P. | 230 471 | -110 879 | 2023. 12. 31. |
| 0,33 % | BofA Global Research (US) | 216 133 | 4695 | 2023. 12. 31. |
| 0,27 % | Ensign Peak Advisors, Inc. | 179 611 | 87 482 | 2023. 12. 31. |
| 0,26 % | Walleye Capital LLC | 169 268 | 10 275 | 2023. 12. 31. |
| 0,25 % | Nomura Asset Management Co., Ltd. | 163 501 | 163 501 | 2023. 11. 30. |
| 0,24 % | American Century Investment Management, Inc. | 161 051 | 191 | 2023. 12. 31. |
| 0,24 % | UBS Financial Services, Inc. | 158 092 | 136 897 | 2023. 12. 31. |
| 0,22 % | Rafferty Asset Management LLC | 148 009 | -16 781 | 2023. 12. 31. |
| 0,22 % | Barclays Bank PLC | 144 345 | 2295 | 2023. 12. 31. |
| 0,22 % | AXA Investment Managers UK Ltd. | 142 170 | -3439 | 2023. 12. 31. |
| 0,21 % | BlackRock Financial Management, Inc. | 139 006 | 3916 | 2023. 12. 31. |
| 0,21 % | Laurion Capital Management LP | 138 531 | 138 531 | 2023. 12. 31. |
| 0,21 % | BNP Paribas Securities Corp. North America | 136 601 | 44 878 | 2023. 12. 31. |
| 0,20 % | Schonfeld Strategic Advisors LLC | 130 542 | 130 542 | 2023. 12. 31. |
| 0,20 % | MacKay Shields LLC | 128 803 | 0 | 2022. 08. 31. |
| 0,19 % | Jane Street Capital, L.L.C. | 128 161 | 68 747 | 2023. 12. 31. |
| 0,19 % | BNY Mellon Asset Management | 127 836 | 4661 | 2023. 12. 31. |
| 0,19 % | Citadel Advisors LLC | 126 328 | 120 403 | 2023. 12. 31. |
| 0,19 % | BlackRock Investment Management, LLC | 123 393 | 1115 | 2023. 12. 31. |
| 0,18 % | Nuveen LLC | 120 076 | -204 | 2023. 12. 31. |
| 0,17 % | Exome Asset Management LLC | 111 300 | 111 300 | 2023. 12. 31. |
| 0,16 % | Mirador Capital Partners LP | 104 759 | -3151 | 2024. 03. 31. |
| 0,15 % | Monashee Investment Management, LLC | 100 209 | 100 209 | 2023. 12. 31. |
| 0,15 % | Schweizerische Nationalbank | 97 000 | 8700 | 2023. 12. 31. |
| 0,14 % | Polar Asset Management Partners Inc. | 94 300 | -38 100 | 2023. 12. 31. |
| 0,12 % | UBS Switzerland AG | 80 235 | 0 | 2023. 12. 31. |
| 0,12 % | Rhumbline Advisers Ltd. Partnership | 76 022 | -652 | 2023. 12. 31. |
| 0,11 % | Acuta Capital Partners, LLC | 69 400 | -52 941 | 2023. 12. 31. |
| 0,10 % | Crestline Investors, Inc. | 67 243 | 4133 | 2023. 12. 31. |
| 0,10 % | BlackRock Advisors (UK) Limited | 63 854 | 1366 | 2024. 03. 31. |
| 0,09 % | Citi Investment Research (US) | 62 341 | -7014 | 2023. 12. 31. |
| 0,09 % | Kennedy Capital Management LLC | 62 172 | -25 222 | 2023. 12. 31. |
| 0,09 % | OrbiMed Advisors, LLC | 58 800 | 58 800 | 2023. 12. 31. |
| 0,08 % | AllianceBernstein L.P. | 54 080 | -39 201 | 2023. 12. 31. |
| 0,08 % | TD Asset Management Inc. | 52 322 | -12 600 | 2023. 12. 31. |
| 0,08 % | Legal & General Investment Management Ltd. | 52 012 | 11 168 | 2023. 12. 31. |
| 0,08 % | Wellington Management Japan Pte Ltd | 51 854 | -16 384 | 2023. 06. 30. |
| 0,08 % | California State Teachers Retirement System | 51 474 | 5721 | 2023. 12. 31. |
| 0,08 % | HBM Partners AG | 50 000 | 0 | 2023. 09. 30. |
| 0,07 % | Goldman Sachs Asset Management, L.P. | 49 355 | 12 961 | 2023. 12. 31. |
| 0,07 % | Susquehanna International Group, LLP | 48 888 | -8572 | 2023. 12. 31. |
| 0,07 % | International Biotechnology Trust PLC | 48 099 | 0 | 2023. 09. 30. |
| 0,07 % | Schroder Investment Management Ltd. (SIM) | 48 099 | 48 099 | 2023. 12. 31. |
| 0,07 % | Credit Suisse Funds AG | 47 998 | 8352 | 2023. 12. 31. |
| 0,07 % | Young (Diane C) | 47 115 | 0 | 2023. 04. 05. |
| 0,07 % | BlackRock Asset Management Ireland Limited | 46 821 | 3562 | 2023. 12. 31. |
| 0,07 % | SG Americas Securities, L.L.C. | 46 083 | -31 928 | 2023. 12. 31. |
| 0,07 % | Monarch Partners Asset Management LLC | 45 479 | 45 479 | 2022. 12. 31. |
| 0,07 % | Qube Research & Technologies Ltd | 44 968 | 40 669 | 2023. 12. 31. |
| 0,07 % | Manulife Investment Management (North America) Limited | 43 427 | -6405 | 2023. 12. 31. |
| 0,06 % | JPMorgan Private Bank (United States) | 41 331 | 36 735 | 2023. 12. 31. |
| 0,06 % | Mellon Investments Corporation | 41 252 | 321 | 2023. 12. 31. |
| 0,06 % | Atom Investors LP | 40 882 | 40 882 | 2023. 12. 31. |
| 0,06 % | State of Wisconsin Investment Board | 40 518 | 8569 | 2023. 12. 31. |
| 0,06 % | Caption Management, LLC | 39 700 | 26 700 | 2023. 12. 31. |
| 0,06 % | Alps Advisors, Inc. | 37 645 | 2797 | 2023. 12. 31. |
| 0,06 % | TwinBeech Capital LP | 37 177 | -25 406 | 2023. 12. 31. |
| 0,06 % | Northern Trust Global Investments | 36 637 | -50 169 | 2023. 12. 31. |
| 0,06 % | T. Rowe Price International Ltd | 36 484 | 2052 | 2023. 12. 31. |
| 0,05 % | Martin (Samuel Bates) | 35 128 | 10 750 | 2024. 01. 02. |
| 0,05 % | PFM Health Sciences, LP | 35 000 | 35 000 | 2023. 12. 31. |
| 0,05 % | JP Morgan Asset Management | 34 139 | -23 937 | 2023. 12. 31. |
| 0,05 % | Kentucky Teachers' Retirement System | 32 697 | 0 | 2023. 12. 31. |
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