7,93 % | RTW Investments L.P. | 4 131 045 | −259 513 | |
7,14 % | Cowen & Co., LLC | 3 721 659 | 0 | |
6,44 % | Morgan Stanley & Co. LLC | 3 358 132 | 455 474 | |
5,67 % | Lynx1 Capital Advisors LLC | 2 956 918 | 292 760 | |
5,04 % | Redmile Group, LLC | 2 625 506 | −1 247 190 | |
3,90 % | Baker Bros. Advisors LP | 2 030 134 | 544 219 | |
3,60 % | Harrison (Seth Loring) | 1 875 313 | 0 | |
3,48 % | BlackRock Institutional Trust Company, N.A. | 1 815 681 | −121 639 | |
3,16 % | The Vanguard Group, Inc. | 1 648 502 | 19 118 | |
20,81 % | Skorpios Trust | 10 843 681 | −3 600 000 | |
2,55 % | Goldman Sachs & Company, Inc. | 1 326 494 | 1 282 757 | |
2,18 % | Granahan Investment Management, LLC | 1 137 887 | 286 686 | |
2,09 % | Cormorant Asset Management, LP | 1 087 807 | 0 | |
1,18 % | Geode Capital Management, L.L.C. | 615 724 | 24 607 | |
1,04 % | State Street Global Advisors (US) | 543 533 | −42 475 | |
0,79 % | DWS Investments UK Limited | 412 778 | 399 016 | |
0,78 % | Krainer (Adrian R) | 404 718 | 0 | |
0,48 % | Victory Capital Management Inc. | 249 370 | 249 370 | |
0,46 % | HOOPP Investment Management | 239 300 | 0 | |
0,44 % | Northern Trust Investments, Inc. | 227 055 | −5 619 | |
0,41 % | Dimensional Fund Advisors, L.P. | 215 294 | −43 128 | |
0,40 % | Birchview Capital, LP | 210 000 | 125 000 | |
0,39 % | Charles Schwab Investment Management, Inc. | 205 242 | −12 097 | |
0,32 % | Jacobs Levy Equity Management, Inc. | 168 028 | −49 577 | |
0,27 % | D. E. Shaw & Co., L.P. | 142 711 | −62 455 | |
0,20 % | GSA Capital Partners LLP | 102 107 | −245 962 | |
0,18 % | BlackRock Financial Management, Inc. | 94 096 | 12 369 | |
0,17 % | State of Wisconsin Investment Board | 86 600 | 7 076 | |
0,16 % | BlackRock Investment Management, LLC | 80 950 | −1 039 | |
0,14 % | Fort Point Capital Partners, LLC | 75 429 | 0 | |
0,14 % | BofA Global Research (US) | 75 339 | 17 781 | |
0,13 % | Kaye (Edward M) | 69 350 | 24 350 | |
0,13 % | BNY Mellon Asset Management | 68 230 | −9 952 | |
0,13 % | BlackRock Asset Management Ireland Limited | 66 225 | −31 938 | |
0,12 % | Goldman Sachs Asset Management, L.P. | 64 937 | −20 631 | |
0,12 % | Nuveen LLC | 62 864 | 0 | |
0,12 % | Los Angeles Capital Management LLC | 62 257 | 0 | |
0,12 % | Gilder Gagnon Howe & Co. LLC | 62 248 | −11 | |
0,12 % | Bellecapital Partners AG | 59 980 | 0 | |
0,11 % | BlackRock Advisors (UK) Limited | 58 525 | −3 224 | |
0,11 % | Woodline Partners LP | 56 904 | 0 | |
0,10 % | Jane Street Capital, L.L.C. | 50 786 | 50 786 | |
0,09 % | Susquehanna Portfolio Strategies, LLC | 45 108 | 45 108 | |
0,08 % | Rhumbline Advisers Ltd. Partnership | 40 971 | −38 | |
0,08 % | Trexquant Investment LP | 39 800 | −87 781 | |
0,08 % | Barclays Bank PLC | 39 271 | 30 831 | |
0,07 % | AllianceBernstein L.P. | 37 340 | −3 980 | |
0,07 % | Dimensional Fund Advisors, Ltd. | 34 328 | 0 | |
0,06 % | Tzianabos (Arthur) | 31 739 | 31 739 | |
0,06 % | Northern Trust Global Investments | 30 537 | −208 | |
