6.89 % | Fred Alger Management, LLC | 3,327,132 | -932,323 | 31.12.2023 |
6.77 % | Adage Capital Management, L.P. | 3,266,645 | 0 | 31.12.2023 |
5.53 % | BlackRock Institutional Trust Company, N.A. | 2,671,316 | 504,121 | 31.12.2023 |
5.37 % | State Street Global Advisors (US) | 2,594,470 | 1,061,628 | 31.12.2023 |
5.31 % | VR Adviser, LLC | 2,563,952 | 590,699 | 31.12.2023 |
4.40 % | The Vanguard Group, Inc. | 2,126,124 | 163,823 | 31.12.2023 |
4.37 % | Lynx1 Capital Advisors LLC | 2,110,401 | 4,401 | 31.12.2023 |
4.16 % | Deerfield Management Company, L.P. | 2,007,729 | -332,389 | 31.12.2023 |
4.15 % | Perceptive Advisors LLC | 2,003,058 | 870,567 | 31.12.2023 |
4.14 % | Bain Capital Life Sciences Investors, LLC | 2,000,000 | 0 | 31.12.2023 |
3.98 % | Holocene Advisors, LP | 1,920,323 | 737,277 | 31.12.2023 |
3.94 % | Commodore Capital LP | 1,900,000 | -625,753 | 31.12.2023 |
3.80 % | T. Rowe Price Investment Management, Inc. | 1,832,854 | 1,832,854 | 31.12.2023 |
3.37 % | Jennison Associates LLC | 1,626,628 | 204,261 | 31.12.2023 |
2.85 % | Redmile Group, LLC | 1,374,189 | -400,063 | 31.12.2023 |
2.80 % | Nichtberger (Steven) | 1,349,483 | 0 | 31.12.2023 |
2.59 % | Polar Capital LLP | 1,250,000 | 1,250,000 | 31.12.2023 |
2.32 % | BlackRock Financial Management, Inc. | 1,121,700 | 947,483 | 31.12.2023 |
1.56 % | Geode Capital Management, L.L.C. | 753,176 | 61,304 | 31.12.2023 |
1.47 % | Invesco Capital Management LLC | 709,297 | -130,328 | 31.12.2023 |
1.39 % | Invesco Advisers, Inc. | 670,629 | 656,211 | 31.12.2023 |
1.12 % | Wellington Management Company, LLP | 539,876 | 293,306 | 31.12.2023 |
1.08 % | Integral Health Asset Management, LLC | 520,000 | 190,000 | 31.12.2023 |
1.06 % | T. Rowe Price Associates, Inc. | 511,979 | 502,722 | 31.12.2023 |
1.01 % | TCG Crossover Management, LLC | 486,795 | 0 | 31.12.2023 |
0.93 % | StemPoint Capital LP | 450,706 | 450,706 | 31.12.2023 |
0.89 % | Sofinnova Investments, Inc | 429,395 | 429,395 | 31.12.2023 |
0.87 % | BlackRock Investment Management (UK) Ltd. | 420,620 | 418,920 | 31.12.2023 |
0.84 % | Victory Capital Management Inc. | 403,927 | 337,277 | 31.12.2023 |
0.72 % | Blackstone Alternative Asset Management, L.P. | 347,494 | 347,494 | 31.12.2023 |
0.62 % | Alkeon Capital Management LLC | 299,955 | 299,955 | 31.12.2023 |
0.60 % | Northern Trust Investments, Inc. | 288,513 | 15,506 | 31.12.2023 |
0.59 % | Point72 Asset Management, L.P. | 284,666 | 284,666 | 31.12.2023 |
0.52 % | Schonfeld Strategic Advisors LLC | 251,615 | 251,615 | 31.12.2023 |
0.51 % | Morgan Stanley & Co. LLC | 245,787 | 169,460 | 31.12.2023 |
0.50 % | Woodline Partners LP | 241,453 | 107,269 | 31.12.2023 |
0.50 % | Nuveen LLC | 239,977 | 103,999 | 31.12.2023 |
0.49 % | Voloridge Investment Management, LLC | 236,400 | 225,638 | 31.12.2023 |
0.48 % | Cutter Capital Management, LP | 230,000 | 230,000 | 31.12.2023 |
0.45 % | Ikarian Capital LLC | 216,620 | 216,620 | 31.12.2023 |
0.43 % | Rafferty Asset Management LLC | 209,263 | 91,113 | 31.12.2023 |
0.42 % | Goldman Sachs & Company, Inc. | 204,632 | -65,053 | 31.12.2023 |
0.41 % | Candriam Luxembourg S.A. | 200,000 | 200,000 | 29.2.2024 |
0.36 % | First Turn Management, LLC | 175,359 | 175,359 | 31.12.2023 |
0.33 % | BofA Global Research (US) | 160,520 | 19,334 | 31.12.2023 |
0.31 % | Norges Bank Investment Management (NBIM) | 151,944 | 151,944 | 31.12.2023 |
0.31 % | Ghost Tree Capital, LLC | 150,000 | 150,000 | 31.12.2023 |
0.30 % | Simon (Mark) | 143,144 | 7,000 | 3.4.2023 |
0.29 % | UBS Financial Services, Inc. | 138,645 | 103,662 | 31.12.2023 |
0.27 % | Barclays Bank PLC | 129,072 | 64,486 | 31.12.2023 |
