| 8,09 % | The Vanguard Group, Inc. | 13 374 376 | -220 731 | 2023. 12. 31. |
| 6,81 % | RTW Investments L.P. | 11 253 551 | -322 986 | 2023. 12. 31. |
| 5,77 % | BlackRock Institutional Trust Company, N.A. | 9 525 170 | 914 758 | 2023. 12. 31. |
| 3,91 % | State Street Global Advisors (US) | 6 465 026 | 1 251 295 | 2023. 12. 31. |
| 3,63 % | EcoR1 Capital, LLC | 5 991 479 | 0 | 2023. 12. 31. |
| 3,19 % | Fidelity Management & Research Company LLC | 5 265 358 | -36 622 | 2023. 12. 31. |
| 3,02 % | T. Rowe Price Associates, Inc. | 4 996 868 | -47 010 | 2023. 12. 31. |
| 25,94 % | Baker Bros. Advisors LP | 42 864 612 | 0 | 2023. 12. 31. |
| 2,27 % | D. E. Shaw & Co., L.P. | 3 754 598 | -1 034 400 | 2023. 12. 31. |
| 1,92 % | Fred Alger Management, LLC | 3 176 775 | 67 892 | 2023. 12. 31. |
| 1,79 % | Emerald Advisers LLC | 2 950 121 | -34 919 | 2023. 12. 31. |
| 1,63 % | Geode Capital Management, L.L.C. | 2 692 152 | 113 770 | 2023. 12. 31. |
| 1,46 % | Palo Alto Investors LP | 2 409 556 | 3763 | 2023. 12. 31. |
| 1,08 % | First Trust Advisors L.P. | 1 777 307 | 148 526 | 2023. 12. 31. |
| 1,07 % | Millennium Management LLC | 1 764 678 | -648 786 | 2023. 12. 31. |
| 0,88 % | Pictet Asset Management Ltd. | 1 461 232 | 109 635 | 2023. 12. 31. |
| 0,87 % | Norges Bank Investment Management (NBIM) | 1 443 218 | -510 938 | 2023. 12. 31. |
| 0,80 % | Jupiter Asset Management Ltd. | 1 322 364 | 46 148 | 2023. 12. 31. |
| 0,78 % | Voloridge Investment Management, LLC | 1 282 177 | 237 676 | 2023. 12. 31. |
| 0,68 % | Charles Schwab Investment Management, Inc. | 1 127 907 | 54 814 | 2023. 12. 31. |
| 0,65 % | Northern Trust Investments, Inc. | 1 073 696 | 32 243 | 2023. 12. 31. |
| 0,52 % | Weatherbie Capital, LLC | 852 248 | 77 793 | 2024. 02. 29. |
| 0,51 % | Manulife Investment Management (North America) Limited | 846 028 | -204 366 | 2023. 12. 31. |
| 0,50 % | Frontier Capital Management Company, LLC | 823 586 | 65 973 | 2023. 12. 31. |
| 0,49 % | Eventide Asset Management, LLC | 809 391 | 809 391 | 2023. 12. 31. |
| 0,48 % | BlackRock Financial Management, Inc. | 787 983 | 315 283 | 2023. 12. 31. |
| 0,47 % | Finepoint Capital LP | 769 653 | 213 100 | 2023. 12. 31. |
| 0,44 % | Frazier Healthcare Partners | 730 917 | 100 020 | 2023. 12. 31. |
| 0,43 % | DWS Investments UK Limited | 702 755 | 641 613 | 2023. 12. 31. |
| 0,42 % | Rice Hall James & Associates, LLC | 692 852 | -3213 | 2023. 12. 31. |
| 0,40 % | Morgan Stanley & Co. LLC | 663 399 | -624 841 | 2023. 12. 31. |
| 0,39 % | Pictet Asset Management (Japan) Ltd. | 651 959 | 220 060 | 2023. 10. 31. |
| 0,39 % | PanAgora Asset Management Inc. | 644 920 | 1922 | 2023. 12. 31. |
