6,07533 % | TCG Crossover Management, LLC | 10 000 000 | 0 | |
5,35562 % | Jennison Associates LLC | 8 815 358 | 4 948 596 | |
4,64030 % | Adage Capital Management, L.P. | 7 637 930 | −300 621 | |
4,20000 % | Bain Capital Life Sciences Investors, LLC | 6 913 208 | −7 319 543 | |
4,03737 % | BlackRock Institutional Trust Company, N.A. | 6 645 503 | 1 131 644 | |
3,80037 % | Farallon Capital Management, L.L.C. | 6 255 406 | −4 652 680 | |
3,59353 % | The Vanguard Group, Inc. | 5 914 947 | 150 346 | |
2,84326 % | Zambon SpA | 4 680 000 | 4 680 000 | |
2,43013 % | Frazier Healthcare Partners | 4 000 000 | 0 | |
2,12637 % | VR Adviser, LLC | 3 500 000 | −3 684 865 | |
14,86711 % | New Enterprise Associates (NEA) | 24 471 264 | 0 | |
1,44765 % | Sofinnova Investments, Inc | 2 382 835 | 2 224 927 | |
1,41365 % | Geode Capital Management, L.L.C. | 2 326 873 | 105 385 | |
1,35094 % | Ramsay (David A) | 2 223 642 | 22 500 | |
1,26873 % | Vivo Capital, LLC | 2 088 323 | 174 974 | |
1,25162 % | Wellington Management Company, LLP | 2 060 173 | 2 060 173 | |
1,10402 % | Janus Henderson Investors | 1 817 213 | −183 289 | |
1,07415 % | State Street Global Advisors (US) | 1 768 053 | 230 739 | |
1,06177 % | AXA Investment Managers UK Ltd. | 1 747 673 | −42 275 | |
0,80984 % | Altium Capital Management LP | 1 333 000 | 1 333 000 | |
0,69866 % | Affinity Asset Advisors LLC | 1 150 000 | 0 | |
0,63360 % | Millennium Management LLC | 1 042 902 | 1 042 902 | |
0,60018 % | Nantahala Capital Management, LLC | 987 903 | −51 461 | |
0,58627 % | PGIM Securities Investment Trust Enterprise | 965 000 | 592 879 | |
0,49469 % | Superstring Capital Management LP | 814 266 | 814 266 | |
0,45565 % | Ghost Tree Capital, LLC | 750 000 | 750 000 | |
0,43626 % | Northern Trust Investments, Inc. | 718 082 | 34 324 | |
0,33941 % | Pauls Matthew | 558 674 | 237 320 | |
0,21511 % | Erickson (Anne) | 354 078 | 354 078 | |
0,21473 % | Caxton Associates LP | 353 441 | −2 960 161 | |
0,18226 % | Lutz (Robert Matthew) | 300 000 | 160 000 | |
0,16309 % | Connor, Clark & Lunn Investment Management Ltd. | 268 447 | 42 218 | |
0,15608 % | Renaissance Technologies LLC | 256 900 | 153 000 | |
0,15597 % | BlackRock Investment Management, LLC | 256 719 | 11 436 | |
0,15118 % | ClariVest Asset Management LLC | 248 842 | 5 942 | |
0,15101 % | Charles Schwab Investment Management, Inc. | 248 562 | 0 | |
0,14859 % | BlackRock Financial Management, Inc. | 244 577 | 764 | |
0,14704 % | BNY Mellon Asset Management | 242 035 | 33 665 | |
0,12350 % | Morgan Stanley & Co. LLC | 203 273 | 144 727 | |
0,11594 % | McCracken (Joseph S) | 190 837 | 22 500 | |
0,10746 % | UBS O'Connor LLC | 176 886 | −203 466 | |
0,10453 % | Two Sigma Investments, LP | 172 057 | 150 215 | |
0,10324 % | Citadel Advisors LLC | 169 940 | 150 355 | |
0,09855 % | Nuveen LLC | 162 212 | 0 | |
0,09721 % | Pratt (Raymond Dennis M.D.) | 160 000 | 150 000 | |
0,08826 % | Dimensional Fund Advisors, L.P. | 145 275 | −18 871 | |
0,08615 % | BlueStar Investment Managers SA | 141 800 | −18 200 | |
0,08305 % | Jump Financial, LLC | 136 700 | 104 174 | |
0,07902 % | Rhumbline Advisers Ltd. Partnership | 130 064 | 8 530 | |
