| 2,53991 % | Matrix Capital Management Company, LP | 38 974 185 | 0 | 2023. 12. 31. |
| 1,78590 % | EcoR1 Capital, LLC | 27 404 070 | 8 500 000 | 2024. 03. 08. |
| 1,11307 % | New Enterprise Associates (NEA) | 17 079 778 | 0 | 2024. 04. 01. |
| 1,03698 % | Baillie Gifford & Co. | 15 912 140 | -1 235 269 | 2023. 12. 31. |
| 0,78769 % | Long Focus Capital Management LLC | 12 086 915 | 774 568 | 2023. 12. 31. |
| 0,71486 % | Baker Bros. Advisors LP | 10 969 282 | 0 | 2023. 12. 31. |
| 0,67927 % | PFM Health Sciences, LP | 10 423 135 | 0 | 2023. 12. 31. |
| 0,36204 % | MPM Capital Inc. | 5 555 461 | -731 640 | 2023. 12. 31. |
| 0,33210 % | BioImpact Capital LLC | 5 095 912 | 0 | 2023. 12. 31. |
| 0,30616 % | BofA Global Research (US) | 4 697 954 | 829 | 2023. 12. 31. |
| 0,28591 % | Tang Capital Management, LLC | 4 387 238 | -779 716 | 2023. 12. 31. |
| 0,22154 % | Citadel Advisors LLC | 3 399 514 | -150 045 | 2023. 12. 31. |
| 0,15807 % | Rock Springs Capital Management LP | 2 425 468 | -362 377 | 2023. 12. 31. |
| 0,11447 % | Morgan Stanley & Co. LLC | 1 756 546 | -95 566 | 2023. 12. 31. |
| 0,11295 % | Fidelity Management & Research Company LLC | 1 733 141 | 0 | 2023. 12. 31. |
| 0,08976 % | Syncona Portfolio Ltd | 1 377 294 | 0 | 2023. 12. 31. |
| 0,08930 % | Renaissance Technologies LLC | 1 370 239 | 342 379 | 2023. 12. 31. |
| 0,06135 % | Baillie Gifford Overseas Ltd. | 941 398 | 0 | 2024. 02. 29. |
| 0,06049 % | JPMorgan Asset Management U.K. Limited | 928 224 | 0 | 2023. 12. 31. |
| 0,04664 % | Redmile Group, LLC | 715 607 | 0 | 2023. 12. 31. |
| 0,03316 % | GSA Capital Partners LLP | 508 808 | 508 808 | 2023. 12. 31. |
| 0,03127 % | Acuitas Investments LLC | 479 789 | 25 | 2023. 12. 31. |
| 0,02874 % | Millennium Management LLC | 441 032 | 140 971 | 2023. 12. 31. |
| 0,02821 % | Rathbones Investment Management Limited | 432 818 | 0 | 2023. 12. 31. |
| 0,02493 % | Bellecapital Partners AG | 382 553 | 0 | 2023. 09. 30. |
| 0,02288 % | Dafna Capital Management, LLC | 351 064 | 0 | 2023. 12. 31. |
| 0,01990 % | State Street Global Advisors (US) | 305 336 | 6235 | 2023. 12. 31. |
| 0,01751 % | Key Client Fiduciary Advisors, LLC | 268 655 | -67 965 | 2024. 03. 31. |
| 0,01302 % | Morgan Stanley Smith Barney LLC | 199 827 | 5077 | 2023. 12. 31. |
| 0,01057 % | Menzel (Garry E) | 162 229 | -47 702 | 2023. 07. 10. |
| 0,00963 % | Harbor Capital Advisors, Inc. | 147 732 | 13 317 | 2023. 12. 31. |
| 0,00768 % | Geode Capital Management, L.L.C. | 117 909 | 0 | 2023. 12. 31. |
| 0,00642 % | Marquette Wealth Management | 98 589 | -760 | 2023. 12. 31. |
