7,47393 % | Loomis, Sayles & Company, L.P. | 1 082 225 | −34 259 | 31.12.2023 |
6,60829 % | ArrowMark Colorado Holdings, LLC | 956 881 | −9115 | 31.12.2023 |
5,33810 % | Sofinnova Investments, Inc | 772 957 | 29 663 | 31.12.2023 |
49,38416 % | Viking Global Investors LP | 7 150 826 | 0 | 31.12.2023 |
4,91961 % | Capital Research Global Investors | 712 360 | −509 361 | 31.12.2023 |
4,78577 % | BofA Global Research (US) | 692 980 | 577 231 | 31.12.2023 |
4,74696 % | Geode Capital Management, L.L.C. | 687 360 | 41 201 | 31.12.2023 |
4,13161 % | Forsyth Douglas | 598 257 | 0 | 21.2.2024 |
32,62574 % | RA Capital Management, LP | 4 724 207 | 0 | 31.12.2023 |
3,71522 % | PFM Health Sciences, LP | 537 964 | 249 347 | 31.12.2023 |
3,00725 % | Russell Investments Trust Company | 435 450 | −23 606 | 31.12.2023 |
29,39298 % | Perceptive Advisors LLC | 4 256 104 | 0 | 31.12.2023 |
22,61258 % | Kayyem (Jon Faiz) | 3 274 301 | 0 | 21.2.2024 |
21,03352 % | Lappe Mark | 3 045 654 | 0 | 21.2.2024 |
17,06906 % | BlackRock Institutional Trust Company, N.A. | 2 471 600 | 179 080 | 31.12.2023 |
16,26763 % | Eckelman (Brendan P) | 2 355 553 | 0 | 21.2.2024 |
16,01227 % | Woodline Partners LP | 2 318 576 | 793 661 | 31.12.2023 |
12,91364 % | The Vanguard Group, Inc. | 1 869 895 | 84 512 | 31.12.2023 |
12,08831 % | TCG Crossover Management, LLC | 1 750 387 | 0 | 31.12.2023 |
11,29645 % | State Street Global Advisors (US) | 1 635 726 | 18 955 | 31.12.2023 |
10,56630 % | Vestal Point Capital, LP | 1 530 000 | 1 530 000 | 31.12.2023 |
10,15131 % | Fidelity Management & Research Company LLC | 1 469 909 | −47 686 | 31.12.2023 |
1,95010 % | Northern Trust Investments, Inc. | 282 375 | 11 557 | 31.12.2023 |
1,83503 % | Morgan Stanley & Co. LLC | 265 712 | −80 617 | 31.12.2023 |
1,80289 % | Millennium Management LLC | 261 058 | 228 730 | 31.12.2023 |
1,75993 % | Citadel Advisors LLC | 254 838 | 12 028 | 31.12.2023 |
1,58747 % | Charles Schwab Investment Management, Inc. | 229 866 | 17 762 | 31.12.2023 |
1,56458 % | Sphera Funds Management Ltd. | 226 551 | −29 820 | 31.12.2023 |
1,51036 % | Two Sigma Investments, LP | 218 700 | −299 170 | 31.12.2023 |
1,15858 % | Platinum Asset Management | 167 763 | −61 273 | 31.12.2023 |
1,00413 % | Wellington Management Company, LLP | 145 398 | −29 501 | 31.12.2023 |
0,94149 % | Wetherby Asset Management LLC | 136 328 | 0 | 31.12.2023 |
0,93280 % | Candriam Belgium S.A. | 135 069 | −20 000 | 31.12.2023 |
0,91091 % | Hightower Advisors, LLC | 131 900 | 0 | 31.12.2023 |
0,90673 % | Schroder Investment Management Ltd. (SIM) | 131 295 | −106 148 | 31.12.2023 |
0,84472 % | Meridian Wealth Advisors, LLC | 122 315 | 0 | 31.12.2023 |
0,75913 % | Polen Capital Management, LLC | 109 922 | −50 737 | 29.2.2024 |
0,73339 % | Susquehanna International Group, LLP | 106 195 | 77 242 | 31.12.2023 |
0,71302 % | Rafferty Asset Management LLC | 103 246 | −12 582 | 31.12.2023 |
0,70289 % | Goldman Sachs & Company, Inc. | 101 778 | −10 302 | 31.12.2023 |
0,69923 % | abrdn Investments Limited | 101 249 | 80 950 | 31.3.2024 |
0,69061 % | Logos Global Management LLC | 100 000 | 100 000 | 31.12.2023 |
0,65608 % | Caption Management, LLC | 95 000 | 95 000 | 31.12.2023 |
0,62095 % | BNY Mellon Asset Management | 89 914 | 6 | 31.12.2023 |
0,62001 % | BlackRock Investment Management, LLC | 89 778 | −2352 | 31.12.2023 |
0,61692 % | Schonfeld Strategic Advisors LLC | 89 330 | 89 330 | 31.12.2023 |
0,61371 % | Barclays Bank PLC | 88 865 | 25 688 | 31.12.2023 |
0,61115 % | BlackRock Financial Management, Inc. | 88 494 | −2412 | 31.12.2023 |
0,57545 % | Nuveen LLC | 83 325 | −5938 | 31.12.2023 |
0,55791 % | UBS Financial Services, Inc. | 80 785 | 42 782 | 31.12.2023 |
