8,62491 % | CPMG, Inc. | 2 896 901 | 0 | 31.12.2022 |
8,04182 % | The Vanguard Group, Inc. | 2 701 056 | 52 356 | 31.12.2022 |
6,20407 % | Perceptive Advisors LLC | 2 083 799 | 2 083 799 | 6.3.2023 |
6,14052 % | First Light Asset Management, LLC | 2 062 453 | 1 007 468 | 31.12.2022 |
6,10325 % | BlackRock Institutional Trust Company, N.A. | 2 049 934 | 42 659 | 31.12.2022 |
4,49393 % | Fred Alger Management, LLC | 1 509 404 | 897 481 | 31.12.2022 |
4,48940 % | Wellington Management Company, LLP | 1 507 882 | −64 384 | 31.12.2022 |
4,36375 % | DWS Investment GmbH | 1 465 678 | 470 000 | 31.12.2022 |
3,88790 % | Adage Capital Management, L.P. | 1 305 853 | 1 065 829 | 31.12.2022 |
3,66208 % | Boxer Capital, L.L.C. | 1 230 004 | −8996 | 31.12.2022 |
3,59126 % | Emerald Advisers LLC | 1 206 217 | 227 247 | 31.12.2022 |
2,95356 % | Sofinnova Investments, Inc | 992 029 | 173 653 | 31.12.2022 |
2,61787 % | Evelyn Potter Rose Survivor's Trust. | 879 281 | 0 | 13.4.2022 |
2,27248 % | Millennium Management LLC | 763 272 | 141 179 | 31.12.2022 |
2,03942 % | State Street Global Advisors (US) | 684 992 | −66 251 | 31.12.2022 |
1,59844 % | Morgan Stanley & Co. LLC | 536 876 | 279 034 | 31.12.2022 |
1,56640 % | Geode Capital Management, L.L.C. | 526 116 | 22 196 | 31.12.2022 |
1,48864 % | Ghost Tree Capital, LLC | 500 000 | −225 000 | 31.12.2022 |
1,41487 % | T. Rowe Price Investment Management, Inc. | 475 222 | 135 | 31.12.2022 |
1,14351 % | Fidelity Management & Research Company LLC | 384 076 | −131 805 | 31.12.2022 |
1,01464 % | Clarus Ventures, LLC | 340 793 | 0 | 31.12.2022 |
0,98846 % | Farallon Capital Management, L.L.C. | 332 000 | 332 000 | 31.12.2022 |
0,95834 % | D. E. Shaw & Co., L.P. | 321 883 | 156 053 | 31.12.2022 |
0,78435 % | BlackRock Financial Management, Inc. | 263 443 | −35 409 | 31.12.2022 |
0,78185 % | Schonfeld Strategic Advisors LLC | 262 604 | −30 896 | 31.12.2022 |
0,69141 % | Goldman Sachs & Company, Inc. | 232 229 | −76 331 | 31.12.2022 |
0,67405 % | Northern Trust Investments, Inc. | 226 396 | 2876 | 31.12.2022 |
0,66684 % | Baker Bros. Advisors LP | 223 976 | 0 | 31.12.2022 |
0,64859 % | Voloridge Investment Management, LLC | 217 847 | −101 933 | 31.12.2022 |
0,61338 % | Charles Schwab Investment Management, Inc. | 206 020 | 3461 | 31.12.2022 |
0,61136 % | Marshall Wace LLP | 205 342 | 193 342 | 31.12.2022 |
0,61129 % | Norges Bank Investment Management (NBIM) | 205 319 | −13 406 | 31.12.2022 |
0,60442 % | BofA Global Research (US) | 203 011 | 32 475 | 31.12.2022 |
0,58249 % | Two Sigma Investments, LP | 195 644 | 122 529 | 31.12.2022 |
0,57813 % | BioImpact Capital LLC | 194 181 | 15 123 | 31.12.2022 |
0,53591 % | Logos Global Management LLC | 180 000 | 180 000 | 31.12.2022 |
0,42119 % | Tri Locum Partners LP | 141 466 | 141 466 | 31.12.2022 |
0,40251 % | Parametric Portfolio Associates LLC | 135 193 | 119 572 | 31.12.2022 |
0,33744 % | AllianceBernstein L.P. | 113 339 | 78 439 | 31.12.2022 |
0,32427 % | JP Morgan Asset Management | 108 916 | −8664 | 31.12.2022 |
0,31891 % | Nuveen LLC | 107 115 | −3318 | 31.12.2022 |
0,29588 % | Jacobs Levy Equity Management, Inc. | 99 378 | −21 751 | 31.12.2022 |
0,26582 % | Squarepoint Capital LLP | 89 284 | 48 065 | 31.12.2022 |
0,25307 % | Integral Health Asset Management, LLC | 85 000 | 85 000 | 31.12.2022 |
0,23599 % | Invesco Capital Management LLC | 79 264 | 63 969 | 31.12.2022 |
0,23036 % | BNY Mellon Asset Management | 77 372 | 1026 | 31.12.2022 |
0,22962 % | Principal Funds, Inc. | 77 124 | 8322 | 30.4.2022 |
0,22387 % | Huff (James Warren) | 75 191 | 0 | 2.3.2023 |
0,22221 % | Citadel Advisors LLC | 74 636 | −87 179 | 31.12.2022 |