| 0,00636 % | Jane Street Capital, L.L.C. | 97 580 | 97 580 | 2023. 12. 31. |
| 0,00594 % | BlackRock Financial Management, Inc. | 91 131 | -22 855 | 2023. 12. 31. |
| 0,00587 % | ACT Capital Management, L.L.C. | 90 000 | 0 | 2022. 09. 30. |
| 0,00541 % | AllianceBernstein L.P. | 82 961 | 41 988 | 2024. 02. 29. |
| 0,00537 % | Bertrand William C Jr | 82 353 | -32 818 | 2024. 01. 17. |
| 0,00533 % | Rawcliffe Adrian | 81 781 | -68 586 | 2024. 01. 17. |
| 0,00528 % | BlackRock Institutional Trust Company, N.A. | 81 027 | -975 206 | 2023. 12. 31. |
| 0,00456 % | Renta 4 Gestora, S.G.I.I.C., S.A. | 70 046 | 32 829 | 2023. 12. 31. |
| 0,00390 % | HRT Financial LP | 59 906 | 59 906 | 2023. 12. 31. |
| 0,00390 % | Two Sigma Investments, LP | 59 837 | -64 674 | 2023. 12. 31. |
| 0,00370 % | Susquehanna International Group, LLP | 56 846 | -110 042 | 2023. 12. 31. |
| 0,00366 % | Wells Fargo Advisors | 56 177 | 1432 | 2023. 12. 31. |
| 0,00354 % | Piccina (Cintia) | 54 359 | 54 359 | 2023. 04. 03. |
| 0,00327 % | Oppenheimer Asset Management Inc. | 50 103 | -18 068 | 2023. 12. 31. |
| 0,00326 % | Barclays Bank PLC | 50 061 | 0 | 2023. 12. 31. |
| 0,00316 % | Lunger (John) | 48 517 | -32 024 | 2024. 01. 17. |
| 0,00241 % | XTX Markets LLC | 36 977 | 36 977 | 2023. 12. 31. |
| 0,00239 % | Northern Trust Investments, Inc. | 36 602 | 0 | 2023. 12. 31. |
| 0,00226 % | Cubist Systematic Strategies, LLC | 34 607 | 34 607 | 2023. 12. 31. |
| 0,00210 % | Wealth Enhancement Advisory Services, LLC | 32 239 | 0 | 2024. 03. 31. |
| 0,00203 % | Main Street Financial Solutions, LLC | 31 190 | 0 | 2023. 12. 31. |
| 0,00200 % | CSS, LLC | 30 702 | -60 000 | 2023. 12. 31. |
| 0,00199 % | DLK Investment Management, LLC | 30 512 | 0 | 2024. 03. 31. |
| 0,00196 % | Simon Quick Advisors, LLC | 30 000 | 0 | 2024. 03. 31. |
| 0,00196 % | Janney Montgomery Scott LLC | 30 000 | 0 | 2023. 12. 31. |
| 0,00187 % | Prosperity Wealth Management, Inc. | 28 620 | -2000 | 2023. 12. 31. |
| 0,00185 % | Virtu Americas LLC | 28 406 | 28 406 | 2023. 12. 31. |
| 0,00179 % | X-Square Capital, LLC | 27 425 | 654 | 2023. 12. 31. |
| 0,00178 % | Stifel, Nicolaus & Company, Incorporated | 27 259 | -2574 | 2023. 12. 31. |
| 0,00173 % | HSBC Global Asset Management (UK) Limited | 26 504 | 440 | 2023. 12. 31. |
| 0,00170 % | JTC Employer Solutions Trusteee Ltd | 26 156 | 26 156 | 2024. 03. 31. |
| 0,00161 % | UBS Financial Services, Inc. | 24 693 | 16 935 | 2023. 12. 31. |
| 0,00156 % | Alleva (Lawrence M) | 23 894 | 0 | 2023. 04. 03. |
| 0,00150 % | Newman, Dignan & Sheerar, Inc. | 23 031 | 23 031 | 2023. 12. 31. |
