| 9,74 % | Hyllengren (Eric J) | 477 171 | -6679 | 2024. 03. 04. |
| 9,48 % | Fidelity Management & Research Company LLC | 464 715 | 229 176 | 2023. 12. 31. |
| 75,37 % | UBS Financial Services, Inc. | 3 693 225 | 3 634 733 | 2023. 12. 31. |
| 6,91 % | Heiden (William K) | 338 500 | 150 000 | 2024. 03. 31. |
| 6,37 % | BNY Mellon Asset Management | 312 333 | 60 449 | 2023. 12. 31. |
| 6,05 % | BNP Paribas Securities Corp. North America | 296 240 | 276 527 | 2023. 12. 31. |
| 6,01 % | BlackRock Investment Management, LLC | 294 328 | -26 563 | 2023. 12. 31. |
| 59,84 % | AQR Capital Management, LLC | 2 932 310 | 2 087 858 | 2023. 12. 31. |
| 59,61 % | Millennium Management LLC | 2 920 980 | 2 593 916 | 2023. 12. 31. |
| 56,82 % | State Street Global Advisors (US) | 2 784 200 | 261 514 | 2023. 12. 31. |
| 5,97 % | Marshall Wace LLP | 292 500 | 292 500 | 2023. 12. 31. |
| 5,96 % | BlackRock Financial Management, Inc. | 292 208 | -384 060 | 2023. 12. 31. |
| 5,63 % | Banard (Charlene A) | 276 010 | -19 040 | 2023. 05. 16. |
| 43,88 % | Geode Capital Management, L.L.C. | 2 150 150 | 73 575 | 2023. 12. 31. |
| 4,87 % | Fust (Matthew K.) | 238 500 | 150 000 | 2024. 03. 31. |
| 4,45 % | Roncarolo (Maria Grazia) | 218 000 | 150 000 | 2024. 03. 31. |
| 4,39 % | T. Rowe Price Associates, Inc. | 215 255 | 55 200 | 2024. 02. 29. |
| 4,26 % | Harbor Capital Advisors, Inc. | 208 827 | 164 206 | 2023. 12. 31. |
| 4,22 % | Mallik (Ameet) | 207 000 | 150 000 | 2024. 03. 31. |
| 4,03 % | Two Sigma Investments, LP | 197 427 | 197 427 | 2023. 12. 31. |
| 38,30 % | Kleiner, Perkins, Caufield & Byers | 1 876 650 | 1 876 650 | 2023. 02. 15. |
| 36,12 % | Morgan Stanley & Co. LLC | 1 769 876 | -252 119 | 2023. 12. 31. |
| 36,03 % | Acadian Asset Management LLC | 1 765 554 | 1 231 161 | 2023. 12. 31. |
| 33,12 % | Touchon (Pascal) | 1 623 023 | -24 844 | 2024. 03. 04. |
| 3,86 % | BofA Global Research (US) | 189 128 | 91 025 | 2023. 12. 31. |
| 3,66 % | Dupont (Jakob) | 179 348 | 136 254 | 2023. 03. 02. |
| 3,50 % | Joshi (Manher) | 171 284 | -12 287 | 2023. 11. 16. |
| 3,41 % | AllianceBernstein L.P. | 167 200 | -9500 | 2023. 12. 31. |
| 3,24 % | JPMorgan Private Bank (United States) | 158 602 | -72 745 | 2023. 12. 31. |
| 25,64 % | JP Morgan Asset Management | 1 256 484 | -3 684 603 | 2023. 12. 31. |
| 21,10 % | D. E. Shaw & Co., L.P. | 1 033 992 | -2 876 424 | 2023. 12. 31. |
| 205,45 % | EcoR1 Capital, LLC | 10 067 043 | 0 | 2023. 12. 31. |
| 20,41 % | Antipodean Advisors LLC | 1 000 000 | 0 | 2023. 09. 30. |
