9,10 % | The Vanguard Group, Inc. | 25 418 388 | 979 857 | |
8,50 % | RA Capital Management, LP | 23 750 601 | 10 428 313 | |
6,68 % | BlackRock Institutional Trust Company, N.A. | 18 646 679 | 1 793 786 | |
5,88 % | Redmile Group, LLC | 16 423 922 | −1 079 495 | |
3,95 % | Janus Henderson Investors | 11 043 986 | −6 640 830 | |
2,89 % | State Street Global Advisors (US) | 8 075 671 | −1 476 181 | |
2,12 % | Fairmount Funds Management LLC | 5 929 592 | 0 | |
2,03 % | Pentwater Capital Management LP | 5 662 500 | 5 662 500 | |
1,98 % | Norges Bank Investment Management (NBIM) | 5 539 334 | 5 424 434 | |
1,93 % | Geode Capital Management, L.L.C. | 5 382 875 | 482 900 | |
1,92 % | Fidelity Investments Canada ULC | 5 360 000 | 5 360 000 | |
1,62 % | D. E. Shaw & Co., L.P. | 4 522 797 | −2 472 442 | |
1,60 % | Millennium Management LLC | 4 473 868 | 2 868 154 | |
1,15 % | Voloridge Investment Management, LLC | 3 221 231 | 708 980 | |
1,06 % | Boxer Capital, L.L.C. | 2 961 000 | 0 | |
1,05 % | Emerald Advisers LLC | 2 933 190 | −344 179 | |
0,89 % | Maverick Capital, Ltd. | 2 493 217 | −25 310 | |
0,83 % | TIG Advisors, L.L.C. | 2 313 670 | 2 313 670 | |
0,79 % | Morgan Stanley & Co. LLC | 2 209 536 | 64 583 | |
0,79 % | Tang Capital Management, LLC | 2 199 137 | 699 137 | |
0,76 % | Medical Strategy GmbH | 2 126 763 | 0 | |
0,74 % | Northern Trust Investments, Inc. | 2 072 998 | 62 196 | |
0,73 % | Nuveen LLC | 2 041 214 | −845 027 | |
0,73 % | Kryger Capital Limited | 2 036 155 | 2 036 155 | |
0,70 % | Wellington Management Company, LLP | 1 954 413 | −11 304 584 | |
0,68 % | Charles Schwab Investment Management, Inc. | 1 892 446 | 61 871 | |
0,65 % | Avidity Partners Management LP | 1 829 215 | −88 692 | |
0,64 % | HOOPP Investment Management | 1 785 296 | 1 485 296 | |
0,63 % | Alpine Associates Management Inc. | 1 761 300 | 1 749 300 | |
0,58 % | Renaissance Technologies LLC | 1 631 240 | 896 600 | |
0,58 % | Magnetar Capital Partners LP | 1 629 285 | 1 629 285 | |
0,55 % | Sofinnova Investments, Inc | 1 546 902 | −498 300 | |
0,54 % | AllianceBernstein L.P. | 1 507 809 | 1 207 295 | |
0,54 % | AQR Capital Management, LLC | 1 506 601 | 1 380 964 | |
0,54 % | Balyasny Asset Management LP | 1 496 758 | 1 484 838 | |
0,53 % | Morgan Stanley Investment Management Inc. (US) | 1 487 210 | −544 787 | |
0,51 % | Gabelli Funds, LLC | 1 422 804 | 1 422 804 | |
0,51 % | Kynam Capital Management LP | 1 422 503 | 1 422 503 | |
0,50 % | Affinity Asset Advisors LLC | 1 404 608 | 1 404 608 | |
0,49 % | QVT Financial LP | 1 375 900 | 0 | |
0,49 % | Westchester Capital Management, LLC | 1 364 927 | 1 364 927 | |
0,45 % | J.P. Morgan Securities LLC | 1 265 347 | 28 617 | |
0,45 % | BlackRock Financial Management, Inc. | 1 243 147 | −259 980 | |
0,42 % | Marshall Wace LLP | 1 187 027 | 1 187 027 | |
0,42 % | Artisan Partners Limited Partnership | 1 172 323 | −2 552 260 | |
0,40 % | Principal Global Investors (Equity) | 1 127 402 | 142 738 | |
0,40 % | Candriam Belgium S.A. | 1 122 598 | 10 | |
0,40 % | Candriam Luxembourg S.A. | 1 122 557 | 0 | |
0,36 % | Pinnacle Associates Ltd. | 1 011 792 | −4 364 | |
