| 9,83 % | Wellington Management Company, LLP | 6.476.561 | 1.044.728 | 31/12/2023 |
| 9,21 % | Fidelity Management & Research Company LLC | 6.073.162 | -200.884 | 31/12/2023 |
| 5,51 % | Eventide Asset Management, LLC | 3.630.013 | 2.030.013 | 31/12/2023 |
| 5,25 % | RTW Investments L.P. | 3.463.201 | 0 | 31/12/2023 |
| 5,03 % | BlackRock Institutional Trust Company, N.A. | 3.313.502 | 429.668 | 31/12/2023 |
| 4,76 % | Polar Capital LLP | 3.135.871 | 709.115 | 31/12/2023 |
| 4,61 % | The Vanguard Group, Inc. | 3.035.675 | 425.500 | 31/12/2023 |
| 4,56 % | Kynam Capital Management LP | 3.005.904 | -194.096 | 31/12/2023 |
| 4,18 % | Point72 Asset Management, L.P. | 2.756.122 | -866.014 | 31/12/2023 |
| 3,67 % | Bellevue Asset Management AG | 2.416.296 | 516.296 | 31/12/2023 |
| 3,61 % | State Street Global Advisors (US) | 2.377.326 | 84.475 | 31/12/2023 |
| 3,38 % | Pictet Asset Management Ltd. | 2.225.448 | 374.478 | 31/12/2023 |
| 1,94 % | Marshall Wace LLP | 1.280.084 | 741.765 | 31/12/2023 |
| 1,70 % | Geode Capital Management, L.L.C. | 1.117.994 | 117.569 | 31/12/2023 |
| 1,51 % | Redmile Group, LLC | 993.803 | -642.135 | 31/12/2023 |
| 1,48 % | Fidelity Institutional Asset Management | 977.247 | 162.173 | 31/12/2023 |
| 1,47 % | Rock Springs Capital Management LP | 969.646 | 469.545 | 31/12/2023 |
| 1,28 % | Sofinnova Investments, Inc | 844.008 | 419.749 | 31/12/2023 |
| 1,14 % | Eversept Partners, LP | 754.107 | 165.964 | 31/12/2023 |
| 1,07 % | Octagon Capital Advisors LP | 707.526 | -52.372 | 31/12/2023 |
| 1,07 % | Commodore Capital LP | 701.967 | -4.698 | 31/12/2023 |
| 0,94 % | Morgan Stanley & Co. LLC | 622.813 | 119.544 | 31/12/2023 |
| 0,75 % | 5AM Ventures | 497.270 | 187.000 | 31/12/2023 |
| 0,62 % | Charles Schwab Investment Management, Inc. | 409.391 | 47.844 | 31/12/2023 |
| 0,61 % | Northern Trust Investments, Inc. | 400.112 | 27.920 | 31/12/2023 |
| 0,61 % | Affinity Asset Advisors LLC | 400.000 | 250.000 | 31/12/2023 |
| 0,59 % | Goldman Sachs & Company, Inc. | 388.404 | 12.964 | 31/12/2023 |
| 0,59 % | Woodline Partners LP | 387.652 | 280.156 | 31/12/2023 |
| 0,59 % | T. Rowe Price Associates, Inc. | 385.809 | -47.814 | 31/12/2023 |
| 0,48 % | Candriam Luxembourg S.A. | 317.509 | 0 | 29/2/2024 |
| 0,48 % | Candriam Belgium S.A. | 317.509 | -5.000 | 31/12/2023 |
| 0,48 % | Sphera Funds Management Ltd. | 315.644 | 135.644 | 31/12/2023 |
| 0,38 % | TSP Capital Management Group, LLC | 251.495 | -200 | 31/12/2023 |
| 0,38 % | Baker Bros. Advisors LP | 247.644 | 247.644 | 31/12/2023 |
| 0,38 % | SilverArc Capital Management, LLC | 247.215 | 247.215 | 31/12/2023 |
| 0,37 % | Medical Strategy GmbH | 243.942 | 6.400 | 31/12/2023 |
| 0,36 % | Invesco Capital Management LLC | 235.612 | 217.783 | 31/12/2023 |
| 0,35 % | Dimensional Fund Advisors, L.P. | 230.471 | -110.879 | 31/12/2023 |
| 0,33 % | BofA Global Research (US) | 216.133 | 4.695 | 31/12/2023 |
| 0,27 % | Ensign Peak Advisors, Inc. | 179.611 | 87.482 | 31/12/2023 |
| 0,26 % | Walleye Capital LLC | 169.268 | 10.275 | 31/12/2023 |
| 0,25 % | Nomura Asset Management Co., Ltd. | 163.501 | 163.501 | 30/11/2023 |
| 0,24 % | American Century Investment Management, Inc. | 161.051 | 191 | 31/12/2023 |
| 0,24 % | UBS Financial Services, Inc. | 158.092 | 136.897 | 31/12/2023 |
| 0,22 % | Rafferty Asset Management LLC | 148.009 | -16.781 | 31/12/2023 |
| 0,22 % | Barclays Bank PLC | 144.345 | 2.295 | 31/12/2023 |
| 0,22 % | AXA Investment Managers UK Ltd. | 142.170 | -3.439 | 31/12/2023 |
| 0,21 % | BlackRock Financial Management, Inc. | 139.006 | 3.916 | 31/12/2023 |
| 0,21 % | Laurion Capital Management LP | 138.531 | 138.531 | 31/12/2023 |
| 0,21 % | BNP Paribas Securities Corp. North America | 136.601 | 44.878 | 31/12/2023 |