| 20,41 % | Staley Capital Advisers, Inc. | 1 000 000 | 0 | 2023. 12. 31. |
| 2,97 % | Rhumbline Advisers Ltd. Partnership | 145 413 | -60 | 2023. 12. 31. |
| 2,87 % | Group One Trading, L.P. | 140 556 | 76 465 | 2023. 12. 31. |
| 2,71 % | Barclays Bank PLC | 132 847 | 116 114 | 2023. 12. 31. |
| 2,70 % | Jane Street Capital, L.L.C. | 132 177 | 108 773 | 2023. 12. 31. |
| 2,44 % | BlackRock (Netherlands) B.V. | 119 737 | 118 284 | 2023. 12. 31. |
| 2,43 % | Hennion & Walsh Asset Management, Inc. | 119 051 | 7923 | 2024. 03. 31. |
| 2,39 % | HRT Financial LP | 117 267 | 117 267 | 2023. 12. 31. |
| 19,21 % | Nguyen (Anhco T) | 941 397 | -10 746 | 2024. 03. 04. |
| 185,85 % | Redmile Group, LLC | 9 106 446 | 2 825 633 | 2023. 12. 31. |
| 17,88 % | Medical Strategy GmbH | 876 186 | -221 061 | 2023. 12. 31. |
| 16,01 % | GSA Capital Partners LLP | 784 367 | 784 367 | 2023. 12. 31. |
| 15,94 % | Jacobs Levy Equity Management, Inc. | 780 986 | 214 090 | 2023. 12. 31. |
| 15,74 % | Northern Trust Investments, Inc. | 771 470 | 52 809 | 2023. 12. 31. |
| 15,71 % | JPMorgan Asset Management U.K. Limited | 769 632 | -2 703 318 | 2023. 12. 31. |
| 15,21 % | Charles Schwab Investment Management, Inc. | 745 145 | -48 412 | 2023. 12. 31. |
| 136,45 % | The Vanguard Group, Inc. | 6 686 043 | 80 110 | 2023. 12. 31. |
| 133,33 % | Citadel Advisors LLC | 6 533 119 | 6 270 068 | 2024. 03. 08. |
| 130,11 % | BlackRock Institutional Trust Company, N.A. | 6 375 547 | -276 910 | 2023. 12. 31. |
| 12,90 % | Murugan (Amar) | 632 107 | -10 044 | 2024. 03. 04. |
| 12,71 % | Renaissance Technologies LLC | 622 911 | -206 200 | 2023. 12. 31. |
| 12,02 % | Gallagher (Carol Giltner) | 588 918 | 150 000 | 2024. 03. 31. |
| 11,24 % | Henrich (Jill) | 550 545 | -3879 | 2024. 03. 04. |
| 11,08 % | Dobmeier (Eric L) | 542 825 | 446 825 | 2023. 11. 10. |
| 10,94 % | Goldman Sachs & Company, Inc. | 536 269 | -3 533 636 | 2023. 12. 31. |
| 10,71 % | Pacific Heights Asset Management, LLC | 525 000 | 0 | 2023. 12. 31. |
| 1,95 % | Private Advisor Group LLC | 95 661 | 198 | 2023. 12. 31. |
| 1,95 % | Seidenberg (Beth C) | 95 583 | 57 000 | 2023. 05. 31. |
| 1,78 % | Susquehanna International Group, LLP | 87 415 | -126 428 | 2023. 12. 31. |
| 1,75 % | Koppikar (Utpal) | 85 856 | -6871 | 2023. 03. 02. |
| 1,70 % | CAPTRUST Financial Advisors | 83 074 | 65 059 | 2023. 12. 31. |
| 1,68 % | Mellon Investments Corporation | 82 425 | 0 | 2023. 12. 31. |
| 1,63 % | Bank Vontobel AG | 80 000 | 80 000 | 2023. 12. 31. |
| 1,51 % | Northern Trust Global Investments | 73 957 | -6304 | 2023. 12. 31. |
