9.10 % | The Vanguard Group, Inc. | 25,418,388 | 979,857 | 31.12.2023 |
8.50 % | RA Capital Management, LP | 23,750,601 | 10,428,313 | 31.12.2023 |
6.68 % | BlackRock Institutional Trust Company, N.A. | 18,646,679 | 1,793,786 | 31.12.2023 |
5.88 % | Redmile Group, LLC | 16,423,922 | -1,079,495 | 31.12.2023 |
3.95 % | Janus Henderson Investors | 11,043,986 | -6,640,830 | 31.12.2023 |
2.89 % | State Street Global Advisors (US) | 8,075,671 | -1,476,181 | 31.12.2023 |
2.12 % | Fairmount Funds Management LLC | 5,929,592 | 0 | 31.12.2023 |
2.03 % | Pentwater Capital Management LP | 5,662,500 | 5,662,500 | 31.12.2023 |
1.98 % | Norges Bank Investment Management (NBIM) | 5,539,334 | 5,424,434 | 31.12.2023 |
1.93 % | Geode Capital Management, L.L.C. | 5,382,875 | 482,900 | 31.12.2023 |
1.92 % | Fidelity Investments Canada ULC | 5,360,000 | 5,360,000 | 31.12.2023 |
1.62 % | D. E. Shaw & Co., L.P. | 4,522,797 | -2,472,442 | 31.12.2023 |
1.60 % | Millennium Management LLC | 4,473,868 | 2,868,154 | 31.12.2023 |
1.15 % | Voloridge Investment Management, LLC | 3,221,231 | 708,980 | 31.12.2023 |
1.06 % | Boxer Capital, L.L.C. | 2,961,000 | 0 | 31.12.2023 |
1.05 % | Emerald Advisers LLC | 2,933,190 | -344,179 | 31.12.2023 |
0.89 % | Maverick Capital, Ltd. | 2,493,217 | -25,310 | 31.12.2023 |
0.83 % | TIG Advisors, L.L.C. | 2,313,670 | 2,313,670 | 31.12.2023 |
0.79 % | Morgan Stanley & Co. LLC | 2,209,536 | 64,583 | 31.12.2023 |
0.79 % | Tang Capital Management, LLC | 2,199,137 | 699,137 | 31.12.2023 |
0.76 % | Medical Strategy GmbH | 2,126,763 | 0 | 30.9.2023 |
0.74 % | Northern Trust Investments, Inc. | 2,072,998 | 62,196 | 31.12.2023 |
0.73 % | Nuveen LLC | 2,041,214 | -845,027 | 31.12.2023 |
0.73 % | Kryger Capital Limited | 2,036,155 | 2,036,155 | 31.12.2023 |
0.70 % | Wellington Management Company, LLP | 1,954,413 | -11,304,584 | 31.12.2023 |
0.68 % | Charles Schwab Investment Management, Inc. | 1,892,446 | 61,871 | 31.12.2023 |
0.65 % | Avidity Partners Management LP | 1,829,215 | -88,692 | 31.12.2023 |
0.64 % | HOOPP Investment Management | 1,785,296 | 1,485,296 | 31.12.2023 |
0.63 % | Alpine Associates Management Inc. | 1,761,300 | 1,749,300 | 31.12.2023 |
0.58 % | Renaissance Technologies LLC | 1,631,240 | 896,600 | 31.12.2023 |
0.58 % | Magnetar Capital Partners LP | 1,629,285 | 1,629,285 | 31.12.2023 |
0.55 % | Sofinnova Investments, Inc | 1,546,902 | -498,300 | 31.12.2023 |
0.54 % | AllianceBernstein L.P. | 1,507,809 | 1,207,295 | 31.12.2023 |
0.54 % | AQR Capital Management, LLC | 1,506,601 | 1,380,964 | 31.12.2023 |
0.54 % | Balyasny Asset Management LP | 1,496,758 | 1,484,838 | 31.12.2023 |
0.53 % | Morgan Stanley Investment Management Inc. (US) | 1,487,210 | -544,787 | 31.12.2023 |
0.51 % | Gabelli Funds, LLC | 1,422,804 | 1,422,804 | 31.12.2023 |
0.51 % | Kynam Capital Management LP | 1,422,503 | 1,422,503 | 31.12.2023 |
0.50 % | Affinity Asset Advisors LLC | 1,404,608 | 1,404,608 | 31.12.2023 |
0.49 % | QVT Financial LP | 1,375,900 | 0 | 31.12.2023 |
0.49 % | Westchester Capital Management, LLC | 1,364,927 | 1,364,927 | 31.12.2023 |
0.45 % | J.P. Morgan Securities LLC | 1,265,347 | 28,617 | 31.12.2023 |
0.45 % | BlackRock Financial Management, Inc. | 1,243,147 | -259,980 | 31.12.2023 |
0.42 % | Marshall Wace LLP | 1,187,027 | 1,187,027 | 31.12.2023 |
0.42 % | Artisan Partners Limited Partnership | 1,172,323 | -2,552,260 | 31.12.2023 |
0.40 % | Principal Global Investors (Equity) | 1,127,402 | 142,738 | 31.12.2023 |
0.40 % | Candriam Belgium S.A. | 1,122,598 | 10 | 31.12.2023 |
0.40 % | Candriam Luxembourg S.A. | 1,122,557 | 0 | 31.12.2023 |
0.36 % | Pinnacle Associates Ltd. | 1,011,792 | -4,364 | 31.12.2023 |
