6.75970 % | BVF Partners L.P. | 24,435,632 | 4,440,300 | 31.12.2023 |
31.54640 % | Artal International S.C.A. | 114,037,070 | 0 | 13.3.2024 |
3.84355 % | Fidelity Management & Research Company LLC | 13,894,062 | 11,617,594 | 18.3.2024 |
1.75252 % | BlackRock Institutional Trust Company, N.A. | 6,335,170 | 357,950 | 31.12.2023 |
1.65437 % | The Vanguard Group, Inc. | 5,980,371 | -397,939 | 31.12.2023 |
1.50798 % | Ulys, L.L.C. | 5,451,204 | 0 | 13.3.2024 |
0.97270 % | Invus Public Equities Advisors, LLC | 3,516,214 | 0 | 13.3.2024 |
0.75322 % | JP Morgan Asset Management | 2,722,804 | 174,669 | 31.12.2023 |
0.65902 % | New Enterprise Associates (NEA) | 2,382,286 | 0 | 31.12.2023 |
0.64979 % | Geode Capital Management, L.L.C. | 2,348,916 | 222,779 | 31.12.2023 |
0.52348 % | State Street Global Advisors (US) | 1,892,319 | 16,180 | 31.12.2023 |
0.52289 % | Columbia Threadneedle Investments (US) | 1,890,200 | 675,522 | 31.12.2023 |
0.47880 % | Pinnacle Associates Ltd. | 1,730,821 | -182,048 | 31.12.2023 |
0.47262 % | Medical Strategy GmbH | 1,708,481 | -322,382 | 31.12.2023 |
0.45179 % | Millennium Management LLC | 1,633,176 | -2,252,577 | 31.12.2023 |
0.37092 % | Debbane (Raymond) | 1,340,847 | 0 | 18.3.2024 |
0.30376 % | Coats (Lonnel) | 1,098,068 | 0 | 18.3.2024 |
0.23906 % | Charles Schwab Investment Management, Inc. | 864,175 | 12,254 | 31.12.2023 |
0.23865 % | Morgan Stanley & Co. LLC | 862,680 | 705,664 | 31.12.2023 |
0.21748 % | Citadel Advisors LLC | 786,160 | 784,249 | 31.12.2023 |
0.21579 % | GSA Capital Partners LLP | 780,077 | 780,077 | 31.12.2023 |
0.21574 % | Northern Trust Investments, Inc. | 779,869 | -87,003 | 31.12.2023 |
0.11558 % | Susquehanna International Group, LLP | 417,813 | 89,307 | 31.12.2023 |
0.11402 % | Renaissance Technologies LLC | 412,175 | 139,920 | 31.12.2023 |
0.11319 % | Nuveen LLC | 409,179 | 0 | 31.12.2023 |
0.09937 % | D. E. Shaw & Co., L.P. | 359,210 | -424,912 | 31.12.2023 |
0.08969 % | Wade (Jeffrey L) | 324,214 | 0 | 18.3.2024 |
0.08962 % | Entrypoint Capital LLC | 323,968 | 323,968 | 31.12.2023 |
0.07814 % | Connor, Clark & Lunn Investment Management Ltd. | 282,467 | -54,597 | 31.12.2023 |
0.07695 % | BNY Mellon Asset Management | 278,154 | 9,754 | 31.12.2023 |
0.07555 % | JPMorgan Private Bank (United States) | 273,102 | 52,943 | 31.12.2023 |
0.07535 % | Jane Street Capital, L.L.C. | 272,367 | 190,437 | 31.12.2023 |
0.07074 % | Main (Alan J) | 255,724 | 0 | 18.3.2024 |
0.06941 % | Virtus Etf Advisers LLC | 250,923 | 129,212 | 31.12.2023 |
0.06941 % | LifeSci Index Partners, LLC | 250,923 | 125,063 | 31.12.2023 |
0.06941 % | BlackRock Investment Management, LLC | 250,893 | 0 | 31.12.2023 |
0.06786 % | AllianceBernstein L.P. | 245,301 | 0 | 31.12.2023 |
0.06671 % | Two Sigma Investments, LP | 241,155 | -439,057 | 31.12.2023 |
0.06648 % | Amouyal (Philippe J) | 240,332 | 0 | 18.3.2024 |
0.06236 % | BlackRock Financial Management, Inc. | 225,432 | -43,034 | 31.12.2023 |
0.06224 % | Citi Investment Research (US) | 224,998 | 188,983 | 31.12.2023 |
0.05829 % | BofA Global Research (US) | 210,725 | 46,249 | 31.12.2023 |
0.04910 % | Crum (Brian T) | 177,497 | 0 | 18.3.2024 |
0.04692 % | UBS Financial Services, Inc. | 169,616 | 44,254 | 31.12.2023 |
0.04568 % | Assenagon Asset Management S.A. | 165,143 | 12,053 | 29.2.2024 |
0.04528 % | Goldman Sachs & Company, Inc. | 163,672 | -98,443 | 31.12.2023 |
0.04500 % | Kassler-Taub (Kenneth B) | 162,672 | 43,047 | 28.2.2024 |
0.04399 % | Sobecki (Christopher J) | 159,023 | 0 | 18.3.2024 |
0.04152 % | CIBC Private Wealth Management | 150,100 | 150,100 | 31.12.2023 |
