9,83 % | EcoR1 Capital, LLC | 6 726 491 | 1 259 428 | |
7,08 % | The Vanguard Group, Inc. | 4 842 174 | 243 167 | |
6,16 % | RTW Investments L.P. | 4 213 483 | 4 213 483 | |
6,09 % | BlackRock Institutional Trust Company, N.A. | 4 168 085 | 357 244 | |
5,45 % | T. Rowe Price Associates, Inc. | 3 728 873 | 1 132 898 | |
4,36 % | Avidity Partners Management LP | 2 985 117 | 370 157 | |
3,66 % | Bellevue Asset Management AG | 2 507 731 | 382 531 | |
3,57 % | Citadel Advisors LLC | 2 439 981 | 1 815 403 | |
2,48 % | Nextech Invest, Ltd. | 1 695 645 | 1 408 394 | |
2,29 % | ArrowMark Colorado Holdings, LLC | 1 569 895 | −517 397 | |
1,88 % | New Leaf Venture Partners LLC | 1 289 521 | 0 | |
1,74 % | Fidelity Institutional Asset Management | 1 189 011 | −374 164 | |
1,73 % | State Street Global Advisors (US) | 1 186 474 | 27 022 | |
1,64 % | Geode Capital Management, L.L.C. | 1 122 627 | 65 237 | |
1,57 % | JP Morgan Asset Management | 1 073 854 | −138 077 | |
1,54 % | Fidelity Management & Research Company LLC | 1 055 008 | −2 250 112 | |
1,54 % | Houston (John G) | 1 054 191 | 119 254 | |
1,49 % | JPMorgan Asset Management U.K. Limited | 1 017 463 | 307 192 | |
1,46 % | Commodore Capital LP | 1 000 000 | 1 000 000 | |
1,36 % | Paradigm BioCapital Advisors LP | 931 303 | 931 303 | |
1,28 % | Norges Bank Investment Management (NBIM) | 877 708 | 175 953 | |
1,15 % | Adage Capital Management, L.P. | 789 485 | 789 485 | |
1,09 % | Holocene Advisors, LP | 744 465 | 744 465 | |
1,09 % | BlackRock Financial Management, Inc. | 743 728 | −6 676 | |
0,92 % | VR Adviser, LLC | 627 788 | 627 788 | |
0,89 % | Boxer Capital, L.L.C. | 608 614 | 608 614 | |
0,83 % | Morgan Stanley & Co. LLC | 566 003 | 245 460 | |
0,74 % | Finepoint Capital LP | 504 700 | 0 | |
0,72 % | Dimensional Fund Advisors, L.P. | 491 877 | 22 479 | |
0,71 % | Aquilo Capital Management, LLC | 489 153 | 0 | |
0,71 % | Candriam Belgium S.A. | 487 555 | 40 004 | |
0,69 % | Charles Schwab Investment Management, Inc. | 469 474 | 39 484 | |
0,68 % | Candriam Luxembourg S.A. | 462 536 | −25 000 | |
0,65 % | Northern Trust Investments, Inc. | 442 512 | 24 794 | |
0,62 % | RA Capital Management, LP | 421 348 | 421 348 | |
0,58 % | American Century Investment Management, Inc. | 395 367 | −418 102 | |
0,57 % | Woodline Partners LP | 387 630 | 215 030 | |
0,52 % | Millennium Management LLC | 358 813 | −469 314 | |
0,52 % | Nuveen LLC | 354 898 | 17 738 | |
0,52 % | Perceptive Advisors LLC | 354 082 | 354 082 | |
0,49 % | Gilder Gagnon Howe & Co. LLC | 333 524 | 162 674 | |
0,45 % | Voloridge Investment Management, LLC | 309 663 | 309 663 | |
0,42 % | Frazier Healthcare Partners | 285 331 | 0 | |
0,41 % | Nordea Funds Oy | 278 737 | −6 317 | |
0,39 % | Brown Advisory | 265 431 | −170 163 | |
0,39 % | Opaleye Management Inc. | 263 700 | 263 700 | |
0,38 % | UBS Financial Services, Inc. | 256 986 | −62 752 | |
0,36 % | Schonfeld Strategic Advisors LLC | 245 868 | 181 874 | |
0,35 % | Renaissance Technologies LLC | 237 573 | 123 873 | |
0,34 % | Great Point Partners, LLC | 234 082 | 234 082 | |
