| 9,35333 % | RTW Investments L.P. | 4 489 596 | 0 | 2023. 12. 31. |
| 7,68756 % | The Vanguard Group, Inc. | 3 690 027 | -32 360 | 2023. 12. 31. |
| 5,83802 % | BlackRock Institutional Trust Company, N.A. | 2 802 249 | 267 537 | 2023. 12. 31. |
| 4,91683 % | Fairmount Funds Management LLC | 2 360 077 | 0 | 2024. 02. 14. |
| 4,12729 % | BVF Partners L.P. | 1 981 100 | -150 000 | 2023. 12. 31. |
| 2,26893 % | Citadel Advisors LLC | 1 089 085 | -206 539 | 2023. 12. 31. |
| 2,16254 % | Perceptive Advisors LLC | 1 038 019 | 556 370 | 2023. 12. 31. |
| 2,08333 % | Deep Track Capital LP | 1 000 000 | -140 745 | 2023. 12. 31. |
| 2,08333 % | RA Capital Management, LP | 1 000 000 | 0 | 2023. 12. 31. |
| 15,30104 % | Antecip Capital, L.L.C. | 7 344 500 | 0 | 2023. 04. 10. |
| 1,92540 % | State Street Global Advisors (US) | 924 190 | 56 543 | 2023. 12. 31. |
| 1,89576 % | Millennium Management LLC | 909 965 | 406 923 | 2023. 12. 31. |
| 1,74417 % | Point72 Asset Management, L.P. | 837 201 | 305 264 | 2023. 12. 31. |
| 1,71313 % | Geode Capital Management, L.L.C. | 822 304 | 43 809 | 2023. 12. 31. |
| 1,56676 % | Alethea Capital Management, LLC | 752 044 | -6750 | 2023. 12. 31. |
| 1,45611 % | Pictet Asset Management Ltd. | 698 932 | 52 503 | 2023. 12. 31. |
| 1,32369 % | Bellevue Asset Management AG | 635 372 | 3885 | 2023. 12. 31. |
| 1,17361 % | Jefferies LLC | 563 335 | 10 140 | 2023. 12. 31. |
| 1,17117 % | Woodline Partners LP | 562 163 | 110 056 | 2023. 12. 31. |
| 1,12677 % | Fidelity Management & Research Company LLC | 540 849 | -981 224 | 2023. 12. 31. |
| 0,97381 % | PFM Health Sciences, LP | 467 427 | -55 783 | 2023. 12. 31. |
| 0,95708 % | Avidity Partners Management LP | 459 400 | 162 600 | 2023. 12. 31. |
| 0,93234 % | Coleman (Mark H) | 447 525 | 0 | 2023. 09. 15. |
| 0,83333 % | Boxer Capital, L.L.C. | 400 000 | 0 | 2023. 12. 31. |
| 0,81824 % | Hood River Capital Management LLC | 392 753 | 9477 | 2023. 12. 31. |
| 0,76179 % | Morgan Stanley & Co. LLC | 365 660 | 314 379 | 2023. 12. 31. |
| 0,76042 % | Adage Capital Management, L.P. | 365 000 | 40 000 | 2023. 12. 31. |
| 0,72232 % | Eventide Asset Management, LLC | 346 712 | 0 | 2023. 12. 31. |
| 0,71079 % | Fidelity Institutional Asset Management | 341 178 | 4695 | 2023. 12. 31. |
| 0,66667 % | Tang Capital Management, LLC | 320 000 | 0 | 2023. 12. 31. |
| 0,64997 % | Northern Trust Investments, Inc. | 311 985 | 8356 | 2023. 12. 31. |
| 0,61604 % | Charles Schwab Investment Management, Inc. | 295 701 | 5830 | 2023. 12. 31. |
| 0,61548 % | First Turn Management, LLC | 295 428 | 295 428 | 2023. 12. 31. |
