7,79 % | RA Capital Management, LP | 46 202 425 | 0 | 31.12.2023 |
6,41 % | BlackRock Institutional Trust Company, N.A. | 38 042 621 | 4 941 607 | 31.12.2023 |
4,99 % | Deep Track Capital LP | 29 583 449 | 3 883 449 | 31.12.2023 |
4,80 % | The Vanguard Group, Inc. | 28 475 212 | 1 914 328 | 31.12.2023 |
4,32 % | State Street Global Advisors (US) | 25 625 606 | 254 221 | 31.12.2023 |
4,07 % | Vivo Capital, LLC | 24 143 681 | 7 619 047 | 31.12.2023 |
3,94 % | TCG Crossover Management, LLC | 23 375 839 | 0 | 31.12.2023 |
3,84 % | New Enterprise Associates (NEA) | 22 776 409 | 0 | 31.12.2023 |
2,48 % | Millennium Management LLC | 14 730 986 | −1 342 120 | 31.12.2023 |
1,85 % | Geode Capital Management, L.L.C. | 10 943 649 | 930 747 | 31.12.2023 |
1,81 % | BioImpact Capital LLC | 10 715 620 | 3139 | 31.12.2023 |
1,74 % | Morgan Stanley & Co. LLC | 10 302 068 | 9 157 822 | 31.12.2023 |
1,60 % | Wellington Management Company, LLP | 9 484 971 | −920 655 | 31.12.2023 |
1,49 % | Sofinnova Investments, Inc | 8 814 497 | 5 111 951 | 31.12.2023 |
1,19 % | Fidelity Management & Research Company LLC | 7 032 352 | −528 714 | 31.12.2023 |
1,15 % | DWS Investment S.A. | 6 826 599 | 6 826 599 | 31.12.2023 |
0,75 % | Northern Trust Investments, Inc. | 4 429 376 | 239 975 | 31.12.2023 |
0,75 % | Segall Bryant & Hamill, LLC | 4 419 820 | −570 679 | 31.12.2023 |
0,70 % | Invesco Capital Management LLC | 4 171 546 | −184 093 | 31.12.2023 |
0,65 % | Charles Schwab Investment Management, Inc. | 3 842 500 | 208 170 | 31.12.2023 |
0,56 % | Armistice Capital LLC | 3 296 000 | −328 000 | 31.12.2023 |
0,51 % | Boxer Capital, L.L.C. | 3 000 000 | 0 | 31.12.2023 |
0,50 % | Ally Bridge Group NY LLC | 2 971 639 | 750 000 | 31.12.2023 |
0,47 % | Goldman Sachs & Company, Inc. | 2 770 966 | −325 946 | 31.12.2023 |
0,35 % | Marshall Wace LLP | 2 078 497 | −3 782 148 | 31.12.2023 |
0,28 % | Rafferty Asset Management LLC | 1 669 087 | −233 179 | 31.12.2023 |
0,27 % | Medical Strategy GmbH | 1 618 263 | −216 663 | 31.12.2023 |
0,27 % | Barclays Bank PLC | 1 575 585 | 11 236 | 31.12.2023 |
0,25 % | Nuveen LLC | 1 473 442 | 7728 | 31.12.2023 |
0,24 % | UBS Financial Services, Inc. | 1 441 603 | 790 423 | 31.12.2023 |
0,23 % | BNY Mellon Asset Management | 1 361 074 | 94 097 | 31.12.2023 |
0,22 % | BlackRock Financial Management, Inc. | 1 323 304 | 4061 | 31.12.2023 |
0,22 % | MML Investors Services, LLC | 1 295 228 | 0 | 31.12.2023 |
0,22 % | Walleye Capital LLC | 1 275 514 | −950 552 | 31.12.2023 |
0,21 % | BlackRock Investment Management, LLC | 1 250 278 | 12 865 | 31.12.2023 |
0,21 % | Russell Investments Trust Company | 1 237 234 | 204 765 | 31.12.2023 |
0,20 % | JP Morgan Asset Management | 1 197 956 | −236 289 | 31.12.2023 |
0,19 % | Kennedy Capital Management LLC | 1 135 195 | 1 135 195 | 31.12.2023 |
0,17 % | BlackRock Advisors (UK) Limited | 989 520 | 34 941 | 31.3.2024 |
0,15 % | Nan Fung Life Sciences | 913 550 | 160 000 | 31.12.2023 |
0,14 % | BlackRock Asset Management Ireland Limited | 828 598 | 48 443 | 31.12.2023 |
0,13 % | Velan Capital Investment Management LP | 778 500 | 0 | 31.12.2023 |
0,13 % | Schweizerische Nationalbank | 773 600 | −232 900 | 31.12.2023 |
0,12 % | BNP Paribas Securities Corp. North America | 714 012 | 196 328 | 31.12.2023 |
0,12 % | Citi Investment Research (US) | 711 949 | −93 962 | 31.12.2023 |
0,12 % | Rhumbline Advisers Ltd. Partnership | 709 143 | 3157 | 31.12.2023 |
0,12 % | Susquehanna International Group, LLP | 699 443 | 227 634 | 31.12.2023 |
0,12 % | Crestline Investors, Inc. | 687 378 | 102 227 | 31.12.2023 |
0,11 % | Credit Suisse Funds AG | 669 128 | 25 745 | 31.12.2023 |
0,11 % | Citadel Advisors LLC | 643 164 | 251 455 | 31.12.2023 |
