15,31122 % | RA Capital Management, LP | 10 805 129 | 0 | 31. 12. 2024 |
9,93921 % | Tang Capital Management, LLC | 7 014 100 | 4 720 381 | 17. 1. 2025 |
5,78245 % | BlackRock Institutional Trust Company, N.A. | 4 080 675 | 339 514 | 31. 12. 2024 |
5,33943 % | Samsara BioCapital, LLC | 3 768 035 | 0 | 31. 12. 2024 |
5,05708 % | New Enterprise Associates (NEA) | 3 568 781 | 0 | 31. 12. 2024 |
5,05111 % | Citadel Advisors LLC | 3 564 568 | 425 333 | 31. 12. 2024 |
4,72344 % | SR One Capital Management, LP | 3 333 333 | 0 | 31. 12. 2024 |
4,47985 % | GSK plc | 3 161 432 | 3 161 432 | 27. 3. 2024 |
4,01947 % | EQT Life Sciences | 2 836 539 | 0 | 12. 2. 2025 |
3,58620 % | The Vanguard Group, Inc. | 2 530 780 | -479 160 | 31. 12. 2024 |
3,57221 % | Wasatch Global Investors Inc | 2 520 909 | 686 229 | 31. 12. 2024 |
3,54856 % | Jefferies LLC | 2 504 219 | 2 254 219 | 31. 12. 2024 |
3,05371 % | Deerfield Management Company, L.P. | 2 155 000 | 0 | 31. 12. 2024 |
2,96199 % | JP Morgan Asset Management | 2 090 274 | 1 374 262 | 31. 12. 2024 |
2,24853 % | Morgan Stanley & Co. LLC | 1 586 787 | 1 413 297 | 31. 12. 2024 |
1,89131 % | Alyeska Investment Group, L.P. | 1 334 696 | 250 000 | 31. 12. 2024 |
1,67402 % | Geode Capital Management, L.L.C. | 1 181 357 | 10 331 | 31. 12. 2024 |
1,61117 % | State Street Global Advisors (US) | 1 137 002 | 38 940 | 31. 12. 2024 |
1,20420 % | Acadian Asset Management LLC | 849 801 | 417 018 | 31. 12. 2024 |
1,16395 % | OrbiMed Advisors, LLC | 821 400 | -659 200 | 31. 12. 2024 |
1,13363 % | Affinity Asset Advisors LLC | 800 000 | 150 000 | 31. 12. 2024 |
1,07280 % | Renaissance Technologies LLC | 757 075 | -127 197 | 31. 12. 2024 |
0,95865 % | Group One Trading, L.P. | 676 519 | 676 519 | 31. 12. 2024 |
0,85042 % | Millennium Management LLC | 600 142 | 364 417 | 31. 12. 2024 |
0,81177 % | Goldman Sachs & Company, Inc. | 572 866 | 211 375 | 31. 12. 2024 |
0,80680 % | Dimensional Fund Advisors, L.P. | 569 357 | 286 181 | 31. 12. 2024 |
0,70852 % | Woodline Partners LP | 500 000 | -129 358 | 31. 12. 2024 |
0,69582 % | Blackstone Alternative Asset Management, L.P. | 491 043 | 0 | 31. 12. 2024 |
0,66320 % | Northern Trust Investments, Inc. | 468 020 | 54 568 | 31. 12. 2024 |
0,53910 % | BofA Global Research (US) | 380 444 | 199 345 | 31. 12. 2024 |
0,49858 % | Commodore Capital LP | 351 848 | -4 310 225 | 31. 12. 2024 |
0,46147 % | BlackRock Financial Management, Inc. | 325 658 | 44 316 | 31. 12. 2024 |
0,43540 % | Two Sigma Investments, LP | 307 263 | -19 721 | 31. 12. 2024 |
0,39913 % | UBS Financial Services, Inc. | 281 668 | 188 302 | 31. 12. 2024 |
0,38381 % | Barclays Bank PLC | 270 857 | 38 291 | 31. 12. 2024 |
0,35685 % | JPMorgan Asset Management U.K. Limited | 251 827 | -17 001 | 31. 12. 2024 |
0,35033 % | Jane Street Capital, L.L.C. | 247 227 | 190 308 | 31. 12. 2024 |
0,31915 % | Wellington Management Company, LLP | 225 224 | 8 883 | 31. 12. 2024 |
0,29048 % | Simplex Trading, LLC | 204 994 | 202 461 | 31. 12. 2024 |
0,28850 % | BNP Paribas Securities Corp. North America | 203 595 | 203 595 | 31. 12. 2024 |
0,26829 % | JPMorgan Private Bank (United States) | 189 331 | 111 048 | 31. 12. 2024 |
0,23779 % | AQR Capital Management, LLC | 167 806 | -146 544 | 31. 12. 2024 |
0,23366 % | BlackRock Investment Management, LLC | 164 894 | 4 577 | 31. 12. 2024 |
0,20817 % | Hastings (Paul J) | 146 909 | 77 122 | 15. 1. 2025 |
0,20591 % | Fidelity Management & Research Company LLC | 145 311 | 12 162 | 31. 12. 2024 |
0,20541 % | Trager (James) | 144 959 | -456 | 18. 6. 2024 |
0,19838 % | ACCI Capital Investments SGIIC, SA | 140 000 | 14 104 | 30. 11. 2024 |
0,19691 % | Innovis Asset Management LLC | 138 962 | 138 962 | 30. 9. 2023 |
0,19272 % | Abaris Investment Management AG | 136 000 | 116 000 | 31. 12. 2023 |