0,21846 % | Thrivent Asset Management, LLC | 73 374 | 36 156 | 31.12.2022 |
0,21249 % | BlackRock Investment Management, LLC | 71 370 | −4437 | 31.12.2022 |
0,21113 % | Ensign Peak Advisors, Inc. | 70 915 | −7200 | 31.12.2022 |
0,19945 % | UBS Asset Management (Americas), Inc. | 66 989 | −5700 | 31.1.2023 |
0,19511 % | Luther King Capital Management Corp. | 65 534 | 0 | 31.12.2022 |
0,19293 % | Schweizerische Nationalbank | 64 800 | 1500 | 31.12.2022 |
0,18784 % | Mcgaughy R Kent Jr | 63 092 | 0 | 13.4.2022 |
0,17565 % | Duquesne Family Office LLC | 58 997 | 0 | 31.12.2022 |
0,17290 % | Hennion & Walsh Asset Management, Inc. | 58 074 | −12 710 | 31.12.2022 |
0,17202 % | Keel Point, LLC | 57 779 | 0 | 31.12.2022 |
0,15600 % | Hightower Advisors, LLC | 52 395 | −3755 | 31.12.2022 |
0,15420 % | Meyer (Colin John) | 51 793 | −5907 | 7.3.2023 |
0,15370 % | Jane Street Capital, L.L.C. | 51 625 | 51 625 | 31.12.2022 |
0,15134 % | BlackRock Advisors (UK) Limited | 50 832 | 1786 | 28.2.2023 |
0,14749 % | BlackRock Investment Management (UK) Ltd. | 49 538 | 2489 | 31.12.2022 |
0,14068 % | Tolleson Wealth Management Inc | 47 250 | 0 | 31.12.2022 |
0,13629 % | BlackRock Asset Management Ireland Limited | 45 777 | −1245 | 31.12.2022 |
0,13584 % | Kennedy Capital Management, Inc. | 45 626 | −27 424 | 31.12.2022 |
0,12845 % | PDT Partners, LLC | 43 144 | −14 990 | 31.12.2022 |
0,12335 % | Soni (Manmeet Singh) | 41 429 | −4209 | 7.3.2023 |
0,12205 % | J.P. Morgan Securities LLC | 40 993 | 40 843 | 31.12.2022 |
0,12204 % | Goldman Sachs Asset Management, L.P. | 40 989 | 1819 | 31.12.2022 |
0,11861 % | Edgestream Partners, L.P. | 39 838 | −41 922 | 31.12.2022 |
0,11717 % | Morgan Stanley Smith Barney LLC | 39 354 | 1402 | 31.12.2022 |
0,11653 % | Credit Suisse Asset Management | 39 141 | 9673 | 31.12.2022 |
0,11597 % | Rhumbline Advisers Ltd. Partnership | 38 952 | 840 | 31.12.2022 |
0,10247 % | Northern Trust Global Investments | 34 417 | 6993 | 31.12.2022 |
0,10241 % | California State Teachers Retirement System | 34 398 | 413 | 31.12.2022 |
0,09658 % | Crestline Investors, Inc. | 32 439 | −4669 | 31.12.2022 |
0,09039 % | LBJ Family Wealth Advisors, Ltd. | 30 359 | 0 | 31.12.2022 |
0,09030 % | Fayez Sarofim & Co. | 30 329 | 0 | 31.12.2022 |
0,08722 % | Arens (Mathew P) | 29 294 | 29 294 | 31.12.2022 |
0,08718 % | BNP Paribas Securities Corp. North America | 29 283 | −32 367 | 31.12.2022 |
0,08718 % | HRT Financial LP | 29 282 | −11 035 | 31.12.2022 |
0,08378 % | KRS Capital Management, LLC | 28 141 | 0 | 31.12.2022 |
0,08023 % | State of Wisconsin Investment Board | 26 947 | −31 552 | 31.12.2022 |
0,07969 % | Anand (Bhaskar) | 26 765 | 2015 | 7.3.2023 |
0,07487 % | GAM Investment Management (Switzerland) AG | 25 146 | 0 | 30.6.2022 |
0,07166 % | Legal & General Investment Management Ltd. | 24 070 | −1134 | 31.12.2022 |
0,07059 % | Madden Asset Management | 23 708 | 0 | 31.12.2022 |
0,07048 % | Graham Capital Management, L.P. | 23 674 | −293 095 | 31.12.2022 |
0,06741 % | Deka Vermögensmanagement GmbH | 22 640 | 0 | 31.12.2022 |
0,06741 % | Deka Investment GmbH | 22 640 | 7500 | 30.6.2022 |
0,06402 % | Mellon Investments Corporation | 21 502 | 845 | 31.12.2022 |
0,06401 % | Jump Financial, LLC | 21 500 | 21 500 | 31.12.2022 |
0,06379 % | SEI Investments Management Corporation | 21 426 | 15 400 | 31.12.2022 |
0,06247 % | Turtle Creek Management, LLC | 20 982 | 0 | 31.12.2022 |
0,05955 % | Hudson Bay Capital Management LP | 20 000 | 20 000 | 31.12.2022 |
0,05906 % | New York State Common Retirement Fund | 19 836 | −9 | 31.12.2022 |
0,05828 % | Group One Trading, L.P. | 19 574 | 19 574 | 31.12.2022 |
0,05794 % | Voya Investment Management LLC | 19 460 | 0 | 31.12.2022 |