| 0,39 % | Fuller & Thaler Asset Management Inc. | 641 185 | 382 385 | 2023. 12. 31. |
| 0,38 % | Connor, Clark & Lunn Investment Management Ltd. | 627 384 | -6085 | 2023. 12. 31. |
| 0,35 % | Nordea Funds Oy | 586 002 | -12 401 | 2023. 12. 31. |
| 0,35 % | Alyeska Investment Group, L.P. | 585 036 | 185 036 | 2023. 12. 31. |
| 0,34 % | Rockefeller Capital Management | 556 337 | 51 164 | 2023. 12. 31. |
| 0,32 % | Goldman Sachs & Company, Inc. | 533 478 | 150 207 | 2023. 12. 31. |
| 0,30 % | BlackRock Advisors (UK) Limited | 487 615 | -3688 | 2024. 03. 31. |
| 0,29 % | BlackRock Asset Management Ireland Limited | 479 114 | -14 209 | 2023. 12. 31. |
| 0,29 % | Woodline Partners LP | 474 159 | 474 159 | 2023. 12. 31. |
| 0,29 % | HOOPP Investment Management | 471 000 | 234 000 | 2023. 12. 31. |
| 0,27 % | Jane Street Capital, L.L.C. | 446 317 | 128 354 | 2023. 12. 31. |
| 0,26 % | Loomis, Sayles & Company, L.P. | 434 114 | 434 114 | 2024. 02. 29. |
| 0,26 % | Rafferty Asset Management LLC | 427 930 | 91 317 | 2023. 12. 31. |
| 0,25 % | Two Sigma Investments, LP | 418 328 | 329 528 | 2023. 12. 31. |
| 0,25 % | Nuveen LLC | 412 426 | -38 876 | 2023. 12. 31. |
| 0,25 % | Columbia Threadneedle Investments (UK) | 408 583 | 26 757 | 2023. 12. 31. |
| 0,25 % | APG Asset Management N.V. | 405 760 | 140 085 | 2023. 09. 30. |
| 0,24 % | Point72 Asset Management, L.P. | 392 827 | 342 184 | 2023. 12. 31. |
| 0,23 % | Cubist Systematic Strategies, LLC | 385 245 | 385 245 | 2023. 12. 31. |
| 0,23 % | Susquehanna International Group, LLP | 375 263 | 52 883 | 2023. 12. 31. |
| 0,22 % | Invesco Capital Management LLC | 365 601 | 97 152 | 2023. 12. 31. |
| 0,21 % | PGIM Quantitative Solutions LLC | 350 416 | 96 800 | 2023. 12. 31. |
| 0,21 % | Barclays Bank PLC | 346 803 | 153 319 | 2023. 12. 31. |
| 0,21 % | BlackRock Investment Management, LLC | 340 328 | 38 498 | 2023. 12. 31. |
| 0,20 % | M&G Investment Management Ltd. | 333 824 | 239 632 | 2023. 12. 31. |
| 0,20 % | Cutter Capital Management, LP | 330 973 | 330 973 | 2023. 12. 31. |
| 0,20 % | BNY Mellon Asset Management | 328 375 | 1091 | 2023. 12. 31. |
| 0,19 % | JP Morgan Asset Management | 321 969 | -83 228 | 2023. 12. 31. |
| 0,19 % | DWS Investment S.A. | 316 830 | 316 830 | 2023. 12. 31. |
| 0,19 % | HRT Financial LP | 310 562 | 281 165 | 2023. 12. 31. |
| 0,19 % | Managed Account Advisors LLC | 309 485 | -37 656 | 2023. 12. 31. |
| 0,19 % | UBS Financial Services, Inc. | 307 359 | 162 663 | 2023. 12. 31. |
| 0,18 % | Balyasny Asset Management LP | 300 875 | 284 557 | 2023. 12. 31. |
| 0,17 % | Old Mutual Investment Group (South Africa) (Pty) Limited | 289 011 | 289 011 | 2023. 06. 30. |