0.03685 % | BlackRock Advisors (UK) Limited | 133,200 | -1,524 | 31.3.2024 |
0.03662 % | BlackRock Asset Management Ireland Limited | 132,371 | 30,535 | 31.12.2023 |
0.03604 % | Rhumbline Advisers Ltd. Partnership | 130,291 | 0 | 31.12.2023 |
0.03514 % | Barclays Bank PLC | 127,016 | 87,827 | 31.12.2023 |
0.02853 % | Deerfield Management Company, L.P. | 103,144 | 103,144 | 31.12.2023 |
0.02785 % | T. Rowe Price International Ltd | 100,691 | 0 | 31.12.2023 |
0.02600 % | Compagnie Lombard Odier SCmA | 94,000 | 0 | 31.12.2023 |
0.02205 % | Northern Trust Global Investments | 79,719 | -143,846 | 31.12.2023 |
0.02202 % | Barker (Samuel L) | 79,617 | 0 | 18.3.2024 |
0.01983 % | Goldman Sachs Asset Management, L.P. | 71,667 | 137 | 31.12.2023 |
0.01671 % | Aperio Group, LLC | 60,389 | 32,077 | 31.12.2023 |
0.01601 % | Mellon Investments Corporation | 57,863 | 0 | 31.12.2023 |
0.01509 % | Amundi Asset Management, SAS | 54,532 | 0 | 31.12.2023 |
0.01501 % | Simplex Trading, LLC | 54,248 | 54,248 | 31.12.2023 |
0.01470 % | Seth (Kiernan) | 53,136 | 31,269 | 28.2.2023 |
0.01458 % | McDermott (Wendy) | 52,694 | 24,216 | 28.2.2024 |
0.01358 % | Russell Investments Trust Company | 49,100 | 0 | 31.12.2023 |
0.01322 % | Alexander (Kristen) | 47,800 | 17,450 | 28.2.2024 |
0.01317 % | Granowitz (Craig B. M.D., Ph.D.) | 47,626 | 0 | 18.3.2024 |
0.01311 % | J.P. Morgan Securities plc | 47,385 | 645 | 31.12.2023 |
0.01303 % | Tudor Investment Corporation | 47,101 | 0 | 31.12.2023 |
0.01274 % | SunAmerica Asset Management, LLC | 46,049 | -186 | 31.12.2023 |
0.01251 % | T. Rowe Price Associates, Inc. | 45,209 | 0 | 31.12.2023 |
0.01235 % | CAPTRUST Financial Advisors | 44,636 | 18 | 31.12.2023 |
0.01217 % | LPL Financial LLC | 43,994 | 17,000 | 31.12.2023 |
0.01211 % | SG Americas Securities, L.L.C. | 43,793 | -14,914 | 31.12.2023 |
0.01191 % | Morgan Stanley Smith Barney LLC | 43,047 | 115 | 31.12.2023 |
0.01162 % | LUNIS Vermögensmanagement AG | 42,000 | 0 | 31.12.2023 |
0.01135 % | Nies (Alan S) | 41,046 | 9,302 | 21.5.2023 |
0.01124 % | KWB Wealth | 40,640 | 0 | 31.3.2024 |
0.01116 % | Swain (Judith L) | 40,332 | 0 | 18.3.2024 |
0.01116 % | Lefkowitz (Robert J) | 40,332 | 0 | 18.3.2024 |
0.01116 % | Palantoni (Frank P) | 40,332 | 9,302 | 21.5.2023 |
0.01097 % | Stifel, Nicolaus & Company, Incorporated | 39,652 | -42,315 | 31.12.2023 |
0.01081 % | DWS Investments UK Limited | 39,082 | 0 | 31.12.2023 |
0.01033 % | Voya Investment Management LLC | 37,359 | 0 | 31.12.2023 |
0.00988 % | University of Texas Investment Management Company | 35,714 | 0 | 31.12.2023 |
0.00961 % | Invesco Capital Management LLC | 34,724 | 10,766 | 31.12.2023 |
0.00953 % | Pathstone | 34,445 | 34,445 | 31.12.2023 |
0.00946 % | Commonwealth Financial Network | 34,184 | -5,385 | 31.12.2023 |
0.00931 % | New York State Common Retirement Fund | 33,670 | -206 | 31.12.2023 |
0.00900 % | BNP Paribas Securities Corp. North America | 32,519 | -88,053 | 31.12.2023 |
0.00890 % | Victory Capital Management Inc. | 32,187 | 5,813 | 31.12.2023 |
0.00889 % | Bayesian Capital Management, LP | 32,119 | 32,119 | 31.12.2023 |
0.00885 % | RPO LLC | 32,000 | 32,000 | 31.12.2023 |
0.00871 % | Prosperity Financial Group, Inc. | 31,500 | 0 | 31.12.2023 |
0.00857 % | ProShare Advisors LLC | 30,982 | 2,933 | 31.12.2023 |
0.00784 % | China Universal Asset Management Co., Ltd. | 28,329 | 22,043 | 31.12.2023 |
0.00747 % | TIAA Trust, National Association | 27,000 | 0 | 31.12.2023 |
0.00740 % | Wells Fargo Bank, N.A. | 26,734 | 5,571 | 31.12.2023 |
0.00732 % | Invesco Advisers, Inc. | 26,458 | -1,521 | 31.12.2023 |