0.35 % | Pictet Asset Management Ltd. | 975,962 | -2,732,177 | 31.12.2023 |
0.35 % | Adage Capital Management, L.P. | 971,928 | 771,928 | 31.12.2023 |
0.35 % | BlackRock Advisors (UK) Limited | 971,070 | 19,799 | 31.1.2024 |
0.34 % | T. Rowe Price Associates, Inc. | 963,620 | -2,811,554 | 31.12.2023 |
0.34 % | Lombard Odier Asset Management (Europe) Ltd | 947,497 | -36,199 | 30.9.2022 |
0.32 % | BlackRock Asset Management Ireland Limited | 902,926 | -16,784 | 31.12.2023 |
0.32 % | Water Island Capital, LLC | 893,758 | 304,893 | 31.12.2023 |
0.32 % | Two Sigma Investments, LP | 887,018 | -2,035,717 | 31.12.2023 |
0.31 % | Avoro Capital Advisors LLC | 875,000 | 875,000 | 31.12.2023 |
0.30 % | Farallon Capital Management, L.L.C. | 842,000 | 842,000 | 31.12.2023 |
0.30 % | American Century Investment Management, Inc. | 836,134 | 137,018 | 31.12.2023 |
0.29 % | Goldman Sachs & Company, Inc. | 809,254 | -64,684 | 31.12.2023 |
0.28 % | Citadel Advisors LLC | 795,458 | -492,084 | 31.12.2023 |
0.27 % | Eventide Asset Management, LLC | 763,000 | -537,000 | 31.12.2023 |
0.27 % | Rock Springs Capital Management LP | 759,365 | 0 | 31.12.2023 |
0.27 % | BofA Global Research (US) | 755,774 | 270,386 | 31.12.2023 |
0.27 % | DWS Investments UK Limited | 751,326 | 630,590 | 31.12.2023 |
0.27 % | Eversept Partners, LP | 748,950 | 748,950 | 31.12.2023 |
0.26 % | Susquehanna International Group, LLP | 736,034 | -238,853 | 31.12.2023 |
0.26 % | AQR Arbitrage, LLC | 719,919 | 719,919 | 31.12.2023 |
0.24 % | IndexIQ Advisors LLC | 682,396 | 682,396 | 31.12.2023 |
0.24 % | Voya Investment Management LLC | 669,351 | 154,215 | 31.12.2023 |
0.24 % | BlackRock Investment Management, LLC | 661,835 | -13,096 | 31.12.2023 |
0.24 % | Decheng Capital LLC | 659,928 | 244,048 | 31.12.2023 |
0.24 % | BNY Mellon Asset Management | 659,833 | -30,822 | 31.12.2023 |
0.23 % | Sio Capital Management, LLC | 644,366 | 411,615 | 31.12.2023 |
0.23 % | Barclays Bank PLC | 640,777 | 302,253 | 31.12.2023 |
0.23 % | Jane Street Capital, L.L.C. | 634,353 | -283,411 | 31.12.2023 |
0.21 % | Superstring Capital Management LP | 598,072 | 598,072 | 31.12.2023 |
0.21 % | First Trust Capital Management L.P. | 596,720 | 596,720 | 31.12.2023 |
0.21 % | CPP Investment Board | 586,990 | 586,990 | 31.12.2023 |
0.20 % | Baillie Gifford & Co. | 566,529 | 0 | 31.10.2023 |
0.19 % | Melqart Asset Management (UK) Limited | 531,324 | 531,324 | 31.12.2023 |
0.19 % | HSBC Global Asset Management (UK) Limited | 519,779 | 519,779 | 31.12.2023 |
0.18 % | Invesco Capital Management LLC | 515,275 | 174,614 | 31.12.2023 |
0.18 % | Picton Mahoney Asset Management | 500,000 | 500,000 | 31.12.2023 |
0.18 % | CM Management, LLC | 500,000 | 0 | 31.12.2023 |
0.17 % | JPMorgan Private Bank (United States) | 482,994 | -20,174 | 31.12.2023 |
0.17 % | Schweizerische Nationalbank | 480,800 | 0 | 31.12.2023 |
0.17 % | Carlson Capital, L.P. | 466,188 | 466,188 | 31.12.2023 |
0.16 % | Slotnik Capital, LLC | 460,000 | 460,000 | 31.12.2023 |
0.16 % | Dimensional Fund Advisors, L.P. | 454,213 | -726,531 | 31.12.2023 |
0.16 % | Fidelity Management & Research Company LLC | 453,168 | -5,326,775 | 31.12.2023 |
0.15 % | Credit Suisse Funds AG | 417,277 | 128,166 | 31.12.2023 |
0.15 % | Segantii Capital Management Limited | 415,000 | 415,000 | 31.12.2023 |
0.15 % | PanAgora Asset Management Inc. | 409,658 | -688,759 | 31.12.2023 |
0.14 % | Woodline Partners LP | 400,000 | -2,033,161 | 31.12.2023 |
0.14 % | GLG LLC | 388,103 | 374,005 | 31.12.2023 |
0.14 % | Mellon Investments Corporation | 382,594 | -482,140 | 31.12.2023 |
0.13 % | Pictet Asset Management (Japan) Ltd. | 372,310 | 372,310 | 31.10.2023 |
0.13 % | Invesco Advisers, Inc. | 370,048 | -375,459 | 31.12.2023 |