9,74 % | Hyllengren (Eric J) | 477 171 | −6 679 | |
9,48 % | Fidelity Management & Research Company LLC | 464 715 | 229 176 | |
75,37 % | UBS Financial Services, Inc. | 3 693 225 | 3 634 733 | |
6,91 % | Heiden (William K) | 338 500 | 150 000 | |
6,37 % | BNY Mellon Asset Management | 312 333 | 60 449 | |
6,05 % | BNP Paribas Securities Corp. North America | 296 240 | 276 527 | |
6,01 % | BlackRock Investment Management, LLC | 294 328 | −26 563 | |
59,84 % | AQR Capital Management, LLC | 2 932 310 | 2 087 858 | |
59,61 % | Millennium Management LLC | 2 920 980 | 2 593 916 | |
56,82 % | State Street Global Advisors (US) | 2 784 200 | 261 514 | |
5,97 % | Marshall Wace LLP | 292 500 | 292 500 | |
5,96 % | BlackRock Financial Management, Inc. | 292 208 | −384 060 | |
5,63 % | Banard (Charlene A) | 276 010 | −19 040 | |
43,88 % | Geode Capital Management, L.L.C. | 2 150 150 | 73 575 | |
4,87 % | Fust (Matthew K.) | 238 500 | 150 000 | |
4,45 % | Roncarolo (Maria Grazia) | 218 000 | 150 000 | |
4,39 % | T. Rowe Price Associates, Inc. | 215 255 | 55 200 | |
4,26 % | Harbor Capital Advisors, Inc. | 208 827 | 164 206 | |
4,22 % | Mallik (Ameet) | 207 000 | 150 000 | |
4,03 % | Two Sigma Investments, LP | 197 427 | 197 427 | |
38,30 % | Kleiner, Perkins, Caufield & Byers | 1 876 650 | 1 876 650 | |
36,12 % | Morgan Stanley & Co. LLC | 1 769 876 | −252 119 | |
36,03 % | Acadian Asset Management LLC | 1 765 554 | 1 231 161 | |
33,12 % | Touchon (Pascal) | 1 623 023 | −24 844 | |
3,86 % | BofA Global Research (US) | 189 128 | 91 025 | |
3,66 % | Dupont (Jakob) | 179 348 | 136 254 | |
3,50 % | Joshi (Manher) | 171 284 | −12 287 | |
3,41 % | AllianceBernstein L.P. | 167 200 | −9 500 | |
3,24 % | JPMorgan Private Bank (United States) | 158 602 | −72 745 | |
25,64 % | JP Morgan Asset Management | 1 256 484 | −3 684 603 | |
21,10 % | D. E. Shaw & Co., L.P. | 1 033 992 | −2 876 424 | |
205,45 % | EcoR1 Capital, LLC | 10 067 043 | 0 | |
20,41 % | Antipodean Advisors LLC | 1 000 000 | 0 | |
20,41 % | Staley Capital Advisers, Inc. | 1 000 000 | 0 | |
2,97 % | Rhumbline Advisers Ltd. Partnership | 145 413 | −60 | |
2,87 % | Group One Trading, L.P. | 140 556 | 76 465 | |
2,71 % | Barclays Bank PLC | 132 847 | 116 114 | |
2,70 % | Jane Street Capital, L.L.C. | 132 177 | 108 773 | |
2,44 % | BlackRock (Netherlands) B.V. | 119 737 | 118 284 | |
2,43 % | Hennion & Walsh Asset Management, Inc. | 119 051 | 7 923 | |
2,39 % | HRT Financial LP | 117 267 | 117 267 | |
19,21 % | Nguyen (Anhco T) | 941 397 | −10 746 | |
185,85 % | Redmile Group, LLC | 9 106 446 | 2 825 633 | |
17,88 % | Medical Strategy GmbH | 876 186 | −221 061 | |
16,01 % | GSA Capital Partners LLP | 784 367 | 784 367 | |
15,94 % | Jacobs Levy Equity Management, Inc. | 780 986 | 214 090 | |
15,74 % | Northern Trust Investments, Inc. | 771 470 | 52 809 | |
15,71 % | JPMorgan Asset Management U.K. Limited | 769 632 | −2 703 318 | |
15,21 % | Charles Schwab Investment Management, Inc. | 745 145 | −48 412 | |
136,45 % | The Vanguard Group, Inc. | 6 686 043 | 80 110 | |