0.26 % | Morgan Stanley Smith Barney LLC | 124,620 | -20,194 | 31.12.2023 |
0.24 % | Ensign Peak Advisors, Inc. | 118,002 | 118,002 | 31.12.2023 |
0.23 % | BlackRock Investment Management, LLC | 109,505 | 28,934 | 31.12.2023 |
0.20 % | BNY Mellon Asset Management | 97,558 | 2,996 | 31.12.2023 |
0.20 % | Charles Schwab Investment Management, Inc. | 96,310 | 305 | 31.12.2023 |
0.19 % | TD Asset Management Inc. | 93,630 | 93,630 | 31.12.2023 |
0.19 % | AllianceBernstein L.P. | 93,332 | -72,071 | 31.12.2023 |
0.18 % | Jane Street Capital, L.L.C. | 88,409 | 88,409 | 31.12.2023 |
0.18 % | RBC Capital Markets Wealth Management | 86,816 | -13,115 | 31.12.2023 |
0.18 % | Citi Investment Research (US) | 86,546 | 36,851 | 31.12.2023 |
0.17 % | BlackRock Advisors (UK) Limited | 82,375 | 2,553 | 31.3.2024 |
0.17 % | Rokos Capital Management LLP | 80,335 | -93,515 | 31.12.2023 |
0.16 % | Weatherbie Capital, LLC | 77,153 | 52,745 | 29.2.2024 |
0.15 % | Two Sigma Investments, LP | 74,791 | 28,066 | 31.12.2023 |
0.14 % | BlackRock Asset Management Ireland Limited | 69,114 | 50,924 | 31.12.2023 |
0.14 % | Neuberger Berman, LLC | 68,329 | 68,329 | 29.2.2024 |
0.14 % | PGIM Securities Investment Trust Enterprise | 67,000 | -118,000 | 31.12.2023 |
0.12 % | Oppenheimer Asset Management Inc. | 60,045 | 60,045 | 31.12.2023 |
0.12 % | Boothbay Fund Management, LLC | 58,755 | 58,755 | 31.12.2023 |
0.11 % | Nicholas Investment Partners, L.P. | 54,586 | 41,408 | 31.12.2023 |
0.11 % | Manulife Investment Management (North America) Limited | 52,677 | 39,427 | 31.12.2023 |
0.11 % | Qube Research & Technologies Ltd | 52,199 | 52,199 | 31.12.2023 |
0.11 % | Schweizerische Nationalbank | 51,000 | -10,100 | 31.12.2023 |
0.10 % | Marda (Anup) | 50,000 | 50,000 | 18.10.2022 |
0.10 % | Nan Fung Life Sciences | 47,150 | 0 | 31.12.2023 |
0.10 % | Exome Asset Management LLC | 46,700 | 46,700 | 31.12.2023 |
0.10 % | Churchill Management Group | 46,606 | -2,750 | 31.3.2024 |
0.10 % | Bridgeway Capital Management, LLC | 46,021 | -4,600 | 31.12.2023 |
0.09 % | Rhumbline Advisers Ltd. Partnership | 44,147 | 1,545 | 31.12.2023 |
0.09 % | MFS Investment Management | 42,890 | -1,560 | 29.2.2024 |
0.08 % | Newton Investment Management North America, LLC | 39,900 | 0 | 31.12.2023 |
0.08 % | Caption Management, LLC | 38,300 | 38,300 | 31.12.2023 |
0.08 % | LPL Financial LLC | 37,638 | -223 | 31.12.2023 |
0.07 % | SEB Investment Management AB | 35,072 | -137 | 29.2.2024 |
0.07 % | Citadel Advisors LLC | 33,880 | 31,417 | 31.12.2023 |
0.07 % | ProFund Advisors LLC | 33,858 | 13,737 | 31.12.2023 |
0.07 % | Goldman Sachs Asset Management, L.P. | 33,505 | 3,138 | 31.12.2023 |
0.07 % | Credit Suisse Funds AG | 33,388 | 13,360 | 31.12.2023 |
0.07 % | Envestnet Asset Management, Inc. | 33,081 | -42,284 | 31.12.2023 |
0.06 % | Assenagon Asset Management S.A. | 29,346 | 2,127 | 29.2.2024 |
0.06 % | Cubist Systematic Strategies, LLC | 29,241 | 29,241 | 31.12.2023 |
0.06 % | California State Teachers Retirement System | 28,717 | -3,444 | 31.12.2023 |
0.06 % | Osaic Holdings, Inc. | 27,680 | -19,690 | 31.12.2023 |
0.05 % | Legal & General Investment Management Ltd. | 25,611 | -6,032 | 31.12.2023 |
0.05 % | Dimensional Fund Advisors, L.P. | 25,375 | -53,330 | 31.12.2023 |
0.05 % | New York State Common Retirement Fund | 25,191 | 14,828 | 31.12.2023 |
0.05 % | Mirae Asset Global Investments (USA) LLC | 23,689 | 6,891 | 31.12.2023 |
0.05 % | Squarepoint Capital LLP | 23,633 | 4,341 | 31.12.2023 |
0.05 % | State of Wisconsin Investment Board | 23,053 | -5,656 | 31.12.2023 |
0.05 % | JPMorgan Private Bank (United States) | 22,779 | 22,779 | 31.12.2023 |