0,06 % | T. Rowe Price International Ltd | 29 789 | 0 | |
0,06 % | UBS Financial Services, Inc. | 29 773 | 9 498 | |
0,06 % | Avantis Investors | 29 048 | 8 696 | |
0,05 % | Acuitas Investments LLC | 28 014 | 9 034 | |
0,05 % | Mellon Investments Corporation | 24 462 | 600 | |
0,05 % | Millennium Management LLC | 23 914 | −251 425 | |
0,04 % | Two Sigma Investments, LP | 22 200 | −19 900 | |
0,04 % | Columbia Threadneedle Investments (US) | 22 054 | −10 978 | |
0,04 % | Susquehanna International Group, LLP | 21 284 | −50 957 | |
0,04 % | American Century Investment Management, Inc. | 21 036 | 4 893 | |
0,04 % | Tulipano (Stephen J) | 20 746 | 8 984 | |
0,04 % | Squarepoint Capital LLP | 19 096 | 3 886 | |
0,03 % | Levin Arthur A | 17 979 | 0 | |
0,03 % | JPMorgan Private Bank (United States) | 17 880 | 17 880 | |
0,03 % | Ohio Public Employees Retirement System | 17 283 | 948 | |
0,03 % | Bridgeway Capital Management, LLC | 17 100 | 17 100 | |
0,03 % | Citadel Advisors LLC | 15 577 | −60 543 | |
0,03 % | Numeric Investors LLC | 15 361 | −98 179 | |
0,03 % | SG Americas Securities, L.L.C. | 15 101 | 1 544 | |
0,03 % | Virginia Retirement System | 14 900 | −700 | |
0,03 % | SEI Investments Management Corporation | 14 897 | 0 | |
0,03 % | MetLife Investment Management, LLC | 14 616 | 0 | |
0,03 % | LSV Asset Management | 14 416 | 0 | |
0,03 % | Zacks Investment Management, Inc. | 14 064 | 14 064 | |
0,03 % | SunAmerica Asset Management, LLC | 13 711 | −56 | |
0,02 % | Algert Global LLC | 12 540 | −4 010 | |
0,02 % | Ikarian Capital LLC | 12 116 | 0 | |
0,02 % | Principal Global Investors (Equity) | 12 037 | −94 | |
0,02 % | Parametric Portfolio Associates LLC | 11 941 | 1 325 | |
0,02 % | Manulife Investment Management (North America) Limited | 11 916 | 0 | |
0,02 % | Vaughan Nelson Investment Management, L.P. | 11 248 | 0 | |
0,02 % | Voya Investment Management LLC | 11 175 | 0 | |
0,02 % | Mairs and Power, Inc. | 10 815 | 0 | |
0,02 % | New York State Common Retirement Fund | 10 642 | −46 | |
0,02 % | State Street Global Advisors Ireland Limited | 10 228 | −37 | |
0,02 % | Wells Fargo Bank, N.A. | 8 500 | 1 682 | |
0,02 % | Nash (Huw Michael) | 7 999 | 7 999 | |
0,02 % | Simplex Trading, LLC | 7 979 | 5 298 | |
0,01 % | BNP Paribas Securities Corp. North America | 7 694 | −20 458 | |
0,01 % | Mackenzie Financial Corporation | 7 192 | 2 793 | |
0,01 % | RBC Wealth Management, International | 5 884 | 1 252 | |
0,01 % | Lazard Asset Management, L.L.C. | 5 779 | 222 | |
0,01 % | BNY Mellon Wealth Management | 5 636 | 426 | |
0,01 % | Conestoga Capital Advisors, LLC | 5 054 | −17 000 | |
0,01 % | Tower Research Capital LLC | 5 039 | 1 298 | |
0,01 % | ProShare Advisors LLC | 5 008 | 965 | |
0,01 % | Fidelity Management & Research Company LLC | 5 000 | 1 272 | |
0,01 % | Invesco Advisers, Inc. | 4 625 | −11 646 | |
0,01 % | California State Teachers Retirement System | 4 540 | −19 111 | |
0,01 % | Horizon Kinetics LLC | 4 233 | 0 | |