15,00068 % | Fidelity Management & Research Company LLC | 7 513 840 | 8 426 | 30. 6. 2024 |
9,94798 % | EcoR1 Capital, LLC | 4 982 945 | 1 968 193 | 30. 6. 2024 |
6,04139 % | Springer Timothy A | 3 026 133 | -4 608 052 | 16. 8. 2024 |
5,87616 % | BlackRock Institutional Trust Company, N.A. | 2 943 371 | 175 446 | 30. 6. 2024 |
5,04292 % | Invus Public Equities Advisors, LLC | 2 525 998 | 312 810 | 30. 6. 2024 |
4,41291 % | The Vanguard Group, Inc. | 2 210 429 | -45 246 | 30. 6. 2024 |
4,29650 % | T. Rowe Price Associates, Inc. | 2 152 117 | -318 042 | 30. 6. 2024 |
3,97415 % | Polaris Venture Partners | 1 990 651 | 0 | 1. 4. 2024 |
3,56000 % | Woodline Partners LP | 1 783 202 | 1 683 202 | 30. 6. 2024 |
3,27033 % | State Street Global Advisors (US) | 1 638 108 | -1 027 402 | 30. 6. 2024 |
2,91735 % | Point72 Asset Management, L.P. | 1 461 302 | -3 225 798 | 30. 6. 2024 |
2,03217 % | Pictet Asset Management Ltd. | 1 017 912 | -168 996 | 30. 6. 2024 |
1,98642 % | Federated Hermes Global Investment Management Corp. | 995 000 | 0 | 30. 6. 2024 |
1,93649 % | Geode Capital Management, L.L.C. | 969 986 | 74 786 | 30. 6. 2024 |
1,22674 % | Tipirneni (Praveen P) | 614 474 | -42 460 | 16. 8. 2024 |
1,22280 % | OrbiMed Advisors, LLC | 612 500 | 54 000 | 30. 6. 2024 |
1,15396 % | Two Sigma Investments, LP | 578 020 | -63 831 | 30. 6. 2024 |
1,06734 % | Goldman Sachs & Company, Inc. | 534 630 | 103 925 | 30. 6. 2024 |
0,97086 % | SilverArc Capital Management, LLC | 486 306 | 2 334 | 30. 6. 2024 |
0,73744 % | MPM BioImpact LLC | 369 384 | 44 051 | 30. 6. 2024 |
0,65451 % | Charles Schwab Investment Management, Inc. | 327 844 | 1 147 | 30. 6. 2024 |
0,64564 % | BlackRock Financial Management, Inc. | 323 403 | 27 905 | 30. 6. 2024 |
0,62802 % | Northern Trust Investments, Inc. | 314 575 | -646 | 30. 6. 2024 |
0,50025 % | Affinity Asset Advisors LLC | 250 573 | 25 573 | 30. 6. 2024 |
0,48898 % | Wellington Management Company, LLP | 244 931 | -5 569 515 | 31. 7. 2024 |
0,46266 % | Dafna Capital Management, LLC | 231 748 | 0 | 30. 6. 2024 |
0,42796 % | Fiduciary Trust Company | 214 366 | 0 | 30. 6. 2024 |
0,42754 % | Candriam Belgium S.A. | 214 154 | -35 779 | 30. 6. 2024 |
0,41570 % | Dimensional Fund Advisors, L.P. | 208 225 | -12 937 | 30. 6. 2024 |
0,32339 % | Citadel Advisors LLC | 161 988 | -704 910 | 30. 6. 2024 |
0,32121 % | Voloridge Investment Management, LLC | 160 896 | 160 896 | 30. 6. 2024 |
0,31912 % | Omega Fund Management, LLC | 159 846 | 0 | 30. 6. 2024 |
0,30509 % | D. E. Shaw & Co., L.P. | 152 819 | -61 637 | 30. 6. 2024 |
0,30057 % | AllianceBernstein L.P. | 150 558 | 38 776 | 30. 6. 2024 |
0,29207 % | Nomura Asset Management Co., Ltd. | 146 300 | 146 300 | 30. 11. 2023 |
0,26968 % | Morgan Stanley & Co. LLC | 135 082 | -67 468 | 30. 6. 2024 |
0,26208 % | Jane Street Capital, L.L.C. | 131 276 | 85 314 | 30. 6. 2024 |
0,25893 % | Nuveen LLC | 129 698 | 3 897 | 30. 6. 2024 |
0,25746 % | Medical Strategy GmbH | 128 962 | -313 051 | 31. 12. 2023 |
0,23516 % | BlackRock Investment Management, LLC | 117 794 | 24 237 | 30. 6. 2024 |
0,22736 % | Ensign Peak Advisors, Inc. | 113 883 | -27 340 | 30. 6. 2024 |
0,22380 % | TD Asset Management Inc. | 112 100 | -13 800 | 30. 6. 2024 |
0,19753 % | Goldman Sachs Asset Management, L.P. | 98 943 | -14 297 | 30. 6. 2024 |
0,19217 % | BNY Mellon Asset Management | 96 256 | 5 819 | 30. 6. 2024 |
0,17721 % | Barclays Bank PLC | 88 766 | 44 039 | 30. 6. 2024 |
0,17162 % | Manulife Investment Management (North America) Limited | 85 966 | 4 021 | 30. 6. 2024 |
0,17156 % | Susquehanna International Group, LLP | 85 932 | 16 033 | 30. 6. 2024 |
0,16814 % | BofA Global Research (US) | 84 223 | -30 339 | 30. 6. 2024 |
0,15981 % | Allianz Global Investors GmbH | 80 049 | -13 621 | 30. 6. 2024 |
0,15879 % | Jump Financial, LLC | 79 539 | 67 387 | 30. 6. 2024 |