133,33 % | Citadel Advisors LLC | 6 533 119 | 6 270 068 | |
130,11 % | BlackRock Institutional Trust Company, N.A. | 6 375 547 | −276 910 | |
12,90 % | Murugan (Amar) | 632 107 | −10 044 | |
12,71 % | Renaissance Technologies LLC | 622 911 | −206 200 | |
12,02 % | Gallagher (Carol Giltner) | 588 918 | 150 000 | |
11,24 % | Henrich (Jill) | 550 545 | −3 879 | |
11,08 % | Dobmeier (Eric L) | 542 825 | 446 825 | |
10,94 % | Goldman Sachs & Company, Inc. | 536 269 | −3 533 636 | |
10,71 % | Pacific Heights Asset Management, LLC | 525 000 | 0 | |
1,95 % | Private Advisor Group LLC | 95 661 | 198 | |
1,95 % | Seidenberg (Beth C) | 95 583 | 57 000 | |
1,78 % | Susquehanna International Group, LLP | 87 415 | −126 428 | |
1,75 % | Koppikar (Utpal) | 85 856 | −6 871 | |
1,70 % | CAPTRUST Financial Advisors | 83 074 | 65 059 | |
1,68 % | Mellon Investments Corporation | 82 425 | 0 | |
1,63 % | Bank Vontobel AG | 80 000 | 80 000 | |
1,51 % | Northern Trust Global Investments | 73 957 | −6 304 | |
1,12 % | T. Rowe Price International Ltd | 54 991 | 0 | |
1,02 % | SG Americas Securities, L.L.C. | 49 924 | 11 181 | |
0,98 % | SunAmerica Asset Management, LLC | 48 141 | −194 | |
0,94 % | Goldman Sachs Asset Management, L.P. | 45 920 | −8 584 | |
0,92 % | State of Wisconsin Investment Board | 45 201 | 0 | |
0,83 % | Voya Investment Management LLC | 40 841 | −78 417 | |
0,81 % | New York State Common Retirement Fund | 39 541 | −143 | |
0,78 % | DWS Investments UK Limited | 38 055 | 0 | |
0,74 % | Cubist Systematic Strategies, LLC | 36 456 | −7 984 | |
0,74 % | Vaughan Nelson Investment Management, L.P. | 36 177 | 0 | |
0,73 % | XTX Markets LLC | 35 560 | 1 321 | |
0,73 % | Point72 Asset Management, L.P. | 35 536 | −519 464 | |
0,68 % | Principal Global Investors (Equity) | 33 306 | −2 161 | |
0,68 % | Invesco Advisers, Inc. | 33 187 | 7 249 | |
0,61 % | Engineers Gate Manager, L.P. | 30 091 | 15 971 | |
0,61 % | Wexford Capital LP | 29 940 | 29 940 | |
0,60 % | Wells Fargo Bank, N.A. | 29 365 | 5 872 | |
0,56 % | Envestnet Asset Management, Inc. | 27 612 | −16 137 | |
0,55 % | Renta 4 Gestora, S.G.I.I.C., S.A. | 27 017 | −571 | |
0,55 % | PGIM Quantitative Solutions LLC | 26 838 | 26 838 | |
0,51 % | Manulife Investment Management (North America) Limited | 25 174 | −17 912 | |
0,51 % | Florida State Board of Administration | 25 159 | 25 159 | |
0,51 % | Wellington Management Company, LLP | 24 955 | −125 | |
0,47 % | Franklin Advisers, Inc. | 23 026 | 0 | |
0,43 % | SVB Wealth LLC | 21 078 | 10 014 | |
0,42 % | RBC Wealth Management, International | 20 661 | 4 842 | |
0,41 % | Tower Research Capital LLC | 20 300 | 12 149 | |
0,41 % | Carson Wealth Management Group | 19 946 | 6 184 | |
0,40 % | Raymond James & Associates, Inc. | 19 591 | −170 051 | |
0,38 % | Virtu Americas LLC | 18 482 | 8 155 | |
0,36 % | Letko, Brosseau & Associates Inc. | 17 500 | 0 | |
0,33 % | Commonwealth Financial Network | 16 293 | 16 293 | |
0,33 % | ProShare Advisors LLC | 16 030 | −3 161 | |