| 0,00150 % | Hunter Associates Investment Management LLC | 23 000 | -1000 | 2023. 12. 31. |
| 0,00136 % | Northern Trust Global Investments | 20 821 | 0 | 2023. 12. 31. |
| 0,00112 % | CAPTRUST Financial Advisors | 17 254 | -4670 | 2023. 12. 31. |
| 0,00109 % | Commonwealth Financial Network | 16 758 | -15 117 | 2023. 12. 31. |
| 0,00106 % | LoCorr Fund Management, LLC | 16 257 | 3466 | 2022. 12. 31. |
| 0,00104 % | Wood (Gavin) | 16 000 | 0 | 2023. 04. 03. |
| 0,00104 % | Goldman Sachs & Company, Inc. | 15 979 | -41 632 | 2023. 12. 31. |
| 0,00102 % | COLUMBIA ADVISORY PARTNERS LLC | 15 585 | 15 585 | 2024. 03. 31. |
| 0,00094 % | Ballentine Partners, LLC | 14 489 | 14 489 | 2024. 03. 31. |
| 0,00091 % | Norry (Elliot) | 13 917 | -32 371 | 2024. 01. 17. |
| 0,00085 % | Procyon Advisors, LLC | 13 000 | 13 000 | 2024. 03. 31. |
| 0,00081 % | Brewer (Joanna Elizabeth) | 12 442 | 12 442 | 2023. 04. 03. |
| 0,00069 % | Tower Research Capital LLC | 10 664 | 2627 | 2023. 12. 31. |
| 0,00067 % | Raymond James & Associates, Inc. | 10 218 | -151 | 2023. 12. 31. |
| 0,00067 % | Scientech Research LLC | 10 205 | 10 205 | 2023. 12. 31. |
| 0,00065 % | Sigal Family Investments, LLC | 10 000 | 0 | 2023. 04. 03. |
| 0,00057 % | Sigal (Charles Elliott) | 8823 | 0 | 2023. 04. 03. |
| 0,00048 % | BlackRock Investment Management (UK) Ltd. | 7423 | 0 | 2023. 12. 31. |
| 0,00043 % | Goldman Sachs Asset Management International | 6547 | 0 | 2024. 01. 31. |
| 0,00042 % | State Street Global Advisors (UK) Ltd. | 6400 | 6400 | 2024. 02. 29. |
| 0,00041 % | Osaic Holdings, Inc. | 6258 | -4200 | 2023. 12. 31. |
| 0,00039 % | Global Retirement Partners, LLC | 6000 | 0 | 2023. 12. 31. |
| 0,00039 % | Rhumbline Advisers Ltd. Partnership | 5912 | 330 | 2023. 12. 31. |
| 0,00038 % | Putnam Investment Management, L.L.C. | 5801 | -19 595 | 2023. 02. 28. |
| 0,00030 % | Lindbrook Capital, LLC | 4610 | 0 | 2023. 12. 31. |
| 0,00027 % | Lazard Asset Management, L.L.C. | 4160 | -193 | 2023. 12. 31. |
| 0,00020 % | Wetzel Investment Advisors Inc | 3000 | 3000 | 2023. 12. 31. |
| 0,00016 % | GF Fund Management Co., Ltd. | 2495 | -542 | 2023. 06. 30. |
| 0,00014 % | BNP Paribas Securities Corp. North America | 2162 | -1891 | 2023. 12. 31. |
| 0,00014 % | Qube Research & Technologies Ltd | 2087 | -19 474 | 2023. 12. 31. |
| 0,00007 % | Sandy Spring Bank | 1050 | 0 | 2023. 12. 31. |
| 0,00004 % | RBC Capital Markets Wealth Management | 592 | 567 | 2023. 12. 31. |
| 0,00003 % | Carmichael Hill & Associates Inc | 525 | 0 | 2023. 12. 31. |