0,10 % | Columbia Threadneedle Investments (US) | 617 363 | 13 262 | 31.12.2023 |
0,10 % | Jane Street Capital, L.L.C. | 613 415 | 425 063 | 31.12.2023 |
0,10 % | Exome Asset Management LLC | 607 500 | 607 500 | 31.12.2023 |
0,09 % | BofA Global Research (US) | 546 796 | −657 273 | 31.12.2023 |
0,09 % | AllianceBernstein L.P. | 512 741 | 0 | 31.12.2023 |
0,08 % | HealthCor Management, L.P. | 500 000 | −1 404 234 | 31.12.2022 |
0,08 % | OrbiMed Advisors, LLC | 485 000 | 485 000 | 31.12.2023 |
0,08 % | Qube Research & Technologies Ltd | 466 674 | 466 674 | 31.12.2023 |
0,08 % | Northern Trust Global Investments | 452 765 | −416 531 | 31.12.2023 |
0,07 % | HRT Financial LP | 437 027 | 437 027 | 31.12.2023 |
0,07 % | California State Teachers Retirement System | 433 890 | −80 667 | 31.12.2023 |
0,07 % | JPMorgan Private Bank (United States) | 432 570 | 335 767 | 31.12.2023 |
0,07 % | Legal & General Investment Management Ltd. | 410 422 | 318 | 31.12.2023 |
0,07 % | Mellon Investments Corporation | 410 071 | 63 795 | 31.12.2023 |
0,07 % | BlackRock Investment Management (UK) Ltd. | 406 060 | −52 603 | 31.12.2023 |
0,07 % | Squarepoint Capital LLP | 392 197 | 149 531 | 31.12.2023 |
0,07 % | Goldman Sachs Asset Management, L.P. | 387 820 | −14 349 | 31.12.2023 |
0,06 % | Fubon Asset Management Company Ltd. | 375 514 | −11 781 | 29.2.2024 |
0,06 % | Assenagon Asset Management S.A. | 373 810 | 27 030 | 29.2.2024 |
0,06 % | State of Wisconsin Investment Board | 372 643 | −18 600 | 31.12.2023 |
0,06 % | Summit Wealth Strategies | 361 961 | 3503 | 31.12.2023 |
0,06 % | Alps Advisors, Inc. | 358 782 | −27 518 | 31.12.2023 |
0,06 % | Private Advisor Group LLC | 351 144 | 3558 | 31.12.2023 |
0,06 % | Allspring Global Investments, LLC | 344 060 | −6962 | 31.3.2024 |
0,05 % | Polen Capital Management, LLC | 325 880 | −172 685 | 29.2.2024 |
0,05 % | Ostrum Asset Management | 311 500 | 311 500 | 31.12.2023 |
0,05 % | ProFund Advisors LLC | 275 823 | −47 034 | 31.12.2023 |
0,04 % | MetLife Investment Management, LLC | 262 662 | 0 | 31.12.2023 |
0,04 % | Manulife Investment Management (North America) Limited | 260 827 | 1301 | 31.12.2023 |
0,04 % | Two Sigma Investments, LP | 255 019 | 255 019 | 31.12.2023 |
0,04 % | SunAmerica Asset Management, LLC | 254 663 | 6123 | 31.12.2023 |
0,04 % | XTX Markets LLC | 253 796 | 197 952 | 31.12.2023 |
0,04 % | Kentucky Teachers' Retirement System | 246 560 | 0 | 31.12.2023 |
0,04 % | HighVista Strategies LLC | 240 234 | 39 341 | 31.12.2023 |
0,04 % | Northern Trust Global Investments Limited | 235 594 | −64 739 | 31.12.2023 |
0,04 % | UBS Asset Management (Switzerland) | 231 106 | 0 | 31.12.2023 |
0,04 % | Commonwealth Financial Network | 230 264 | 11 967 | 31.12.2023 |
0,04 % | Osaic Holdings, Inc. | 227 206 | −71 969 | 31.12.2023 |
0,04 % | Cambridge Investment Research Advisors, Inc. | 225 373 | −36 122 | 31.12.2023 |
0,04 % | DWS Investments UK Limited | 222 922 | −5892 | 31.12.2023 |
0,04 % | New York State Common Retirement Fund | 210 890 | 25 959 | 31.12.2023 |
0,03 % | Voya Investment Management LLC | 204 125 | 3881 | 31.12.2023 |
0,03 % | Rosalind Advisors, Inc. | 200 000 | 200 000 | 31.12.2023 |
0,03 % | SG Americas Securities, L.L.C. | 192 445 | 173 370 | 31.12.2023 |
0,03 % | Invesco Advisers, Inc. | 188 784 | −13 367 | 31.12.2023 |
0,03 % | T. Rowe Price International Ltd | 187 779 | 16 501 | 31.12.2023 |
0,03 % | Jefferies LLC | 183 391 | −71 109 | 31.12.2023 |
0,03 % | Inspire Investing | 181 369 | 35 584 | 31.12.2023 |
0,03 % | Janus Henderson Investors | 181 018 | −292 | 31.12.2023 |
0,03 % | BlackRock Asset Management Canada Limited | 171 769 | 41 746 | 31.12.2023 |