9,87331 % | Artisan Partners Limited Partnership | 5 749 227 | −246 181 | |
8,19423 % | Fidelity Management & Research Company LLC | 4 771 502 | −21 813 | |
6,92192 % | Westfield Capital Management Company, L.P. | 4 030 634 | 228 457 | |
6,86036 % | Janus Henderson Investors | 3 994 785 | 140 252 | |
6,85185 % | T. Rowe Price Investment Management, Inc. | 3 989 830 | 5 327 | |
6,44952 % | Avoro Capital Advisors LLC | 3 755 555 | 85 555 | |
5,57838 % | Wellington Management Company, LLP | 3 248 293 | −28 879 | |
3,74595 % | Capital International Investors | 2 181 268 | 12 825 | |
2,60752 % | MFS Investment Management | 1 518 356 | 254 634 | |
2,48145 % | T. Rowe Price Associates, Inc. | 1 444 950 | −192 898 | |
17,35772 % | RA Capital Management, LP | 10 107 400 | −612 155 | |
1,81854 % | Franklin Advisers, Inc. | 1 058 937 | −148 698 | |
1,47038 % | Invesco Advisers, Inc. | 856 203 | 237 928 | |
1,36175 % | TimesSquare Capital Management, LLC | 792 945 | −49 856 | |
1,29492 % | Sofinnova Investments, Inc | 754 032 | 0 | |
1,24618 % | Putnam Investment Management, L.L.C. | 725 651 | −46 711 | |
1,07333 % | Vestal Point Capital, LP | 625 000 | 625 000 | |
1,01140 % | AllianceBernstein L.P. | 588 936 | −13 938 | |
0,92727 % | Spyglass Capital Management LLC | 539 948 | −74 670 | |
0,91346 % | Capital World Investors | 531 910 | 3 296 | |
0,86888 % | Brown Advisory | 505 947 | −4 162 | |
0,72691 % | Mikkelsen Jan Moller | 423 279 | 423 279 | |
0,72618 % | Goldman Sachs & Company, Inc. | 422 854 | 12 881 | |
0,71184 % | Medical Strategy GmbH | 414 506 | −6 000 | |
0,62138 % | SEI Investments Management Corporation | 361 830 | −34 610 | |
0,62001 % | DWS Investment GmbH | 361 029 | 0 | |
0,60398 % | Paradigm BioCapital Advisors LP | 351 700 | 351 700 | |
0,58882 % | Fidelity Institutional Asset Management | 342 867 | −100 | |
0,52849 % | American Century Investment Management, Inc. | 307 737 | −21 537 | |
0,52355 % | BlackRock Institutional Trust Company, N.A. | 304 862 | 12 231 | |
0,50531 % | Florida State Board of Administration | 294 243 | 128 050 | |
0,49803 % | Rock Springs Capital Management LP | 290 000 | −135 500 | |
0,48944 % | Q Global Advisors, LLC | 285 000 | 0 | |
0,48556 % | ARS Investment Partners LLC | 282 744 | −3 174 | |
0,45536 % | D. E. Shaw & Co., L.P. | 265 157 | 44 604 | |
0,42002 % | TD Asset Management Inc. | 244 578 | −22 782 | |
0,35128 % | New York State Common Retirement Fund | 204 548 | −152 | |
0,34974 % | Pictet Asset Management Ltd. | 203 654 | 32 784 | |
0,34261 % | The Vanguard Group, Inc. | 199 499 | −233 494 | |
0,33231 % | Fred Alger Management, LLC | 193 502 | −76 503 | |
0,32493 % | Allspring Global Investments, LLC | 189 208 | −13 964 | |
0,31059 % | Eventide Asset Management, LLC | 180 857 | −394 581 | |
0,29464 % | Citadel Advisors LLC | 171 571 | 171 323 | |
0,29003 % | Rice Hall James & Associates, LLC | 168 883 | −904 | |
0,28336 % | Camber Capital Management LP | 165 000 | 165 000 | |
0,28125 % | Finepoint Capital LP | 163 772 | 0 | |
0,27671 % | Mellon Investments Corporation | 161 126 | −16 274 | |
0,26032 % | First Turn Management, LLC | 151 587 | 151 587 | |
0,24730 % | Adage Capital Management, L.P. | 144 000 | −382 371 | |