| 0,20 % | Schonfeld Strategic Advisors LLC | 130.542 | 130.542 | 31/12/2023 |
| 0,20 % | MacKay Shields LLC | 128.803 | 0 | 31/8/2022 |
| 0,19 % | Jane Street Capital, L.L.C. | 128.161 | 68.747 | 31/12/2023 |
| 0,19 % | BNY Mellon Asset Management | 127.836 | 4.661 | 31/12/2023 |
| 0,19 % | Citadel Advisors LLC | 126.328 | 120.403 | 31/12/2023 |
| 0,19 % | BlackRock Investment Management, LLC | 123.393 | 1.115 | 31/12/2023 |
| 0,18 % | Nuveen LLC | 120.076 | -204 | 31/12/2023 |
| 0,17 % | Exome Asset Management LLC | 111.300 | 111.300 | 31/12/2023 |
| 0,16 % | Mirador Capital Partners LP | 104.759 | -3.151 | 31/3/2024 |
| 0,15 % | Monashee Investment Management, LLC | 100.209 | 100.209 | 31/12/2023 |
| 0,15 % | Schweizerische Nationalbank | 97.000 | 8.700 | 31/12/2023 |
| 0,14 % | Polar Asset Management Partners Inc. | 94.300 | -38.100 | 31/12/2023 |
| 0,12 % | UBS Switzerland AG | 80.235 | 0 | 31/12/2023 |
| 0,12 % | Rhumbline Advisers Ltd. Partnership | 76.022 | -652 | 31/12/2023 |
| 0,11 % | Acuta Capital Partners, LLC | 69.400 | -52.941 | 31/12/2023 |
| 0,10 % | Crestline Investors, Inc. | 67.243 | 4.133 | 31/12/2023 |
| 0,10 % | BlackRock Advisors (UK) Limited | 63.854 | 1.366 | 31/3/2024 |
| 0,09 % | Citi Investment Research (US) | 62.341 | -7.014 | 31/12/2023 |
| 0,09 % | Kennedy Capital Management LLC | 62.172 | -25.222 | 31/12/2023 |
| 0,09 % | OrbiMed Advisors, LLC | 58.800 | 58.800 | 31/12/2023 |
| 0,08 % | AllianceBernstein L.P. | 54.080 | -39.201 | 31/12/2023 |
| 0,08 % | TD Asset Management Inc. | 52.322 | -12.600 | 31/12/2023 |
| 0,08 % | Legal & General Investment Management Ltd. | 52.012 | 11.168 | 31/12/2023 |
| 0,08 % | Wellington Management Japan Pte Ltd | 51.854 | -16.384 | 30/6/2023 |
| 0,08 % | California State Teachers Retirement System | 51.474 | 5.721 | 31/12/2023 |
| 0,08 % | HBM Partners AG | 50.000 | 0 | 30/9/2023 |
| 0,07 % | Goldman Sachs Asset Management, L.P. | 49.355 | 12.961 | 31/12/2023 |
| 0,07 % | Susquehanna International Group, LLP | 48.888 | -8.572 | 31/12/2023 |
| 0,07 % | International Biotechnology Trust PLC | 48.099 | 0 | 30/9/2023 |
| 0,07 % | Schroder Investment Management Ltd. (SIM) | 48.099 | 48.099 | 31/12/2023 |
| 0,07 % | Credit Suisse Funds AG | 47.998 | 8.352 | 31/12/2023 |
| 0,07 % | Young (Diane C) | 47.115 | 0 | 5/4/2023 |
| 0,07 % | BlackRock Asset Management Ireland Limited | 46.821 | 3.562 | 31/12/2023 |
| 0,07 % | SG Americas Securities, L.L.C. | 46.083 | -31.928 | 31/12/2023 |
| 0,07 % | Monarch Partners Asset Management LLC | 45.479 | 45.479 | 31/12/2022 |
| 0,07 % | Qube Research & Technologies Ltd | 44.968 | 40.669 | 31/12/2023 |
| 0,07 % | Manulife Investment Management (North America) Limited | 43.427 | -6.405 | 31/12/2023 |
| 0,06 % | JPMorgan Private Bank (United States) | 41.331 | 36.735 | 31/12/2023 |
| 0,06 % | Mellon Investments Corporation | 41.252 | 321 | 31/12/2023 |
| 0,06 % | Atom Investors LP | 40.882 | 40.882 | 31/12/2023 |
| 0,06 % | State of Wisconsin Investment Board | 40.518 | 8.569 | 31/12/2023 |
| 0,06 % | Caption Management, LLC | 39.700 | 26.700 | 31/12/2023 |
| 0,06 % | Alps Advisors, Inc. | 37.645 | 2.797 | 31/12/2023 |
| 0,06 % | TwinBeech Capital LP | 37.177 | -25.406 | 31/12/2023 |
| 0,06 % | Northern Trust Global Investments | 36.637 | -50.169 | 31/12/2023 |
| 0,06 % | T. Rowe Price International Ltd | 36.484 | 2.052 | 31/12/2023 |
| 0,05 % | Martin (Samuel Bates) | 35.128 | 10.750 | 2/1/2024 |
| 0,05 % | PFM Health Sciences, LP | 35.000 | 35.000 | 31/12/2023 |
| 0,05 % | JP Morgan Asset Management | 34.139 | -23.937 | 31/12/2023 |
| 0,05 % | Kentucky Teachers' Retirement System | 32.697 | 0 | 31/12/2023 |
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