| 0,17 % | Voya Investment Management LLC | 284 344 | 28 637 | 2023. 12. 31. |
| 0,17 % | Qube Research & Technologies Ltd | 280 259 | 67 340 | 2023. 12. 31. |
| 0,17 % | Squarepoint Capital LLP | 277 052 | 118 040 | 2023. 12. 31. |
| 0,16 % | Goldman Sachs Asset Management, L.P. | 270 692 | -64 662 | 2023. 12. 31. |
| 0,16 % | Algert Global LLC | 260 877 | 149 343 | 2023. 12. 31. |
| 0,15 % | Morgan Stanley Investment Management Inc. (US) | 248 988 | 131 750 | 2023. 12. 31. |
| 0,15 % | PENN Capital Management Company, Inc. | 247 324 | -41 959 | 2023. 12. 31. |
| 0,15 % | Capital Fund Management S.A. | 243 812 | 68 120 | 2023. 12. 31. |
| 0,15 % | Walleye Capital LLC | 242 705 | 144 104 | 2023. 12. 31. |
| 0,15 % | Parametric Portfolio Associates LLC | 241 737 | 12 207 | 2023. 12. 31. |
| 0,15 % | Birchview Capital, LP | 240 400 | 0 | 2023. 12. 31. |
| 0,14 % | BNP Paribas Securities Corp. North America | 229 765 | -75 403 | 2023. 12. 31. |
| 0,13 % | Citi Investment Research (US) | 222 718 | 75 854 | 2023. 12. 31. |
| 0,13 % | MacKay Shields LLC | 219 900 | 168 389 | 2022. 08. 31. |
| 0,13 % | New York State Common Retirement Fund | 213 639 | -19 870 | 2023. 12. 31. |
| 0,13 % | Schweizerische Nationalbank | 209 804 | -22 600 | 2023. 12. 31. |
| 0,12 % | TD Asset Management Inc. | 206 496 | -19 200 | 2023. 12. 31. |
| 0,12 % | J.P. Morgan Securities LLC | 200 192 | 196 753 | 2023. 12. 31. |
| 0,12 % | Columbia Threadneedle Investments (US) | 194 199 | 15 307 | 2023. 12. 31. |
| 0,12 % | Mellon Investments Corporation | 191 783 | -14 790 | 2023. 12. 31. |
| 0,11 % | BofA Global Research (US) | 188 210 | -236 603 | 2023. 12. 31. |
| 0,11 % | Sector Gamma AS | 188 111 | 8326 | 2023. 12. 31. |
| 0,11 % | Congress Asset Management Company, LLP | 184 666 | 31 105 | 2023. 12. 31. |
| 0,11 % | Renaissance Technologies LLC | 184 000 | 184 000 | 2023. 12. 31. |
| 0,11 % | Rhumbline Advisers Ltd. Partnership | 183 284 | -1116 | 2023. 12. 31. |
| 0,11 % | T. Rowe Price International Ltd | 181 641 | -4642 | 2023. 12. 31. |
| 0,11 % | International Biotechnology Trust PLC | 179 702 | 28 702 | 2023. 09. 30. |
| 0,11 % | BlackRock Investment Management (UK) Ltd. | 179 287 | 92 048 | 2023. 12. 31. |
| 0,11 % | Empire Life Investments Inc. | 174 815 | 467 | 2023. 12. 31. |
| 0,09 % | Citadel Advisors LLC | 153 034 | 147 625 | 2023. 12. 31. |
| 0,09 % | Envestnet Asset Management, Inc. | 150 932 | -20 883 | 2023. 12. 31. |
| 0,09 % | Jennison Associates LLC | 150 100 | 40 500 | 2024. 02. 29. |
| 0,09 % | Erste Asset Management GmbH | 148 300 | 15 700 | 2023. 12. 31. |
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