0,35 % | Pictet Asset Management Ltd. | 975 962 | −2 732 177 | |
0,35 % | Adage Capital Management, L.P. | 971 928 | 771 928 | |
0,35 % | BlackRock Advisors (UK) Limited | 971 070 | 19 799 | |
0,34 % | T. Rowe Price Associates, Inc. | 963 620 | −2 811 554 | |
0,34 % | Lombard Odier Asset Management (Europe) Ltd | 947 497 | −36 199 | |
0,32 % | BlackRock Asset Management Ireland Limited | 902 926 | −16 784 | |
0,32 % | Water Island Capital, LLC | 893 758 | 304 893 | |
0,32 % | Two Sigma Investments, LP | 887 018 | −2 035 717 | |
0,31 % | Avoro Capital Advisors LLC | 875 000 | 875 000 | |
0,30 % | Farallon Capital Management, L.L.C. | 842 000 | 842 000 | |
0,30 % | American Century Investment Management, Inc. | 836 134 | 137 018 | |
0,29 % | Goldman Sachs & Company, Inc. | 809 254 | −64 684 | |
0,28 % | Citadel Advisors LLC | 795 458 | −492 084 | |
0,27 % | Eventide Asset Management, LLC | 763 000 | −537 000 | |
0,27 % | Rock Springs Capital Management LP | 759 365 | 0 | |
0,27 % | BofA Global Research (US) | 755 774 | 270 386 | |
0,27 % | DWS Investments UK Limited | 751 326 | 630 590 | |
0,27 % | Eversept Partners, LP | 748 950 | 748 950 | |
0,26 % | Susquehanna International Group, LLP | 736 034 | −238 853 | |
0,26 % | AQR Arbitrage, LLC | 719 919 | 719 919 | |
0,24 % | IndexIQ Advisors LLC | 682 396 | 682 396 | |
0,24 % | Voya Investment Management LLC | 669 351 | 154 215 | |
0,24 % | BlackRock Investment Management, LLC | 661 835 | −13 096 | |
0,24 % | Decheng Capital LLC | 659 928 | 244 048 | |
0,24 % | BNY Mellon Asset Management | 659 833 | −30 822 | |
0,23 % | Sio Capital Management, LLC | 644 366 | 411 615 | |
0,23 % | Barclays Bank PLC | 640 777 | 302 253 | |
0,23 % | Jane Street Capital, L.L.C. | 634 353 | −283 411 | |
0,21 % | Superstring Capital Management LP | 598 072 | 598 072 | |
0,21 % | First Trust Capital Management L.P. | 596 720 | 596 720 | |
0,21 % | CPP Investment Board | 586 990 | 586 990 | |
0,20 % | Baillie Gifford & Co. | 566 529 | 0 | |
0,19 % | Melqart Asset Management (UK) Limited | 531 324 | 531 324 | |
0,19 % | HSBC Global Asset Management (UK) Limited | 519 779 | 519 779 | |
0,18 % | Invesco Capital Management LLC | 515 275 | 174 614 | |
0,18 % | Picton Mahoney Asset Management | 500 000 | 500 000 | |
0,18 % | CM Management, LLC | 500 000 | 0 | |
0,17 % | JPMorgan Private Bank (United States) | 482 994 | −20 174 | |
0,17 % | Schweizerische Nationalbank | 480 800 | 0 | |
0,17 % | Carlson Capital, L.P. | 466 188 | 466 188 | |
0,16 % | Slotnik Capital, LLC | 460 000 | 460 000 | |
0,16 % | Dimensional Fund Advisors, L.P. | 454 213 | −726 531 | |
0,16 % | Fidelity Management & Research Company LLC | 453 168 | −5 326 775 | |
0,15 % | Credit Suisse Funds AG | 417 277 | 128 166 | |
0,15 % | Segantii Capital Management Limited | 415 000 | 415 000 | |
0,15 % | PanAgora Asset Management Inc. | 409 658 | −688 759 | |
0,14 % | Woodline Partners LP | 400 000 | −2 033 161 | |
0,14 % | GLG LLC | 388 103 | 374 005 | |
0,14 % | Mellon Investments Corporation | 382 594 | −482 140 | |
0,13 % | Pictet Asset Management (Japan) Ltd. | 372 310 | 372 310 | |
0,13 % | Invesco Advisers, Inc. | 370 048 | −375 459 | |