0,19169 % | Parametric Portfolio Associates LLC | 135 274 | -57 232 | 31. 12. 2024 |
0,17715 % | Charles Schwab Investment Management, Inc. | 125 013 | -20 319 | 31. 12. 2024 |
0,17684 % | Brandenberger (Ralph Erik) | 124 796 | 45 053 | 15. 1. 2025 |
0,16625 % | Nuveen LLC | 117 325 | 0 | 31. 12. 2024 |
0,15574 % | Cubist Systematic Strategies, LLC | 109 906 | -6 222 | 31. 12. 2024 |
0,14674 % | Thrivent Asset Management, LLC | 103 551 | 103 551 | 31. 12. 2024 |
0,14022 % | PGIM Quantitative Solutions LLC | 98 950 | -66 100 | 31. 12. 2024 |
0,13132 % | Mahmood (Nadir Ahmeduddin) | 92 676 | 62 000 | 3. 1. 2025 |
0,12985 % | Hager (Alicia J) | 91 635 | 42 916 | 15. 1. 2025 |
0,12888 % | American Century Investment Management, Inc. | 90 952 | 7 378 | 31. 12. 2024 |
0,12868 % | Stifel, Nicolaus & Company, Incorporated | 90 811 | 9 359 | 31. 12. 2024 |
0,12711 % | Shook (David M.D.) | 89 704 | 50 362 | 15. 1. 2025 |
0,12194 % | BNY Mellon Asset Management | 86 054 | 0 | 31. 12. 2024 |
0,12031 % | Davis (Aaron I) | 84 900 | 84 900 | 8. 1. 2024 |
0,11985 % | Samalin Wealth | 84 575 | 84 575 | 31. 12. 2024 |
0,11960 % | Aristides Capital, L.L.C. | 84 400 | 84 400 | 31. 12. 2024 |
0,11505 % | Rhumbline Advisers Ltd. Partnership | 81 191 | 2 135 | 31. 12. 2024 |
0,11434 % | AllianceBernstein L.P. | 80 690 | 0 | 31. 12. 2024 |
0,10464 % | HSBC Global Asset Management (UK) Limited | 73 845 | 37 433 | 31. 12. 2024 |
0,10399 % | Walleye Capital LLC | 73 387 | 73 387 | 31. 12. 2024 |
0,10004 % | State of Wisconsin Investment Board | 70 600 | -52 302 | 31. 12. 2024 |
0,09986 % | Dimensional Fund Advisors, Ltd. | 70 470 | 0 | 30. 11. 2024 |
0,08644 % | Bellecapital AG | 61 000 | 20 000 | 31. 7. 2024 |
0,07326 % | Jennison Associates LLC | 51 700 | 0 | 31. 10. 2024 |
0,07249 % | Jain Global LLC | 51 159 | 51 159 | 31. 12. 2024 |
0,06784 % | Susquehanna International Group, LLP | 47 878 | 47 878 | 31. 12. 2024 |
0,06612 % | Levin (Alyssa) | 46 662 | 46 662 | 15. 1. 2025 |
0,06504 % | PGIM Fixed Income | 45 900 | 16 600 | 31. 12. 2024 |
0,06399 % | Avantis Investors | 45 155 | 18 824 | 31. 3. 2024 |
0,06294 % | Mellon Investments Corporation | 44 418 | 1 | 31. 12. 2024 |
0,05793 % | Citi Investment Research (US) | 40 880 | 429 | 31. 12. 2024 |
0,05384 % | BlackRock Investment Management (UK) Ltd. | 37 993 | 37 993 | 31. 12. 2024 |
0,05153 % | DWS Investments UK Limited | 36 363 | 8 946 | 31. 12. 2024 |
0,04842 % | BlackRock Advisors (UK) Limited | 34 170 | 230 | 31. 1. 2025 |
0,04809 % | BlackRock Asset Management Ireland Limited | 33 940 | 33 940 | 31. 12. 2024 |
0,04737 % | Wolverine Trading, LLC | 33 426 | 33 426 | 31. 12. 2024 |
0,04638 % | Mirae Asset Global Investments (USA) LLC | 32 731 | 3 644 | 31. 12. 2024 |
0,04520 % | Morgan Stanley Smith Barney LLC | 31 896 | 23 887 | 31. 12. 2024 |
0,04401 % | Wells Fargo Bank, N.A. | 31 056 | 6 763 | 31. 12. 2024 |
0,04258 % | Forefront Analytics, LLC | 30 046 | 12 400 | 31. 12. 2024 |
0,04108 % | abrdn Inc. | 28 988 | 0 | 31. 12. 2024 |
0,03966 % | Goldman Sachs Asset Management, L.P. | 27 991 | -33 751 | 31. 12. 2024 |
0,03818 % | Assenagon Asset Management S.A. | 26 947 | 2 365 | 31. 1. 2025 |
0,03728 % | Corebridge Financial Inc. | 26 306 | -1 986 | 31. 12. 2024 |
0,03616 % | INTECH Investment Management LLC | 25 518 | 9 244 | 31. 12. 2024 |
0,03459 % | SG Americas Securities, L.L.C. | 24 413 | 3 816 | 31. 12. 2024 |
0,03395 % | T. Rowe Price International Ltd | 23 958 | 7 030 | 31. 12. 2024 |
0,03376 % | Vaughan Nelson Investment Management, L.P. | 23 826 | 10 285 | 30. 9. 2024 |
0,03229 % | Nuveen Asset Management, LLC | 22 788 | 21 627 | 31. 12. 2024 |
0,03229 % | SEI Investments Management Corporation | 22 788 | 22 788 | 31. 12. 2024 |
0,03121 % | Vanguard Personalized Indexing Management, LLC | 22 023 | 7 972 | 31. 12. 2024 |