0,15525 % | Capital Fund Management S.A. | 77 767 | 58 100 | 30. 6. 2024 |
0,14885 % | Rafferty Asset Management LLC | 74 557 | -146 237 | 30. 6. 2024 |
0,14574 % | HOOPP Investment Management | 73 000 | 73 000 | 30. 6. 2024 |
0,13302 % | Atom Investors LP | 66 628 | -20 002 | 30. 6. 2024 |
0,13052 % | Rhumbline Advisers Ltd. Partnership | 65 379 | 13 677 | 30. 6. 2024 |
0,12530 % | BlackRock Asset Management Ireland Limited | 62 765 | 3 150 | 30. 6. 2024 |
0,11759 % | Schweizerische Nationalbank | 58 900 | 0 | 30. 6. 2024 |
0,11572 % | Connor, Clark & Lunn Investment Management Ltd. | 57 965 | -46 665 | 30. 6. 2024 |
0,10994 % | T. Rowe Price International Ltd | 55 070 | 1 643 | 30. 6. 2024 |
0,10773 % | Mellon Investments Corporation | 53 963 | 21 651 | 30. 6. 2024 |
0,10730 % | PGIM Quantitative Solutions LLC | 53 747 | -26 180 | 30. 6. 2024 |
0,09515 % | Saturn V Capital Management LP | 47 660 | -37 972 | 30. 6. 2024 |
0,08628 % | BlackRock Investment Management (UK) Ltd. | 43 220 | 9 516 | 30. 6. 2024 |
0,08277 % | UBS Financial Services, Inc. | 41 460 | -107 534 | 30. 6. 2024 |
0,07797 % | Alps Advisors, Inc. | 39 054 | 3 762 | 30. 6. 2024 |
0,06813 % | Millennium Management LLC | 34 125 | 34 125 | 30. 6. 2024 |
0,06610 % | Algert Global LLC | 33 108 | 16 531 | 30. 6. 2024 |
0,06339 % | Wellington Management Singapore Pte. Ltd. | 31 751 | 31 751 | 31. 3. 2024 |
0,06339 % | Wellington Management Japan Pte Ltd | 31 751 | -13 447 | 30. 6. 2023 |
0,05999 % | California State Teachers Retirement System | 30 048 | -631 | 30. 6. 2024 |
0,05968 % | Carmignac Gestion | 29 892 | 29 892 | 31. 7. 2024 |
0,05832 % | Legal & General Investment Management Ltd. | 29 214 | -185 | 30. 6. 2024 |
0,05694 % | Victory Capital Management Inc. | 28 520 | -580 | 30. 6. 2024 |
0,05660 % | UBS Asset Management (Americas), Inc. | 28 350 | 28 350 | 31. 3. 2023 |
0,05364 % | First Trust Advisors L.P. | 26 867 | 26 867 | 30. 6. 2024 |
0,05285 % | PDT Partners, LLC | 26 474 | -34 663 | 30. 6. 2024 |
0,04991 % | Tudor Investment Corporation | 25 002 | -882 | 30. 6. 2024 |
0,04951 % | T. Rowe Price Japan, Inc. | 24 799 | 15 500 | 30. 4. 2024 |
0,04877 % | Aperio Group, LLC | 24 427 | 629 | 30. 6. 2024 |
0,04873 % | Northern Trust Global Investments | 24 409 | 1 106 | 30. 6. 2024 |
0,04855 % | UBS Fund Management (Switzerland) AG | 24 319 | -7 904 | 30. 6. 2024 |
0,04789 % | Mirae Asset Global Investments (USA) LLC | 23 986 | 4 698 | 30. 6. 2024 |
0,04736 % | Squarepoint Capital LLP | 23 723 | 23 723 | 30. 6. 2024 |
0,04618 % | American Century Investment Management, Inc. | 23 134 | 16 606 | 30. 6. 2024 |
0,04607 % | MetLife Investment Management, LLC | 23 077 | 3 665 | 30. 6. 2024 |
0,04425 % | DeVaul (William David) | 22 167 | 0 | 8. 7. 2024 |
0,04284 % | Y-Intercept (Hong Kong) Ltd | 21 459 | 21 459 | 30. 6. 2024 |
0,04278 % | Corebridge Financial Inc | 21 431 | 21 431 | 30. 6. 2024 |
0,04033 % | Healthinvest Partners AB | 20 199 | 5 247 | 30. 6. 2024 |
0,03859 % | ExodusPoint Capital Management, LP | 19 330 | 19 330 | 30. 6. 2024 |
0,03814 % | State of Wisconsin Investment Board | 19 105 | -993 | 30. 6. 2024 |
0,03753 % | SunAmerica Asset Management, LLC | 18 797 | 533 | 31. 3. 2024 |
0,03546 % | Edgestream Partners, L.P. | 17 760 | 17 760 | 30. 6. 2024 |
0,03503 % | DWS Investments UK Limited | 17 547 | -1 922 | 30. 6. 2024 |
0,03495 % | Wells Fargo Bank, N.A. | 17 504 | 5 837 | 30. 6. 2024 |
0,03427 % | Kentucky Teachers' Retirement System | 17 167 | 0 | 30. 6. 2024 |
0,03418 % | Citi Investment Research (US) | 17 122 | -173 223 | 30. 6. 2024 |
0,03389 % | JPMorgan Private Bank (United States) | 16 976 | 2 137 | 30. 6. 2024 |
0,03294 % | Guggenheim Investments | 16 502 | -7 291 | 31. 8. 2024 |
0,03265 % | UBS Asset Management (Switzerland) | 16 354 | 4 400 | 30. 6. 2024 |