| 1,12 % | T. Rowe Price International Ltd | 54 991 | 0 | 2023. 12. 31. |
| 1,02 % | SG Americas Securities, L.L.C. | 49 924 | 11 181 | 2023. 12. 31. |
| 0,98 % | SunAmerica Asset Management, LLC | 48 141 | -194 | 2023. 12. 31. |
| 0,94 % | Goldman Sachs Asset Management, L.P. | 45 920 | -8584 | 2023. 12. 31. |
| 0,92 % | State of Wisconsin Investment Board | 45 201 | 0 | 2023. 12. 31. |
| 0,83 % | Voya Investment Management LLC | 40 841 | -78 417 | 2023. 12. 31. |
| 0,81 % | New York State Common Retirement Fund | 39 541 | -143 | 2023. 12. 31. |
| 0,78 % | DWS Investments UK Limited | 38 055 | 0 | 2023. 12. 31. |
| 0,74 % | Cubist Systematic Strategies, LLC | 36 456 | -7984 | 2023. 12. 31. |
| 0,74 % | Vaughan Nelson Investment Management, L.P. | 36 177 | 0 | 2023. 12. 31. |
| 0,73 % | XTX Markets LLC | 35 560 | 1321 | 2023. 12. 31. |
| 0,73 % | Point72 Asset Management, L.P. | 35 536 | -519 464 | 2023. 12. 31. |
| 0,68 % | Principal Global Investors (Equity) | 33 306 | -2161 | 2023. 12. 31. |
| 0,68 % | Invesco Advisers, Inc. | 33 187 | 7249 | 2023. 12. 31. |
| 0,61 % | Engineers Gate Manager, L.P. | 30 091 | 15 971 | 2023. 12. 31. |
| 0,61 % | Wexford Capital LP | 29 940 | 29 940 | 2023. 12. 31. |
| 0,60 % | Wells Fargo Bank, N.A. | 29 365 | 5872 | 2023. 12. 31. |
| 0,56 % | Envestnet Asset Management, Inc. | 27 612 | -16 137 | 2023. 12. 31. |
| 0,55 % | Renta 4 Gestora, S.G.I.I.C., S.A. | 27 017 | -571 | 2023. 12. 31. |
| 0,55 % | PGIM Quantitative Solutions LLC | 26 838 | 26 838 | 2023. 12. 31. |
| 0,51 % | Manulife Investment Management (North America) Limited | 25 174 | -17 912 | 2023. 12. 31. |
| 0,51 % | Florida State Board of Administration | 25 159 | 25 159 | 2023. 12. 31. |
| 0,51 % | Wellington Management Company, LLP | 24 955 | -125 | 2024. 02. 29. |
| 0,47 % | Franklin Advisers, Inc. | 23 026 | 0 | 2023. 12. 31. |
| 0,43 % | SVB Wealth LLC | 21 078 | 10 014 | 2023. 12. 31. |
| 0,42 % | RBC Wealth Management, International | 20 661 | 4842 | 2023. 12. 31. |
| 0,41 % | Tower Research Capital LLC | 20 300 | 12 149 | 2023. 12. 31. |
| 0,41 % | Carson Wealth Management Group | 19 946 | 6184 | 2024. 03. 31. |
| 0,40 % | Raymond James & Associates, Inc. | 19 591 | -170 051 | 2023. 12. 31. |
| 0,38 % | Virtu Americas LLC | 18 482 | 8155 | 2023. 12. 31. |
| 0,36 % | Letko, Brosseau & Associates Inc. | 17 500 | 0 | 2023. 12. 31. |
| 0,33 % | Commonwealth Financial Network | 16 293 | 16 293 | 2023. 12. 31. |
| 0,33 % | ProShare Advisors LLC | 16 030 | -3161 | 2023. 12. 31. |
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