| 0,55384 % | Driehaus Capital Management, LLC | 265 842 | 16 953 | 2023. 12. 31. |
| 0,49962 % | Wellington Management Company, LLP | 239 819 | 2265 | 2023. 12. 31. |
| 0,48599 % | Nuveen LLC | 233 273 | 16 950 | 2023. 12. 31. |
| 0,44164 % | Morgan Stanley Smith Barney LLC | 211 986 | 7285 | 2023. 12. 31. |
| 0,40651 % | Norges Bank Investment Management (NBIM) | 195 123 | -61 274 | 2023. 12. 31. |
| 0,39971 % | Barclays Bank PLC | 191 862 | 175 164 | 2023. 12. 31. |
| 0,34931 % | Jeffs (Roger A) | 167 668 | 0 | 2024. 03. 15. |
| 0,34375 % | Ghost Tree Capital, LLC | 165 000 | 55 000 | 2023. 12. 31. |
| 0,33445 % | BofA Global Research (US) | 160 534 | 136 659 | 2023. 12. 31. |
| 0,32554 % | Goldman Sachs & Company, Inc. | 156 261 | 48 311 | 2023. 12. 31. |
| 0,32364 % | Checkpoint Capital L.P. | 155 346 | 155 346 | 2023. 12. 31. |
| 0,31950 % | BlackRock Asset Management Ireland Limited | 153 360 | -6457 | 2023. 12. 31. |
| 0,30379 % | BlackRock Advisors (UK) Limited | 145 817 | -1580 | 2024. 03. 31. |
| 0,30057 % | BlackRock Financial Management, Inc. | 144 273 | 38 954 | 2023. 12. 31. |
| 0,29880 % | U.S. Bancorp Asset Management, Inc. | 143 424 | 4653 | 2023. 12. 31. |
| 0,29132 % | Loomis, Sayles & Company, L.P. | 139 832 | 139 832 | 2024. 02. 29. |
| 0,28820 % | Iridian Asset Management LLC | 138 337 | -6696 | 2023. 12. 31. |
| 0,28750 % | Altium Capital Management LP | 138 000 | 46 000 | 2023. 12. 31. |
| 0,27237 % | Tri Locum Partners LP | 130 738 | -11 772 | 2023. 12. 31. |
| 0,26810 % | JP Morgan Asset Management | 128 688 | -24 497 | 2023. 12. 31. |
| 0,25539 % | T. Rowe Price Associates, Inc. | 122 586 | 115 719 | 2023. 12. 31. |
| 0,24790 % | Medical Strategy GmbH | 118 990 | -4300 | 2023. 12. 31. |
| 0,22259 % | Schonfeld Strategic Advisors LLC | 106 842 | 39 144 | 2023. 12. 31. |
| 0,21963 % | BNY Mellon Asset Management | 105 421 | 230 | 2023. 12. 31. |
| 0,21835 % | WCM Investment Management | 104 808 | 8845 | 2023. 12. 31. |
| 0,21193 % | Citi Investment Research (US) | 101 727 | -935 | 2023. 12. 31. |
| 0,21013 % | Ally Bridge Group NY LLC | 100 862 | -9738 | 2023. 12. 31. |
| 0,19768 % | Frontier Capital Management Company, LLC | 94 888 | -65 788 | 2023. 12. 31. |
| 0,19456 % | BioImpact Capital LLC | 93 387 | -199 | 2023. 12. 31. |
| 0,19340 % | Jane Street Capital, L.L.C. | 92 831 | -32 750 | 2023. 12. 31. |
| 0,18427 % | BlackRock Investment Management, LLC | 88 450 | 1660 | 2023. 12. 31. |
| 0,18302 % | Artia Global Partners LP | 87 848 | 0 | 2023. 12. 31. |
| 0,17726 % | Candriam Belgium S.A. | 85 084 | 35 000 | 2023. 12. 31. |
| 0,17670 % | Peregrine Capital Management, LLC | 84 817 | -6274 | 2023. 12. 31. |