0,24159 % | BofA Global Research (US) | 140 677 | −94 453 | |
0,23835 % | Tekla Capital Management LLC_NLE | 138 791 | 15 000 | |
0,23835 % | abrdn Inc. | 138 791 | 138 791 | |
0,22699 % | Perceptive Advisors LLC | 132 176 | 132 176 | |
0,22627 % | Saturn V Capital Management LLC | 131 759 | 19 286 | |
0,21450 % | Schonfeld Strategic Advisors LLC | 124 901 | 86 001 | |
0,21204 % | Dafna Capital Management, LLC | 123 472 | −12 740 | |
0,19451 % | Thrivent Asset Management, LLC | 113 264 | −2 190 | |
0,19081 % | HSBC Global Asset Management (UK) Limited | 111 107 | 111 107 | |
0,17227 % | Principal Global Investors (Equity) | 100 313 | 15 598 | |
0,17096 % | Tri Locum Partners LP | 99 550 | 99 550 | |
0,17066 % | Candriam Luxembourg S.A. | 99 375 | 0 | |
0,17066 % | Candriam Belgium S.A. | 99 375 | −40 000 | |
0,14804 % | BNP Paribas Asset Management USA, Inc. | 86 202 | 41 334 | |
0,14025 % | Baillie Gifford & Co. | 81 670 | −4 651 | |
0,13945 % | Pictet Asset Management (Japan) Ltd. | 81 199 | 81 199 | |
0,12594 % | Voloridge Investment Management, LLC | 73 335 | 53 427 | |
0,12021 % | Tang Capital Management, LLC | 70 000 | 60 000 | |
0,11600 % | Ensign Peak Advisors, Inc. | 67 544 | 0 | |
0,11415 % | Morgan Stanley & Co. LLC | 66 470 | 44 517 | |
0,10701 % | Columbia Threadneedle Investments (US) | 62 310 | 1 734 | |
0,09461 % | Geode Capital Management, L.L.C. | 55 090 | 535 | |
0,09300 % | AEGON Investment Management B.V. | 54 156 | −2 390 | |
0,08879 % | Gray Foundation | 51 700 | 51 700 | |
0,07880 % | Adar1 Capital Management LLC | 45 884 | 45 884 | |
0,07758 % | JPMorgan Private Bank (United States) | 45 172 | −6 802 | |
0,07439 % | INVESCO Asset Management Limited | 43 320 | −2 486 | |
0,06546 % | Assenagon Asset Management S.A. | 38 120 | 2 800 | |
0,06251 % | Resolute Capital Asset Partners LLC | 36 400 | −1 100 | |
0,06144 % | Baillie Gifford Overseas Ltd. | 35 774 | 1 418 | |
0,05948 % | Matisse Capital | 34 635 | 8 380 | |
0,05877 % | Parametric Portfolio Associates LLC | 34 224 | 857 | |
0,05431 % | Newton Investment Management North America, LLC | 31 627 | −1 397 | |
0,05404 % | Jane Street Capital, L.L.C. | 31 468 | 6 751 | |
0,05367 % | State Street Global Advisors (US) | 31 252 | 525 | |
0,05313 % | BlackRock Advisors (UK) Limited | 30 939 | 1 697 | |
0,05225 % | Goldman Sachs Asset Management International | 30 423 | 0 | |
0,05152 % | Deka Vermögensmanagement GmbH | 30 000 | 0 | |
0,04840 % | BlackRock Asset Management Ireland Limited | 28 183 | 3 454 | |
0,04817 % | CAPTRUST Financial Advisors | 28 051 | 4 022 | |
0,04809 % | Jefferies LLC | 28 000 | 25 500 | |
0,04796 % | UBS Financial Services, Inc. | 27 927 | −15 304 | |
0,04649 % | Evoke Advisors | 27 069 | 27 069 | |
0,04293 % | Altium Capital Management LP | 25 000 | 25 000 | |
0,04207 % | Henry James International Management, Inc. | 24 495 | 0 | |
0,04139 % | Wellington Management Japan Pte Ltd | 24 099 | 3 863 | |
0,03913 % | Manulife Investment Management (North America) Limited | 22 788 | −2 785 | |
0,03845 % | Millennium Management LLC | 22 391 | −20 461 | |
0,03512 % | Morgan Stanley Smith Barney LLC | 20 450 | −180 | |
0,03435 % | Deka Investment GmbH | 20 000 | 4 940 | |
0,03435 % | Ghost Tree Capital, LLC | 20 000 | −65 000 | |