0,50523 % | Exome Asset Management LLC | 73 158 | 73 158 | 31.12.2023 |
0,49371 % | AllianceBernstein L.P. | 71 489 | −20 040 | 31.12.2023 |
0,38794 % | Ensign Peak Advisors, Inc. | 56 173 | 0 | 31.12.2023 |
0,37862 % | BlackRock Advisors (UK) Limited | 54 824 | 2537 | 31.3.2024 |
0,35499 % | Goldman Sachs Asset Management, L.P. | 51 402 | 4013 | 31.12.2023 |
0,33941 % | Rhumbline Advisers Ltd. Partnership | 49 147 | 322 | 31.12.2023 |
0,33459 % | Birchview Capital, LP | 48 448 | −22 000 | 31.12.2023 |
0,32062 % | HAP Trading, LLC | 46 426 | 46 426 | 31.12.2023 |
0,31176 % | BlackRock Asset Management Ireland Limited | 45 143 | 3702 | 31.12.2023 |
0,30863 % | Citi Investment Research (US) | 44 690 | −4554 | 31.12.2023 |
0,30438 % | Gyon Technologies Capital Management, LP | 44 074 | 44 074 | 31.12.2022 |
0,30356 % | State of Wisconsin Investment Board | 43 956 | −8926 | 31.12.2023 |
0,28298 % | IndexIQ Advisors LLC | 40 976 | −1568 | 31.3.2024 |
0,27969 % | Qube Research & Technologies Ltd | 40 499 | 40 499 | 31.12.2023 |
0,27032 % | Invesco Capital Management LLC | 39 143 | 31 795 | 31.12.2023 |
0,26727 % | Schweizerische Nationalbank | 38 700 | −18 900 | 31.12.2023 |
0,26206 % | Jane Street Capital, L.L.C. | 37 946 | −4369 | 31.12.2023 |
0,24766 % | Simplex Trading, LLC | 35 861 | 35 225 | 31.12.2023 |
0,24171 % | Ghost Tree Capital, LLC | 35 000 | 0 | 31.12.2023 |
0,22864 % | Alps Advisors, Inc. | 33 107 | 33 107 | 31.12.2023 |
0,22304 % | Assenagon Asset Management S.A. | 32 296 | 2344 | 29.2.2024 |
0,21176 % | Parametric Portfolio Associates LLC | 30 663 | −5110 | 31.12.2023 |
0,21106 % | Hennion & Walsh Asset Management, Inc. | 30 561 | 744 | 31.3.2024 |
0,21046 % | Northern Trust Global Investments | 30 474 | −5346 | 31.12.2023 |
0,19510 % | Alpine Associates Management Inc. | 28 251 | 12 959 | 31.3.2024 |
0,18232 % | Deka Vermögensmanagement GmbH | 26 400 | 0 | 31.12.2023 |
0,18232 % | Deka Investment GmbH | 26 400 | 0 | 31.12.2022 |
0,16989 % | Bellevue Asset Management AG | 24 600 | −24 200 | 31.12.2023 |
0,16700 % | Mellon Investments Corporation | 24 181 | 96 | 31.12.2023 |
0,16427 % | Wilmington Trust Investment Advisors, Inc. | 23 786 | −4647 | 31.12.2023 |
0,16240 % | Campbell & Company, Inc. | 23 516 | 23 516 | 31.12.2023 |
0,15988 % | California State Teachers Retirement System | 23 150 | −7554 | 31.12.2023 |
0,15689 % | JPMorgan Private Bank (United States) | 22 718 | 2425 | 31.12.2023 |
0,15305 % | UBS Asset Management (Switzerland) | 22 161 | 0 | 31.12.2023 |
0,14153 % | Mirae Asset Global Investments (USA) LLC | 20 494 | 1331 | 31.12.2023 |
0,13634 % | Credit Suisse Funds AG | 19 742 | −2364 | 31.12.2023 |
0,13357 % | Alaethes Wealth LLC | 19 341 | 0 | 31.12.2023 |
0,13305 % | Legal & General Investment Management Ltd. | 19 265 | −2896 | 31.12.2023 |
0,13249 % | JP Morgan Asset Management | 19 185 | −299 409 | 31.12.2023 |
0,12693 % | Tudor Investment Corporation | 18 379 | −3331 | 31.12.2023 |
0,12565 % | MetLife Investment Management, LLC | 18 194 | 0 | 31.12.2023 |
0,11826 % | ProFund Advisors LLC | 17 124 | −2622 | 31.12.2023 |
0,11789 % | SunAmerica Asset Management, LLC | 17 071 | −69 | 31.12.2023 |
0,11213 % | Prelude Capital Management, LLC | 16 236 | 3015 | 31.12.2023 |
0,10535 % | Aperio Group, LLC | 15 255 | 3062 | 31.12.2023 |
0,10359 % | Soleus Capital Management, L.P. | 15 000 | −534 183 | 31.12.2023 |
0,10332 % | DWS Investments UK Limited | 14 961 | −418 | 31.12.2023 |
0,10124 % | RS Crum INC | 14 659 | 0 | 31.12.2023 |
0,09985 % | LMR Partners LLP | 14 458 | 0 | 31.12.2023 |
0,09814 % | Wells Fargo Advisors | 14 211 | −550 | 31.12.2023 |