0,32 % | Goldman Sachs & Company, Inc. | 215 728 | 115 219 | |
0,31 % | BlackRock Advisors (UK) Limited | 208 919 | 10 242 | |
0,30 % | Wasatch Global Investors Inc | 207 426 | −15 516 | |
0,29 % | BNP Paribas Securities Corp. North America | 197 052 | 97 661 | |
0,29 % | Amundi Asset Management US, Inc. | 195 720 | 4 423 | |
0,27 % | Cassidy (Sean A) | 186 707 | −1 702 | |
0,26 % | Integral Health Asset Management, LLC | 175 000 | 175 000 | |
0,26 % | BlackRock Asset Management Ireland Limited | 174 728 | 974 | |
0,24 % | Parkman Healthcare Partners LLC | 167 001 | 62 884 | |
0,23 % | UBS Asset Management (Americas), Inc. | 155 129 | 45 932 | |
0,23 % | BofA Global Research (US) | 155 036 | 47 492 | |
0,22 % | Invesco Capital Management LLC | 150 516 | 129 312 | |
0,22 % | Taylor (Ian) | 150 207 | 37 549 | |
0,22 % | Wanjia Asset Management Co., Ltd. | 150 000 | 0 | |
0,22 % | BlackRock Investment Management, LLC | 149 116 | 26 694 | |
0,21 % | TD Asset Management Inc. | 146 948 | 52 076 | |
0,21 % | Yale University | 143 522 | 143 522 | |
0,21 % | Credit Suisse Funds AG | 142 108 | 86 845 | |
0,20 % | Citi Investment Research (US) | 138 656 | 133 966 | |
0,20 % | Federated MDTA LLC | 138 028 | 33 770 | |
0,20 % | BNY Mellon Asset Management | 136 085 | −2 556 | |
0,20 % | Rhenman & Partners Asset Management AB | 134 270 | 49 270 | |
0,19 % | Nordea Investment Management AB (Denmark) | 131 494 | 55 | |
0,17 % | First Trust Advisors L.P. | 114 105 | 1 569 | |
0,17 % | Goldman Sachs Asset Management, L.P. | 113 731 | 19 590 | |
0,15 % | T. Rowe Price International Ltd | 103 250 | 10 554 | |
0,15 % | Putnam Investment Management, L.L.C. | 103 118 | 87 671 | |
0,15 % | Parametric Portfolio Associates LLC | 101 826 | 36 189 | |
0,14 % | Jane Street Capital, L.L.C. | 97 217 | 46 894 | |
0,14 % | Banque Pictet & Cie S.A. | 92 933 | 92 933 | |
0,13 % | UBS O'Connor LLC | 91 132 | −19 050 | |
0,13 % | Schweizerische Nationalbank | 89 500 | −10 200 | |
0,13 % | Manulife Investment Management (North America) Limited | 89 228 | 21 911 | |
0,12 % | D. E. Shaw & Co., L.P. | 84 931 | 64 131 | |
0,12 % | Barclays Bank PLC | 83 621 | 49 824 | |
0,12 % | Shannon (Timothy M) | 80 643 | 0 | |
0,12 % | Tang Capital Management, LLC | 80 000 | 0 | |
0,11 % | Algert Global LLC | 74 571 | −98 847 | |
0,11 % | HOOPP Investment Management | 74 000 | 74 000 | |
0,11 % | Columbia Threadneedle Investments (US) | 73 975 | 15 190 | |
0,10 % | Zacks Investment Management, Inc. | 71 695 | 64 306 | |
0,10 % | CastleArk Management, LLC | 71 570 | 71 570 | |
0,10 % | JPMorgan Private Bank (United States) | 70 612 | 22 263 | |
0,10 % | Rhumbline Advisers Ltd. Partnership | 68 890 | −110 | |
0,10 % | Conestoga Capital Advisors, LLC | 67 640 | −1 837 | |
0,10 % | Bank Vontobel AG | 66 000 | 66 000 | |
0,10 % | Sectoral Asset Management Inc. | 66 000 | 58 990 | |
0,09 % | Berkowitz (Noah) | 63 452 | 63 452 | |
0,09 % | Hennion & Walsh Asset Management, Inc. | 61 862 | 25 778 | |
0,09 % | Trexquant Investment LP | 61 243 | 61 243 | |