0,07640 % | Qube Research & Technologies Ltd | 125 749 | 125 749 | |
0,07531 % | Barclays Bank PLC | 123 956 | 107 928 | |
0,07130 % | Lowrance (David L. CPA) | 117 355 | 99 562 | |
0,06454 % | UBS Financial Services, Inc. | 106 236 | 51 765 | |
0,05603 % | Assenagon Asset Management S.A. | 92 230 | 6 700 | |
0,05555 % | BlackRock Advisors (UK) Limited | 91 429 | 3 459 | |
0,05524 % | Alps Advisors, Inc. | 90 919 | 90 919 | |
0,05403 % | Walleye Capital LLC | 88 926 | 88 926 | |
0,04872 % | BofA Global Research (US) | 80 201 | −17 367 | |
0,04412 % | IndexIQ Advisors LLC | 72 624 | 72 624 | |
0,04178 % | Goldman Sachs Asset Management, L.P. | 68 767 | 23 891 | |
0,04041 % | BlackRock Asset Management Ireland Limited | 66 509 | 66 509 | |
0,03888 % | Invesco Capital Management LLC | 63 992 | 23 830 | |
0,03843 % | Northern Trust Global Investments | 63 256 | 24 | |
0,03673 % | Jane Street Capital, L.L.C. | 60 458 | 60 458 | |
0,03630 % | JPMorgan Private Bank (United States) | 59 754 | 59 754 | |
0,03550 % | Goldman Sachs & Company, Inc. | 58 433 | 15 004 | |
0,03224 % | Mellon Investments Corporation | 53 066 | 1 | |
0,03029 % | SG Americas Securities, L.L.C. | 49 862 | 12 720 | |
0,02954 % | MetLife Investment Management, LLC | 48 616 | 8 073 | |
0,02861 % | Aperio Group, LLC | 47 091 | 11 450 | |
0,02773 % | Entrypoint Capital LLC | 45 643 | 45 643 | |
0,02728 % | SunAmerica Asset Management, LLC | 44 903 | −181 | |
0,02682 % | Acuitas Investments LLC | 44 142 | 5 942 | |
0,02369 % | Invesco Advisers, Inc. | 38 998 | 8 649 | |
0,02322 % | BNP Paribas Securities Corp. North America | 38 225 | 25 038 | |
0,02278 % | Sivia Capital Partners, LLC | 37 500 | 1 500 | |
0,02275 % | Voya Investment Management LLC | 37 446 | 0 | |
0,02215 % | Credit Suisse Funds AG | 36 460 | 36 460 | |
0,02182 % | Manulife Investment Management (North America) Limited | 35 915 | 0 | |
0,02141 % | Hawkins (Richard James) | 35 241 | 33 341 | |
0,02121 % | Vaughan Nelson Investment Management, L.P. | 34 918 | 0 | |
0,02015 % | DWS Investments UK Limited | 33 165 | 12 379 | |
0,01987 % | Susquehanna International Group, LLP | 32 701 | 32 701 | |
0,01766 % | T. Rowe Price International Ltd | 29 067 | 1 747 | |
0,01677 % | Wells Fargo Bank, N.A. | 27 598 | 5 487 | |
0,01615 % | J.P. Morgan Securities plc | 26 580 | 26 302 | |
0,01566 % | Farther Finance Advisors, LLC | 25 782 | 25 782 | |
0,01566 % | Florida State Board of Administration | 25 780 | 0 | |
0,01532 % | Telemus Capital, LLC | 25 214 | 0 | |
0,01500 % | Dimensional Fund Advisors, Ltd. | 24 684 | 0 | |
0,01434 % | ProShare Advisors LLC | 23 601 | 11 865 | |
0,01368 % | AllianceBernstein L.P. | 22 510 | 3 510 | |
0,01367 % | Elam (Nevan C) | 22 500 | −6 744 | |
0,01367 % | Sun (Ricky) | 22 500 | 22 500 | |
0,01367 % | van (Es-Johansson An) | 22 500 | 22 500 | |
0,01284 % | Advisory Research, Inc. | 21 129 | 21 129 | |
0,01267 % | Brown Advisory | 20 854 | 0 | |
0,01252 % | Schonfeld Strategic Advisors LLC | 20 600 | 20 600 | |
0,01211 % | Vanguard Investments Australia Ltd. | 19 936 | 19 936 | |
0,01185 % | Tower Research Capital LLC | 19 507 | 16 959 | |