| 0,17518 % | Lindbrook Capital, LLC | 84 086 | -233 | 2023. 12. 31. |
| 0,17259 % | Cannell & Co. | 82 845 | -21 345 | 2023. 12. 31. |
| 0,17218 % | Nicholas Investment Partners, L.P. | 82 645 | -312 335 | 2023. 12. 31. |
| 0,16758 % | HSBC Global Asset Management (UK) Limited | 80 437 | -68 375 | 2023. 12. 31. |
| 0,16479 % | Rhenman & Partners Asset Management AB | 79 100 | 39 000 | 2023. 12. 31. |
| 0,16436 % | Jess S. Morgan & Company, Inc | 78 895 | -25 994 | 2022. 09. 30. |
| 0,15643 % | Candriam Luxembourg S.A. | 75 084 | 0 | 2024. 02. 29. |
| 0,15208 % | ACT Capital Management, L.L.C. | 73 000 | 73 000 | 2022. 09. 30. |
| 0,15007 % | Privium Fund Management BV | 72 032 | 0 | 2023. 12. 31. |
| 0,14564 % | First Trust Advisors L.P. | 69 909 | 794 | 2023. 12. 31. |
| 0,14476 % | Hennion & Walsh Asset Management, Inc. | 69 483 | 8867 | 2024. 03. 31. |
| 0,13930 % | Moody Aldrich Partners, LLC | 66 866 | -6767 | 2023. 12. 31. |
| 0,13896 % | Atika Capital Management LLC | 66 700 | -4300 | 2023. 12. 31. |
| 0,12971 % | HighVista Strategies LLC | 62 263 | 5299 | 2023. 12. 31. |
| 0,12604 % | Schweizerische Nationalbank | 60 500 | -11 200 | 2023. 12. 31. |
| 0,12583 % | ClearBridge Investments, LLC | 60 400 | 60 400 | 2024. 03. 31. |
| 0,12146 % | International Biotechnology Trust PLC | 58 300 | 0 | 2023. 09. 30. |
| 0,12146 % | Schroder Investment Management Ltd. (SIM) | 58 300 | 58 300 | 2023. 12. 31. |
| 0,11709 % | Lighthouse Partners | 56 202 | 56 202 | 2023. 12. 31. |
| 0,11181 % | DWS Investment Management Americas, Inc. | 53 670 | 10 661 | 2023. 12. 31. |
| 0,10565 % | WMS Partners LLC | 50 711 | -30 000 | 2023. 12. 31. |
| 0,10549 % | Rhumbline Advisers Ltd. Partnership | 50 637 | -208 | 2023. 12. 31. |
| 0,10417 % | Affinity Asset Advisors LLC | 50 000 | 50 000 | 2023. 12. 31. |
| 0,10353 % | Baldwin Brothers, LLC. | 49 695 | 700 | 2024. 03. 31. |
| 0,10324 % | Goldman Sachs Asset Management, L.P. | 49 554 | -1745 | 2023. 12. 31. |
| 0,10203 % | Mellon Investments Corporation | 48 976 | -1886 | 2023. 12. 31. |
| 0,09476 % | Putnam Investment Management, L.L.C. | 45 486 | -74 780 | 2023. 12. 31. |
| 0,09319 % | Invesco Advisers, Inc. | 44 733 | -16 436 | 2023. 12. 31. |
| 0,09232 % | Neuberger Berman, LLC | 44 315 | 40 050 | 2023. 12. 31. |
| 0,08965 % | Credit Suisse Funds AG | 43 033 | 182 | 2023. 12. 31. |
| 0,08808 % | Pizzie (Nick) | 42 277 | 0 | 2023. 04. 10. |
| 0,08602 % | AllianceBernstein L.P. | 41 290 | 0 | 2023. 12. 31. |
| 0,08359 % | UBS Financial Services, Inc. | 40 125 | 7341 | 2023. 12. 31. |
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